Holistic Remedies · Ingredient
Ursolic acid
Formula: C30H48O3 · MW: 456.7110000000002 · Drug-likeness: 0.414
⚗️ Identity
Name
Ursolic acid
Aliases / Synonyms
77-52-1; Prunol; Malol; Urson; 3beta-Hydroxyurs-12-en-28-oic acid; Micromerol; (3beta)-3-Hydroxyurs-12-en-28-oic acid; (+)-Ursolic acid; 3beta-Hydroxy-12-ursen-28-ic acid
🧪 Chemistry
Molecular Weight
456.7110
LogP
7.0895
Drug-likeness
0.414
Oral Bioavailability
16.7750
H-Bond Acceptors
2
H-Bond Donors
2
Rotatable Bonds
1
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
WCGUUGGRBIKTOS-GPOJBZKASA-N
4
Clinical Trials
3
Meta-Analyses
38
PubMed References
Top Conditions Studied with Ursolic acid
📋 Sample Trials
NCT04421716
Testing the Bioavailability of Phytonutrients, Curcumin and Ursolic Acid
Completed · Early_Phase 1 · Bioavailability of Phytonutrients
NCT02337933
Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome
Completed · Phase 2 · Metabolic Syndrome X
NCT02401113
Effect of Ursolic Acid of Loquat Extract on Function of Muscle
Completed · Phase 2|Phase 3 · Sarcopenia
NCT05776862
Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)
Recruiting · Phase 2 · Spinal Cord Injuries|Tetraplegia|Paraple
📊 Sample Meta-Analyses
CRD42020202069
Systematic Review of Curcumin and Ursolic Acid in Relation to Prostate Cancer
Prostate cancer
CRD42023439138
Anti-inflammatory and antioxidant activity of ursolic acid: A systematic review and meta-analysis
Ursolic acid is a naturally occurring pentacyclic triterpene carboxylic acid pri
CRD42023428067
The effects of ursolic acid on cardiometabolic risk factors: A systematic review and meta-analysis of randomized controlled trials
Cardiovascular disease (CVD) is the significant reason for morbidity and mortali
📚 Sample References
PMID 31322286
Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations
Br J Pharmacol · 2019
PMID 29799788
Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1
FASEB J · 2018
PMID 28334682
Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation
Redox Biol · 2017
PMID 27897418
Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease
J Cachexia Sarcopenia Muscle · 2017
PMID 27472952
Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer
Protein Cell · 2016
PMID 27036874
Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
J Exp Clin Cancer Res · 2016
🏥 Linked Health Topics 2 · matched via study conditions