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Ingredient
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Gene Target
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Disease
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

1,8 cineole

Open on HERB 2.0 ↗
1
Clinical Trials
1
Meta-Analyses
5
PubMed References
Top Conditions Studied with 1,8 cineole
Community-acquired Pneumonia 1
📋 Sample Trials
NCT05002192
A Retrospective, Real-world Study of ELP Used in the Expectorant Treatment of Community-acquired Pneumonia
Unknown
📊 Sample Meta-Analyses
CRD42022294114
The Protective Effect of 1, 8-cineole (Eucalyptol) on Respiratory System：A Systematic Review and Meta-Analysis from animal studies
📚 Sample References
PMID 31883118
Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis
Br J Pharmacol · 2019
PMID 28240768
Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol
Br J Pharmacol · 2017
PMID 31926243
1,8-Cineole promotes G0/G1 cell cycle arrest and oxidative stress-induced senescence in HepG2 cells and sensitizes cells to anti-senescence drugs
Life Sci · 2020
⚗️ All Ingredient data fields for 1,8 cineole
⚗️ Identity
Name
1,8 cineole
Aliases / Synonyms
Eucalyptol; cineole; 1,8-Cineole; 470-82-6; 1,8-Cineol; Cajeputol; 1,8-Epoxy-p-menthane; Eucalyptole; Eucapur; Zineol
🧪 Chemistry
Molecular Weight
154.2530
LogP
2.7441
Drug-likeness
0.521
H-Bond Acceptors
1
🔬 Structures
Canonical SMILES
CC1(C2CCC(O1)(CC2)C)C
Isomeric SMILES
CC1(C2CCC(O1)(CC2)C)C
InChIKey
WEEGYLXZBRQIMU-UHFFFAOYSA-N
InChI
InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3
🔗 External References
HERB DB
HBIN002102 ↗
PubChem CID
2758 ↗
CAS Number
470-82-6 ↗
DrugBank
DB03852 ↗
NPASS
NPC287331
HIT
C0063
TCMID
40329; 40332; 23467; 40330; 3689; 23468; 7480; 24964; 23299; 239
TCMSP
MOL000122; MOL001016; MOL011132; MOL000904; MOL000917; MOL005970
TCM-ID
9654; 16061; 4463; 9655; 9653; 5676
🔍 Raw view — every non-empty column on this row (33 fields)
name
1,8 cineole
common names
Eucalyptol; cineole; 1,8-Cineole; 470-82-6; 1,8-Cineol; Cajeputol; 1,8-Epoxy-p-menthane; Eucalyptole; Eucapur; Zineol
herb ingredient id
HBIN002102
canonical smiles
CC1(C2CCC(O1)(CC2)C)C
isomeric smiles
CC1(C2CCC(O1)(CC2)C)C
inchi
InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3
inchikey
WEEGYLXZBRQIMU-UHFFFAOYSA-N
mol wt
154.2530
num h acceptors
1
num h donors
0
mol logp
2.7441
num rotatable bonds
0
drug likeness
0.521
cas id
470-82-6
tcmid ingredient id
40329; 40332; 23467; 40330; 3689; 23468; 7480; 24964; 23299; 239
tcmsp ingredient id
MOL000122; MOL001016; MOL011132; MOL000904; MOL000917; MOL005970
tcm id ingredient id
9654; 16061; 4463; 9655; 9653; 5676
pubchem cid
2758
drugbank id
DB03852
npass id
NPC287331
hit id
C0063

📋 Clinical Trials

1 · subject of clinical study
NCT05002192 A Retrospective, Real-world Study of ELP Used in the Expectorant Treatment of Co
→ Community-acquired Pneumonia

📊 Meta-Analyses

1 · systematic review
CRD42022294114 The Protective Effect of 1, 8-cineole (Eucalyptol) on Respiratory System：

📚 PubMed References

5 · cited research
PMID 31883118 Eucalyptol alleviates inflammation and pain responses in a mouse model of gout a
Br J Pharmacol
PMID 28240768 Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediat
Br J Pharmacol
PMID 31926243 1,8-Cineole promotes G0/G1 cell cycle arrest and oxidative stress-induced senesc
Life Sci
PMID 34685597 1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and
Cells
PMID 35964659 Eucalyptol prevents bleomycin-induced pulmonary fibrosis and M2 macrophage polar
Eur J Pharmacol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables