Research & Evidence
Functional foods research and evidence: PubMed counts by food, what the counts miss, the CORDIOPREV Mediterranean diet trial, and how to judge a food claim.
Content last updated . This page has not been medically reviewed.
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Evidence snapshot
Counts of PubMed records that mention each food or term. A count shows how much has been published, not whether a food works. Many searches also catch non-health research (farm crops, food chemistry) and other forms such as juice, extract and supplements. [1]| Food or term | Records tagged as randomized controlled trials | Records tagged as any clinical trial | All PubMed records that mention it | Check it yourself |
|---|---|---|---|---|
| Yogurt | 588 | 662 | 7,451 | PubMed search |
| Kefir | 36 | 43 | 1,425 | PubMed search |
| Kimchi | 9 | 12 | 1,196 | PubMed search |
| Sauerkraut | 5 | 5 | 297 | PubMed search |
| Kombucha | 6 | 8 | 699 | PubMed search |
| Miso | 33 | 49 | 1,038 | PubMed search |
| Tempeh | 10 | 11 | 263 | PubMed search |
| Natto | 15 | 20 | 752 | PubMed search |
| Oats | 566 | 733 | 15,066 | PubMed search |
| Barley | 266 | 369 | 23,666 | PubMed search |
| Legumes (beans, lentils, chickpeas) | 1451 | 2373 | 103,746 | PubMed search |
| Flaxseed | 339 | 406 | 5,644 | PubMed search |
| Chia seeds | 40 | 48 | 1,961 | PubMed search |
| Walnuts | 187 | 207 | 4,743 | PubMed search |
| Almonds | 223 | 245 | 4,762 | PubMed search |
| Pistachios | 44 | 53 | 1,541 | PubMed search |
| Pumpkin seeds | 13 | 17 | 669 | PubMed search |
| Avocado | 60 | 73 | 2,575 | PubMed search |
| Blueberries | 110 | 132 | 4,544 | PubMed search |
| Pomegranate | 147 | 161 | 4,597 | PubMed search |
| Citrus (includes orange juice, grapefruit) | 654 | 860 | 25,475 | PubMed search |
| Tomato (includes lycopene research) | 422 | 554 | 46,451 | PubMed search |
| Broccoli and cruciferous vegetables | 158 | 213 | 6,565 | PubMed search |
| Leafy greens (spinach, kale) | 83 | 108 | 11,725 | PubMed search |
| Beetroot and beet juice | 361 | 377 | 1,675 | PubMed search |
| Oily fish and salmon | 444 | 593 | 21,482 | PubMed search |
| Soy (includes soy products and soybean crop research) | 2185 | 2719 | 77,923 | PubMed search |
| Black tea | 128 | 151 | 3,321 | PubMed search |
| Coffee | 653 | 874 | 23,620 | PubMed search |
| Fortified foods | 279 | 317 | 3,484 | PubMed search |
| Plant sterols and stanols | 302 | 340 | 2,106 | PubMed search |
| "Functional food" (the term itself) | 346 | 379 | 24,268 | PubMed search |
| Probiotics | 3369 | 3742 | 60,556 | PubMed search |
| Prebiotics | 825 | 919 | 20,145 | PubMed search |
| "Superfood" (the term itself) | 6 | 6 | 409 | PubMed search |
Counted 2026-10-22 using NCBI E-utilities. Counts include studies of extracts, blends and non-health topics, and a trial can find no effect. A higher count means more human research has been indexed, not that something works.
What this means
- Large counts (soy, legumes, tomato, citrus) include crop science and lycopene or hesperidin research; do not read them as food-trial counts.
- Fermented foods have much smaller trial counts than the probiotic capsule literature: probiotics have over 3,000 randomized-trial records, yogurt about 600, kefir about 36, kimchi about 9, kombucha about 6. Many probiotic trials are of capsules, not food.
- Terms like "functional food" and "superfood" are themselves search topics: "superfood" has few randomized trials.
An eating-pattern trial
In the CORDIOPREV randomized trial, 1,002 people with coronary heart disease ate a Mediterranean or a low-fat diet; the primary endpoint occurred in 87 of 502 Mediterranean-diet participants and 111 of 500 low-fat participants, with hazard ratios from 0.719 to 0.753, mainly in men. [2] It tests a pattern, not a single food.How to judge a food claim
- Randomized trial or observational?
- Marker or outcome?
- Whole food, juice, powder or supplement?
- How large, how long, how many people?
- Who funded it? (We did not check funding for every study.)
- Does the claim need a medical reviewer? Our pages do not have one yet.
See Claim checks and Comparisons.
Frequently asked questions
Does a higher PubMed count mean a food is better?
No; it only means more has been published. [1]
References
- National Library of Medicine. PubMed. Record counts retrieved 2026-10-22 through NCBI E-utilities.
- Delgado-Lista J et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. Lancet 2022. PMID 35525255.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.