Holistic Remedies · Ingredient
Zerumbone
Formula: C15H22O · MW: 218.3399999999999 · Drug-likeness: 0.556
⚗️ Identity
Name
Zerumbone
Aliases / Synonyms
471-05-6; (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one; (E,E,E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one; 2E,6E,9E-humulatrien-8-one; CHEBI:63892; CHEMBL245412; Zerumbone (6CI,7CI); erumbone; MFCD03700769
🧪 Chemistry
Molecular Weight
218.3400
LogP
4.2144
Drug-likeness
0.556
Oral Bioavailability
49.7590
H-Bond Acceptors
1
🔗 External References
0
Clinical Trials
0
Meta-Analyses
11
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 23035900
Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells
J Biomed Sci · 2012
PMID 32066466
Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling
J Neuroinflammation · 2020
PMID 32194397
Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models
Front Pharmacol · 2020
PMID 32454937
Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation
Oxid Med Cell Longev · 2020
PMID 34045963
Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages
Front Pharmacol · 2021
PMID 34046952
Zerumbone, a ginger sesquiterpene, inhibits migration, invasion, and metastatic behavior of human malignant glioblastoma multiforme in vitro
Biofactors · 2021