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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Dihydroartemisinin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Dihydroartemisinin

Malaria in pregnancy 3 Uncomplicated falciparum malaria 2 Malaria 1 Polycystic Ovary Syndrome 1 Vivax Malaria 1 The systematic review focuses on malaria treatment. It conta 1 Severe Malaria; Cause of morbidity and mortality in under-fi 1 Malaria. Peripheral or placental parasitaemia 1 Malaria in pregnancy (MIP) refers to the occurrence of a mal 1

📋 Sample Trials

NCT05465135

The Effect of Dihydroartemisinin in PCOS

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42018084651

Dihydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria prevention in pregnancy

Malaria in pregnancy (MIP) refers to the occurrence of a malaria infection in a

CRD42018100327

Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated plasmodium vivax malaria in endemic countries: a meta-analysis and trial sequential analysis

Vivax Malaria

CRD42020165435

Dihydroartemisinin-piperaquine versus Sulfadoxine-pyrimethamine efﬁcacy and safety for intermittent preventive treatment of Plasmodium falciparum malaria during pregnancy: meta-analysis of randomized control trials

Malaria. Peripheral or placental parasitaemia

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Dihydroartemisinin

⚗️ Identity

Name

Dihydroartemisinin

Aliases / Synonyms

71939-50-9; Artenimol; Cotexin; Alaxin; 81496-82-4; Dihydroqinghaosu; Dihydroartemisinine; Cotecxin; Di-hydroqinghaosu

🧪 Chemistry

Molecular Weight

284.3520

LogP

2.1867

Drug-likeness

0.691

Oral Bioavailability

50.7500

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C

Isomeric SMILES

C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C

InChIKey

BJDCWCLMFKKGEE-ISOSDAIHSA-N

InChI

InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1

🔗 External References

HERB DB

HBIN023813 ↗

PubChem CID

3000518 ↗

CAS Number

71939-50-9 ↗

SymMap

8864

TCMID

23056

TCMSP

MOL007425

🔍 Raw view — every non-empty column on this row (31 fields)

name

Dihydroartemisinin

common names

71939-50-9; Artenimol; Cotexin; Alaxin; 81496-82-4; Dihydroqinghaosu; Dihydroartemisinine; Cotecxin; Di-hydroqinghaosu

herb ingredient id

HBIN023813

canonical smiles

CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C

isomeric smiles

C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C

inchi

InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1

inchikey

BJDCWCLMFKKGEE-ISOSDAIHSA-N

mol wt

284.3520

num h acceptors

num h donors

mol logp

2.1867

num rotatable bonds

drug likeness

0.691

ob score

50.7500

cas id

71939-50-9

symmap mol id

8864

tcmid ingredient id

23056

tcmsp ingredient id

MOL007425

pubchem cid

3000518

🏥 Linked Health Topics

1 · diseases via target pathways

Polycystic Ovary Syndrome

syndrome

📋 Clinical Trials

1 · subject of clinical study

NCT05465135 The Effect of Dihydroartemisinin in PCOS

→ Polycystic Ovary Syndrome

📊 Meta-Analyses

11 · systematic review

CRD42018084651 Dihydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria pre

→ Malaria in pregnancy (MIP) refers to the occurrenc

CRD42018100327 Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated plasmo

→ Vivax Malaria

CRD42020165435 Dihydroartemisinin-piperaquine versus Sulfadoxine-pyrimethamine efﬁcacy and safe

→ Malaria. Peripheral or placental parasitaemia

CRD42020175259 Cardiac effects of repeat courses of dihydroartemisinin-piperaquine for malaria

→ Malaria

CRD42020182354 Efficacy and safety of dihydroartemisinin-piperaquine versus artemether-lumefant

→ Uncomplicated falciparum malaria

CRD42020196127 Safety and efficacy of dihydroartemisinin-piperaquine as an alternative to sulfa

→ Malaria in pregnancy

CRD42020200337 Efficacy and safety of dihydroartemisinin Piperaquine versus artemether-lumefant

→ Uncomplicated falciparum malaria

CRD42022310041 Safety and Tolerability of Repeated Doses of Dihydroartemisinin-Piperaquine for

→ Malaria in pregnancy

CRD42023432718 Monitoring of the efficacy of artemisinin-based combination therapies and trend

→ The systematic review focuses on malaria treatment

CRD42023437173 Is dihydroartemisinin-piperaquine comparable to sulfadoxine-pyrimethamine in the

→ Malaria in pregnancy

CRD42023451008 A systematic review of the safety of Dihydroartemisinin-piperaquine used for mal

→ Severe Malaria; Cause of morbidity and mortality i

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables