Holistic Remedies · Ingredient
Trans-caffeic acid
Formula: C9H8O4 · MW: 180.159 · Drug-likeness: 0.472
⚗️ Identity
Name
Trans-caffeic acid
Aliases / Synonyms
caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 501-16-6; 3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; (E)-3-(3,4-dihydroxyphenyl)acrylic acid
🧪 Chemistry
Molecular Weight
180.1590
LogP
1.1956
Drug-likeness
0.472
H-Bond Acceptors
3
H-Bond Donors
3
Rotatable Bonds
2
🔗 External References
4
Clinical Trials
3
Meta-Analyses
5
PubMed References
Top Conditions Studied with Trans-caffeic acid
📋 Sample Trials
NCT02556814
Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
Completed · Phase 4 · Immune Thrombocytopenia
NCT04648917
GASC1 Inhibitor Caffeic Acid for Squamous Esophageal Cell Cancer (ESCC)
Unknown · Phase 3 · Esophagus Cancer, Stage III
NCT02351622
Caffeic Acid Tablets as a Second-line Therapy for ITP
Completed · Phase 3 · Immune Thrombocytopenia
NCT03070262
The Efficacy and Safety of Caffeic Acid for Esophageal Cancer
Unknown · Phase 3 · Esophagus Cancer
📊 Sample Meta-Analyses
CRD42021215920
Caffeic acid and its derivatives potential therapeutics effects on different melanoma cell lines: a project to a sistematic review
CRD42023408316
Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a systematic review and meta-analysis
The main ingredient of caffeic acid tablet is caffeic acid, also known as "3, 4-
CRD42023408324
Efficacy and safety of caffeic acid tablets in the treatment of thrombocytopenia: a systematic review and meta-analysis
Thrombocytopenias
📚 Sample References
PMID 33432954
Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models
Food Funct · 2021
PMID 33562019
Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib
Int J Mol Sci · 2021
PMID 33567596
Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
Nutrients · 2021
PMID 33785337
Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats
Life Sci · 2021
PMID 36191632
The novel prolyl hydroxylase-2 inhibitor caffeic acid upregulates hypoxia inducible factor and protects against hypoxia
Eur J Pharmacol · 2022