Holistic Remedies · Ingredient
Sanguinarine
Formula: C20H14NO4+ · MW: 332.3350000000001 · Drug-likeness: 0.365
⚗️ Identity
Name
Sanguinarine
Aliases / Synonyms
2447-54-3; Pseudochelerythrine; Sanguinarin; sangvinarin; SANGUINARIUM; Veadent; Sangrovit; Dimethylenedioxy benzphenanthridine; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-
🧪 Chemistry
Molecular Weight
332.3350
LogP
3.4281
Drug-likeness
0.365
Oral Bioavailability
37.8080
H-Bond Acceptors
4
🔗 External References
0
Clinical Trials
0
Meta-Analyses
13
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31819036
Sanguinarine inhibits epithelial-mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma
Cell Death Dis · 2019
PMID 31402318
Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling
Cell Chem Biol · 2019
PMID 31163195
p53-dependent upregulation of miR-16-2 by sanguinarine induces cell cycle arrest and apoptosis in hepatocellular carcinoma
Cancer Lett · 2019
PMID 30735839
Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage
Free Radic Biol Med · 2019
PMID 27154977
Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine
Free Radic Biol Med · 2016
PMID 26472194
ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine
Free Radic Biol Med · 2015