Holistic Remedies · Ingredient
Tetrandrine
Formula: C38H42N2O6 · MW: 622.7620000000003 · Drug-likeness: 0.238
⚗️ Identity
Name
Tetrandrine
Aliases / Synonyms
518-34-3; D-Tetrandrine; (+)-Tetrandrine; Tetrandrin; Fanchinine; Sinomenine A; (S,S)-Tetrandrine; hanjisong; DL-Tetrandine
🧪 Chemistry
Molecular Weight
622.7620
LogP
7.1624
Drug-likeness
0.238
Oral Bioavailability
26.6400
H-Bond Acceptors
8
Rotatable Bonds
4
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
WVTKBKWTSCPRNU-KYJUHHDHSA-N
0
Clinical Trials
1
Meta-Analyses
19
PubMed References
Top Conditions Studied with Tetrandrine
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
CRD42021242651
Tetrandrine combined with acetylcysteine for the treatment of silicosis：A systematic review and meta-analysis
Silicosis is an occupational lung disease mainly characterized by diffuse fibros
📚 Sample References
PMID 30674869
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis
Cell Death Dis · 2019
PMID 29866132
Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy
J Exp Clin Cancer Res · 2018
PMID 29700286
c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation
Cell Death Dis · 2018
PMID 29605511
Tetrandrine inhibits deregulated cell cycle in pancreatic cancer cells: Differential regulation of p21Cip1/Waf1, p27Kip1 and cyclin D1
Cancer Lett · 2018
PMID 29401630
Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase
FASEB J · 2018
PMID 29334999
The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells
J Exp Clin Cancer Res · 2018