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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Huperzine a

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Huperzine a

Alzheimer Disease 2 Biomarkers, Pharmacological 1 Huperzine A, an alkaloid initially identified from the Chine 1 Huperzine A, an alkaloid initially identified from the Chine 1 Dementia (Alzheimer’s disease or Vascular dementia) or Mild 1 Alzheimer’s disease, first described by German psychiatrist 1 Presbycusis|Tinnitus|Cognitive Impairment 1 Cocaine Dependence|Cocaine Addiction|Cocaine Abuse|Substance 1

📋 Sample Trials

NCT01030692

Rivastigmine and Huperzine A as Treatments for Cocaine Dependence

Completed · Phase 1

NCT03101722

Effects of Huperzine a on Presbycusis(Δ,kHz, DB,MMSE, AD)

Enrolling_By_Invitation

NCT01194336

Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance

Completed

📊 Sample Meta-Analyses

CRD42015024796

Huperzine A for major depressive disorder: a review of the literature

Huperzine A, an alkaloid initially identified from the Chinese herbal medicine H

CRD42015024198

Huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis

Huperzine A, an alkaloid initially identified from the Chinese herbal medicine H

CRD42015023354

Comparative efficacy and safety of Huperzine A and Ginkgo biloba extract in patients with Alzheimer’s disease: a network meta-analysis of randomized controlled trials

Alzheimer disease

📚 Sample References

PMID 21289607

Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model

Neuropsychopharmacology · 2011

⚗️ All Ingredient data fields for Huperzine a

⚗️ Identity

Name

Huperzine a

Aliases / Synonyms

(-)-huperzine A; 102518-79-6; (-)-huperazine A; Selagine; Huperzin A; L-huperzine A; (-)-Selagine; Hup A; CHEMBL395280

🧪 Chemistry

Molecular Weight

242.3220

LogP

1.9975

Drug-likeness

0.684

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3

Isomeric SMILES

C/C=C/1\[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3

InChIKey

ZRJBHWIHUMBLCN-YQEJDHNASA-N

InChI

InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1

🔗 External References

HERB DB

HBIN029630 ↗

PubChem CID

854026 ↗

TCMID

9685

TCM-ID

13083

🔍 Raw view — every non-empty column on this row (28 fields)

name

Huperzine a

common names

(-)-huperzine A; 102518-79-6; (-)-huperazine A; Selagine; Huperzin A; L-huperzine A; (-)-Selagine; Hup A; CHEMBL395280

herb ingredient id

HBIN029630

canonical smiles

CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3

isomeric smiles

C/C=C/1\[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3

inchi

InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1

inchikey

ZRJBHWIHUMBLCN-YQEJDHNASA-N

mol wt

242.3220

num h acceptors

num h donors

mol logp

1.9975

num rotatable bonds

drug likeness

0.684

tcmid ingredient id

9685

tcm id ingredient id

13083

pubchem cid

854026

📋 Clinical Trials

4 · subject of clinical study

NCT01030692 Rivastigmine and Huperzine A as Treatments for Cocaine Dependence

→ Cocaine Dependence|Cocaine Addiction|Cocaine Abuse

NCT03101722 Effects of Huperzine a on Presbycusis(Δ,kHz, DB,MMSE, AD)

→ Presbycusis|Tinnitus|Cognitive Impairment

NCT01194336 Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Som

→ Biomarkers, Pharmacological

NCT00083590 Huperzine A in Alzheimer's Disease

→ Alzheimer Disease

📊 Meta-Analyses

6 · systematic review

CRD42015024796 Huperzine A for major depressive disorder: a review of the literature

→ Huperzine A, an alkaloid initially identified from

CRD42015024198 Huperzine A for cognitive deficits in schizophrenia: a systematic review and met

→ Huperzine A, an alkaloid initially identified from

CRD42015023354 Comparative efficacy and safety of Huperzine A and Ginkgo biloba extract in pati

→ Alzheimer disease

CRD42012003249 Huperzine A preparation for Alzheimer’s disease: a systematic review and meta-an

→ Alzheimer’s disease, first described by German psy

CRD42020168194 Effects of Huperzine A on Dementia and Mild Cognitive Impairment: an Overview of

→ Dementia (Alzheimer’s disease or Vascular dementia

CRD42023468989 Systematic review and network meta-analysis of predictive validity of streptozoc

📚 PubMed References

1 · cited research

PMID 21289607 Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic

Neuropsychopharmacology

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables