THERAPIES & TRADITIONS · GUIDE
Gotu Kola (Mandukaparni) in Ayurveda
Gotu kola (Centella asiatica, mandukaparni) in Ayurveda: traditional uses, the name overlap with brahmi, what trials found, and liver injury reports and EU safety limits.
Content last updated . This page has not been medically reviewed.
Back to AyurvedaWhat it is and how Ayurveda describes it
Centella asiatica, called gotu kola in English and mandukaparni in Ayurveda, is described in a 2021 review as an Ayurvedic and traditional Chinese medicine used for different health problems, and also as an edible vegetable in some diets. [5] A review of "brahmi" explains that the Ayurvedic name corresponds to two plants, Bacopa monnieri and Centella asiatica, both discussed under the medhya rasayana group of memory-supporting herbs. [6] Because of this overlap, read the Latin name on a label. See bacopa (brahmi) for the other plant, and how Ayurvedic herbs are classified for the tradition's terms.We did not find a source we could read that gives the classical-text description of mandukaparni's properties, so this page does not restate them.
What research has measured
Memory and thinking
No good evidence of benefit (for cognition)A 2017 systematic review of 5 randomized trials of gotu kola alone and 6 of products containing it [7] [8] found no significant difference from placebo in any cognitive domain. [9] It concluded there is not strong evidence for cognitive benefit. [10]
Alertness and mood
Insufficient evidenceThe same review found improved alertness and lower anger scores. [10] A 2026 scoping review found two small randomized trials in healthy people (58 in total) reporting better alertness and one open-label anxiety study (33 patients), and said the evidence base was insufficient for a pooled analysis. [11] [12]
Chronic venous insufficiency (leg vein problems)
Promising but limitedA 2013 review of 8 randomized trials suggested possible benefit for signs and symptoms but said it must be read with caution because reporting was poor. [13] [14]
Wound healing
Insufficient evidenceA 2022 review found 4 clinical trials and said more studies were needed to judge the effect. [15] [16]
Minor wounds, traditional European use
Traditional use onlyThe EU herbal committee lists a traditional herbal medicinal product used to aid healing of minor wounds, applied to the skin. [17] [18]
The cognitive reviewers noted that the dose regimen, plant preparation, standardization and product variation limit the conclusions. [19] The EU listing is a traditional-use status for skin use. It is not proof of benefit, and it does not cover swallowed supplements.
A 2025 trial in India compared gotu kola (mandukaparni) and bacopa (brahmi) with each other in 180 healthy boys, without a placebo group, so it cannot show that either herb works. [20]
Where this fits
Gotu kola appears in some Ayurvedic skin and brain products. See Ayurvedic skin and hair products and Ayurveda for memory and brain health. For other liver concerns see liver injury from Ayurvedic herbs.Frequently asked questions
Is gotu kola the same as brahmi?
Not exactly. "Brahmi" corresponds to two plants in Ayurveda, Bacopa monnieri and Centella asiatica (gotu kola, mandukaparni). [6]
Does gotu kola improve memory?
A 2017 meta-analysis found no significant difference from placebo in cognitive domains, though alertness and anger scores improved. [9] [10]
Can gotu kola damage the liver?
Case reports describe jaundice and liver injury after taking it, including a recurrence on re-exposure in one patient. [1] [2]
Is gotu kola safe in pregnancy?
Safety in pregnancy and lactation has not been established, and the EU skin-use monograph does not recommend use. [3]
Is gotu kola approved for wounds?
In the EU it has a traditional-use herbal monograph for aiding healing of minor wounds when applied to the skin, which is not the same as proof from trials. [17] [16]
More details: evidence, limits and cautions
The details behind this page: cautions, limits of the evidence and where sources disagree. Open any note to read it.
Safety first
Safety, liver and other cautions
- Liver. Besides the three adult cases above, a published letter describes liver toxicity attributed to gotu kola in a child; we could read only its title and index record. [1] [21] Case reports cannot say how common this is.
- Trial tolerability. None of the studies in the 2017 cognition review reported adverse effects. [22] The case reports above show that rare harm can still occur.
- Pregnancy, breastfeeding and children. Safety has not been established, and the EU skin-use monograph does not recommend use in these groups. [3] [4]
- Allergy. The EU monograph lists hypersensitivity to Centella and to other plants in the carrot family (Apiaceae) as a contraindication. [23]
- Medicines. The EU monograph reports no known interactions, [24] but that is for a short-term skin product. Ask a pharmacist, especially if you take medicines that affect the liver. See medicine interactions and liver safety.
References
- Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica (case reports). Rev Esp Enferm Dig 2005. Read 2026-10-22.
- Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica (case reports). Rev Esp Enferm Dig 2005. Read 2026-10-22.
- European Medicines Agency, HMPC, European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1 (EMA/HMPC/489142/2020, first published 2 September 2022). Read 2026-10-22.
- European Medicines Agency, HMPC, European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1 (EMA/HMPC/489142/2020, first published 2 September 2022). Read 2026-10-22.
- Biswas D et al. Ethnobotany, phytochemistry, pharmacology, and toxicity of Centella asiatica (L.) Urban: a comprehensive review. Phytother Res 2021. Read 2026-10-22.
- Shinomol GK et al. Exploring the role of “Brahmi” (Bacopa monnieri and Centella asiatica) in brain function and therapy. Recent Pat Endocr Metab Immune Drug Discov 2011. Read 2026-10-22.
- Puttarak P et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Sci Rep 2017. Read 2026-10-22.
- Puttarak P et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Sci Rep 2017. Read 2026-10-22.
- Puttarak P et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Sci Rep 2017. Read 2026-10-22.
- Puttarak P et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Sci Rep 2017. Read 2026-10-22.
- Therapeutic potential of gotu kola, phosphatidylcholine and taurine in mood disorders: a systematic scoping review. Complement Med Res 2026. Read 2026-10-22.
- Therapeutic potential of gotu kola, phosphatidylcholine and taurine in mood disorders: a systematic scoping review. Complement Med Res 2026. Read 2026-10-22.
- Chong NJ, Aziz Z. A systematic review of the efficacy of Centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency. Evid Based Complement Alternat Med 2013. Read 2026-10-22.
- Chong NJ, Aziz Z. A systematic review of the efficacy of Centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency. Evid Based Complement Alternat Med 2013. Read 2026-10-22.
- Arribas-López E et al. A systematic review of the effect of Centella asiatica on wound healing. Int J Environ Res Public Health 2022. Read 2026-10-22.
- Arribas-López E et al. A systematic review of the effect of Centella asiatica on wound healing. Int J Environ Res Public Health 2022. Read 2026-10-22.
- European Medicines Agency, HMPC, European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1 (EMA/HMPC/489142/2020, first published 2 September 2022). Read 2026-10-22.
- European Medicines Agency, HMPC, European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1 (EMA/HMPC/489142/2020, first published 2 September 2022). Read 2026-10-22.
- Puttarak P et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Sci Rep 2017. Read 2026-10-22.
- Verma J et al. Comparative efficacy of Medhya Rasayana, Bacopa monnieri and Centella asiatica in enhancing memory and IQ of 8-10 year-old healthy boys: a prakriti-based randomized controlled trial. J Ayurveda Integr Med 2025 (PMC12270740). Read 2026-10-22.
- Dantuluri S et al. Gotu kola induced hepatotoxicity in a child: need for caution with alternative remedies (letter, record and title read only). Dig Liver Dis 2011. Read 2026-10-22.
- Puttarak P et al. Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Sci Rep 2017. Read 2026-10-22.
- European Medicines Agency, HMPC, European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1 (EMA/HMPC/489142/2020, first published 2 September 2022). Read 2026-10-22.
- European Medicines Agency, HMPC, European Union herbal monograph on Centella asiatica (L.) Urb., herba, Revision 1 (EMA/HMPC/489142/2020, first published 2 September 2022). Read 2026-10-22.