natural remedies · Ingredient
Caffeine
Formula: C8H10N4O2 · MW: 194.194 · Drug-likeness: 0.538
⚗️ Identity
Name
Caffeine
Aliases / Synonyms
58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina
🧪 Chemistry
Molecular Weight
194.1940
LogP
-1.0293
Drug-likeness
0.538
Oral Bioavailability
89.4580
H-Bond Acceptors
6
🔗 External References
191
Clinical Trials
131
Meta-Analyses
21
PubMed References
Top Conditions Studied with Caffeine
📋 Sample Trials
NCT04685005
"WakeUp" for Vigilance Following Lunch
Completed · Fatigue
NCT00611416
The Role of Tea Catechins and Caffeine in Relation to Energy Metabolism
Completed · Obesity
NCT00117520
The Effect of Caffeine in Elderly Citizens
Completed · Phase 4 · Healthy Elderly Citizens
NCT00130026
Caffeine in the Prevention of Post-operative Nausea and Vomiting
Completed · Postoperative Nausea and Vomiting
NCT00182312
Caffeine for Apnea of Prematurity (CAP)
Completed · Phase 3 · Apnea of Prematurity
NCT00184912
The Effect of Caffeine on Ischemic Preconditioning
Completed · Caffeine|Ischemic Preconditioning|Ischem
📊 Sample Meta-Analyses
CRD42022363638
What is the evidence of the use of beta alanine, creatine, caffeine and coenzyme Q10 in the treatment of neurodegenerative diseases?
Clinical results, Biological (biochemical and immunological analyses) and behavi
CRD42015015714
Is caffeine intake a risk factor leading to infertility? An epidemiological systematic review of analytical studies
Infertility describe a woman who is unable to conceive as well as being unable
CRD42015020333
The effects of coffee and caffeine consumption on fecundity and fertility: a systematic review and dose-response mate-analysis
Fecundity and fertility outcomes. The outcomes will be studied among couples wit
CRD42015024074
Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults [Cochrane Protocol]
The Cochrane Pain, Palliative and Supportive Care Group
CRD42015026609
Systematic review of the adverse bone and calcium balance effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children
Bone and calcium balance
CRD42015026673
Systematic review of the adverse cardiovascular effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children
Cardiovascular
📚 Sample References
PMID 31595831
Ilex paraguariensis extract provides increased resistance against oxidative stress and protection against Amyloid beta-induced toxicity compared to caffeine in Caenorhabditis elegans
Nutr Neurosci · 2021
PMID 32050085
Immunomodulatory benefits of mesenchymal stem cells treated with Caffeine in adjuvant-induced arthritis
Life Sci · 2020
PMID 32392893
Maternal Caffeine Intake Disrupts Eggshell Integrity and Retards Larval Development by Reducing Yolk Production in a Caenorhabditis elegans Model
Nutrients · 2020
PMID 32513156
Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway
Respir Res · 2020
PMID 32621279
Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder
Mol Neurobiol · 2020
PMID 32831996
Prevention of Oxygen-Induced Inflammatory Lung Injury by Caffeine in Neonatal Rats
Oxid Med Cell Longev · 2020
🏥 Linked Health Topics 12 · matched via study conditions
Apnea
phenotype
Rheumatoid Arthritis
syndrome
Asthma
syndrome
Atrial Fibrillation
syndrome
Birth Weight
phenotype
Bronchopulmonary Dysplasia
syndrome
Fatigue
phenotype
Hiv Infections
group
Huntington Disease
syndrome
Intermittent Claudication
phenotype
Liver Cirrhosis
syndrome
Musculoskeletal Pain
phenotype