modern wellness · Symptom

Adrenal insufficiency

🩺 HPO Source

HPO ID

HPO Label

Adrenal insufficiency

HPO Definition

Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.

HPO Curator Comment

Adrenal insufficiency may cause persistent vomiting, anorexia, hypoglycemia, poor weight gain in a child, or unexplained weight loss in an adult, malaise, fatigue, muscular weakness, unexplained isotonic or hyponatremic dehydration, hyperkalemia, hypotension, hypoglycemia and especially generalized hyperpigmentation.

🔤 Synonyms (1)

Synonyms

Hypoadrenalism

🔗 Cross-References (4)

SNOMEDCT_US111563005

SNOMEDCT_US237785004

SNOMEDCT_US386584007

UMLSC0001623

🔼 Broader Terms (1)

HP:0011733Abnormality of adrenal physiology

🏥 Conditions where Adrenal insufficiency appears

27 · bridged via HPO ↔ OMIM

syndrome OMIM 201810

3 Beta-Hydroxysteroid Dehydrogenase Deficiency

freq: 1/4 ev: PCS

syndrome OMIM 240200

Addison Disease

phenotype OMIM 240200

Adrenal Hypoplasia

syndrome OMIM 613743

Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete

syndrome OMIM 615510

Alacrima, Achalasia, And Mental Retardation Syndrome

freq: 0/13 ev: PCS

syndrome OMIM 201750

Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis

freq: 1/3 ev: PCS

syndrome OMIM 240300

Autoimmune Polyendocrinopathy Syndrome, Type I, Autosomal Dominant

freq: 49/68 ev: PCS

disease OMIM 240200

Congenital Absence of Adrenal Gland

syndrome OMIM 307030

Deficiency of Glycerol Kinase

freq: 20/20 ev: TAS

syndrome OMIM 231550

Glucocorticoid Deficiency With Achalasia

freq: 15/17 ev: PCS

syndrome OMIM 240200

Hypoadrenocorticism, Familial

syndrome OMIM 300166

Microphthalmia, Syndromic 2

freq: HP:0040283 ev: TAS

phenotype OMIM 617053

Mirage Syndrome

freq: 11/11 ev: PCS

syndrome OMIM 618238

Mitochondrial Complex I Deficiency, Nuclear Type 16

freq: 1/1 ev: PCS

syndrome OMIM 609981

Natural Killer Cell Deficiency, Familial Isolated

freq: 6/6 ev: PCS

syndrome OMIM 617575

Nephrotic Syndrome, Type 14

syndrome OMIM 262600

Panhypopituitarism

syndrome OMIM 202370

Peroxisome Biogenesis Disorder 2B

syndrome OMIM 614863

Peroxisome Biogenesis Disorder 4B

syndrome OMIM 262600

Pituitary Dwarfism Type 3

syndrome OMIM 262700

Pituitary Hormone Deficiency, Combined, 4

syndrome OMIM 240300

Polyglandular Deficiency Syndrome, Persian-Jewish Type

freq: 49/68 ev: PCS

syndrome OMIM 240300

Polyglandular Type I Autoimmune Syndrome

freq: 49/68 ev: PCS

syndrome OMIM 176270

Prader-Willi Syndrome

freq: 1/82 ev: PCS

syndrome OMIM 609734

Proopiomelanocortin Deficiency

syndrome OMIM 278000

freq: 1/1 ev: PCS

syndrome OMIM 300200

X-Linked Adrenal Hypoplasia