modern wellness · Symptom
Abnormal circulating insulin-like growth factor-binding protein acid-labile subunit concentration
🩺 HPO Source
HPO ID
HPO Label
Abnormal circulating insulin-like growth factor-binding protein acid-labile subunit concentration
HPO Definition
A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier. This term refers specifically to the circulating concentration of the acid-labile subunit.
🔼 Broader Terms (1)