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Each record is a registered study, a systematic-review registration or a publication. A registered or ongoing study is not a finding, and animal or cell research does not show an effect in people. The same study can appear under more than one subject, so the number of records is not a count of independent studies. You can also search an exact DOI, PubMed ID, NCT or CRD number. How to read these records.

46 study records (showing up to 30 per record type)

• Registered trial NCT06030141 Not completed: Recruiting
  Investigation of the Effect of Nigella Sativa Oil and Sesame Oil in Preventing Phlebitis
  Condition or outcome area: Phlebitis|Peripheral Venous Catheterization
  2023-11-15 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT05952102 Not completed: Recruiting
  Nigella Sativa as an Adjuvant Therapy in the Treatment of Pediatric Pneumonia
  Condition or outcome area: Nigella Sativa Oil as an Adjuvant Therapy in the Treatment of Pneumonia
  2023-08-01 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04914767 Phase 1 Completed (results not assessed here)
  Nigella 5 in the Treatment of SARS COV2 (COVID-19)
  Condition or outcome area: SARS-CoV2 Infection
  2021-03-01 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT05069246 Phase 2 Completed (results not assessed here)
  The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on Gingival IL-6 and IL-18 and Antimicrobial Efficacy.
  Condition or outcome area: Gingivitis
  2020-12-08 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04553705 Phase 2 / Phase 3 Completed (results not assessed here)
  Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)
  Condition or outcome area: Covid19|Immunodeficiency
  2020-09-20 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04292314 Phase 2 / Phase 3 Completed (results not assessed here)
  Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia
  Condition or outcome area: Iron Overload|Oxidative Stress|Thalassemia Major
  2019-11-01 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT01735097 Completed (results not assessed here)
  Effect of Nigella Sativa in the Treatment of Palmer Arsenical Keratosis
  Condition or outcome area: Arsenical Keratosis
  2013-01 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT00327054 Phase 1 / Phase 2 Completed (results not assessed here)
  Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia
  Condition or outcome area: Hypercholesterolemia|Hypertension|Diabetes Mellitus|Metabolic Syndrome X
  2006-02 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04476420 Phase 3 Completed (results not assessed here)
  Comparative Effect of Nigella Sativa and Conventional Management for OSMF
  Condition or outcome area: Oral Submucous Fibrosis
  2021-02-11 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04981743 Not completed: Unknown
  The Efficacy of Nigella Sativa Versus VitaminD3 as Supplement Therapy in Coronavirus Disease 2019 (COVID-19)
  Condition or outcome area: Covid19
  2021-07-21 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT01531062 Phase 2 Completed (results not assessed here)
  Effect of Nigella Sativa on Lipid Profiles in Elderly
  Condition or outcome area: Dyslipidemia
  2011-09 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04686461 Not completed: Unknown
  Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis
  Condition or outcome area: Keratotic Nodular Size
  2019-10-20 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04401202 Phase 2 Completed (results not assessed here)
  Nigella Sativa in COVID-19
  Condition or outcome area: COVID-19|SARS-CoV-2
  2020-05-21 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04719247 Completed (results not assessed here)
  Clinical and Radiographic Evaluation of Turmeric, Thymus Vulgaris, Nigella Sativa and Aloe Vera as Pulpotomy Medicaments in Primary Teeth
  Condition or outcome area: Pulpitis - Irreversible
  2019-11-01 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT05245019 Completed (results not assessed here)
  Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity
  Condition or outcome area: Electrolyte Disturbance|Saliva Altered
  2022-02-01 · Subject: Hui Xiang; 茴香; Fennel Fruit; Foeniculum Vulgare · ClinicalTrials.gov
• Registered trial NCT05245019 Completed (results not assessed here)
  Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity
  Condition or outcome area: Electrolyte Disturbance|Saliva Altered
  2022-02-01 · Subject: Dou Kou; 豆蔻; Round Cardamon Fruit;Round Cardarnon Fruit; Amomi Fructus Rotundus;Fructus Amomi Rotundus · open the herb record · ClinicalTrials.gov
• Registered trial NCT03711487 Phase 2 Completed (results not assessed here)
  The Effect of Foeniculum Vulgare Ironing on Gastrointestinal Recovery After Colorectal Resection
  Condition or outcome area: Colorectal Surgery|Foeniculum|Ileus
  2018-10-20 · Subject: Hui Xiang; 茴香; Fennel Fruit; Foeniculum Vulgare · ClinicalTrials.gov
• Registered trial NCT04347382 Phase 3 Completed (results not assessed here)
  Honey & Nigella Sativa Trial Against COVID-19
  Condition or outcome area: Coronavirus Infection|Sars-CoV2
  2020-04-30 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Registered trial NCT04767087 Phase 2 / Phase 3 Not completed: Unknown
  Honey and Nigella Sativa in COVID-19 Prophylaxis
  Condition or outcome area: Covid19
  2021-03-05 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · ClinicalTrials.gov
• Systematic review registration CRD42023475329 Registered protocol, no results here: Review Ongoing
  Clinical Uses of Nigella Sativa in Pediatrics: A systematic Review of Randomized Controlled Trials
  Condition or outcome area: To study the clinical uses of Nigella sativa in pediatrics and to evaluate the safety and efficacy of using Nigella sativa in pediatrics.
  2023-11-08 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023469401 Registered protocol, no results here: Review Ongoing
  The influence of Nigella sativa for treatment of allergic rhinitis: A meta-analysis.
  Condition or outcome area: AR is a non-infectious inflammatory disease of nasal mucosa involving a variety of immune cells, cytokines and inflammatory mediators. The typical symptoms are paroxysmal sneezing, clear nose, nasal itching and nasal congestion. It can be accompanied by eye symptoms, including itching, tearing, redness and burning sensation, and recurrent .Recent studies showed that the prevalence of AR in China and Europe is 11.1 to 17.6% and 23 to 30%, respectively. At present, the clinical treatment plan of A
  2023-10-15 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023452296 Registered protocol, no results here: Review Ongoing
  Endothelial function responses to nigella sativa (black seed) supplementation: A systematic review and Meta-analysis of randomized controlled trials
  Condition or outcome area: the effect of sleep deprivation on cardiac autonomic activity.
  2023-09-04 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023449783 Registered protocol, no results here: Review Ongoing
  A systematic review and meta-analysis exploring the potential of Nigella Sativa (Black seed) in preventing and treating COVID-19 and respiratory system illnesses
  Condition or outcome area: Nigella sativa seed, a pungent herb from the Ranunculaceae family, possesses remarkable medicinal properties. In ancient Egypt, this herb was utilized in the treatment of various ailments. The N. sativa plant contains small black seeds known as black cumin, which are pharmacologically rich in Thymquinone. These seeds are also abundant in flavonoids, tannins, essential fatty acids, essential amino acids, ascorbic acid, iron and calcium. Consequently, it is believed that they exhibit analgesic qua
  2023-07-31 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023444753 Registered protocol, no results here: Review Ongoing
  Effects of Nigella Sativa Supplementation on Lipid Profiles in Adults: A systematic review and Meta-analysis of Randomized Controlled Trials
  Condition or outcome area: people with 18< years old
  2023-07-23 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023408916 Registered protocol, no results here: Review Completed published
  Effect of Nigella Sativa on adipokines: a systematic review
  Condition or outcome area: Adipokines including leptin, adiponectin, and resistin
  2023-03-28 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023470384 Registered protocol, no results here: Review Ongoing
  The effect of nigella sativa on anthropometric indicators in adults
  Condition or outcome area: In this review the effect of nigella sativa on anthropometric control will be studied
  2023-10-18 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42023390278 Registered protocol, no results here: Review Ongoing
  Nigella sativa for the treatment of COVID-19 patients: a rapid systematic review and meta-analysis of randomized controlled trials
  Condition or outcome area: COVID-19.
  2023-01-09 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42022383237 Registered protocol, no results here: Review Ongoing
  The Effect of Nigella sativa (black seed) on Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  Condition or outcome area: patients with different disease
  2022-12-22 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42022354647 Registered protocol, no results here: Review Ongoing
  The effects of nigella sativa supplementation on body composition in adults: A systematic review and dose-response meta-analysis
  Condition or outcome area: Healthy, overweight or obese individuals, and those with any metabolic non-communicable disease such as cardiovascular disorders dyslipidemia, hypercholesterolemia, metabolic syndrome
  2022-08-30 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42022347964 Registered protocol, no results here: Review Ongoing
  Effect of Nigella sativa seed supplementation on blood pressure: An updated systematic review and dose-response meta-analysis of randomized controlled trials
  Condition or outcome area: different disease
  2022-07-31 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42022328568 Registered protocol, no results here: Review Ongoing
  Effect of nigella sativa supplementation on cardiovascular risk factors in adults: A systematic review and meta-analysis of randomized controlled trials
  Condition or outcome area: The effect of Nigella sativa on cardiovascular risk factors will be examined in this review.
  2022-05-10 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42021293571 Registered protocol, no results here: Review Ongoing
  Effectiveness of the use of Nigella sativa L. in the treatment of acne: a systematic review with meta-analysis
  Condition or outcome area: Acne vulgaris is a chronic disease characterized by the presence of open and closed comedones and inflammatory lesions that mainly affect the face, chest and back. It affects approximately 80% of adolescents and young adults and requires prolonged therapy for satisfactory improvement (DIKICIER, 2019).
  2021-12-27 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42021290320 Registered protocol, no results here: Review Ongoing
  Nigella sativa (black seed) effects on plasma lipid concentrations in humans
  Condition or outcome area: The effects of Nigella sativa on lipid profiles parameters in patients with metabolic diseases, metabolic syndrome, dyslipidemia, and patients who are obese/overweight, and in healthy populations, with a particular focus on adults. Nigella sativa (black cumin or black seed), as a very helpful herbal remedy, can alter biochemical indices such as lipid profiles. An herbal supplement could therefore help in improving such conditions, along with standard drug treatments.
  2021-12-10 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42020150929 Registered protocol, no results here: Review Completed published
  The effect of Nigella sativa on lipid profiles and cardio-metabolic parameters: a protocol for a systematic review and meta-analysis
  Condition or outcome area: The effects of Nigella sativa on lipid profiles and cardio-metabolic parameters in patients with CVD (cardiovascular disease), patients with dyslipidemia, and patients who are obese/overweight, and in healthy populations, with a particular focus on adults. Nigella sativa (black cumin or black seed), as a very helpful herbal remedy, can alter biochemical indices such as lipid profiles and blood pressure, which is important as any changes in lipid profile or atherogenic factors and blood pressure
  2020-02-25 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42019133047 Registered protocol, no results here: Review Completed published
  A systematic review of the potential effects of Nigella sativa on rheumatoid arthritis
  Condition or outcome area: Rheumatoid arthritis
  2019-05-31 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42019109017 Registered protocol, no results here: Review Ongoing
  The effect of Nigella sativa on measures of antioxidant and inflammatory factors: a systematic review and meta-analysis
  Condition or outcome area: Obesity, diabetes, healthy populations, adults, and Nigella sativa supplementation. Nigella sativa or black cumin is a very beneficial herbal which can alter biochemical indices such as antioxidants and inflammatory factors. Any changes in liver and kidney parameters could indicate the development of inflammation, and many chronic diseases such as obesity or diabetes. Finding a suitable herbal treatment could help to prevent these conditions.
  2019-03-13 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42018102229 Registered protocol, no results here: Review Completed published
  The effect of cumin on the measures of liver and kidney parameters: a systematic review and meta-analysis
  Condition or outcome area: Obesity; Diabetes; healthy population; adults
  2018-07-23 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42015027655 Registered protocol, no results here: Review Completed not published
  Nigella sativa as an anticancerous drug against breast cancer: a systematic review
  Condition or outcome area: Breast Cancer
  2015-10-28 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Systematic review registration CRD42018085698 Registered protocol, no results here: Review Ongoing
  Fennel (foeniculum vulgare) on managment of menopausal symptoms
  Condition or outcome area: Menopausal symptoms including hot flashes, psychological health, insomnia and etc.
  2018-01-22 · Subject: Xiao Hui Xiang; 小茴香; Fennel; Fennel Fruit; Foeniculi Fructus; Fructus Foeniculi · open the herb record
• Systematic review registration CRD42015023725 Registered protocol, no results here: Review Ongoing
  The effect of fennel on primary dysmenorrhea: a systematic review protocol
  Condition or outcome area: Worldwide primary dysmenorrhea is one of the most important public health problems among young females which interferes with their social responsibility. Primary dysmenorrhea is defined as painful menstrual cramps of uterus without any obvious gynecological problem. The standard treatment to relieve pain is medical therapy by oral contraceptive or non steroidal anti-inflammatory drugs (NSAIDs such as Mefenamic Acid or Ibuprofen). Due to side effects of chemical therapy it seems that some herbal
  2015-06-27 · Subject: Xiao Hui Xiang; 小茴香; Fennel; Fennel Fruit; Foeniculi Fructus; Fructus Foeniculi · open the herb record
• Systematic review registration CRD42021268620 Registered protocol, no results here: Review Ongoing
  Comparative effects of nutraceuticals on body weight and waist circumference: a protocol for a network meta-analysis of randomised clinical trials
  Condition or outcome area: Effect of nutraceuticals on body weight and waist circumference in adults.
  2021-08-18 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record
• Publication PMID 35871718 Research model: Clinical Experiment
  Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial
  Condition or outcome area: atherosclerosis; coronary artery disease; endothelial dysfunction
  Phytother Res · 2022 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · DOI 10.1002/ptr.7568
• Publication PMID 35483558 Research model: Cell Experiment
  The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells
  Condition or outcome area: metabolic diseases; metabolic syndrome; diabetes; cardiovascular disease
  Biochim Biophys Acta Mol Cell Biol Lipids · 2022 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · DOI 10.1016/j.bbalip.2022.159155
• Publication PMID 33957004 Research model: Clinical Experiment
  A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients
  Condition or outcome area: hypertensive; hypertension; Hypertensive
  Phytother Res · 2021 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · DOI 10.1002/ptr.7140
• Publication PMID 32510754 Research model: Clinical Experiment
  Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus
  Condition or outcome area: type 2 diabetes mellitus
  Phytother Res · 2020 · Subject: Zai Pei Hei Zhong Cao; 栽培黑种草; Cultivated Fennelflower; Nigella Sativa · open the herb record · DOI 10.1002/ptr.6707
• Publication PMID 33502415 Research model: Animal & Cell Experiment
  Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma
  Condition or outcome area: prostate cancer; skin cancer; malignant tumors; Hepatocellular carcinoma
  Food Funct · 2021 · Subject: Hui Xiang; 茴香; Fennel Fruit; Foeniculum Vulgare · DOI 10.1039/d0fo02243h