natural remedies · Ingredient
Silymarin
Formula: C25H22O10 · MW: 482.4410000000002 · Drug-likeness: 0.374
⚗️ Identity
Name
Silymarin
Aliases / Synonyms
Silybin; 65666-07-1; Legalon; 84604-20-6; (2R,3R)-3,5,7-trihydroxy-2-[(2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; Silibin; 142796-20-1; 36804-17-8; Apihepar
🧪 Chemistry
Molecular Weight
482.4410
LogP
2.3627
Drug-likeness
0.374
H-Bond Acceptors
10
H-Bond Donors
5
Rotatable Bonds
4
🔗 External References
24
Clinical Trials
11
Meta-Analyses
9
PubMed References
Top Conditions Studied with Silymarin
Non-Alcoholic Fatty Liver Disease 4
Hepatitis C 2
Melasma 2
HIV Infections|Hepatitis C 1
Breast Cancer|Peripheral Neuropathy|Cardiac Toxicities|Hepat 1
inflammation and oxidative stress 1
Hepatitis C|Non-Alcoholic Fatty Liver Disease 1
Atrial Fibrillation New Onset 1
Cardiometabolic syndrome (CMS) is a combination of disorders 1
Hepatitis C, Chronic 1
b-thalassemia major, and the role of silymarin in patients o 1
Upper GI Cancer|Cisplatin Adverse Reaction 1
📋 Sample Trials
NCT01018615
Safety, Metabolism, and Antioxidant Activity of Silymarin and Green Tea Extract in Patients With Chronic Hepatitis C
Completed · Phase 1 · Chronic Hepatitis C|Oxidative Stress
NCT01292161
Effects of Silybum Marianum on Treatment of Patients With Chronic Hepatitis C
Completed · Phase 2 · Hepatitis C
NCT03659058
Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR
Completed · Fibrosis, Liver
NCT03982849
Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma
Completed · Phase 2 · Melasma
NCT00030030
Evaluating Silymarin for Chronic Hepatitis C
Completed · Phase 2 · Hepatitis C, Chronic
NCT00055718
Silymarin (Milk Thistle Extract) in Treating Patients With Acute Lymphoblastic Leukemia Who Are Receiving Chemotherapy
Completed · Phase 2 · Drug/Agent Toxicity by Tissue/Organ|Leuk
📊 Sample Meta-Analyses
CRD42020207994
The effects of silymarin administration on type 2 diabetes mellitus: a systematic review and meta-analysis
Metabolic status in patients with type 2 diabetes mellitus.
CRD42021267070
The efficacy of silymarin treatment for non-alcoholic fatty liver disease or non-alcoholic steatohepatitis: a systematic review and meta-analysis
The NAFLD is a common chronic liver disease. It influences life health worldwide
CRD42022353487
Effects of silymarin on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials
The prevalence of metabolic syndrome (MetS), a complex of metabolic abnormalitie
CRD42018088484
Effectiveness of silymarin for patients with beta-thalassemia major
Silymarin Silymarin for patients with beta-thalassemia major
CRD42017071315
The therapeutic value of silymarin and conventional iron chelation therapy combinations in b-thalassemia major patients
b-thalassemia major, and the role of silymarin in patients on traditional iron c
CRD42023421876
Effect of silymarin supplementation on liver, kidney and oxidative stress Markers: A GRADE-assessed systematic review and meta-analysis
Milk thistle (Silybum marianum (L.) Gaertn), as a herb has been used as a herbal
📚 Sample References
PMID 20964710
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
J Pineal Res · 2011
PMID 20578796
Silymarin: a novel antioxidant with antiglycation and antiinflammatory properties in vitro and in vivo
Antioxid Redox Signal · 2011
PMID 33577847
Silymarin nanoliposomes attenuate renal injury on diabetic nephropathy rats via co-suppressing TGF-β/Smad and JAK2/STAT3/SOCS1 pathway
Life Sci · 2021
PMID 35056941
The Beneficial Additive Effect of Silymarin in Metformin Therapy of Liver Steatosis in a Pre-Diabetic Model
Pharmaceutics · 2021
PMID 35154575
Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial
Oxid Med Cell Longev · 2022
PMID 35326098
The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
Antioxidants (Basel) · 2022
🏥 Linked Health Topics 8 · matched via study conditions