natural remedies · Ingredient
Berberine
Formula: C20H18NO4+ · MW: 336.3670000000001 · Drug-likeness: 0.674
⚗️ Identity
Name
Berberine
Aliases / Synonyms
2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin; Berberone; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium
🧪 Chemistry
Molecular Weight
336.3670
LogP
3.0963
Drug-likeness
0.674
Oral Bioavailability
36.8610
H-Bond Acceptors
4
Rotatable Bonds
2
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
InChIKey
YBHILYKTIRIUTE-UHFFFAOYSA-N
2
Clinical Trials
0
Meta-Analyses
75
PubMed References
Top Conditions Studied with Berberine
📋 Sample Trials
NCT05845931
Sex Differences in Berberine Pharmacokinetics
Recruiting · Pharmacokinetic Study in Healthy Volunte
NCT05947370
Berberine on the Secretion of Incretin
Completed · Early_Phase 1 · Diabetes Mellitus
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31037132
Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
Theranostics · 2019
PMID 28990249
Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer
Cell Prolif · 2017
PMID 25682924
Berberine inhibits the proliferation of human uterine leiomyoma cells
Fertil Steril · 2015
PMID 22019891
A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome
Eur J Endocrinol · 2012
PMID 21496227
Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells
Mol Cancer · 2011
PMID 31399854
Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of tumour-associated fibroblast-induced colonic epithelial cells through regulation of TGF-β signalling
J Cell Commun Signal · 2020
🏥 Linked Health Topics 1 · matched via study conditions