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Gene Target
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Disease
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Evidence
23,241
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Huperzine a
4
Clinical Trials
6
Meta-Analyses
1
PubMed References
Top Conditions Studied with Huperzine a
Alzheimer Disease 2
Biomarkers, Pharmacological 1
Huperzine A, an alkaloid initially identified from the Chine 1
Huperzine A, an alkaloid initially identified from the Chine 1
Dementia (Alzheimer’s disease or Vascular dementia) or Mild 1
Alzheimer’s disease, first described by German psychiatrist 1
Presbycusis|Tinnitus|Cognitive Impairment 1
Cocaine Dependence|Cocaine Addiction|Cocaine Abuse|Substance 1
📋 Sample Trials
NCT01030692
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
Completed · Phase 1
NCT03101722
Effects of Huperzine a on Presbycusis(Δ,kHz, DB,MMSE, AD)
Enrolling_By_Invitation
NCT01194336
Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance
Completed
📊 Sample Meta-Analyses
CRD42015024796
Huperzine A for major depressive disorder: a review of the literature
Huperzine A, an alkaloid initially identified from the Chinese herbal medicine H
CRD42015024198
Huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis
Huperzine A, an alkaloid initially identified from the Chinese herbal medicine H
CRD42015023354
Comparative efficacy and safety of Huperzine A and Ginkgo biloba extract in patients with Alzheimer’s disease: a network meta-analysis of randomized controlled trials
Alzheimer disease
📚 Sample References
PMID 21289607
Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model
Neuropsychopharmacology · 2011
⚗️ All Ingredient data fields for Huperzine a
⚗️ Identity
Name
Huperzine a
Aliases / Synonyms
(-)-huperzine A; 102518-79-6; (-)-huperazine A; Selagine; Huperzin A; L-huperzine A; (-)-Selagine; Hup A; CHEMBL395280
🧪 Chemistry
Molecular Weight
242.3220
LogP
1.9975
Drug-likeness
0.684
H-Bond Acceptors
2
H-Bond Donors
2
🔬 Structures
Canonical SMILES
CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3
Isomeric SMILES
C/C=C/1\[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3
InChIKey
ZRJBHWIHUMBLCN-YQEJDHNASA-N
InChI
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
🔗 External References
🔍 Raw view — every non-empty column on this row (28 fields)
name
Huperzine a
common names
(-)-huperzine A; 102518-79-6; (-)-huperazine A; Selagine; Huperzin A; L-huperzine A; (-)-Selagine; Hup A; CHEMBL395280
herb ingredient id
HBIN029630
canonical smiles
CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3
isomeric smiles
C/C=C/1\[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3
inchi
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
inchikey
ZRJBHWIHUMBLCN-YQEJDHNASA-N
mol wt
242.3220
num h acceptors
2
num h donors
2
mol logp
1.9975
num rotatable bonds
0
drug likeness
0.684
tcmid ingredient id
9685
tcm id ingredient id
13083
pubchem cid
854026
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