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Each record is a registered study, a systematic-review registration or a publication. A registered or ongoing study is not a finding, and animal or cell research does not show an effect in people. The same study can appear under more than one subject, so the number of records is not a count of independent studies. You can also search an exact DOI, PubMed ID, NCT or CRD number. How to read these records.

32 study records (showing up to 30 per record type)

• Registered trial NCT00137098 Completed (results not assessed here)
  Coronary Care Caffeine: Influence of Coffee on Heart Rate Post Myocardial Infarction
  Condition or outcome area: Myocardial Infarction
  2003-09 · Subject: Caffeine; NCGC00015208-02; DHCplus; KBio2_001781; W222402_ALDRICH; NINDS_000730; EINECS 200-362-1; Spectrum5_000423; BSPBio_001921; KBio1_000730 · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02929901 Phase 2 / Phase 3 Completed (results not assessed here)
  The Effects of Coffee Main Constituents (Caffeine and Chlorogenic Acid) Supplementation on Inflammatory, Metabolic Factors, Hepatic Steatosis and Fibrosis in None- Alcoholic Fatty Liver Patients With Type 2 Diabetes
  Condition or outcome area: Type 2 Diabetes Nonalcoholic Fatty Liver
  2016-12 · Subject: Caffeine; NCGC00015208-02; DHCplus; KBio2_001781; W222402_ALDRICH; NINDS_000730; EINECS 200-362-1; Spectrum5_000423; BSPBio_001921; KBio1_000730 · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT02751840 Phase 3 Completed (results not assessed here)
  Effects of Caffeine and Coffee on Resting Metabolic Rate, Comparing Normal Weight Men to Obese Men
  Condition or outcome area: Asymptomatic Conditions
  2014-10 · Subject: Caffeine; NCGC00015208-02; DHCplus; KBio2_001781; W222402_ALDRICH; NINDS_000730; EINECS 200-362-1; Spectrum5_000423; BSPBio_001921; KBio1_000730 · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT04911582 Completed (results not assessed here)
  Does the Bioactive Substance in Coffee, Cafestol, Have Preventive Properties on Type-2-diabetes? (Acute Substudy)
  Condition or outcome area: Obesity, Abdominal
  2021-05-25 · Subject: Cafestol · open the ingredient record · ClinicalTrials.gov
• Registered trial NCT05181176 Not completed: Unknown
  Effect of Coffee and Tea Consumption on Adolescent Weight Control
  Condition or outcome area: Body Weight
  2021-01-01 · Subject: Lv Cha; 绿茶; Green Tea; Folium Camelliae Sinensis · open the herb record · ClinicalTrials.gov
• Registered trial NCT05181176 Not completed: Unknown
  Effect of Coffee and Tea Consumption on Adolescent Weight Control
  Condition or outcome area: Body Weight
  2021-01-01 · Subject: Cha Ye; 茶叶; Common Tea; Camellia Sinensis · open the herb record · ClinicalTrials.gov
• Registered trial NCT03248115 Completed (results not assessed here)
  Bioavailability of Green Tea and Coffee Polyphenols
  Condition or outcome area: Diet, Food, and Nutrition|Dietary Supplements
  2013-04-10 · Subject: Lv Cha; 绿茶; Green Tea; Folium Camelliae Sinensis · open the herb record · ClinicalTrials.gov
• Registered trial NCT01089920 Completed (results not assessed here)
  Dose Response Bioavailability of Coffee and Green Tea Antioxidants in Humans
  Condition or outcome area: Healthy
  2009-09 · Subject: Lv Cha; 绿茶; Green Tea; Folium Camelliae Sinensis · open the herb record · ClinicalTrials.gov
• Systematic review registration CRD42023482359 Registered protocol, no results here: Review Ongoing
  The effect of caffeine and coffee on patients with multiple sclerosis: a systematic review
  Condition or outcome area: Multiple Sclerosis
  2023-11-23 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42023456247 Registered protocol, no results here: Review Ongoing
  Tea, coffee and caffeine intake and risk of dementia and Alzheimer's Disease: a systematic review and meta-analysis of observational studies
  Condition or outcome area: Dementia and Alzheimer's Disease
  2023-08-31 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42023451120 Registered protocol, no results here: Review Ongoing
  Does coffee/caffeine consumption after having a myocardial infarction decrease the risk of overall mortality?
  Condition or outcome area: All-cause mortality and cardiovascular mortality
  2023-08-14 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42023430430 Registered protocol, no results here: Review Ongoing
  Umbrella Review of the Effects of Tea, Coffee and Caffeine Intake on Cognitive Function in Older Adults: Assessing Study Quality and Methodological Limitations
  Condition or outcome area: normal cognition, cognitive impairment, mild cognitive impairment (MCI), dementia, Alzheimer disease
  2023-06-21 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42023421164 Registered protocol, no results here: Review Ongoing
  Systematic review of caffeine consumption during pregnancy and its neurocognitive impacts on children.
  Condition or outcome area: Caffeine, derived from the xanthine alkaloids, is a purine-based heterocyclic organic compound. It is heavily consumed around the world, especially in coffee. In 1980, the Food and Drug Administration (FDA) issued a warning advising pregnant women to restrict or abstain from its use, as even typical levels of caffeine consumption result in increased maternal blood concentrations during pregnancy, with a risk of toxicity to the fetus. Epidemiological studies have shown that the main concerns of c
  2023-05-05 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42023408316 Registered protocol, no results here: Review Ongoing
  Efficacy and safety of caffeic acid tablets in the treatment of leukopenia: a systematic review and meta-analysis
  Condition or outcome area: The main ingredient of caffeic acid tablet is caffeic acid, also known as "3, 4-hydroxycinnamic acid" or "3, 4-dihydroxy phenyl acrylic acid", which is a phenolic compound and classified as cinnamic acid . Its molecular formula: C9H8O4, relative molecular weight: 180.16Da. It is widely found in many plant foods and herbs such as fruits, wine, coffee, olive oil, and legumes . Caffeic acid has antidepressant, antihyperglycemic, antioxidant, anticancer, antiviral, anti-inflammatory, and immunomodul
  2023-03-26 · Subject: Trans-caffeic acid; Caffeic Acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 501-16-6; 3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid · open the ingredient record
• Systematic review registration CRD42022371494 Registered protocol, no results here: Review Ongoing
  The association between coffee and caffeine consumption and hypertension risk: an umbrella and meta-analysis review
  Condition or outcome area: Any observational studies including prospective cohort, case-control and cross-sectional study which assessed the risk of hypertension (presented as OR, HR and RR) in the highest category of exposure in comparison with the lowest one will be eligible. These studies should be conducted on adults, and provided details on the criteria for HTN detection.
  2022-11-14 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42022309571 Registered protocol, no results here: Review Ongoing
  The effect of caffeine consumption in coffee in adults and the elderly in the prevention of cardiovascular disease, a systematic review
  Condition or outcome area: Coffee is a drink consumed daily worldwide and it is believed nowadays that coffee can harm cardiovascular health by promoting increased blood pressure and cardiac arrhythmias due to its effect of increasing this heart rate by stimulating the system sympathetic nervous, increasing adrenaline levels. For a long time and still today, coffee had a reputation as a food that was harmful to health. The importance of the work is to show evidence on how the biochemical effects of caffeine in coffee beha
  2022-03-11 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42022298824 Registered protocol, no results here: Review Ongoing
  Association between dietary caffeine, coffee, tea consumption and depressive symptoms in adults: A systematic review and dose-response meta-analysis of observational studies
  Condition or outcome area: Depressive symptoms
  2022-01-16 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42022295943 Registered protocol, no results here: Review Ongoing
  The effect of caffeine from coffee consumption on the control of Diabetes Mellitus, type 2: a systematic review
  Condition or outcome area: Coffee is a drink consumed daily worldwide. This drink has caffeine as its main compound. The quality of caffeine in coffee can be studied under several aspects when related to benefits for human health. One aspect is the effects on insulin levels in individuals with type 2 diabetes mellitus.Studying these effects can bring several benefits to the health of these populations.
  2022-01-02 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42021267731 Registered protocol, no results here: Review Ongoing
  Relationship between maternal caffeine and coffee intake and pregnancy loss
  Condition or outcome area: During pregnancy, caffeine consumption has been connected to different adverse outcomes containing spontaneous abortion, congenital disabilities, and low birth weight
  2021-08-13 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42021248736 Registered protocol, no results here: Review Ongoing
  Coffee, caffeine intake and risk of hypertension: a systematic review and dose-response meta-analysis
  Condition or outcome area: About one third of the world's adults have high blood pressure. Deaths caused by high blood pressure have increased by 56.1% over the past decade, and despite significant advances in pharmacological treatment, high blood pressure remains the leading cause of premature death worldwide. Coffee is one of the most popular beverages worldwide and contains substantial amounts of caffeine, making caffeine the most widely consumed psychoactive agent. Recently, several new cohort studies have explored co
  2021-05-15 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42021243102 Registered protocol, no results here: Review Ongoing
  Effect of caffeine on energy intake and appetite
  Condition or outcome area: Caffeine, a psychostimulant most commonly ingested in the forms of coffee, energy drink, and tea, is often believed to have an effect on weight loss. Several studies have demonstrated metabolic effects of caffeine in human or animal experiments such as enhanced thermogenesis or alteration of lipid or glucose metabolisms that may lead to weight loss. However, the effect of caffeine on appetite or the perception of hunger remains unclear.
  2021-04-15 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42021227665 Registered protocol, no results here: Review Ongoing
  Type of Coffee, Tea, Caffeine intake and Risk of Rheumatoid Arthritis: A Dose–Response Meta-Analysis of Cohort Studies
  Condition or outcome area: Rheumatoid arthritis (RA) is a most prevalent autoimmune disease which can lead to daily activity dysfunction and decrease quality of life, diagnosed by joint function deterioration, erosion of cartilage and bone distraction. This condition may increase the risk of cardiovascular disease, cancer, and respiratory complications. The incidence rate of RA in industrialized countries is 5 to 10 per 1000 person. The cause of RA is not clear; nevertheless, studies have demonstrated that genetic and env
  2021-02-04 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42020196488 Registered protocol, no results here: Review Completed not published
  The effects of caffeine on voice-related measures: a systematic review
  Condition or outcome area: Hydration is essential for voice production. Systemic and superficial dehydration may adversely affect vocal fold mucosa, resulting to increased viscosity and consequently to increased vocal effort. Caffeine is considered as one of the most consumed psychoactive substances in the world and can be found in a variety of products (e.g. coffee, tea, energy drinks). One of the most common effects of caffeine is diuresis, which can lead in alternation of hydration status. As a dehydrating agent, it is
  2020-08-01 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42018106874 Registered protocol, no results here: Review Ongoing
  Coffee and caffeine consumption effects on gastrointestinal motility in healthy subjects: a systematic review
  Condition or outcome area: Coffee or caffeine consumption effects on the gastrointestinal motility of healthy individuals, in the form of action on the gastric emptying rate, effects on sphincter pressure, peristaltic movements, intestinal movements, colonic motility and stimulation of defecation.
  2018-11-14 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42018106870 Registered protocol, no results here: Review Ongoing
  What is the impact of the consumption of foods and beverages containing caffeine on the management of headache: a systematic review
  Condition or outcome area: Foods and beverages containing caffeine in their composition are highly consumed in many countries, especially coffee as the most consumed beverage after water. It has been shown that caffeine isolated or in combination with other drugs has multiple systemic effects that include activity on headaches. Deeper investigation into how frequent the consumption of these foods and beverages can positively or negatively influence headache management needs to be better clarified.
  2018-09-03 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42018102736 Registered protocol, no results here: Review Ongoing
  Differences in the risk for adverse pregnancy and birth outcome of coffee, tea and other caffeine containing beverage consumption during pregnancy: a meta-analysis
  Condition or outcome area: Caffeine containing beverages are frequently consumed during pregnancy. Caffeine has several physiological effects that finally can impair intrauterine growth and may lead to adverse pregnancy outcome such as spontaneous abortion, stillbirth, low birth weight, small for gestational age, preterm delivery or even eclampsia. However, other substances naturally being in the caffeine containing beverages (such as polyphenols, chlorogenic acid, etc.) may modify the effect of caffeine. Considering the
  2018-07-24 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Systematic review registration CRD42015020333 Registered protocol, no results here: Review Ongoing
  The effects of coffee and caffeine consumption on fecundity and fertility: a systematic review and dose-response mate-analysis
  Condition or outcome area: Fecundity and fertility outcomes. The outcomes will be studied among couples with natural fertility and among women and couples receiving fertility treatment.
  2015-06-09 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record
• Publication PMID 35958020 Research model: Animal & Cell Experiment
  Chlorogenic Acid, the Main Antioxidant in Coffee, Reduces Radiation-Induced Apoptosis and DNA Damage via NF-E2-Related Factor 2 (Nrf2) Activation in Hepatocellular Carcinoma
  Condition or outcome area: hepatocellular carcinoma; tumor
  Oxid Med Cell Longev · 2022 · Subject: Heriguard; Chlorogenic Acid; CHLOROGENIC ACID; 327-97-9; 3-O-Caffeoylquinic acid; Chlorogenate; 3-(3,4-Dihydroxycinnamoyl)quinic acid; 3-Caffeoylquinic acid; Hlorogenic acid; trans-Chlorogenic acid · open the ingredient record · DOI 10.1155/2022/4566949
• Publication PMID 35628642 Research model: Animal Experiment
  Coffee Polyphenol, Chlorogenic Acid, Suppresses Brain Aging and Its Effects Are Enhanced by Milk Fat Globule Membrane Components
  Int J Mol Sci · 2022 · Subject: Heriguard; Chlorogenic Acid; CHLOROGENIC ACID; 327-97-9; 3-O-Caffeoylquinic acid; Chlorogenate; 3-(3,4-Dihydroxycinnamoyl)quinic acid; 3-Caffeoylquinic acid; Hlorogenic acid; trans-Chlorogenic acid · open the ingredient record · DOI 10.3390/ijms23105832
• Publication PMID 36615664 Research model: Clinical Experiment
  Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes
  Condition or outcome area: non-alcoholic fatty liver disease; fibrosis; obese; liver fibrosis; Type-2-Diabetes
  Nutrients · 2023 · Subject: Caffeine; 58-08-2; Guaranine; 1,3,7-Trimethylxanthine; Methyltheobromine; Theine; Thein; Cafeina; Koffein; Mateina · open the ingredient record · DOI 10.3390/nu15010004
• Publication PMID 34715299 Research model: Animal Experiment
  Coffea arabica extracts and their chemical constituents in a murine model of gouty arthritis: How they modulate pain and inflammation
  Condition or outcome area: hypernociception; asthenia; inflammation; wounds; oedema; migraine; flu; headache; asthma; gout; attenuated gout; anemia
  J Ethnopharmacol · 2021 · Subject: Xiao Guo Ka Fei; 小果咖啡; Arabian Coffeetree Equivalent Plant: Coffea Liberica; Coffea Arabica · open the herb record · DOI 10.1016/j.jep.2021.114778
• Publication PMID 22734486 Research model: Cell Experiment
  Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma
  Condition or outcome area: Mesothelioma
  J Biomed Sci · 2012 · Subject: Cafestol; 469-83-0; cafesterol; CCRIS 1518; UNII-AC465T6Q6W; (-)-cafestol; AC465T6Q6W; CHEBI:3291; CAFESTOL [MI]; DTXSID3040986 · open the ingredient record · DOI 10.1186/1423-0127-19-60