Holistic Remedies · Ingredient
Xanthohumol
Formula: C21H22O5 · MW: 354.402 · Drug-likeness: 0.411
⚗️ Identity
Name
Xanthohumol
Aliases / Synonyms
6754-58-1; 569-83-5; Xantho-flav; 1-(2,4-Dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; UNII-T4467YT1NT; (E/Z)-Xanthohumol; T4467YT1NT; (E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; CHEBI:66331
🧪 Chemistry
Molecular Weight
354.4020
LogP
4.2168
Drug-likeness
0.411
Oral Bioavailability
1.0180
H-Bond Acceptors
5
H-Bond Donors
3
Rotatable Bonds
6
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
ORXQGKIUCDPEAJ-YRNVUSSQSA-N
6
Clinical Trials
0
Meta-Analyses
13
PubMed References
Top Conditions Studied with Xanthohumol
📋 Sample Trials
NCT02432651
Xanthohumol and Prevention of DNA Damage
Completed · Phase 1 · Oxidative Stress
NCT03735420
Xanthohumol Metabolism and Signature
Active_Not_Recruiting · Phase 1 · Healthy
NCT04590508
A Phase 2 Clinical Trial: Xanthohumol Metabolism and Signature (XMaS) in Crohn's Disease
Active_Not_Recruiting · Phase 2 · Crohn Disease
NCT04847193
Hop Compounds and Immune System
Completed · Inflammatory Response
NCT01367431
Xanthohumol and Metabolic Syndrome
Completed · Metabolic Syndrome
NCT05711212
Effects of Xanthohumol on Resting Energy Expenditure and Substrate Oxidation in Healthy Women
Completed · Resting Energy Expenditure
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 28285192
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis
Redox Biol · 2017
PMID 28188927
Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release
Free Radic Biol Med · 2017
PMID 25843659
Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded protein response
Free Radic Biol Med · 2015
PMID 23503627
Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis
Arch Toxicol · 2013
PMID 32509787
Xanthohumol Inhibits the Growth of Keratin 18-Overexpressed Esophageal Squamous Cell Carcinoma in vitro and in vivo
Front Cell Dev Biol · 2020
PMID 33036258
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D3 Plus Nicotine
Antioxidants (Basel) · 2020
🏥 Linked Health Topics 1 · matched via study conditions