modern wellness · Symptom

Palmoplantar hyperkeratosis

🩺 HPO Source

HPO ID

HPO Label

Palmoplantar hyperkeratosis

HPO Definition

Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot.

HPO Curator Comment

The terms hyperkeratosis and keratoderma have been used interchangeably throughout the literature.

🔤 Synonyms (7)

Synonyms

Hyperkeratosis of palms and solesHyperkeratosis of the palms and solesPalmoplantar keratosesPalmoplantar keratosisThick palms and solesThickened palms and solesThickening of the outer layer of the skin of the palms and soles

🔗 Cross-References (2)

SNOMEDCT_US706885006

UMLSC0022596

🔼 Broader Terms (2)

HP:0007556Plantar hyperkeratosis

HP:0010765Palmar hyperkeratosis

🏥 Conditions where Palmoplantar hyperkeratosis appears

40 · bridged via HPO ↔ OMIM

syndrome OMIM 170650

Aggressive Periodontitis

freq: 0/4 ev: PCS

syndrome OMIM 617388

Autoinflammation With Arthritis And Dyskeratosis

freq: 3/3 ev: PCS

syndrome OMIM 615280

Cardiofaciocutaneous Syndrome 4

freq: 3/3 ev: PCS

syndrome OMIM 605676

Cardiomyopathy Dilated With Woolly Hair And Keratoderma

freq: 1/2 ev: PCS

syndrome OMIM 158350

Cerebellar Granule Cell Hypertrophy And Megalencephaly

syndrome OMIM 158350

Cerebelloparenchymal Disorder Vi

syndrome OMIM 242300

Collodion Fetus

freq: 16/17 ev: PCS

syndrome OMIM 242300

Congenital Ichthyosis

freq: 16/17 ev: PCS

syndrome OMIM 609165

Congenital Reticular Ichthyosiform Erythroderma

freq: 4/6 ev: PCS

syndrome OMIM 615108

Cowden Syndrome 5

syndrome OMIM 259100

Cranioosteoarthropathy

disease OMIM 125595

Dermatopathia Pigmentosa Reticularis

syndrome OMIM 613989

Dyskeratosis Congenita, Autosomal Dominant 2

syndrome OMIM 224230

Dyskeratosis Congenita, Autosomal Recessive 1

freq: 3/3 ev: PCS

syndrome OMIM 602032

Ectodermal Dysplasia, Pure Hair-Nail Type

freq: 0/8 ev: PCS

syndrome OMIM 604536

Ectodermal Dysplasia/ Skin Fragility Syndrome

freq: 2/2 ev: PCS

syndrome OMIM 226670

Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy

syndrome OMIM 131760

Epidermolysis Bullosa Herpetiformis Dowling-Meara

disease OMIM 131900

Epidermolysis Bullosa Simplex Kobner

freq: 2/5 ev: PCS

syndrome OMIM 615425

Epidermolysis Bullosa Simplex, Autosomal Recessive 2

freq: 0/1 ev: PCS

syndrome OMIM 609165

Erythrokeratoderma, Reticular

freq: 4/6 ev: PCS

syndrome OMIM 617526

Erythrokeratodermia Variabilis Et Progressiva 4

freq: 4/4 ev: PCS

syndrome OMIM 231550

Glucocorticoid Deficiency With Achalasia

disease OMIM 158350

Hamartoma Syndrome, Multiple

syndrome OMIM 129500

Hidrotic Ectodermal Dysplasia

disease OMIM 113800

Hyperkeratosis, Epidermolytic

syndrome OMIM 259100

Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1

syndrome OMIM 615328

Hypohidrosis, Enamel Hypoplasia, Palmoplantar Keratoderma, Intellectual Disability Syndrome

syndrome OMIM 242300

Ichthyosis Congenita I

freq: 16/17 ev: PCS

syndrome OMIM 242300

Ichthyosis Congenita Ii

freq: 16/17 ev: PCS

disease OMIM 617574

Ichthyosis, Congenital, Autosomal Recessive 13

syndrome OMIM 607602

Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis

freq: 0/2 ev: PCS

syndrome OMIM 602540

Ichthyosis, Hystrix-Like, With Deafness

freq: 1/1 ev: PCS

syndrome OMIM 144200

Keratoderma, Palmoplantar, Diffuse

syndrome OMIM 144200

Keratoderma, Palmoplantar, Epidermolytic

syndrome OMIM 144200

Keratosis of Greither

syndrome OMIM 144200

Keratosis Palmaris Et Plantaris Familiaris

syndrome OMIM 148700

Keratosis Palmoplantaris Striata 1

freq: 15/15 ev: PCS

disease OMIM 158350

Lhermitte-Duclos Disease

syndrome OMIM 257980

Odontoonychodermal Dysplasia

freq: 2/3 ev: PCS