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Research & Evidence

Functional foods research and evidence: PubMed counts by food, what the counts miss, the CORDIOPREV Mediterranean diet trial, and how to judge a food claim.

Content last updated . This page has not been medically reviewed.

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Evidence snapshot

Counts of PubMed records that mention each food or term. A count shows how much has been published, not whether a food works. Many searches also catch non-health research (farm crops, food chemistry) and other forms such as juice, extract and supplements. [1]
Food or termRecords tagged as randomized controlled trialsRecords tagged as any clinical trialAll PubMed records that mention itCheck it yourself
Yogurt5886627,451PubMed search
Kefir36431,425PubMed search
Kimchi9121,196PubMed search
Sauerkraut55297PubMed search
Kombucha68699PubMed search
Miso33491,038PubMed search
Tempeh1011263PubMed search
Natto1520752PubMed search
Oats56673315,066PubMed search
Barley26636923,666PubMed search
Legumes (beans, lentils, chickpeas)14512373103,746PubMed search
Flaxseed3394065,644PubMed search
Chia seeds40481,961PubMed search
Walnuts1872074,743PubMed search
Almonds2232454,762PubMed search
Pistachios44531,541PubMed search
Pumpkin seeds1317669PubMed search
Avocado60732,575PubMed search
Blueberries1101324,544PubMed search
Pomegranate1471614,597PubMed search
Citrus (includes orange juice, grapefruit)65486025,475PubMed search
Tomato (includes lycopene research)42255446,451PubMed search
Broccoli and cruciferous vegetables1582136,565PubMed search
Leafy greens (spinach, kale)8310811,725PubMed search
Beetroot and beet juice3613771,675PubMed search
Oily fish and salmon44459321,482PubMed search
Soy (includes soy products and soybean crop research)2185271977,923PubMed search
Black tea1281513,321PubMed search
Coffee65387423,620PubMed search
Fortified foods2793173,484PubMed search
Plant sterols and stanols3023402,106PubMed search
"Functional food" (the term itself)34637924,268PubMed search
Probiotics3369374260,556PubMed search
Prebiotics82591920,145PubMed search
"Superfood" (the term itself)66409PubMed search

Counted 2026-10-22 using NCBI E-utilities. Counts include studies of extracts, blends and non-health topics, and a trial can find no effect. A higher count means more human research has been indexed, not that something works.

What this means

  • Large counts (soy, legumes, tomato, citrus) include crop science and lycopene or hesperidin research; do not read them as food-trial counts.
  • Fermented foods have much smaller trial counts than the probiotic capsule literature: probiotics have over 3,000 randomized-trial records, yogurt about 600, kefir about 36, kimchi about 9, kombucha about 6. Many probiotic trials are of capsules, not food.
  • Terms like "functional food" and "superfood" are themselves search topics: "superfood" has few randomized trials.

An eating-pattern trial

In the CORDIOPREV randomized trial, 1,002 people with coronary heart disease ate a Mediterranean or a low-fat diet; the primary endpoint occurred in 87 of 502 Mediterranean-diet participants and 111 of 500 low-fat participants, with hazard ratios from 0.719 to 0.753, mainly in men. [2] It tests a pattern, not a single food.

How to judge a food claim

  1. Randomized trial or observational?
  2. Marker or outcome?
  3. Whole food, juice, powder or supplement?
  4. How large, how long, how many people?
  5. Who funded it? (We did not check funding for every study.)
  6. Does the claim need a medical reviewer? Our pages do not have one yet.

See Claim checks and Comparisons.

Frequently asked questions

Does a higher PubMed count mean a food is better?

No; it only means more has been published. [1]

References

  1. National Library of Medicine. PubMed. Record counts retrieved 2026-10-22 through NCBI E-utilities.
  2. Delgado-Lista J et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet 2022. PMID 35525255.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.