modern wellness · Symptom

Hyperkeratosis

🩺 HPO Source

HPO ID

HPO Label

Hyperkeratosis

HPO Definition

Hyperkeratosis is a histopathological term defining a thickened stratum corneum and may be present in many different skin conditions, with many possible overlaps. Hyperkeratosis refers to the increased thickness of the stratum corneum, the outer layer of the skin. Hyperkeratosis is subclassified as orthokeratotic or parakeratotic. Orthokeratotic hyperkeratosis refers to the thickening of the keratin layer with preserved keratinocyte maturation, while parakeratotic hyperkeratosis shows retained n

🔤 Synonyms (1)

Synonyms

Epidermal hyperkeratosis

🔗 Cross-References (5)

MEDDRA10020649

SNOMEDCT_US26996000

SNOMEDCT_US396228006

SNOMEDCT_US399955009

UMLSC0870082

🔼 Broader Terms (1)

HP:0011368Epidermal thickening

🏥 Conditions where Hyperkeratosis appears

40 · bridged via HPO ↔ OMIM

syndrome OMIM 101850

Acrokeratoelastoidosis of Costa

syndrome OMIM 101900

Acrokeratosis Verruciformis of Hopf

freq: 1/1 ev: PCS

syndrome OMIM 615510

Alacrima, Achalasia, And Mental Retardation Syndrome

freq: 3/11 ev: PCS

syndrome OMIM 308300

Bloch Sulzberger Syndrome

syndrome OMIM 617052

Bone Marrow Failure Syndrome 3

freq: 1/4 ev: PCS

disease OMIM 115150

Cardio-Facio-Cutaneous Syndrome

freq: 7/17 ev: PCS

syndrome OMIM 615279

Cardiofaciocutaneous Syndrome 3

freq: 3/3 ev: PCS

syndrome OMIM 615821

Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis

freq: 1/1 ev: PCS

syndrome OMIM 615522

syndrome OMIM 167900

Confluent And Reticulate Papillomatosis

syndrome OMIM 612379

Congenital Disorder of Glycosylation Type 1Q

syndrome OMIM 609180

Congenital Disorder of Glycosylation, Type If

syndrome OMIM 614576

Congenital Disorder of Glycosylation, Type Iil

freq: 3/5 ev: PCS

syndrome OMIM 610768

Congenital Disorder of Glycosylation, Type Im

freq: 1/4 ev: PCS

syndrome OMIM 308050

Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects

freq: 2/2 ev: PCS

syndrome OMIM 246200

Donohue Syndrome

syndrome OMIM 129900

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

syndrome OMIM 604292

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3

syndrome OMIM 615028

Epidermolysis Bullosa, Nonspecific, Autosomal Recessive

freq: 1/1 ev: PCS

disease OMIM 131850

Epidermolysis Bullosa, Pretibial

syndrome OMIM 617525

Erythrokeratodermia Variabilis Et Progressiva 3

freq: 3/3 ev: PCS

syndrome OMIM 617526

Erythrokeratodermia Variabilis Et Progressiva 4

freq: 4/4 ev: PCS

syndrome OMIM 133190

Erythrokeratodermia With Ataxia

freq: 14/19 ev: PCS

syndrome OMIM 608013

Gaucher Disease, Perinatal Lethal

syndrome OMIM 145250

Hyperpigmentation, Familial Progressive

syndrome OMIM 137940

Hypotrichosis, Lymphedema, Telangiectasia, Renal Defect Syndrome

syndrome OMIM 308205

Ichthyosis Follicularis Atrichia Photophobia Syndrome

freq: 1/13 ev: PCS

syndrome OMIM 256500

Ichthyosis Linearis Circumflexa

freq: 4/4 ev: PCS

syndrome OMIM 602400

Ichthyosis With Hypotrichosis, Autosomal Recessive

syndrome OMIM 615024

Ichthyosis, Congenital, Autosomal Recessive 10

disease OMIM 617574

Ichthyosis, Congenital, Autosomal Recessive 13

disease OMIM 617571

Ichthyosis, Congenital, Autosomal Recessive 14

freq: 6/6 ev: PCS

syndrome OMIM 242100

Ichthyosis, Congenital, Autosomal Recessive 2

syndrome OMIM 606545

Ichthyosis, Congenital, Autosomal Recessive 3

syndrome OMIM 612281

Ichthyosis, Congenital, Autosomal Recessive 6

freq: 6/23 ev: PCS

syndrome OMIM 613943

Ichthyosis, Congenital, Autosomal Recessive 8

freq: 1/1 ev: PCS

syndrome OMIM 615023

Ichthyosis, Congenital, Autosomal Recessive 9

freq: 5/5 ev: PCS

syndrome OMIM 602540

Ichthyosis, Hystrix-Like, With Deafness

syndrome OMIM 614457

Ichthyosis, Spastic Quadriplegia, And Mental Retardation

syndrome OMIM 246200

Insulin Receptor, Defect In