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Each record is a registered study, a systematic-review registration or a publication. A registered or ongoing study is not a finding, and animal or cell research does not show an effect in people. The same study can appear under more than one subject, so the number of records is not a count of independent studies. You can also search an exact DOI, PubMed ID, NCT or CRD number. How to read these records.

31 study records (showing up to 30 per record type)

• Registered trial NCT04466436 Not completed: Unknown
  Anaesthesia and Tryptophan Pathway
  Condition or outcome area: Tryptophan Pathway
  2020-07-08 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02963545 Completed (results not assessed here)
  TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke
  Condition or outcome area: Cerebral Infarction
  2012-10 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02612259 Phase 2 Completed (results not assessed here)
  A Phase II, Randomized, Double-blind, Placebo-controlled, in Parallel Groups Clinical Trial to Assess the Safety and Efficacy of Dietary Supplementation With Tryptophan to Achieve Weight Loss, and Its Neuropsychological Effects in Adolescents With Obesity
  Condition or outcome area: Obesity
  2012-01 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02018588 Completed (results not assessed here)
  Tryptophan Requirement of Healthy School Age Children
  Condition or outcome area: Healthy
  2013-12 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT00865202 Phase 3 Completed (results not assessed here)
  A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium
  Condition or outcome area: Post-operative Delirium
  2008-12 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT04505800 Completed (results not assessed here)
  Tryptophan Supplementation to Improve Night Shift Workers' Health
  Condition or outcome area: Sleep|Mood|Burnout|Melatonin Deficiency|Cortisol Deficiency
  2019-09-01 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT03017768 Completed (results not assessed here)
  The Effect of Acute Tryptophan Depletion (ATD) on Esophageal Sensitivity in Healthy Volunteers
  Condition or outcome area: Esophageal Sensitivity
  2016-06 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02402179 Completed (results not assessed here)
  Metabolic Availability of Tryptophan From White Maize
  Condition or outcome area: Healthy
  2015-03 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02067975 Phase 2 / Phase 3 Completed (results not assessed here)
  Tryptophan MRI in People With Schizophrenia and Healthy Controls
  Condition or outcome area: Schizophrenia
  2014-08-14 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT00192725 Completed (results not assessed here)
  Tryptophan Depletion in Acute Mania
  Condition or outcome area: Bipolar Disorder
  2003-03 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT00000324 Phase 2 Completed (results not assessed here)
  Tryptophan and Behavior Therapy for Cocaine Abuse - 1
  Condition or outcome area: Cocaine-Related Disorders
  1997-03 · Subject: Tryptophane; Tryptophan; HSDB 4142; Tryptophan, L-(8CI); AC1Q4U80; L-Tryptophan, Vetec(TM) reagent grade, >=98%; alpha-Aminoindole-3-propionic acid; SR-01000075590-1; ZINC83315; 1-beta-3-Indolylalanine · open the ingredient record · ClinicalTrials.gov
• Systematic review registration CRD42023459005 Registered protocol, no results here: Review Ongoing
  Role of dietary supplements in type 2 diabetes mellitus with coronary heart disease: a systematic review and network meta-analysis
  Condition or outcome area: Outcomes associated with populations in type 2 diabetes mellitus with coronary heart disease.
  2023-09-10 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42023388936 Registered protocol, no results here: Review Ongoing
  The effects of changes in the concentration of tryptophan derivatives on chronic musculoskeletal pain – a systematic review and meta-analysis
  Condition or outcome area: Chronic pain is a prevalent affliction that greatly impacts people's daily lives and can, in some instances, even lead to depression. Despite it being such a common issue, most patients do not get the appropriate treatment. Therefore, a deeper knowledge of chronic pain and its associations is crucial for new methods on how to diagnose, manage, and treat chronic pain. Tryptophan is one of our bodies' nine essential amino acids to function properly. Tryptophan helps the body produce metabolites su
  2023-01-14 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42022357640 Registered protocol, no results here: Review Ongoing
  Tryptophan catabolite changes in alcoholism: a systematic review and meta-analysis
  Condition or outcome area: Alcohol is the most extensive addictive substance in the world. The harmful use of alcohol causes increasing concern on the personal and public health, which results in more than 3.3 million deaths every year. Alcohol use disorder is highly comorbid with mental and physical diseases. The pathophysiology of alcohol use disorder remains to be fully elucidated but accumulating evidence have shown abnormal tryptophan catabolism in alcoholics.
  2022-09-13 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42021278725 Registered protocol, no results here: Review Ongoing
  Effects of Tryptophan Supplementation on Depressive Disorder: Systematic Review with Meta-Analysis
  Condition or outcome area: Depression is one of the most common and frequent mental disorders nowadays, and its most used conventional treatments involve pharmacological therapy through the use of antidepressants and non-pharmacological treatments such as psychotherapy. However, adjuvant and adherence treatments have been increasingly used as potential therapeutic resources for depression, such as a healthy diet that is able to provide key nutrients for proper brain functioning, for example, tryptophan, an essential amino
  2021-10-25 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42020188649 Registered protocol, no results here: Review Completed published
  A systematic review of the use of tryptophan as a treatment for Attention Deficit Hyperactivity Disorder
  Condition or outcome area: Attention Deficit/Hyperactivity Disorder (ADHD) is characterised by poor attention, heightened impulsivity and hyperactivity (American Psychiatric Association, 2000). Consequences of the disorder include higher risk of other psychiatric and physical health conditions and poorer academic and occupational functioning (Doggett, 2004; Hodgkins, Montejano, Sasane, & Huse, 2011; National Institute for Health and Clinical Excellence, 2009).
  2020-06-30 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42020160043 Registered protocol, no results here: Review Ongoing
  The impact of tryptophan supplementation on sleep quality: a systematic review
  Condition or outcome area: Sleep quality outcomes (e.g. sleep duration, sleep latency, sleep efficiency, global sleep score, etc.)
  2020-04-28 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42022358205 Registered protocol, no results here: Review Ongoing
  Melatonin therapy, an efficient adjuvant approach to lipid profile status: a systematic review and meta-analysis
  Condition or outcome area: Diabetes mellitus is a metabolic disorder, defined by abnormally elevated blood glucose, resulting from the defects in insulin secretion or insulin resistance in diabetic patients. Chronic hyperglycemia can cause severe damages to various cells or organs, such as the retina, heart, kidney, and blood vessels in diabetic patients. Melatonin (N-acetyl-5-methoxytryptamine), an endogenous antioxidant, is a tryptophan derivative that is mostly produced by the pineal gland and has a key role in the reg
  2022-09-16 · Subject: Melatonin; 73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine · open the ingredient record
• Systematic review registration CRD42022352070 Registered protocol, no results here: Review Ongoing
  Melatonin and tryptophan influence on sleep quality in women undergoing breast cancer treatment: a systematic review
  Condition or outcome area: Breast cancer is a heterogeneous group of diseases, with different behaviors. The heterogeneity of this cancer can be observed by the varied clinical and morphological manifestations, different genetic signatures and consequent differences in therapeutic responses (INCA, 2022). It is usually a therapeutic approach in breast cancer, radiotherapy and hormone therapy as part of the primary treatment, in addition to surgery. It is known that there is a change in the prevalence of insomnia during the
  2022-08-25 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42022352070 Registered protocol, no results here: Review Ongoing
  Melatonin and tryptophan influence on sleep quality in women undergoing breast cancer treatment: a systematic review
  Condition or outcome area: Breast cancer is a heterogeneous group of diseases, with different behaviors. The heterogeneity of this cancer can be observed by the varied clinical and morphological manifestations, different genetic signatures and consequent differences in therapeutic responses (INCA, 2022). It is usually a therapeutic approach in breast cancer, radiotherapy and hormone therapy as part of the primary treatment, in addition to surgery. It is known that there is a change in the prevalence of insomnia during the
  2022-08-25 · Subject: Melatonin; 73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine · open the ingredient record
• Systematic review registration CRD42021252462 Registered protocol, no results here: Review Ongoing
  Tryptophan levels and its metabolites in the pathogenesis of postpartum blues and postpartum depression: a meta-analysis and systematic review
  Condition or outcome area: Peripartum period, pregnancy Postpartum depression / postpartum blues, maternal mental health Serum tryptophan, serum kynurenine, tryptophan metabolites
  2021-06-18 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42021293595 Registered protocol, no results here: Review Ongoing
  Validating the Instruments and Methodologies Used for the Quantification of Kynurenine Pathway Metabolites in Biofluids: A Systematic Review and Meta-Analysis
  Condition or outcome area: This systematic review and meta-analysis studies the analytical profiling of the essential amino acid tryptophan, and kynurenine, a major metabolite of the kynurenine pathway.
  2021-12-26 · Subject: Kynurenine; 343-65-7; dl-Kynurenine; 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid; rac Kynurenine; 3-Anthraniloylalanine; 3-Anthraniloyl-DL-alanine; Alanine, 3-anthraniloyl-; (+-)-Kynurenine; (+/-)-Kynurenine · open the ingredient record
• Systematic review registration CRD42020159274 Registered protocol, no results here: Review Ongoing
  Dysregulation of tryptophan-kynurenine pathway associated metabolites in patients with dementia or cognitive impairment: a meta-analysis
  Condition or outcome area: Dementia, cognitive and affective symptomology, and aging. Dementia is an overall term for diseases and conditions characterized by a decline in memory, language, problem solving and other thinking skills that affect a person’s ability to perform everyday activities. Alzheimer’s disease is the most common type of dementia, but there are many other kinds (e.g. vascular dementia, Creutzfeldt-Jakob disease, lewy body dementia, down syndrome, frontotemporal dementia, Huntington’s disease, mixed deme
  2020-03-11 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42020159274 Registered protocol, no results here: Review Ongoing
  Dysregulation of tryptophan-kynurenine pathway associated metabolites in patients with dementia or cognitive impairment: a meta-analysis
  Condition or outcome area: Dementia, cognitive and affective symptomology, and aging. Dementia is an overall term for diseases and conditions characterized by a decline in memory, language, problem solving and other thinking skills that affect a person’s ability to perform everyday activities. Alzheimer’s disease is the most common type of dementia, but there are many other kinds (e.g. vascular dementia, Creutzfeldt-Jakob disease, lewy body dementia, down syndrome, frontotemporal dementia, Huntington’s disease, mixed deme
  2020-03-11 · Subject: Kynurenine; 343-65-7; dl-Kynurenine; 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid; rac Kynurenine; 3-Anthraniloylalanine; 3-Anthraniloyl-DL-alanine; Alanine, 3-anthraniloyl-; (+-)-Kynurenine; (+/-)-Kynurenine · open the ingredient record
• Systematic review registration CRD42021273120 Registered protocol, no results here: Review Ongoing
  The role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome: a systematic review
  Condition or outcome area: Pregnant women without any restriction regarding study setting (such as first-line and tertiary care treatment).
  2021-09-11 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record
• Systematic review registration CRD42021273120 Registered protocol, no results here: Review Ongoing
  The role of the tryptophan and kynurenine pathway in maternal, foetal and placental health, and pregnancy outcome: a systematic review
  Condition or outcome area: Pregnant women without any restriction regarding study setting (such as first-line and tertiary care treatment).
  2021-09-11 · Subject: Kynurenine; 343-65-7; dl-Kynurenine; 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid; rac Kynurenine; 3-Anthraniloylalanine; 3-Anthraniloyl-DL-alanine; Alanine, 3-anthraniloyl-; (+-)-Kynurenine; (+/-)-Kynurenine · open the ingredient record
• Publication PMID 34326168 Research model: Animal & Cell Experiment
  Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation
  Condition or outcome area: tumor; cancer; lung cancer
  J Immunother Cancer · 2021 · Subject: Tryptophane; Tryptophan; L-tryptophan; tryptophan; 73-22-3; h-Trp-oh; L-Tryptophane; (S)-Tryptophan; trofan; tryptacin · open the ingredient record · DOI 10.1136/jitc-2021-002840
• Publication PMID 32098277 Research model: Cell Experiment
  Pharmacological Targets of Kaempferol Within Inflammatory Pathways-A Hint Towards the Central Role of Tryptophan Metabolism
  Condition or outcome area: malignancies; tumor; neurodegenerative or cardiovascular disorders
  Antioxidants (Basel) · 2020 · Subject: Campherol; Kaempferol; kaempferol; 520-18-3; Kaempherol; Robigenin; Populnetin; Rhamnolutein; Trifolitin; Kempferol · open the ingredient record · DOI 10.3390/antiox9020180
• Publication PMID 36089660 Research model: Animal Experiment
  Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism
  Phytother Res · 2022 · Subject: Berberime; Berberine; berberine; 2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin · open the ingredient record · DOI 10.1002/ptr.7616
• Publication PMID 35026522 Research model: Cell Experiment
  Abrine promotes cell proliferation and inhibits apoptosis of interleukin-1β-stimulated chondrocytes via PIM2/VEGF signalling in osteoarthritis
  Condition or outcome area: joint disorder; anterior cruciate ligament transection; chronic inflammation; Osteoarthritis
  Phytomedicine · 2022 · Subject: Abrine; L-Abrine; 526-31-8; N-Methyl-L-tryptophan; Nalpha-Methyl-L-tryptophan; L-(+)-Abrine; N-Methyl-L-tryptophane; (2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoic acid; methyl-l-tryptophan; N-Me-Trp-OH · open the ingredient record · DOI 10.1016/j.phymed.2021.153906
• Publication PMID 28456683 Research model: Animal Experiment
  Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism
  Pharmacol Res · 2017 · Subject: Patchouli alcohol; 5986-55-0; Patchoulol; patchouli camphor; Patchoulic alcohol; patchoulanol; (-)-patchoulol; (-)-patchouli alcohol; HHH8CPR1M2; solid · open the ingredient record · DOI 10.1016/j.phrs.2017.04.017