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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Papaverine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Papaverine

Kidney Cancer 1 Induction of Labor|Pain, Acute|Labor Pain|Delivery Delayed 1 Tinnitus in adults with chronic or acute tinnitus through th 1 Papaverine is commonly used to prevent vasospasm in aneurysm 1 Radial Artery Spasm 1 Radial Artery Injury Prevetion 1 Pediatrics|Anesthesia|Vasospasm 1 Lung Non-Small Cell Carcinoma 1

📋 Sample Trials

NCT03894904

Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients

Completed · Phase 4

NCT04030663

The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter

Completed · Early_Phase 1

NCT04162834

Effect of Papaverine on Renal Artery Blood Flow Volume

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42021283057

Papaverine and outcome following aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis

Papaverine is commonly used to prevent vasospasm in aneurysmal subarachnoid haem

CRD42023446824

A systematic review and meta-analysis of the effects of plant-based substances and nutritional supplements therapy on tinnitus severity perception in adult patients

Tinnitus in adults with chronic or acute tinnitus through these domains: a) Tinn

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Papaverine

⚗️ Identity

Name

Papaverine

Aliases / Synonyms

Papaverin; 58-74-2; Papanerine; Robaxapap; Papanerin; Papaverina; Cerespan; Pavabid; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline

🧪 Chemistry

Molecular Weight

339.3910

LogP

3.8600

Drug-likeness

0.682

Oral Bioavailability

64.0430

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC

Isomeric SMILES

COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC

InChIKey

XQYZDYMELSJDRZ-UHFFFAOYSA-N

InChI

InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3

🔗 External References

HERB DB

HBIN038790 ↗

PubChem CID

4680 ↗

CAS Number

58-74-2 ↗

NPASS

NPC195268

HIT

C0290

SymMap

257

TCMID

16611

TCMSP

MOL006980

TCM-ID

14108

🔍 Raw view — every non-empty column on this row (34 fields)

name

Papaverine

common names

Papaverin; 58-74-2; Papanerine; Robaxapap; Papanerin; Papaverina; Cerespan; Pavabid; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline

herb ingredient id

HBIN038790

canonical smiles

COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC

isomeric smiles

COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC

inchi

InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3

inchikey

XQYZDYMELSJDRZ-UHFFFAOYSA-N

mol wt

339.3910

num h acceptors

num h donors

mol logp

3.8600

num rotatable bonds

drug likeness

0.682

ob score

64.0430

cas id

58-74-2

symmap mol id

257

tcmid ingredient id

16611

tcmsp ingredient id

MOL006980

tcm id ingredient id

14108

pubchem cid

4680

npass id

NPC195268

hit id

C0290

🏥 Linked Health Topics

1 · diseases via target pathways

Kidney Cancer

disease

📋 Clinical Trials

6 · subject of clinical study

NCT03894904 Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Pati

→ Pediatrics|Anesthesia|Vasospasm

NCT04030663 The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial

→ Radial Artery Injury Prevetion

NCT04162834 Effect of Papaverine on Renal Artery Blood Flow Volume

→ Kidney Cancer

NCT03824327 Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Can

→ Lung Non-Small Cell Carcinoma

NCT05861765 The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cer

→ Radial Artery Spasm

NCT05759364 The Effect of IV PAPAVERINE 80 mg Prior to Catheter Balloon Insertion on Bishop

→ Induction of Labor|Pain, Acute|Labor Pain|Delivery

📊 Meta-Analyses

2 · systematic review

CRD42021283057 Papaverine and outcome following aneurysmal subarachnoid haemorrhage: Systematic

→ Papaverine is commonly used to prevent vasospasm i

CRD42023446824 A systematic review and meta-analysis of the effects of plant-based substances a

→ Tinnitus in adults with chronic or acute tinnitus

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables