Healthy Aging
Understand Longevity Research & Claims
Headlines about living to 100 or reversing ageing often rest on mouse studies or blood markers rather than on people living longer or staying independent. This page helps you tell the difference, see which habits have the strongest human evidence, and judge supplement and clinic claims before you spend money or take risks.
General information, not medical advice. Last updated November 1, 2026. Written by the AlternativeMed editorial team. Not medically reviewed.
Start here
- Ask three questions of any longevity claim: was it tested in people, did it measure a real outcome (living longer, staying independent, fewer falls or fractures) rather than a blood number, and who paid for the study.
- Put your effort first into habits with human evidence: staying physically active, including strength training, not smoking, a healthy weight and a good-quality diet.
- Before buying a longevity supplement or booking an anti-aging clinic, show the product to your pharmacist or doctor, especially if you take any medicine.
Be careful with
- Natural does not mean safe. The National Institute on Aging (NIA) says a supplement can have side effects and can make a prescribed medicine weaker or stronger.
- Some medicines are being studied for ageing in research settings. They are prescription medicines with real risks and are not something to obtain or take on your own because of a headline.
- Do not stop or change a prescribed medicine because of anything you read about longevity; talk to the prescriber or pharmacist.
Get help when
- Unplanned weight loss, new confusion, falls, or loss of independence: these need a medical check, not an anti-aging product (see the warning signs guide).
- Side effects after starting any supplement, such as rash, stomach upset, palpitations or feeling unwell.
- Being offered a clinic programme that involves hormones, infusions or prescription medicines for "anti-aging": ask your own doctor for an independent opinion first.
- You take several medicines or have kidney, liver or heart conditions and want to add supplements.
About Understand Longevity Research & Claims
What this goal means
This goal is about understanding how longevity research works and how to judge claims, not about a specific symptom. Longevity claims range from solid lifestyle findings to products sold on early or animal-only research. The aim is to know which is which.
Related goals cover the practical side: independence, falls, nutrition and medicines. This page is the claims-reading guide that sits beside them.
1Common experiences
People often meet longevity ideas through a news story, a podcast, social media or an advert for a supplement or a clinic. It is easy to feel that everyone else is doing something you are missing, or that ageing can be switched off with the right product.
NIA notes that adverts for supplements sometimes promise to help you live longer, and that there is often little, if any, science supporting these claims.
1Why claims get ahead of the evidence
Three kinds of evidence are easily mixed up. An animal or lab study can show that something extended life in mice. A biomarker study shows a blood level or test changed in people. A human outcome study shows people actually lived longer, stayed independent or had fewer diseases.
For example, a drug that extends life in genetically varied mice was reported in 2009 and 2011 studies, while resveratrol did not significantly change survival in the same kind of mice. In people, trials of NAD precursors raised blood NAD levels, but that is a step removed from healthier ageing.
Industry links matter too. Some of the supplement and drug trials we read were run by, or had authors employed by, the company concerned.
2,3,4,5,6Conditions and situations that make this relevant
The claims matter most when someone is living with frailty, muscle loss, memory change or several medicines, because the wrong product can cost money, delay real care or interact with treatment. Pages on frailty, sarcopenia and memory changes cover those conditions.
1Realistic expectations
No supplement we found has been shown in human trials to extend lifespan. The strongest human findings concern habits: in a large US cohort study, adults with five low-risk lifestyle factors (never smoking, healthy weight, regular activity, moderate alcohol and a high-quality diet) had much lower mortality than those with none, and the authors projected about 12 to 14 more years of life expectancy at age 50. This was observational, so it shows association rather than proof, and we do not suggest starting to drink alcohol.
Resistance training has the best trial support for physical function in older people: a Cochrane review of 121 trials with 6,700 people found a large effect on strength and modest gains in gait speed.
7,8Who this applies to
Adults of any age who are curious about longevity, and especially people over 50, carers and families who are being sold products or programmes. If you are pregnant, breastfeeding or under 18, do not use longevity products without a clinician's advice; the research we found is in adults.
1Related conditions and symptoms
Frailty: What It Means and What Helps → Sarcopenia and Muscle Loss With Age → Mild Cognitive Impairment and Dementia → Unintentional Weight Loss: Why It Matters →
A manageable starting plan
An educational starting point, not a personal prescription. Adjust it to your own situation and any advice from your clinician.
Your first actions
- Pick one habit with strong evidence, such as starting or continuing strength training, and schedule it.
- Use the three questions on every claim: people, real outcome, who paid.
- Bring every supplement and medicine to a pharmacist or doctor review.
Optional additions
- Read the claim-check pages for any specific product you are considering.
- Ask your clinician about standard checkups and screening that suit your age.
What to track
- Which products you take, since when, and any side effects.
- Your weekly activity and strength sessions.
- Questions to ask at your next medicines review.
When to reassess
If a product has not clearly helped the specific thing you wanted within the time you set, or causes side effects, stop it and speak to a pharmacist or clinician. Never stop a prescribed medicine without advice.
When to seek professional support
- A pharmacist for supplement and medicine interactions.
- A doctor or nurse for checkups and independent opinions on clinics.
- Local exercise classes and physiotherapists for supervised strength and balance work.
What helps
Ordered by how well the research supports each step. Evidence strength is shown on every card; precautions sit next to the advice.
Start here
Check what was actually measured
Moderate certaintyAddresses: Separates real benefit from a changed blood number
Why it may help: A review by the Biomarkers of Aging Consortium says clinical translation of ageing biomarkers remains limited and that they need validating so they are robust and responsive in individuals. A rise in a blood marker is not the same as living longer or staying well.
How to apply it: When you read a claim, find the outcome: lifespan, falls, fractures, walking ability, or just a lab value. If it is only a lab value or an animal result, treat it as early.
Who it may suit: Anyone reading longevity news or product pages.
Precautions: This is a reading habit, not a treatment. It does not replace medical advice.
9Build strength training into your week
High certaintyAddresses: Better strength and physical function
Why it may help: A Cochrane review of 121 randomized trials with 6,700 older people found progressive resistance training improved muscle strength (a large effect) and physical ability, with modest gains in walking speed. Serious adverse events were rare, though the review notes adverse events were poorly recorded.
How to apply it: Choose supervised or well-instructed strength exercises two to three times a week, as used in most of the trials, and build up gradually. See the linked pages for how to start.
Who it may suit: Most older adults; ask a clinician first if you have heart disease, joint problems, balance problems or have been inactive.
Precautions: Stop and get medical help for chest pain, fainting or severe breathlessness. Muscle soreness is common at first.
8Strength Training and Protein for Older Adults → Maintain the Muscle You Have →
Back the whole healthy-lifestyle package
Moderate certaintyAddresses: Lower risk of early death in observational data
Why it may help: In the Nurses' Health Study and Health Professionals Follow-up Study (up to 34 years of follow-up, 42,167 deaths), people with all five low-risk lifestyle factors had a hazard ratio of 0.26 for all-cause mortality compared with none. Observational findings cannot prove cause, but the direction matches other evidence on activity and not smoking.
How to apply it: Work on whichever factor is hardest for you first: tobacco, activity, weight, diet quality. Small steps count.
Who it may suit: Adults of all ages; the cohorts were mostly health professionals, so results may not apply equally to everyone.
Precautions: The study counted moderate alcohol as low-risk; health agencies do not advise starting to drink. Talk to a clinician about tobacco, weight and activity plans.
7Stay Active Throughout Your Life → Build Heart-Healthy Habits →
Additional options
Ask about falls prevention and home safety
High certaintyAddresses: Fewer falls
Why it may help: A Cochrane review of falls prevention trials concluded that group and home-based exercise programmes and home safety interventions reduce the rate of falls and risk of falling, and that Tai Chi reduces the risk of falling. Education alone did not significantly reduce falls.
How to apply it: Ask your doctor or local health service about exercise classes and a home safety check.
Who it may suit: Older adults, especially after a fall.
Precautions: A fall with a head injury, or on blood thinners, needs prompt medical care.
10Bring every supplement to a medicines review
Moderate certaintyAddresses: Spots interactions and unneeded products
Why it may help: NIA says supplements can have unwanted effects such as unsafe interactions with prescription drugs, may not work at all, and that you can waste money on unneeded ones. It suggests telling your doctor about every supplement.
How to apply it: List everything you take, including powders and teas, and review it with a pharmacist or doctor once a year.
Who it may suit: Anyone taking supplements or medicines.
Precautions: Do not stop a prescribed medicine yourself.
1Still being studied
Creatine combined with strength training
Low certaintyAddresses: Possible extra gain in lean mass and strength
Why it may help: A meta-analysis of randomized trials in 357 older adults found creatine plus resistance training increased fat-free mass and chest and leg press strength more than training alone; the authors said more studies were needed. This is a muscle outcome, not a longevity outcome.
How to apply it: Studied alongside supervised resistance training over roughly three months. Discuss it with a clinician first.
Who it may suit: Older adults already doing strength training.
Precautions: People with kidney disease should ask their care team first. The effect is for the combination, not creatine alone.
11Daily multivitamin-mineral for memory test scores
Low certaintyAddresses: Small difference on a cognition score
Why it may help: In COSMOS-Mind, 2,262 people (mean age 73) taking a daily multivitamin-mineral for three years had slightly better global cognition scores than placebo (mean z 0.07). The authors said confirmation in more diverse groups is needed. It is not evidence of longer life.
How to apply it: Studied as a daily multivitamin for three years.
Who it may suit: Older adults who decide with their clinician that a multivitamin is reasonable.
Precautions: Ask a pharmacist about interactions; more is not better.
12,1Supplements for Healthy Aging: Creatine, Calcium and Vitamin D, Collagen and Antioxidants →
Food & nutrition
Food and longevity claims
We did not find a single food, juice or superfood shown in the sources we read to extend human life. NIA says eating a variety of healthy foods is the best way to get the nutrients you need; supplements can have unwanted effects and may not work at all.
The lifestyle cohort study counted high diet quality as one low-risk factor among five, which is a pattern rather than one food. For practical eating advice for older adults, see the linked nutrition page.
1,7Remedies & supplements
Traditional use, laboratory findings and human trials are kept apart. "Natural" does not mean safe.
NMN (nicotinamide mononucleotide)
Low certaintyStudied form and route: Oral NAD precursor supplement
Intended outcome: Raises blood NAD; possible small walking and sleep-score changes
Human evidence: An 80-person trial in healthy middle-aged adults found higher blood NAD, longer six-minute walking distance and better survey scores than placebo over 60 days; the blood biological-age score rose in the placebo group but stayed unchanged in the NMN groups. A 60-person trial in older adults found no difference on its main stepping test, but faster 4-metre walking and better sleep-questionnaire scores at 12 weeks.
Laboratory findings: The trial authors state that animal studies suggest NMN improves healthspan; we did not review those studies.
Limits: Short trials, small numbers, some authors employed by companies in the field. We did not find evidence of longer life, fewer falls or disease prevention.
Interactions and precautions: No safety issues were found in these short trials, but long-term safety is unknown. Check with a pharmacist if you take medicines; avoid in pregnancy and breastfeeding unless a clinician advises.
4,5NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
Nicotinamide riboside (NR)
Not enough evidenceStudied form and route: Oral NAD precursor supplement
Intended outcome: Raises blood NAD; cognition unchanged in one trial
Human evidence: A crossover trial in healthy middle-aged and older adults found NR was well tolerated and stimulated NAD+ metabolism; the authors suggested future trials look at blood pressure and arterial stiffness. In older adults with mild cognitive impairment, 10 weeks of NR raised blood NAD+ 2.6-fold but cognition scores remained stable.
Limits: Short and small. The MCI trial authors said a larger, longer trial is needed.
Interactions and precautions: Ask a clinician before use if you have memory problems, take medicines, are pregnant or breastfeeding.
13,14NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
Resveratrol
Not enough evidenceStudied form and route: Plant polyphenol supplement
Intended outcome: Vessel-lining markers in some trials; no lifespan evidence
Human evidence: A systematic review and meta-analysis of randomized trials reported improved endothelial health markers.
Laboratory findings: Did not significantly change survival in genetically varied mice.
Limits: A marker finding, not a longevity outcome.
Interactions and precautions: Supplements can interact with prescribed medicines; check with a pharmacist.
15,3Resveratrol and polyphenols → NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
Antioxidant pills (vitamins A, C, E, beta-carotene, selenium)
Evidence againstStudied form and route: High-dose supplements
Intended outcome: No mortality benefit; possible harm
Human evidence: A Cochrane review of 78 trials found no evidence to support antioxidant supplements for preventing mortality; beta-carotene and vitamin E seemed to increase mortality, and higher doses of vitamin A may too.
Limits: Trials covered varied populations and doses.
Interactions and precautions: Smokers and people with disease should take advice before using beta-carotene or vitamin A pills.
16Supplements for Healthy Aging: Creatine, Calcium and Vitamin D, Collagen and Antioxidants →
Creatine with resistance training
Low certaintyStudied form and route: Powder or capsule used alongside strength training
Intended outcome: Possible extra lean mass and strength
Human evidence: Meta-analysis of 357 older adults found more fat-free mass and chest and leg press strength than training alone.
Limits: Few studies; effect shown with training, not on its own; not a longevity outcome.
Interactions and precautions: Ask your care team first if you have kidney disease.
11Therapies & care
Established care for ageing well is delivered by your own doctor, pharmacist and rehabilitation professionals. This page does not recommend any medicine or dose, and you should not start, stop or change a prescribed medicine because of longevity claims; discuss it with your prescriber.
Supervised or instructed strength and balance programmes
High certaintyExercise-based care Cochrane reviews found progressive resistance training improves strength and physical function in older people, and that exercise programmes and home safety interventions reduce falls.
Who it may suit: Older adults, including those at risk of falls.
Precautions: Get clinician guidance first if you have heart disease, joint problems or have been inactive.
8,10Strength Training and Protein for Older Adults → Falls and Balance →
Medicines and supplement review with a pharmacist or doctor
Moderate certaintyMedical review NIA advises talking with your doctor about any supplement and notes that supplements can interact with prescription drugs.
Who it may suit: Anyone taking several products.
Precautions: Do not stop prescribed medicines on your own.
1Independent opinion before an anti-aging clinic programme
Not enough evidenceConsumer safety We did not find trial evidence in the sources we read that hormone, infusion or prescription programmes sold for anti-aging extend healthy life in people. Ask your own doctor for a second view first.
Who it may suit: Anyone offered an anti-aging programme.
Precautions: Programmes involving prescription medicines carry medical risks.
6,17What to avoid
Habits, products and claims that can get in the way. Never stop a prescribed medicine without talking to the professional who prescribed it.
Risks that apply to most people
Treating a mouse study as proof for people
High certaintyWhy: An mTOR-blocking drug was reported to extend lifespan in genetically varied mice, and resveratrol did not significantly change survival in a related study. Mouse results often do not carry over to people.
Who it applies to: Anyone reading longevity news.
Try instead: Look for randomized trials in people that measured real outcomes.
2,3NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
Letting a product replace the basics
Moderate certaintyWhy: The best-supported benefits we found come from activity, especially strength training, and from the lifestyle factors in cohort studies, not from supplements.
Who it applies to: Anyone considering a longevity product.
Try instead: Put time and money into movement, food, sleep and checkups first.
8,7Personal triggers to check
Starting a high-dose antioxidant supplement for longevity
Evidence againstWhy: A Cochrane review of 78 trials found no evidence to support antioxidant supplements for preventing death; in low-risk-of-bias trials they significantly increased mortality (RR 1.04), and beta-carotene and vitamin E seemed to increase mortality.
Who it applies to: People taking vitamin A, C, E, beta-carotene or selenium pills for anti-ageing.
Try instead: Get antioxidants from food and ask a clinician before using high-dose pills.
16Supplements for Healthy Aging: Creatine, Calcium and Vitamin D, Collagen and Antioxidants →
Products that need caution
NMN and NR (NAD booster) products sold as anti-aging
Not enough evidenceWhy: Trials of 60 to 80 people over weeks raised blood NAD and showed small changes in some walking or sleep measures; one trial in people with mild cognitive impairment saw no change in cognition scores. We did not find trials showing longer life or fewer diseases.
Who it applies to: Adults tempted by NAD booster products.
Try instead: Treat as experimental; read the claim-check page and ask a pharmacist.
4,5,14,13NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
Resveratrol and "polyphenol" anti-aging blends
Not enough evidenceWhy: Resveratrol did not significantly change survival in mice. A meta-analysis of randomized trials reported improved endothelial (blood-vessel lining) markers, which is a marker finding rather than a longevity outcome.
Who it applies to: People buying resveratrol or similar products.
Try instead: Eat a varied plant-rich diet and ask a clinician about any pill.
3,15NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
Unsupported claims
"Senolytics clear old cells and reverse ageing"
Not enough evidenceWhy: In a phase 2 trial in 60 postmenopausal women, the main bone-marker endpoint did not differ from control; the authors say further studies are needed. A small preliminary report in people with diabetic kidney disease looked at senescent-cell markers only.
Who it applies to: Clinic and social media claims.
Try instead: Regard as research; do not seek these medicines outside a trial.
17,18NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
"Anti-aging drugs are proven in people"
Evidence againstWhy: A one-year trial in healthy adults of an mTOR-blocking drug did not significantly change its main outcome, visceral fat, and a feasibility trial in older adults tested safety only. A diabetes medicine blunted muscle gains from strength training in adults 65 and older.
Who it applies to: Anti-aging clinics and online sellers.
Try instead: Ask your own doctor for an independent opinion.
6,19,20NAD, NMN, Resveratrol and Longevity Claims: What Humans Show →
"Your biological age test tells you what to do"
Low certaintyWhy: The Biomarkers of Aging Consortium says clinical translation of these tests remains limited and that they need validating in individuals.
Who it applies to: Direct-to-consumer test kits.
Try instead: Use standard checkups your clinician recommends.
9Common mistakes
Taking vitamin D and calcium only to prevent fractures and falls
Moderate certaintyWhy: VITAL (25,871 adults) found vitamin D3 did not significantly lower fractures among generally healthy adults not selected for deficiency, and a falls analysis found no reduction. The falls review says vitamin D may help people with low starting levels.
Who it applies to: Generally healthy older adults.
Try instead: Ask a clinician whether you need a blood test or supplement.
21,22,10Copying a protocol without telling your clinician
High certaintyWhy: NIA advises talking with your doctor before taking a supplement and notes interactions with prescription drugs.
Who it applies to: Anyone on medicines.
Try instead: Share the full list with your pharmacist.
1Evidence & safety
What the research shows
The sources we read support a few clear points: resistance training improves strength and function in older people, exercise and home safety reduce falls, and cohort data link healthy lifestyle factors with lower mortality. Longevity supplements and medicines are mostly supported by mouse studies or short human trials of blood markers; we did not find trials showing they extend human lifespan, and high-dose antioxidant pills were linked with higher mortality in a Cochrane review.
Limits of the evidence
- We read a limited set of trials, reviews and one NIA page; this is not an exhaustive review.
- Lifestyle cohort findings are observational and cannot prove cause.
- Many NAD, drug and supplement trials are small, short and some are linked to the companies concerned.
- Research moves quickly; check for newer trials.
Precautions and interactions
- Natural does not mean safe; supplements can interact with medicines.
- Never stop or change a prescribed medicine because of longevity claims.
- Research medicines for ageing are not for self-treatment.
Life-stage considerations
- Pregnancy and breastfeeding: do not use longevity supplements unless a clinician advises; the trials we read were in adults.
- Children and teenagers: longevity products are not appropriate.
- Older adults: more medicines mean more interaction risk; review with a pharmacist.
- People with kidney, liver or heart conditions: ask your care team before any supplement.
Warning signs
- Unplanned weight loss, new confusion or a fall with head injury need prompt medical care.
- Side effects after starting any product, such as rash, palpitations or severe stomach upset.
- Chest pain, fainting or severe breathlessness during exercise: stop and get urgent care.
- Low mood or loss of interest lasting two weeks or more: see a doctor.
Claim checks
NMN or NR will slow ageing
Insufficient evidence
4,5,14Resveratrol is an anti-aging supplement
Insufficient evidence
3,15Antioxidant pills help you live longer
Against
16Senolytic or other anti-aging drugs are proven in people
Insufficient evidence
17,6,19Vitamin D prevents fractures and falls in healthy older adults
Mixed to against
21,22Strength training helps older people stay functional
Supported
8Questions people ask
What is the difference between lifespan and healthspan?
Lifespan is how long you live; healthspan is how many of those years you stay well and independent. Most useful trials measure outcomes that relate to healthspan, such as walking, strength and falls.
Do mouse results apply to people?
Not reliably. An mTOR-blocking drug extended life in mice in the studies we read, while resveratrol did not significantly change survival. Human trials are needed.
Does NMN make you live longer?
We did not find human trials showing that. Trials raised blood NAD and showed small, short-term changes in some walking and sleep measures.
Are biological-age tests worth buying?
Experts in the Biomarkers of Aging Consortium say clinical translation remains limited and that tests need validation in individuals.
What has the best evidence for ageing well?
Strength training for function and exercise plus home safety for fewer falls have randomized trial support. Healthy lifestyle factors are linked with lower mortality in cohort studies.
Are antioxidant supplements good for ageing?
A Cochrane review found no evidence to support them for preventing death and some signals of harm.
Do vitamin D and calcium prevent fractures?
VITAL found no significant effect of vitamin D3 on fractures in generally healthy adults not selected for deficiency. Ask your doctor whether you need testing.
Should I try creatine?
Creatine has been studied together with strength training in older adults with modest gains in muscle. Ask a clinician first, especially with kidney problems.
Is it safe to take supplements with my medicines?
Not always. NIA says supplements can make prescribed medicines weaker or stronger. Ask a pharmacist.
Where can I read product-specific checks?
See the claim-check pages linked below for NAD, NMN and resveratrol, and for supplements for healthy aging.
References
- National Institute on Aging. Dietary Supplements for Older Adults. Read 2026-11-01. source
- Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009. Read 2026-11-01. source
- Miller RA, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011. Read 2026-11-01. source
- Yi L, et al. The efficacy and safety of beta-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023. Read 2026-11-01. source
- Morifuji M, et al. Ingestion of beta-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study. Geroscience. 2024. Read 2026-11-01. source
- Moel M, et al. Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results. Aging (Albany NY). 2025. Read 2026-11-01. source
- Li Y, et al. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018. Read 2026-11-01. source
- Liu CJ, Latham NK. Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev. 2009. Read 2026-11-01. source
- Biomarkers of Aging Consortium; Herzog CMS, et al. Challenges and recommendations for the translation of biomarkers of aging. Nat Aging. 2024. Read 2026-11-01. source
- Gillespie LD, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012. Read 2026-11-01. source
- Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults: a meta-analysis. Med Sci Sports Exerc. 2014. Read 2026-11-01. source
- Baker LD, et al. Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial (COSMOS-Mind). Alzheimers Dement. 2023. Read 2026-11-01. source
- Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018. Read 2026-11-01. source
- Orr ME, et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. Geroscience. 2024. Read 2026-11-01. source
- Mohammadipoor N, et al. Resveratrol supplementation efficiently improves endothelial health: a systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022. Read 2026-11-01. source
- Bjelakovic G, et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2012. Read 2026-11-01. source
- Farr JN, et al. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nat Med. 2024. Read 2026-11-01. source
- Hickson LJ, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019. Read 2026-11-01. source
- Kraig E, et al. A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort. Exp Gerontol. 2018. Read 2026-11-01. source
- Walton RG, et al. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: a randomized, double-blind, placebo-controlled, multicenter trial. Aging Cell. 2019. Read 2026-11-01. source
- LeBoff MS, et al. Supplemental vitamin D and incident fractures in midlife and older adults (VITAL). N Engl J Med. 2022. Read 2026-11-01. source
- LeBoff MS, et al. VITAL: Effects of vitamin D supplements on risk of falls in the US population. J Clin Endocrinol Metab. 2020. Read 2026-11-01. source
Related on AlternativeMed
Related goals
Maintain Your Everyday Independence → Reduce Your Risk of Falls → Stay Well Nourished as You Age → Review Medicines & Supplements Safely → Keep Up With Preventive Care → Maintain the Muscle You Have → Stay Active Throughout Your Life →
Ingredients, foods and supplements
Creatine and collagen → Vitamin D → Resveratrol and polyphenols →
Research, safety and claim-check resources
Supplements for Healthy Aging: Creatine, Calcium and Vitamin D, Collagen and Antioxidants → NAD, NMN, Resveratrol and Longevity Claims: What Humans Show → Healthy Aging Research and Evidence → Healthy Aging: Warning Signs and When to Get Help → Longevity & Healthy Aging → Healthy Aging →