natural remedies · Ingredient
Taxifolin
Formula: C15H12O7 · MW: 304.254 · Drug-likeness: 0.501
⚗️ Identity
Name
Taxifolin
Aliases / Synonyms
480-18-2; (+)-Taxifolin; dihydroquercetin; Distylin; Taxifoliol; 24198-97-8; (2R,3R)-Dihydroquercetin; (+)-Dihydroquercetin; Lavitol
🧪 Chemistry
Molecular Weight
304.2540
LogP
1.1863
Drug-likeness
0.501
Oral Bioavailability
57.8420
H-Bond Acceptors
7
H-Bond Donors
5
Rotatable Bonds
1
🔗 External References
1
Clinical Trials
0
Meta-Analyses
18
PubMed References
Top Conditions Studied with Taxifolin
📋 Sample Trials
NCT05190432
Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
Active_Not_Recruiting · Antioxidative Stress|Cold|Influenza|Agin
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31036637
Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy
Proc Natl Acad Sci U S A · 2019
PMID 32120244
Dihydroquercetin protects against renal fibrosis by activating the Nrf2 pathway
Phytomedicine · 2020
PMID 32508636
Dihydroquercetin Activates AMPK/Nrf2/HO-1 Signaling in Macrophages and Attenuates Inflammation in LPS-Induced Endotoxemic Mice
Front Pharmacol · 2020
PMID 32828744
Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular regeneration
Chem Biol Interact · 2020
PMID 33157091
Taxifolin improves disorders of glucose metabolism and water-salt metabolism in kidney via PI3K/AKT signaling pathway in metabolic syndrome rats
Life Sci · 2020
PMID 33325949
Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis
Food Funct · 2021
🔗 Knowledge Graph Connections
Open full graph →Real research connections from HERB 2.0, TCMSP, and clinical evidence sources. 25 related entities shown — click any to follow the trail.
🌿 Herbs containing this compound · 1
🧬 Gene targets · 12
Prostaglandin G/H synthase 2
binding 0.873
Heat shock protein HSP 90
binding 0.833
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform
binding 0.813
Aldose reductase
binding 0.793
Prostaglandin G/H synthase 1
binding 0.793
Retinoic acid receptor RXR-alpha
binding 0.786
Apolipoprotein B-100
DGAT2
DGAT2
ICAM1
ICAM1
Metal-binding activator 1
Microsomal triglyceride transfer protein large subunit
Transcription factor p65
🏥 Linked health topics · 12
Abdominal aortic aneurysm
disease
Adenomatous polyposis
disease
Alzheimer'S Disease
syndrome
Analgesics
disease
Angioedema
phenotype
Arthritis
syndrome
Bladder cancer
disease
Breast cancer
disease
Cancer, unspecific
disease
Carcinoma in situ, unspecified
disease
Cardiovascular disease, unspecified
disease
Carpal Tunnel Syndrome
syndrome