Holistic Remedies · Ingredient
Tripterine
Formula: C29H38O4 · MW: 450.6190000000003 · Drug-likeness: 0.466
⚗️ Identity
Name
Tripterine
Aliases / Synonyms
celastrol; 34157-83-0; Tripterin; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; NSC 70931; UNII-L8GG98663L; CHEBI:63959; L8GG98663L
🧪 Chemistry
Molecular Weight
450.6190
LogP
6.6977
Drug-likeness
0.466
Oral Bioavailability
17.8410
H-Bond Acceptors
3
H-Bond Donors
2
Rotatable Bonds
1
🔗 External References
0
Clinical Trials
0
Meta-Analyses
24
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 30268831
Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function
EBioMedicine · 2018
PMID 31040884
LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer
Ther Adv Med Oncol · 2019
PMID 31982489
SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells
Pharmacol Res · 2020
PMID 31635084
Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ-TEAD Biosensors
Cancers (Basel) · 2019
PMID 31053160
Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
J Exp Clin Cancer Res · 2019
PMID 30821426
The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms
Aging Cell · 2019