Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Cocaine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Cocaine

Cocaine Use Disorder 8 Cocaine Dependence 6 Cocaine-Related Disorders 3 The consumption of psychoactive substances has been consider 2 Hyperthermia|Cocaine Use|Exercise 1 Suicide Attempts, suicidal ideation or suicidal individuals 1 Any Ear Nose or Throat Conditions|With Identified Need for a 1 Cocaine’s intense stimulant effect and addictive properties 1 Epistaxis 1 Snorted consumption of cocaine has been steadily increasing. 1 Active Cocaine Users 1 Cocaine-induced destructive midline lesions, i.e. mucosal, c 1

📋 Sample Trials

NCT00451230

Metabolic Effects of Cocaine

Completed

NCT01851473

Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

Completed · Phase 1

NCT01906346

Impact of a Non-Drug Choice on Cocaine Reinforcement

Completed · Early_Phase 1

📊 Sample Meta-Analyses

CRD42023393427

Behavioral techniques in effective harm reduction interventions with cocaine users: a systematic review

Harm reduction interventions using behavior modification techniques

CRD42022378254

Acute Cocaine Use and Outcomes After Ischemic or Hemorrhage Stroke: A Systematic Review of Clinical Evidence

Ischemic and Hemorrhagic Stroke

CRD42021285082

A systematic review of the interaction of cocaine in anesthesia.

This research will clarify the main interactions of cocaine in anesthesia and wi

📚 Sample References

PMID 31557508

Chemokine CCR5 and cocaine interactions in the brain: Cocaine enhances mesolimbic CCR5 mRNA levels and produces place preference and locomotor activation that are reduced by a CCR5 antagonist

Brain Behav Immun · 2020

PMID 29859319

Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production

Neurobiol Dis · 2018

PMID 31266052

Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone

Neuropsychopharmacology · 2020

⚗️ All Ingredient data fields for Cocaine

⚗️ Identity

Name

Cocaine

Aliases / Synonyms

Benzoylmethylecgonine; Neurocaine; Kokain; L-Cocaine; Cocain; Cocaina; beta-Cocain; (-)-Cocaine; cocainum

🧪 Chemistry

Molecular Weight

303.3580

LogP

1.8677

Drug-likeness

0.798

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC

Isomeric SMILES

CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC

InChIKey

ZPUCINDJVBIVPJ-LJISPDSOSA-N

InChI

InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1

🔗 External References

HERB DB

HBIN021188 ↗

PubChem CID

446220 ↗

NPASS

NPC281104

HIT

C1115

SymMap

14724

TCMID

3860

TCM-ID

5554

🔍 Raw view — every non-empty column on this row (31 fields)

name

Cocaine

common names

Benzoylmethylecgonine; Neurocaine; Kokain; L-Cocaine; Cocain; Cocaina; beta-Cocain; (-)-Cocaine; cocainum

herb ingredient id

HBIN021188

canonical smiles

CN1C2CCC1C(C(C2)OC(=O)C3=CC=CC=C3)C(=O)OC

isomeric smiles

CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC

inchi

InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1

inchikey

ZPUCINDJVBIVPJ-LJISPDSOSA-N

mol wt

303.3580

num h acceptors

num h donors

mol logp

1.8677

num rotatable bonds

drug likeness

0.798

symmap mol id

14724

tcmid ingredient id

3860

tcm id ingredient id

5554

pubchem cid

446220

npass id

NPC281104

hit id

C1115

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Cocaine-Related Disorders

group

Cocaine Dependence

disease

📋 Clinical Trials

12 · subject of clinical study

NCT00451230 Metabolic Effects of Cocaine

→ Cocaine Dependence

NCT01851473 Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

→ Cocaine Use|Pharmacokinetics

NCT01906346 Impact of a Non-Drug Choice on Cocaine Reinforcement

→ Cocaine Dependence

NCT02141620 n-Acetylcysteine and Cocaine

→ Cocaine Abuse|Cocaine Dependence

NCT02233647 Phendimetrazine and Cocaine

→ Cocaine Use Disorder

NCT02239913 Topiramate-Phentermine Combinations for Cocaine Dependence

→ Cocaine Use Disorder

NCT02383043 Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Dr

→ Active Cocaine Users

NCT02393599 Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorc

→ Cocaine Abuse

NCT02500836 Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Top

→ Any Ear Nose or Throat Conditions|With Identified

NCT02522325 Reinforcing Effects of Cocaine During Phendimetrazine Maintenance

→ Cocaine Use Disorder

NCT03471182 Investigation of Cocaine Addiction Using mGluR5 PET and fMRI

→ Cocaine Dependence

NCT03937986 Suvorexant and Cocaine

→ Cocaine Use Disorder

📊 Meta-Analyses

12 · systematic review

CRD42023393427 Behavioral techniques in effective harm reduction interventions with cocaine use

→ Harm reduction interventions using behavior modifi

CRD42022378254 Acute Cocaine Use and Outcomes After Ischemic or Hemorrhage Stroke: A Systematic

→ Ischemic and Hemorrhagic Stroke

CRD42021285082 A systematic review of the interaction of cocaine in anesthesia.

→ This research will clarify the main interactions o

CRD42016035486 Crack-cocaine use and health consequences: systematic review and meta-analysis

CRD42017052277 Maternal, fetal and neonatal consequences associated with crack cocaine use duri

→ Crack cocaine is a drug of abuse that stimulates t

CRD42018094623 Systematic review of mortality among people with regular or problematic use of o

→ The purpose of this review is to present an update

CRD42019124464 Cocaine addiction in mental disorders: a self-medication hypothesis systematic r

→ Lifetime prevalence of drug use and dependence dis

CRD42020163942 Effectiveness of Cocaine and Psychostimulant Prevention Interventions: A Systema

→ Drug overdose deaths involving cocaine and psychos

CRD42020170154 Is the consumption of crack/cocaine and marijuana associated with the presence o

→ Periodontitis is currently defined as a chronic, m

CRD42020179683 A systematic review and meta-analysis of the prevalence of cocaine-induced psych

→ Among the psychiatric consequences of cocaine use,

CRD42021271847 Predictive factors for cocaine use disorder treatment outcomes: a systematic rev

→ Cocaine is the most commonly psychostimulant used

CRD42021272414 Effects of cocaine use on cardiovascular events: a systematic review and meta-an

→ Cardiovascular events in cocaine users

📚 PubMed References

12 · cited research

PMID 31557508 Chemokine CCR5 and cocaine interactions in the brain: Cocaine enhances mesolimbi

Brain Behav Immun

PMID 29859319 Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF productio

Neurobiol Dis

PMID 31266052 Sequential cocaine-alcohol self-administration produces adaptations in rat nucle

Neuropsychopharmacology

PMID 31805281 Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates co

Neuropharmacology

PMID 31998080 Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosom

Front Cell Neurosci

PMID 32978730 HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitoc

Mol Neurobiol

PMID 33120991 Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia

Int J Mol Sci

PMID 33485963 Cocaine abstinence modulates NMDA receptor subunit expression: An analysis of th

Prog Neuropsychopharmacol Biol Psychiatry

PMID 33505956 Effects of Cocaine on Human Glial-Derived Extracellular Vesicles

Front Cell Dev Biol

PMID 33668403 Cocaine Induces Cytoskeletal Changes in Cardiac Myocytes: Implications for Cardi

Int J Mol Sci

PMID 33905097 Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Ac

Neurosci Bull

PMID 34316031 Repeated cocaine administration upregulates CB2 receptor expression in striatal

Acta Pharmacol Sin

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables