natural remedies · Ingredient
Stigmasterol
Formula: C29H48O · MW: 412.7020000000002 · Drug-likeness: 0.457
⚗️ Identity
Name
Stigmasterol
Aliases / Synonyms
83-48-7; Stigmasterin; beta-Stigmasterol; Stigmasta-5,22-dien-3beta-ol; (24S)-5,22-Stigmastadien-3beta-ol; Stigmasta-5,22-dien-3-beta-ol; UNII-99WUK5D0Y8; Stigmasta-5,22-dien-3-ol, (3beta,22E)-; Delta5-Stigmasterol
🧪 Chemistry
Molecular Weight
412.7020
LogP
7.8008
Drug-likeness
0.457
H-Bond Acceptors
1
H-Bond Donors
1
Rotatable Bonds
5
🔗 External References
0
Clinical Trials
0
Meta-Analyses
6
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 24107941
Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study
J Neurosci · 2013
PMID 24107776
Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease
Sci Transl Med · 2013
PMID 31759199
Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine
J Nutr Biochem · 2020
PMID 33041661
Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway
Cancer Cell Int · 2020
PMID 33285471
The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons
Phytomedicine · 2021
PMID 33708631
Stigmasterol Simultaneously Induces Apoptosis and Protective Autophagy by Inhibiting Akt/mTOR Pathway in Gastric Cancer Cells
Front Oncol · 2021
🔗 Knowledge Graph Connections
Open full graph →Real research connections from HERB 2.0, TCMSP, and clinical evidence sources. 25 related entities shown — click any to follow the trail.
🌿 Herbs containing this compound · 1
🧬 Gene targets · 12
Prostaglandin G/H synthase 2
binding 0.898
Amine oxidase [flavin-containing] B
binding 0.864
Prostaglandin G/H synthase 1
binding 0.857
Amine oxidase [flavin-containing] A
binding 0.841
Muscarinic acetylcholine receptor M1
binding 0.839
Muscarinic acetylcholine receptor M3
binding 0.831
Leukotriene A-4 hydrolase
binding 0.825
Mineralocorticoid receptor
binding 0.822
Muscarinic acetylcholine receptor M2
binding 0.821
NCOA1
NCOA1
binding 0.821
PGR
PGR
binding 0.818
Alcohol dehydrogenase 1C
binding 0.817
🏥 Linked health topics · 12
Abdominal aortic aneurysm
disease
Acute ureteric colic
disease
Adenomatous polyposis
disease
Airway hyperreactivity
disease
Alcoholism
disease
Alzheimer'S Disease
syndrome
Analgesics
disease
Anxiety disorder, unspecified
disease
Anxiety Disorders
group
Arterial embolism and thrombosis
disease
Arthritis
syndrome
Asthma
syndrome