Holistic Remedies · Ingredient
Ursodeoxycholic acid
Formula: C24H40O4 · MW: 392.5800000000002 · Drug-likeness: 0.659
⚗️ Identity
Name
Ursodeoxycholic acid
Aliases / Synonyms
ursodiol; 128-13-2; Actigall; ursodeoxycholate; UDCA; Ursofalk; Ursolvan; Ursodesoxycholic acid; UrSO
🧪 Chemistry
Molecular Weight
392.5800
LogP
4.4779
Drug-likeness
0.659
H-Bond Acceptors
3
H-Bond Donors
3
Rotatable Bonds
4
🔗 External References
46
Clinical Trials
20
Meta-Analyses
7
PubMed References
Top Conditions Studied with Ursodeoxycholic acid
Primary Biliary Cholangitis 4
Healthy 3
Liver Cirrhosis, Biliary 2
Primary Biliary Cirrhosis 2
Cholestasis is a common pediatric disease with an incidence 1
Fibrosis, Liver 1
Rheumatoid Arthritis 1
Bone Regeneration 1
Primary biliary cirrhosis; bezafibrate; ursodeoxycholic acid 1
Liver Transplantation|Ischemia-reperfusion Injury|Cholestasi 1
Cholelithiasis is highly incident after bariatric surgery, r 1
Diarrhea 1
📋 Sample Trials
NCT03659058
Impact of Ursodeoxycholic Acid, Silymarin, Antioxidants and Colchicine on Fibrosis Regression in HCV After SVR
Completed · Fibrosis, Liver
NCT01857284
Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis
Completed · Phase 3 · Primary Biliary Cirrhosis
NCT00200343
Efficacy and Safety Study of Ursodeoxycholic Acid to Treat Chronic Hepatitis C
Completed · Phase 3 · Chronic Hepatitis C
NCT01073202
Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation
Completed · Liver Transplantation|Ischemia-reperfusi
NCT01088607
Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis
Completed · Phase 1 · Primary Sclerosing Cholangitis
NCT01149304
Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity
Completed · Phase 2 · Colorectal Cancer|Liver Metastases|Irrad
📊 Sample Meta-Analyses
CRD42022343104
Role of Ursodeoxycholic acid in preventing parenteral nutrition associated liver disease in neonates
Neonates with TPN induced cholestasis and UCDA
CRD42021266663
Role of Ursodeoxycholic Acid in Neonatal Indirect Hyperbilirubinemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Neonatal jaundice is a hyperbilirubinemia manifesting as a yellowish discolorati
CRD42021223744
Effects of ursodeoxycholic acid and its taurine/glycine conjugated species on apoptosis, oxidative stress and inflammation in the brain: A systematic review
CRD42021234064
Ursodeoxycholic acid in the treatment of neonatal jaudice:a systematic review and meta-analysis
Neonatal hyperbilirubinemia is one of the most common diseases that requires med
CRD42022326534
Effect of ursodeoxycholic acid on the outcome of biliary atresia: A systematic review and meta-analysis
Biliary atresia (BA) is a common hepatic disease affecting only neonates and inf
CRD42022354052
Efficacy and safety of ursodeoxycholic acid in children with cholestasis: a systematic review and meta-analysis
Cholestasis is a common pediatric disease with an incidence rate of about 1/5 00
📚 Sample References
PMID 31812332
Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis
J Autoimmun · 2020
PMID 31960968
Ursodeoxycholic acid attenuates the expression of proinflammatory cytokines in periodontal cells
J Periodontol · 2020
PMID 31985529
Ursodeoxycholic Acid Treatment Preferentially Improves Overall Survival Among African Americans With Primary Biliary Cholangitis
Am J Gastroenterol · 2020
PMID 32004633
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2
Free Radic Biol Med · 2020
PMID 33178028
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway
Front Pharmacol · 2020
PMID 33710617
Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis
Eur J Immunol · 2021
🏥 Linked Health Topics 12 · matched via study conditions
Rheumatoid Arthritis
syndrome
Primary Biliary Cirrhosis
syndrome
Cholestasis
syndrome
Diarrhea
phenotype
Short Bowel Syndrome
syndrome
Gestational Diabetes
phenotype
Fibrosis, Liver
syndrome
Rhegmatogenous Retinal Detachment
syndrome
Non-Alcoholic Fatty Liver Disease
syndrome
Primary Sclerosing Cholangitis
syndrome
Colorectal cancer
disease
Gastric Cancer
disease