Vitamins & Supplements · Formula
Plant Protein Powders
Plant protein powders (soy, pea, rice, hemp and blends) · also called Vegan protein powder, plant-based protein powder, proteína vegetal en polvo
Plant protein powders are protein separated from soy, peas, rice, hemp or other plants, sold alone or as blends, to mix into drinks and food. They are mainly studied for muscle and strength gains alongside weight training. Trials mostly found results similar to whey, but they were small and short, and two pea trials were linked to a pea-protein maker, one of them funded by it. Soy and pea are common allergens, and metal levels in powders vary.
General information, not medical advice. Last substantive update · Not medically reviewed. A named clinician has not signed off on this page. How this page is made
About Plant Protein Powders
Plant protein powders are concentrated protein from soy, peas, rice, hemp or blends. In small trials with weight training they gave muscle and strength gains similar to whey. Soy and pea allergy, kidney disease and variable metal levels are the main cautions.
What plant protein powders are
A plant protein powder is protein taken out of a plant, dried and sold as a powder to stir into water, milk or food. The studies describe soy protein isolate, pea protein, rice protein concentrate and hemp products, and blends of several plants.
They are sold as dietary supplements. NCCIH says the US FDA is not authorized to review most dietary supplements for safety and effectiveness before they are marketed, so quality depends on the maker.
What is usually inside, and who buys them
The main ingredient is a plant protein: soy, pea, rice or hemp, alone or mixed. Blends are common because plant proteins differ in their amino acids. Whey is the usual comparison. Other ingredients such as flavours or sweeteners vary by product and were not studied in the research read, so read the label.
Authors of the trials say plant powders are wanted by people with allergies, dietary restrictions or personal choices, and by vegan athletes. Pages on soy, pea, rice and hemp, whey, protein quality and testing are linked under related pages.
What the label words mean
Serving is the amount the maker says one scoop or portion is. The protein per serving is the first number to check, then the protein source, because soy, pea, rice and hemp differ. A blend lists several plant proteins; a proprietary blend is a mix where the maker does not give the amount of each part.
The allergen statement matters: in the US the food source of a major allergen such as soy must appear on the label. Nothing here is a product recommendation, and no brands are named.
Food versus powders
Soy, peas and rice are also eaten as foods such as beans, peas and rice. Powders are concentrated protein without the rest of the plant. The trials on this page tested powders, not foods. One trial found that a vegan diet of plant foods plus a soy powder gave the same muscle gains as a mixed diet plus whey when total protein was matched.
Amounts of protein in foods were not read from USDA or NIH sources, so none are stated.
What the research shows
No trial tested plant protein powders as one group, so the evidence comes from separate products. Pooled results show no clear difference between plant and animal protein for absolute lean mass or strength in people who already eat enough protein, with a small edge for animal protein for percent lean mass in adults under 50.
Pea, rice and hemp trials are small, and two pea trials were linked to a pea-protein maker, one of them funded by it. Soy protein lowered LDL cholesterol a little in pooled trials. Recovery claims are not established.
At a glance
Traditional uses history, not proof
- Soy, peas, rice and hemp seed are long-standing foods
- Powders are a modern product sold to people who avoid dairy or animal products
Studied for research
- Muscle and strength gains with resistance training, low certainty
- Plant versus animal protein, pooled lean mass and strength, low certainty
- Blood cholesterol with soy protein, moderate certainty
- Recovery after hard exercise, very low certainty
- Protein quality and amino acid make-up, laboratory measure only
Main compounds
- Plant protein isolates and concentrates
- Leucine, lysine and methionine
- Pea protein Pis s 1 (allergen)
Common forms
- Single-source powder (soy, pea, rice, hemp)
- Blends of several plant proteins
- Mass-gain type powders
- Powders mixed into drinks and food
Research links: 2018 pooled analysis: soy versus animal protein with resistance training (9 studies) · 2021 review: animal versus plant protein, lean mass and strength (16 trials) · 2025 review: plant proteins and recovery after resistance exercise (24 studies) · 2019 pooled analysis: soy protein and LDL cholesterol (43 trials) · 2020 risk assessment: heavy metals in protein powders · Research Library · Genes & Biomarkers Library
What it is and its history
- Accepted scientific name
- Plant protein powders (soy, pea, rice, hemp and blended protein supplements)
- Common names
- Plant protein powder (English); Vegan protein powder (English); Plant-based protein powder (English); Proteína vegetal en polvo (Spanish); Proteína de origen vegetal (Spanish)
- Family or group
- Protein supplement made from plants. The studies read name soy, pea, rice, hemp, potato, oat, lupin, wheat, corn and microalgae isolates, and blends of them.
- Harvest and processing
- The studies describe the powders as isolates or concentrates, meaning the protein has been separated from the rest of the plant. How each is made was not read from a source.
- Look-alikes and adulterants
- Name: Whey protein; Note: Animal protein from milk; the usual comparison in trials. Has its own page.; Name: Collagen peptides; Note: Animal-derived protein sold as powder, with different uses. Has its own page.; Name: Soy foods; Note: Tofu, soy milk and similar foods; not the same as a concentrated soy protein powder.; Name: Whole beans, peas and rice; Note: Whole foods that supply protein with fibre and other nutrients.
- Sustainability and conservation
- Not assessed.
What is inside, and how it may work
What it contains and how those compounds act in cells and animals. Laboratory and animal mechanisms are not proven effects in people.
Main compounds
| Compound | Family | Where it is concentrated | Activity studied | Level of evidence |
|---|---|---|---|---|
| Plant protein isolates and concentrates | protein | Seeds and grains (soy, pea, hemp, rice, and others) Not read from a source for products. Essential amino acids were 21% to 22% of oat, lupin and wheat isolates in one lab study. | The ingredient tested in the training and recovery trials. 6 12 1 | Human data |
| Leucine, lysine and methionine | essential amino acids | Varies by plant Methionine and lysine averaged 1.0% and 3.6% of plant isolates versus 2.5% and 7.0% for animal proteins; leucine ranged 5.1% (hemp) to 13.5% (corn). | Amino acids that plant proteins are often lower in; leucine is linked to the muscle response. 6 24 | Laboratory |
| Pea storage protein Pis s 1 | allergen | Pea seed Not read from a source. | A major allergen in a small study of pea-allergic children. 14 | Laboratory |
Mechanisms, receptors and pathways
| Target or pathway | Gene or receptor | What was found | Level |
|---|---|---|---|
| Muscle protein building after a protein serving | Not specified in the sources read | Soy and wheat gave a lower muscle protein-building response than several animal proteins in short studies. Possible reasons: lower digestibility, lower leucine, and more of the amino acids being cleared by the gut and liver. Untested ways to improve it include adding amino acids, eating more or mixing sources. 24 | Human data |
| Blending plant proteins | Not specified | Mixing plant proteins, or plant and animal proteins, gave amino acid make-up closer to animal protein in a lab study. A 2025 review reported some blends reached whey-like muscle protein building at adequate amounts. 6 7 | Laboratory and human |
| Cholesterol (soy protein) | Not specified in the abstract | Soy protein lowered LDL cholesterol by a small amount in pooled trials. The abstract does not explain how. 4 | Human data |
Absorption, metabolism and elimination
- Absorption
- Plant proteins are digested into amino acids. Lower digestibility of some plant proteins is proposed in one review; absorption of specific powders was not measured in the abstracts read.
- Distribution
- Not found.
- Metabolism
- Not found.
- Elimination
- The NIDDK says protein breaks down into waste that the kidneys remove.
- Bioavailability
- A calculated digestibility-adjusted score (DIAAS) was below 75 for pea, rice and hemp and 75 or above for whey and soy.
Isolated compounds versus whole extracts
A powder is a concentrated protein that has been separated from the plant. Whole foods such as beans, peas and rice come with fibre, minerals and other compounds, and the trials here tested powders, not whole foods. One trial compared a whole plant-based diet topped up with soy isolate against a mixed diet topped up with whey and found no difference.
Nutritional composition
Amounts of protein in foods such as beans, peas and rice were not read from USDA or NIH sources for this page, so none are stated. Trials tested powders, not foods.
1 moderate certainty2 low certainty1 very low certainty1 not enough evidence
What was looked at
The 5 benefits and uses checked for Plant Protein Powders, each with how strong the evidence is. Tap one to open it.
- Muscle and strength gains when paired with resistance trainingLow certainty
- Plant versus animal protein, pooled results for lean mass and strengthLow certainty
- Recovery after hard exerciseVery low certainty
- Blood cholesterol (soy protein)Moderate certainty
- Amino acid make-up and protein quality (laboratory measure)Not enough evidence
Lab markers tracked in the studies
Lean mass and muscle thicknessMuscle strengthLDL cholesterolProtein quality score (DIAAS)
What is Plant Protein Powders good for?
The main studied uses and how strong the human evidence is for each. Most trials are small, short and in young or trained people, and each result is for the named product and does not carry over to other powders.
Benefits, one by one
Each card is a research question, not a promise. Tap a goal to filter. Open a card to see the studies, doses and limits.
Muscle and strength gains when paired with resistance training
Low certaintyTrials that paired soy, pea or rice powders with weight training mostly found muscle and strength gains similar to whey, though the groups were small and the training itself drove much of the gain. Two of the pea trials were linked to a pea-protein maker, one of them funded by it. Hemp was tested in one small trial against soy.
6 studiesProducts differ: soy isolate, pea isolate, rice concentrate, hemp pro…
Studies, doses and limits
What the trials found
A pooled analysis of 9 studies (266 people) found whey and soy gave similar strength and lean-mass gains. A 12-week trial of 161 young men found only a trend between pea, whey and placebo for biceps thickness (P = 0.09), with a subgroup of the weakest participants gaining more on pea than placebo. An 84-day trial in sedentary adults found no significant difference between pea and whey. In 24 trained men, rice and whey gave similar results over 8 weeks. A pilot of 15 people found no difference between pea and whey. In 34 trained adults, hemp raised arm-muscle thickness in women and soy did in men.
Results
Similar to whey in these trials, but the trials are small and short, and none of them proves a plant powder works better than eating enough protein from ordinary food.
Effect sizes as reported
Soy versus whey: strength and lean mass not different (p = 0.64 to 0.96). Pea trials: group differences not significant (P = 0.09 in the main analysis). Rice versus whey: lean mass p = 0.37, strength p = 0.51 to 0.80.
Why this rating
Low because most trials are small, short and in young or trained people, two pea trials were linked to the pea-protein maker, one of them funded by it, several trials had no placebo, and a pooled review of 16 trials leaned slightly toward animal protein for percent lean mass. Not rated lower because several independent trials point the same way.
Form and dose studied
Products differ: soy isolate, pea isolate, rice concentrate, hemp product. Amounts used appear only in the studies table.
Who was studied
Mostly healthy young men, many already trained. Few women, older adults or people with health conditions.
Limits
Results are for the named product and group and do not carry over to other powders. Every trial included resistance training, so the results say nothing about powders without exercise.
Why researchers looked
Plant powders are sold to people who avoid dairy or animal products, so researchers asked whether they build muscle as well as whey does.
Traditional use
Soy, peas and rice have long been eaten as foods. Concentrated powders made from them are a modern product, so food history says little about powders.
Proposed mechanism Hypothesis
Not established. Protein supplies the building blocks for muscle, and training supplies the signal. Whether the amino acid make-up of a plant powder changes the result in people who already eat enough protein is not settled.
A proposed mechanism does not show that the effect happens in people.
No safety signal in these trials, which were short. See the Safety tab for allergy, metals and kidney cautions.
Plant versus animal protein, pooled results for lean mass and strength
Low certaintyPooling many trials, the source of protein did not change absolute lean mass or strength. Animal protein leaned ahead for percent lean mass, mainly in adults under 50. A vegan-versus-omnivore trial with a soy top-up found no difference.
3 studiesPlant proteins varied; the vegan group used soy protein isolate as a …
Studies, doses and limits
What the trials found
A 2021 review pooled 16 randomised trials: protein source did not change absolute lean mass or muscle strength, while animal protein favoured percent lean mass; in adults under 50 it gave 0.41 kg more lean mass (0.08 to 0.74). Total protein intake in the studies was generally above the recommended allowance. A 12-week trial matched 19 vegans and 19 omnivores at the same total protein, topped up with soy isolate or whey: leg lean mass rose about 1.2 kg in both and there were no differences.
Results
No clear winner in people who already eat enough protein, with a small lean-mass edge for animal protein in younger adults.
Effect sizes as reported
Under-50s: absolute lean mass +0.41 kg (95% CI 0.08 to 0.74) and +0.50% (0.00 to 1.01) in favour of animal protein. Vegan versus omnivore: no between-group difference (all p > 0.05).
Why this rating
Low because the pooled review mixes foods and supplements and many plant sources, and the one matched-diet trial was in 38 untrained young men. The abstracts do not give trial-quality ratings.
Form and dose studied
Plant proteins varied; the vegan group used soy protein isolate as a top-up.
Who was studied
Healthy adults; the age split suggests the small edge for animal protein is in people under 50.
Limits
The review pools different foods, powders and training programmes. The vegan trial compared whole diets, not powders alone.
Why researchers looked
Short lab studies show whey raising muscle protein building more than soy, so researchers checked whether that shows up in months of training.
Traditional use
Mixed diets have always combined plant and animal proteins. These studies compare the two sources, mostly as foods and supplements together.
Proposed mechanism Proposed mechanism
Proposed, not shown for powders: some plant proteins have less leucine, lysine or methionine, and may be digested less fully, so the muscle response to a single serving can be lower.
A proposed mechanism does not show that the effect happens in people.
No safety outcomes in the abstracts read.
Recovery after hard exercise
Very low certaintyA 2025 review found single plant proteins generally gave limited recovery benefit compared with whey in the first hours after exercise. Some blends reached whey-like muscle protein building, and some studies saw less soreness or fewer muscle-damage markers. The evidence is thin and uneven.
2 studiesSoy, pea, rice, hemp, potato and blends; amounts differed between stu…
Studies, doses and limits
What the trials found
A 2025 systematic review of 24 studies (22 randomised, 2 not) in healthy young adults looked at soy, pea, rice, hemp, potato and blended plant proteins. It found limited benefit from single plant proteins compared with animal protein such as whey, mainly in acute recovery. Some blends stimulated muscle protein building at levels comparable to whey when used at adequate amounts. Some studies reported better subjective recovery or lower muscle-damage markers with soy or pea. The authors did not pool the results because the studies were too different.
Results
Limited and mixed. Recovery claims are not established.
Effect sizes as reported
No pooled effect sizes (the review did not combine results).
Why this rating
Very low because the review found moderate-to-high risk of bias in many studies, small groups and very different products and outcomes, and could not pool results.
Form and dose studied
Soy, pea, rice, hemp, potato and blends; amounts differed between studies.
Who was studied
Healthy young adults after resistance exercise.
Limits
Small studies, mostly in high-income countries, different outcomes. Not specific to one product.
Why researchers looked
After hard training, muscles are sore and damaged, so people ask whether a protein drink helps them recover faster.
Proposed mechanism Proposed mechanism
Proposed: a protein with enough leucine and a balanced amino acid make-up may switch on muscle repair. Blends of plant proteins may fill gaps in a single source.
A proposed mechanism does not show that the effect happens in people.
No safety outcomes were reported in the abstract.
Blood cholesterol (soy protein)
Moderate certaintyA pooled analysis of 43 trials found soy protein lowered LDL (so-called bad) cholesterol by a small amount compared with other proteins, about 3 to 4 percent. This is about soy protein only, not pea, rice or hemp, and not heart-attack outcomes.
1 studiesSoy protein foods and products; the median amount used in trials is i…
Studies, doses and limits
What the trials found
The 2019 meta-analysis pooled 43 of the 46 trials the FDA had identified, in adults with starting LDL between 110 and 201 mg/dL. Compared with non-soy protein, soy protein lowered LDL by 4.76 mg/dL (95% CI 2.80 to 6.71) and total cholesterol by 6.41 mg/dL (3.52 to 9.30). About three quarters of trials showed a drop, though few were individually significant, and results varied between trials.
Results
A small LDL drop with soy protein. Not shown for other plant proteins.
Effect sizes as reported
LDL -4.76 mg/dL (-6.71 to -2.80); total cholesterol -6.41 mg/dL (-9.30 to -3.52); median trial length 6 weeks.
Why this rating
Moderate because it is a pooled analysis of randomised trials with a consistent direction. Not rated higher because the effect is small, results differed between trials (heterogeneity 55%), trials were short, and cholesterol is a blood marker rather than heart disease.
Form and dose studied
Soy protein foods and products; the median amount used in trials is in the studies table.
Who was studied
Adults with LDL cholesterol from 110 to 201 mg/dL.
Limits
Short trials; soy only; a blood marker, not a heart outcome. Not tested on blends or on pea, rice or hemp.
Why researchers looked
Soy protein was allowed an FDA heart-health claim based on cholesterol lowering, and the FDA was reviewing whether to withdraw it, so the trials were pooled again.
Traditional use
Soy foods are eaten widely in East Asia. The trials here tested soy protein products, not traditional soy foods in general.
Proposed mechanism Not established
Not established in the abstract read. The pooled analysis reports the cholesterol change, not how it happens.
A proposed mechanism does not show that the effect happens in people.
See the Safety tab for the soy allergy caution.
Amino acid make-up and protein quality (laboratory measure)
Not enough evidenceIn the lab, plant protein isolates usually have less lysine, methionine and sometimes leucine than animal proteins, and scores of protein quality are lower for pea, rice and hemp than for whey and soy. Mixing plant proteins raised scores. This is a measure of composition, not proof of a health difference.
3 studiesIsolates of oat, lupin, wheat, hemp, microalgae, soy, brown rice, pea…
Studies, doses and limits
What the trials found
A laboratory study of commercial isolates found essential amino acids were 21% to 22% of oat, lupin and wheat isolates against 43% for whey. Leucine ranged from 5.1% (hemp) to 13.5% (corn), against 9.0% in milk. Methionine and lysine averaged 1.0% and 3.6% in plant proteins, against 2.5% and 7.0% in animal proteins. A 2020 overview of published data found whey and soy averaged 75 or more on the DIAAS quality score, while pea, rice and hemp averaged below 75; potato, soy and pea could raise the score of a mix. A 2015 review noted that few studies had measured the muscle response to plant proteins, mostly soy and wheat.
Results
Composition differs between plant and animal proteins and among plant proteins. What this means for people is not shown.
Effect sizes as reported
Plant methionine 1.0% and lysine 3.6% versus animal 2.5% and 7.0% of protein; DIAAS whey and soy 75 or more, pea, rice and hemp below 75.
Why this rating
Insufficient for any health claim: these are laboratory and calculated measures. The overview was written by employees of a potato-protein company, and two authors of the lab study report fees from dairy and nutrition firms.
Form and dose studied
Isolates of oat, lupin, wheat, hemp, microalgae, soy, brown rice, pea, corn and potato were measured. One sample per type in many cases, so brands differ.
Limits
Composition and calculated scores only. A score below 75 gets no quality claim; it does not mean the protein is unhealthy.
Why researchers looked
Muscle needs all the essential amino acids, so researchers measure which ones each protein lacks.
Traditional use
People have long combined plant foods, such as rice with beans, to get a fuller set of amino acids. That is a food habit; these studies measure isolates.
Proposed mechanism Hypothesis
Lower leucine, lysine or methionine, and possibly lower digestibility, may explain the lower muscle response seen in some short studies. Not shown to change results for people who eat enough protein overall.
A proposed mechanism does not show that the effect happens in people.
None.
Connections to the rest of health
How Plant Protein Powders connects to the rest of our health knowledge graph. Every link says what kind of connection it is. A safety link (for example to the liver) is a warning, not a benefit. A study that merely mentions a topic never creates a benefit link.
Explore every connection: goals, body systems, organs, symptoms, genes
A. Wellness goals
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Peak Performance | Low certainty | Muscle and strength gains when paired with resistance training: Trials that paired soy, pea or rice powders with weight training mostly found muscle and strength gains similar to whey, though the groups were small and the training itself drove much of the gain. Two of the pea trials were linked to a pea-protein maker, one of them funded by it. Hemp was tested in one small trial against soy. | 12 1 16 13 2 10 | |
| Balanced Nutrition | Low certainty | Muscle and strength gains when paired with resistance training: Trials that paired soy, pea or rice powders with weight training mostly found muscle and strength gains similar to whey, though the groups were small and the training itself drove much of the gain. Two of the pea trials were linked to a pea-protein maker, one of them funded by it. Hemp was tested in one small trial against soy. Plant versus animal protein, pooled results for lean mass and strength: Pooling many trials, the source of protein did not change absolute lean mass or strength. Animal protein leaned ahead for percent lean mass, mainly in adults under 50. A vegan-versus-omnivore trial with a soy top-up found no difference. | 12 1 16 13 2 10 11 9 | |
| Healthy Aging | Low certainty | Plant versus animal protein, pooled results for lean mass and strength: Pooling many trials, the source of protein did not change absolute lean mass or strength. Animal protein leaned ahead for percent lean mass, mainly in adults under 50. A vegan-versus-omnivore trial with a soy top-up found no difference. | 11 9 12 | |
| Recovery Optimization | Very low certainty | Recovery after hard exercise: A 2025 review found single plant proteins generally gave limited recovery benefit compared with whey in the first hours after exercise. Some blends reached whey-like muscle protein building, and some studies saw less soreness or fewer muscle-damage markers. The evidence is thin and uneven. | 7 24 | |
| Muscle Recovery | Very low certainty | Recovery after hard exercise: A 2025 review found single plant proteins generally gave limited recovery benefit compared with whey in the first hours after exercise. Some blends reached whey-like muscle protein building, and some studies saw less soreness or fewer muscle-damage markers. The evidence is thin and uneven. | 7 24 | |
| Heart Health | Moderate certainty | Blood cholesterol (soy protein): A pooled analysis of 43 trials found soy protein lowered LDL (so-called bad) cholesterol by a small amount compared with other proteins, about 3 to 4 percent. This is about soy protein only, not pea, rice or hemp, and not heart-attack outcomes. | 4 | |
| Balanced Nutrition | Not enough evidence | Amino acid make-up and protein quality (laboratory measure): In the lab, plant protein isolates usually have less lysine, methionine and sometimes leucine than animal proteins, and scores of protein quality are lower for pea, rice and hemp than for whey and soy. Mixing plant proteins raised scores. This is a measure of composition, not proof of a health difference. | 6 8 24 |
B. Body systems
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Bones Joints Muscles | Biological association | Low certainty | Studied for: Muscle and strength gains when paired with resistance training Studied for: Recovery after hard exercise | 12 1 16 13 2 10 7 24 |
| Musculoskeletal System | Biological association | Low certainty | Studied for: Muscle and strength gains when paired with resistance training Studied for: Plant versus animal protein, pooled results for lean mass and strength | 12 1 16 13 2 10 11 9 7 24 |
| Nutrition | Biological association | Low certainty | Studied for: Plant versus animal protein, pooled results for lean mass and strength Studied for: Amino acid make-up and protein quality (laboratory measure) | 11 9 12 6 8 24 |
| Cardiovascular System | Biological association | Moderate certainty | Studied for: Blood cholesterol (soy protein) | 4 |
E. Health conditions
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Soy allergy | Adverse effect or risk | Authoritative guidance | Soybeans are a major food allergen; a powder or blend containing soy can trigger reactions. Preparation or compound: Soy protein powders and blends containing soy |
19 17 |
| Pea allergy | Adverse effect or risk | Laboratory study | Pea protein Pis s 1 was a major allergen in a small study of pea-allergic children. Preparation or compound: Pea protein powders |
14 22 |
| Chronic kidney disease | Authoritative guidance | Some people with kidney disease may need to adjust protein; ask a dietitian first. Preparation or compound: Protein supplements in general |
23 | |
| High LDL cholesterol | Preliminary | Soy protein lowered LDL cholesterol by a small amount in a pooled analysis of 43 trials. Preparation or compound: Soy protein |
4 | |
| Muscle gain with training | Preliminary | Plant powders gave muscle and strength gains similar to whey in small trials with resistance training. Preparation or compound: Soy, pea and rice protein |
12 1 13 |
I. Biomarkers
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Lean mass and muscle thickness | Biological association | Low certainty | Measured in trials: rose with training in every group; mostly not different between plant powders and whey. A lab change is not the same as a health benefit. | 12 1 13 10 |
| Muscle strength | Biological association | Low certainty | Measured in trials: rose with training; not different between plant powders and whey. A lab change is not the same as a health benefit. | 12 16 2 |
| LDL cholesterol | Biological association | Moderate certainty | Measured in trials: lower with soy protein than with non-soy protein, by a small amount. A lab change is not the same as a health benefit. | 4 |
| Protein quality score (DIAAS) | Biological association | Not enough evidence | Measured in trials: whey and soy 75 or more; pea, rice and hemp below 75; mixes of plant proteins scored higher. A lab change is not the same as a health benefit. | 8 |
K. Biological pathways
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Leucine | Preliminary mechanism | Laboratory | An essential amino acid linked to the muscle response; lower in some plant proteins, as low as 5.1% in hemp isolate versus 9.0% in milk protein. | 6 |
| Lysine and methionine | Preliminary mechanism | Laboratory | Essential amino acids that were typically lower in plant protein isolates than animal proteins. | 6 |
| Whey protein | Preliminary mechanism | Human | The animal protein used as the comparison in most trials on this page. | 12 1 13 16 |
L. Active compounds
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Plant protein isolates and concentrates | Biological association | Human | The ingredient tested in the training and recovery trials. Preparation or compound: Seeds and grains (soy, pea, hemp, rice, and others) |
6 12 1 |
| Leucine, lysine and methionine | Biological association | Laboratory | Amino acids that plant proteins are often lower in; leucine is linked to the muscle response. Preparation or compound: Varies by plant |
6 24 |
| Pea storage protein Pis s 1 | Biological association | Laboratory | A major allergen in a small study of pea-allergic children. Preparation or compound: Pea seed |
14 |
Each connection is stored with the ingredient, the connected record, the kind of connection, the evidence status, the supporting studies, the preparation or compound involved, and a review date (last reviewed October 26, 2026).
Evidence at a glance: what the research found for 5 outcomes
Each outcome below is one thing researchers measured. Certainty is how far the evidence can be trusted, not how well it works. The full studies are on the next tab.
The evidence
The research centre for Plant Protein Powders. Every record here was checked against PubMed or the publisher's page; we never list a study we have not verified.
Evidence by outcome
Bars show how many studies we found for each outcome, not how well it works. People are added up across trials only (reviews are not added, to avoid double counting).
How we rate evidence
High certainty
Several well-run trials or reviews agree; further research is unlikely to change the picture much.
Moderate certainty
Good trials point the same way, but some doubt remains.
Low certainty
Small, short or inconsistent trials. The finding could change with better research.
Very low certainty
Very little or very weak human data. Treat as a possibility only.
Mixed findings
Trials or reviews disagree with each other.
Not enough evidence
Not enough human research to say either way.
Evidence against
Good research found no benefit, or found harm.
We take the reviewers' own risk-of-bias and GRADE statements where they exist, and otherwise judge from study size, design, consistency, directness and whether a product matches what is sold. Many publications do not make evidence high. Method note: We started from our earlier summary of plant protein powders, then searched PubMed again and re-read the abstract of every review, trial and lab study cited. Only abstracts were read. Official pages from the FDA, NHS, NIDDK and NCCIH were read in full; the NIH Office of Dietary Supplements page could not be read and is marked unverified.
Study library: every study we checked 24
| Study | Design | People | Product, dose, length | Result |
|---|---|---|---|---|
| Babault 2015 Pea proteins oral supplementation promotes muscle thickness gains during resistance training: a double-blind, randomized, Placebo-controlled clinical trial vs. Whey protein. J Int Soc Sports Nutr · PMID 25628520 · DOI |
Randomised controlled trial |
161 Males aged 18 to 35 doing 12 weeks of upper-arm resistance training (pea n = 53, whey n = 54, placebo n = 54) |
Pea protein (a branded pea isolate) versus whey protein versus placebo Powder 25 g twice a day (amount used in the trial) 12 weeks · vs Whey protein and placebo |
Thickness rose with training in all groups (24.9 to 27.3 mm). Between groups there was only a trend (P = 0.09). In the weakest participants thickness rose more with pea (+20.2%) than placebo (+8.6%), with whey in between (+15.6%). Strength rose with time with no difference between groups. Between-group thickness P = 0.09; weakest-participant subgroup P < 0.05 (Not given in the abstract) Methods, limits and fundingOutcomes: Biceps muscle thickness (ultrasound) and strength (isokinetic dynamometer) Limitations: Main comparison did not reach significance; the pea-versus-placebo finding is from a subgroup analysis. Young men only. Funding and conflicts: Several authors are affiliated with Roquette, the maker of the pea protein tested. Industry-linked. Registration: NCT02128516 Read: abstract |
| Banaszek 2019 The Effects of Whey vs. Pea Protein on Physical Adaptations Following 8-Weeks of High-Intensity Functional Training (HIFT): A Pilot Study. Sports (Basel) · PMID 30621129 · DOI |
Randomised controlled trial |
15 15 people (8 men, 7 women, average age about 39) doing high-intensity functional training four times a week |
Pea protein versus whey protein Powder 24 g before and after training on training days and between meals on other days (amount used in the trial) 8 weeks · vs Whey protein |
Both groups got stronger in squat and deadlift. No training effect on body composition or muscle thickness, and no differences between pea and whey on any measure. No group differences for any measure (Not given in the abstract) Methods, limits and fundingOutcomes: Muscle thickness, body composition, squat and deadlift strength, workout performance Limitations: Pilot study with 15 people (8 whey, 7 pea). Too small to detect differences. No placebo group. Funding and conflicts: One author later became part-owner of a gym; no other conflicts reported. Read: abstract |
| Bandara 2020 A human health risk assessment of heavy metal ingestion among consumers of protein powder supplements. Toxicol Rep · PMID 33005567 · DOI |
Modelling analysis |
Risk model built on reported metal levels from a Consumer Reports analysis of 15 protein powders and a follow-up study of 133 products (where 40% were reported to have elevated metals) | Arsenic, cadmium, mercury and lead in protein powders, modelled for 1 or 3 servings a day Protein powders (the abstract names whey and mass-gain types) Modelled at one or three servings a day (a modelling assumption, not advice) · vs US EPA reference doses and CDC blood lead guidance value |
The modelled exposure did not pose an increased health risk (hazard index below 1). The highest hazard indices, approaching 1, were in mass-gain type powders and the lowest in whey powders. Arsenic or cadmium drove most of the index. Estimated blood lead stayed below the CDC value of 5 micrograms per decilitre. The authors conclude typical intake would not cause adverse effects from heavy metals. Hazard index below 1 for all products modelled; highest near 1 in mass-gain powders (Not applicable) Methods, limits and fundingOutcomes: Hazard index for the four metals; estimated adult blood lead Limitations: A model built on two earlier testing reports, not new lab testing. The abstract does not report a plant-versus-animal comparison. Funding and conflicts: The authors declare no competing interests. Read: abstract |
| Blanco Mejia 2019 A Meta-Analysis of 46 Studies Identified by the FDA Demonstrates that Soy Protein Decreases Circulating LDL and Total Cholesterol Concentrations in Adults. J Nutr · PMID 31006811 · DOI |
Systematic review meta analysis |
46 controlled trials in adults with starting LDL cholesterol from 110 to 201 mg/dL; 43 trials gave data | Soy protein compared with non-soy protein Soy protein foods and products (form varied) Median 25 g a day across trials (amount used in trials) Median follow-up 6 weeks · vs Non-soy protein |
Soy protein lowered LDL by 4.76 mg/dL and total cholesterol by 6.41 mg/dL compared with non-soy protein, about 3 to 4% for LDL. About three quarters of trials showed a drop, though few were individually significant. Results varied between trials. LDL -4.76 mg/dL; total cholesterol -6.41 mg/dL (LDL -6.71 to -2.80 mg/dL; total cholesterol -9.30 to -3.52 mg/dL (heterogeneity I2 55% and 74%)) Methods, limits and fundingOutcomes: LDL cholesterol and total cholesterol Limitations: Short trials (median 6 weeks); cholesterol is a blood marker, not a heart-attack outcome; trials used soy foods and products, not only powders. Funding and conflicts: No conflict statement in the record read. Registration: NCT03468127 Read: abstract |
| Devries 2018 Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis. J Nutr · PMID 30383278 · DOI |
Systematic review meta analysis |
1358 28 randomised trials in adults WITHOUT kidney disease (1,358 people) |
Higher-protein diets compared with normal or lower-protein diets (all sources) Food and supplements, not powders alone Higher intake defined in the review as 1.5 g per kg a day or more, 20% of energy or more, or 100 g a day or more More than 4 days · vs Normal or lower-protein diet |
The change in kidney function did not differ between higher and lower protein intakes. The authors conclude higher protein does not adversely affect kidney function in healthy adults. This does not apply to people who already have kidney disease. Change in GFR: SMD 0.11 (-0.05 to 0.27) Methods, limits and fundingOutcomes: Glomerular filtration rate (a kidney function measure) Limitations: Healthy adults only; risk of selection bias in some trials; not specific to plant powders. Funding and conflicts: No conflict statement in the record read. Read: abstract |
| Gorissen 2018 Protein content and amino acid composition of commercially available plant-based protein isolates. Amino Acids · PMID 30167963 · DOI |
Laboratory analysis |
Laboratory analysis of commercial protein isolates: oat, lupin, wheat, hemp, microalgae, soy, brown rice, pea, corn, potato, plus milk, whey, caseinate, casein, egg and human muscle for comparison | Plant protein isolates compared with animal proteins Isolate powders · vs Animal proteins and human muscle protein |
Essential amino acids made up 21% to 22% of oat, lupin and wheat isolates, against 43% for whey, 39% milk, 34% casein and 32% egg. Leucine ranged from 5.1% (hemp) to 13.5% (corn), against 9.0% in milk. Methionine and lysine were typically lower in plant proteins (1.0% and 3.6%) than animal proteins (2.5% and 7.0%). Blends of plant proteins, or of plant and animal proteins, can give a make-up closer to animal protein. Plant methionine 1.0 ± 0.3% and lysine 3.6 ± 0.6% versus animal 2.5 ± 0.1% and 7.0 ± 0.6% (percent of protein) (Not applicable) Methods, limits and fundingOutcomes: Essential amino acid content and amino acid make-up Limitations: Composition only; it does not show what happens in people. One sample per protein type in many cases, so a brand may differ. Funding and conflicts: Two authors report speaking or consulting fees from FrieslandCampina and Nutricia; the industrial partners joined project discussions. Read: abstract |
| Govindasamy 2025 Effect of Plant-Based Proteins on Recovery from Resistance Exercise-Induced Muscle Damage in Healthy Young Adults-A Systematic Review. Nutrients · PMID 40806155 · DOI |
Systematic review |
24 studies (22 randomised, 2 not randomised) in healthy young adults after resistance exercise | Soy, pea, rice, hemp, potato and blended plant proteins Powder or drink 15 to 50 g, usually after exercise (range across studies) Varied · vs Mostly animal protein such as whey |
Single plant proteins generally gave limited recovery benefit compared with animal proteins such as whey, particularly in the hours after exercise. Some plant blends reached whey-like muscle protein building at adequate amounts. Some studies saw better self-reported recovery or fewer muscle-damage markers with soy or pea. No pooling was done. No pooled effect (no meta-analysis done) (Not applicable) Methods, limits and fundingOutcomes: Muscle protein building, soreness, inflammation markers, muscle function, fatigue Limitations: Small studies, moderate-to-high risk of bias in many, very different products and outcomes. Funding and conflicts: The authors declare no conflicts of interest. Read: abstract |
| Herreman 2020 Comprehensive overview of the quality of plant- And animal-sourced proteins based on the digestible indispensable amino acid score. Food Sci Nutr · PMID 33133540 · DOI |
Narrative review |
Published amino acid and digestibility data for 5 animal and 12 plant proteins | Protein quality score (DIAAS) of animal and plant proteins · vs Animal proteins |
Whey and soy averaged 75 or more (high quality). Pea, rice, hemp, canola, lupin, corn, oat, fava bean, rapeseed and gelatin averaged below 75. Potato, soy and pea proteins could complement other plant proteins and raise the score of a mix. Scores varied a lot even within one protein source. Whey and soy DIAAS 75 or more; pea, rice and hemp below 75 (Not applicable) Methods, limits and fundingOutcomes: Digestible indispensable amino acid score (DIAAS) Limitations: A calculated score from published data, not a trial in people. A score below 75 gets no quality claim; it does not mean the protein is unhealthy. Funding and conflicts: All four authors are employees of Avebe, a company in the potato-protein business. Industry-linked. Read: abstract |
| Hevia-Larraín 2021 High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and Omnivores. Sports Med · PMID 33599941 · DOI |
Controlled human study |
38 19 habitual vegan and 19 omnivore young men, untrained, doing supervised resistance training twice a week |
Soy protein isolate top-up (vegans) versus whey protein top-up (omnivores) to reach the same total protein Powder Protein intake adjusted to 1.6 g per kg body weight a day (amount used in the trial) 12 weeks · vs Omnivore group on whey |
Both groups gained similar leg lean mass (about 1.2 kg) and strength, with no differences between groups. Leg lean mass +1.2 kg in both groups; no between-group differences (all p > 0.05) (Not given in the abstract) Methods, limits and fundingOutcomes: Leg lean mass, muscle cross-section, muscle fibre size, leg-press strength Limitations: Groups were whole diets (plant foods plus soy versus mixed foods plus whey), not powders alone. Untrained young men; retrospectively registered. Funding and conflicts: No conflict statement in the record read. Registration: NCT03907059 (registered after the study) Read: abstract |
| Kaviani 2024 Effects of hemp supplementation during resistance training in trained young adults. Eur J Appl Physiol · PMID 37847288 · DOI |
Randomised controlled trial |
34 22 men and 12 women (average age about 30), already resistance-trained, training about four times a week |
Hemp product (40 g protein and 9 g oil per serving) versus soy product matched for protein and calories Powder 60 g of product a day (amount used in the trial) 8 weeks · vs Soy product |
Hemp raised elbow-flexor muscle thickness in females (p = 0.012) and soy raised it in males (p < 0.01). Twitch torque was kept after a fatigue test in males on hemp compared with males on soy. The authors call this sex-specific effects. Elbow flexor thickness: females on hemp 2.6 to 3.1 cm; males on soy 3.7 to 4.0 cm (Not given in the abstract) Methods, limits and fundingOutcomes: Lean mass, muscle thickness, strength, nerve activation, inflammation markers, bone breakdown marker Limitations: Small trial split by sex into groups of a few people; hemp compared with soy, not with whey or placebo. Funding and conflicts: No conflict statement in the record read. Registration: NCT02529917 Read: abstract |
| Lim 2021 Animal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients · PMID 33670701 · DOI |
Systematic review meta analysis |
18 randomised trials in the review, 16 pooled; total protein intake was generally above the recommended allowance in the studies | Animal protein versus plant protein (foods and supplements together) Mixed Varied by trial Varied · vs Animal protein versus plant protein |
Protein source did not change absolute lean mass or muscle strength. Animal protein favoured percent lean mass. In adults under 50, animal protein gave a little more absolute and percent lean mass. Under-50s: absolute lean mass +0.41 kg (animal protein); percent lean mass +0.50% (0.08 to 0.74 kg; 0.00 to 1.01%) Methods, limits and fundingOutcomes: Absolute lean mass, percent lean mass, muscle strength Limitations: Pools foods and supplements, many plant sources and different training. Number of people not given in the abstract. Funding and conflicts: No conflict statement in the record read. Read: abstract |
| Messina 2018 No Difference Between the Effects of Supplementing With Soy Protein Versus Animal Protein on Gains in Muscle Mass and Strength in Response to Resistance Exercise. Int J Sport Nutr Exerc Metab · PMID 29722584 · DOI |
Systematic review meta analysis |
266 9 studies in people doing resistance training; 5 compared soy with whey, 4 compared soy with other animal proteins (beef, milk or dairy) |
Soy protein supplement versus whey or other animal protein Powder (form not detailed in the abstract) Varied by study (not given in the abstract) Studies of 6 weeks or longer · vs Whey or other animal protein |
Whey or soy both raised strength and there was no difference between them. Lean mass did not differ either. Soy versus the pooled animal proteins also showed no difference. Bench press chi-square 0.02 (p = 0.90); squat 0.22 (p = 0.64); lean mass 0.00 (p = 0.96) for whey versus soy (Not given in the abstract) Methods, limits and fundingOutcomes: Strength (bench press, squat) and lean body mass change Limitations: Only 9 studies, small groups. Abstract does not report trial quality or who funded the studies. Funding and conflicts: No conflict statement in the record read. Read: abstract |
| Moon 2020 Effects of daily 24-gram doses of rice or whey protein on resistance training adaptations in trained males. J Int Soc Sports Nutr · PMID 33261645 · DOI |
Randomised controlled trial |
24 24 healthy resistance-trained men (average age 32.8) doing a standard training programme |
Rice protein concentrate versus whey protein concentrate Powder 24 g a day (amount used in the trial) 8 weeks · vs Whey protein concentrate |
Both groups gained lean mass and strength with training. No significant differences between rice and whey for lean mass, strength, endurance or peak power. Lean mass change difference p = 0.37; bench-press 1RM p = 0.51; leg-press 1RM p = 0.80 (95% confidence intervals were used but are not given in the abstract) Methods, limits and fundingOutcomes: Body composition (DXA), bench-press and leg-press strength, endurance, anaerobic power Limitations: Only 12 people per group, 8 weeks, men only, no placebo group. Funding and conflicts: One author is an inventor on a related patent and says he was not involved in data collection, analysis or writing. Registration: NCT04411173 (registered after the study) Read: abstract |
| Popp 2020 Pea (Pisum sativum) allergy in children: Pis s 1 is an immunodominant major pea allergen and presents IgE binding sites with potential diagnostic value. Clin Exp Allergy · PMID 32078204 · DOI |
Laboratory human samples |
19 19 children sensitized to pea (14 with a doctor's diagnosis of pea allergy, 5 who tolerated pea); median ages 3.5 and 4.5 years |
Blood tests of antibodies to pea proteins · vs Children who tolerated pea |
11 of 14 pea-allergic children (78%) and 1 of 5 pea-tolerant children (20%) were sensitized to Pis s 1, a pea storage protein. The authors call it a major allergen in this group. 11 of 14 allergic children sensitized to Pis s 1 (Not applicable) Methods, limits and fundingOutcomes: Which pea proteins allergic children react to Limitations: Only 19 children, a laboratory and blood-test study. It does not show how often pea powders cause reactions. Funding and conflicts: No conflict statement in the record read. Read: abstract |
| Ring 2021 Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers. Molecules · PMID 34299622 · DOI |
Laboratory analysis |
36 36 protein powders sold in Ireland in 2016 and 2017, tested for 21 elements |
Metals in protein powder (arsenic, cadmium, mercury, lead and others) Protein powders (types not given in the abstract) · vs Health-risk calculations |
Concentrations of potentially toxic elements were at acceptable levels. The authors say excessive and prolonged use of some products may put consumers at slightly raised risk of cancer or other harm over a lifetime, and advise following the maker's serving recommendations. No numbers given in the abstract (Not applicable) Methods, limits and fundingOutcomes: Metal levels and a consumer health-risk assessment Limitations: 36 products from one country and years ago; the abstract does not separate plant from animal powders. Funding and conflicts: The authors declare no conflict of interest. Read: abstract |
| Singh 2024 Efficacy of Pea Protein Supplementation in Combination with a Resistance Training Program on Muscle Performance in a Sedentary Adult Population: A Randomized, Comparator-Controlled, Parallel Clinical Trial. Nutrients · PMID 38999765 · DOI |
Randomised controlled trial |
Healthy sedentary adults doing a weekly resistance-training programme (number of people not given in the abstract) | Pea protein versus whey protein Powder Not given in the abstract 84 days · vs Whey protein |
No significant difference between pea and whey in strength, muscle mass or product liking. Strength rose 16.1% with pea (p = 0.01) and 11.1% with whey (p = 0.06) from baseline. Both products were safe and well tolerated. Pea +16.1% versus whey +11.1% whole-body strength change from baseline; groups not significantly different (Not given in the abstract) Methods, limits and fundingOutcomes: Whole-body muscle strength, muscle mass, product liking, adverse events, blood tests Limitations: No placebo group, so the training itself may explain much of the gain. Number of people not given in the abstract. Funding and conflicts: Funded by Roquette Canada; several authors are employed by Roquette. Industry-funded. Read: abstract |
| Spolidoro 2023 Prevalence estimates of eight big food allergies in Europe: Updated systematic review and meta-analysis. Allergy · PMID 37405695 · DOI |
Systematic review meta analysis |
93 studies of food allergy in Europe, published up to 2021 | Prevalence of allergy to eight common foods, including soy |
For soy, self-reported lifetime allergy was 0.5% and challenge-verified allergy was 0.3%. Cow's milk, egg, peanut and others were more common by self-report. Pea was not among the eight foods studied. Soy: 0.5% self-reported lifetime; 0.3% challenge-verified (Self-reported 0.3% to 0.7%; challenge-verified 0.1% to 0.4%) Methods, limits and fundingOutcomes: Self-reported and challenge-verified food allergy Limitations: European data only; rates differ by region; says nothing about reaction rates to powders. Funding and conflicts: No conflict statement in the record read. Read: abstract |
| Wu 2026 Trends in microchemical detection methods for illegal adulterants and heavy metals in sports nutrition supplements. Environ Res · PMID 42314961 · DOI |
Narrative review |
Review of laboratory methods used to find illegal adulterants and heavy metals in sports supplements, including protein powders | Detection of adulterants and metals in sports supplements Powders, capsules, drinks |
The review lists protein powders among sports products tested for heavy metals (lead, cadmium, arsenic, mercury and others) and, for other product types, drug-like adulterants. The abstract gives no contamination rates for protein powders. No numbers given in the abstract (Not applicable) Methods, limits and fundingOutcomes: Which contaminants testing studies look for, and how Limitations: A review of testing methods, not a survey of protein powders. Abstract only. Funding and conflicts: The authors declare no competing interests. Read: abstract |
| s-fda-allergens FDA: Food Allergies (page content current as of 2026-03-11) · Source |
Health agency n/a |
Methods, limits and fundingRead: full-text | ||
| s-fda-supplements FDA: Dietary Supplements (page content current as of 2024-10-01) · Source |
Health agency n/a |
Methods, limits and fundingRead: full-text | ||
| s-nccih-wisely NCCIH: Using Dietary Supplements Wisely (page shows last updated January 2019) · Source |
Health agency n/a |
Methods, limits and fundingRead: full-text | ||
| s-nhs-food-allergy NHS: Food allergy (page last reviewed 2026-08-20) · Source |
Health agency n/a |
Methods, limits and fundingRead: full-text | ||
| s-niddk-ckd NIDDK: Healthy Eating for Adults with Chronic Kidney Disease (last reviewed January 2025) · Source |
Health agency n/a |
Methods, limits and fundingRead: full-text | ||
| van Vliet 2015 The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption. J Nutr · PMID 26224750 · DOI |
Narrative review |
Review of studies of muscle protein building after eating plant or animal protein | Plant versus animal protein · vs Animal protein |
Soy and wheat proteins gave a lower muscle protein-building response than several animal proteins in the studies reviewed. Possible reasons are lower digestibility and lower leucine. Few studies had measured the response to plant proteins, mostly soy and wheat. Ways to improve it (adding amino acids, eating more, mixing sources) had not yet been tested. No pooled effect (Not applicable) Methods, limits and fundingOutcomes: Muscle protein synthesis after eating protein Limitations: Review from 2015; narrow set of plant proteins studied (mostly soy and wheat). Funding and conflicts: No conflict statement in the record read. Read: abstract |
What we do not know yet
- No long trial (a year or more) of plant powders was found, so lasting effects are unknown.
- Few trials include women, older adults or people with health conditions.
- No trial compared a plant powder with extra ordinary food at the same protein total in people who were not training.
- No trial was found that tested a blend against a single-source plant powder for muscle or recovery in people.
- No study of label accuracy for plant protein powders was found.
- No trial of plant protein powders in pregnancy, breastfeeding or children was found.
How new research is added
New studies are found by a saved PubMed search and placed in a review queue before the page changes.
Lab markers
What changed in blood or saliva tests during trials. A changed number is not the same as feeling or being healthier, and we give no "normal ranges".
Metabolic 1
LDL cholesterol
Lower with soy protein than with non-soy protein, by a small amount in trials
LDL cholesterol is the cholesterol carried in the blood by low-density particles. Higher levels are linked with heart disease risk.
Moderate certaintyResults and what it means
Why it was measured
A standard blood test used to judge heart risk and to compare diets.
Statistical vs. clinical meaning
A small drop (about 3 to 4%). The trials did not measure heart attacks or strokes.
Safety implication
None reported in the abstract.
| Study | Result | People | Product |
|---|---|---|---|
| 4 | LDL -4.76 mg/dL (95% CI -6.71 to -2.80); total cholesterol -6.41 mg/dL | 43 trials in adults with LDL 110 to 201 mg/dL | Soy protein versus non-soy protein, median 6 weeks |
Other 3
Lean mass and muscle thickness
Rose with training in every group; mostly not different between plant powders and whey in trials
Lean mass is the weight of everything that is not fat (mostly muscle, water and organs), measured by a body scan. Muscle thickness is measured by ultrasound on one muscle.
Low certaintyResults and what it means
Why it was measured
To see whether adding a protein powder to training builds more muscle than training alone or than another protein.
Statistical vs. clinical meaning
Gains came mainly from training. The powders were compared with each other, and only one trial had a placebo group.
Safety implication
None reported in these abstracts.
| Study | Result | People | Product |
|---|---|---|---|
| 12 | No difference in lean mass between whey and soy (p = 0.96) | 9 studies, 266 people | Soy versus whey or other animal protein |
| 1 | Biceps thickness 24.9 to 27.3 mm over 12 weeks; group difference a trend only (P = 0.09) | 161 young men | Pea versus whey versus placebo |
| 13 | Lean mass change similar for rice and whey (p = 0.37) | 24 trained men | Rice versus whey |
| 10 | Hemp raised elbow-muscle thickness in females; soy raised it in males | 34 trained adults | Hemp versus soy |
Muscle strength
Rose with training; not different between plant powders and whey in trials
Strength is often tested as the heaviest weight a person can lift once (one-repetition maximum, 1RM) or by a machine that measures force.
Low certaintyResults and what it means
Why it was measured
To check that a gain in muscle also means a gain in how much a person can lift.
Statistical vs. clinical meaning
Similar strength gains, in small and sometimes industry-funded trials.
Safety implication
The pea-versus-whey trial reported both products as safe and well tolerated.
| Study | Result | People | Product |
|---|---|---|---|
| 12 | No difference in bench press or squat strength between whey and soy (p = 0.90 and 0.64) | 9 studies, 266 people | Soy versus whey |
| 16 | Whole-body strength +16.1% with pea and +11.1% with whey; difference between groups not significant | Healthy sedentary adults | Pea versus whey with resistance training |
| 2 | Squat and deadlift rose in both groups with no group difference | 15 adults | Pea versus whey with functional training |
Protein quality score (DIAAS)
Whey and soy 75 or more; pea, rice and hemp below 75; mixes of plant proteins scored higher in trials
DIAAS (digestible indispensable amino acid score) is a calculated number that combines how many essential amino acids a protein has with how well they are digested.
Not enough evidenceResults and what it means
Why it was measured
To compare proteins by quality. A score of 75 or more is called high quality; below 75 gets no quality claim.
Statistical vs. clinical meaning
Shows why some labels offer blends. It does not show that people eating enough protein lose out.
Safety implication
Not applicable.
| Study | Result | People | Product |
|---|---|---|---|
| 8 | Whey and soy averaged 75 or more; pea, rice and hemp averaged below 75; potato, soy and pea raised the score of mixes | 5 animal and 12 plant proteins from published data | Calculated from amino acid content and digestibility |
Safety
What studies and official sources say about side effects, medicines and who should check first. Each point shows what kind of evidence it comes from.
Main points to know 3
- Soy and pea are common allergens, and blends can contain several. The US FDA lists soybeans among nine major food allergens, and the NHS lists soybeans and peas among the foods most likely to cause allergic reactions. In a European pooled review, about 0.3% of people had challenge-verified soy allergy. In a small study of 19 children who were sensitized to pea, one pea protein (Pis s 1) was a major allergen in the allergic ones. A serious reaction is an emergency. People with a known soy or pea allergy should check the allergen statement on any powder and ask a doctor or allergist first. Authoritative guidance, pooled review and laboratory study 19 22 17 14
- Chronic kidney disease: ask a doctor or dietitian before adding protein. The NIDDK says protein breaks down into waste that the kidneys clear, that some people with chronic kidney disease may need to adjust protein so waste does not build up, and that too little protein can cause malnutrition. In a pooled review of 28 trials in adults without kidney disease, higher protein intake did not harm kidney function. That finding does not apply to people who already have kidney disease. Authoritative guidance and meta analysis 23 5
- Heavy metals and product quality vary, and supplements are not approved before sale. A 2020 risk model based on two testing reports found the modelled metal exposure from protein powders did not pose an increased health risk, with the highest values in mass-gain powders and the lowest in whey. A 2021 Irish lab study of 36 powders found acceptable levels but cautioned against excessive and prolonged use. NCCIH says the FDA is not authorized to review most dietary supplements for safety and effectiveness before they are marketed. Modelling analysis, laboratory analysis and authoritative guidance 3 15 21
Side effects 4
| Effect | How often | Severity and recovery | Evidence |
|---|---|---|---|
| Allergic reactions to soy or pea (hives, swelling, breathing trouble) Pea allergy rates were not in the sources read. | Soy: 0.3% challenge-verified allergy and 0.5% self-reported across Europe. No rate for reactions to powders was found. | Can be severe or life-threatening Mild reactions settle; severe ones need emergency treatment | Pooled review and authoritative guidance 17 22 19 |
| Side effects reported in the pea-versus-whey trial The authors say both products were safe and well tolerated in healthy sedentary adults over 84 days. | Not given in the abstract | Not given Not given | Randomised trial (industry funded) 16 |
| Kidney function in healthy adults on higher protein Healthy adults only. Not about people with kidney disease. | No adverse change in kidney filtration across 28 trials (1,358 people) | Not applicable Not applicable | Meta-analysis 5 |
| Stomach upset, bloating or taste complaints Absence from an abstract is not proof there are none. Reactions to added sweeteners or other ingredients were not studied in the sources read. | Not reported in the abstracts read | Not applicable Not applicable | Absence of evidence |
Liver
No liver injury from plant protein powders was found in the sources read. A liver-safety reference (LiverTox) was not opened for this page.
How often. No frequency was found.
Monitoring. No agency monitoring advice was found.
This is a safety connection. It is not evidence that Plant Protein Powders supports liver health.
Medicines and supplements 3
| With | Why it matters | Importance | Evidence | What to do |
|---|---|---|---|---|
| Prescription medicines (general) prescription | No mechanism found. | No interaction study between plant protein powders and any medicine was found in the sources read. | Absence of evidence Not enough evidence | Absence of a study is not proof of safety. Tell a doctor or pharmacist about every supplement you use. |
| Thyroid medicine and soy prescription | Not read from a source for this page. | People often ask whether soy products affect thyroid medicine. No source on this was read for this page, so nothing is claimed. | Question only Not enough evidence | Ask a doctor or pharmacist if you take thyroid medicine and use soy products. |
| Other protein products and supplements (stacking) supplement | Several products can each add protein, metals or the same allergen. | Metal exposure in the Irish study was judged acceptable at normal use; the authors cautioned against excessive and prolonged use. No study of stacking several protein products was found. | Laboratory analysis and absence of evidence Not enough evidence 15 | Count the protein and allergens from every shake, bar and powder you use, and follow the maker's serving guidance. Ask a pharmacist about combinations. |
Who should check first 4
| Situation | Advice | Evidence |
|---|---|---|
| Known soy or pea allergy | Avoid a powder that contains the allergen unless an allergist says otherwise. Check the allergen statement on every blend. | Authoritative guidance and laboratory study 19 22 14 |
| Chronic kidney disease | Ask a doctor or kidney dietitian before adding protein powder; protein needs can be different. | Authoritative guidance 23 |
| Pregnancy and breastfeeding | No safety study of plant protein powders in pregnancy or breastfeeding was found in the sources read. Ask a doctor or midwife before using them. | Absence of evidence |
| Children and teenagers | No trial of plant protein powders in children was found in the sources read. The pea allergy study was in young children. Ask a paediatrician before giving a protein powder. | Absence of evidence and laboratory study 14 |
Overdose, product quality and regulators
Summary. Protein is a normal part of food. For powders, the concern read in the sources is metals and allergens, not the protein itself.
Animal. Not reviewed.
High dose or long term signals. The Irish lab study cautioned that excessive and prolonged use of some products may put consumers at slightly raised lifetime risk. The risk model assumed one or three servings a day. Long-term safety of plant powders was not found in trials.
Overdose response. Not found.
Genotoxicity. Not researched.
Metal levels were judged acceptable in the two studies read, but both rely on older samples and neither abstract compares plant with animal powders. Some labs report a wide range between brands.
Modelled health risk of metals. Using testing data from 15 and 133 products, modelled exposure for one or three servings a day did not pose an increased health risk. The highest values, approaching the threshold, were in mass-gain powders; the lowest in whey powders. Arsenic or cadmium drove the result. 3
Metals in 36 powders sold in Ireland (2016 to 2017). Concentrations were at acceptable levels, but the authors cautioned that excessive and prolonged use of some products may slightly raise lifetime risk. 15
Other contaminants in sports supplements. A 2026 review of testing methods lists protein powders among sports products checked for heavy metals, and other product types for drug-like adulterants. It gives no rates for protein powders in its abstract. 18
Label accuracy. No laboratory study of whether plant protein powders contain the protein amount on the label was found in the sources read, so none is claimed.
| Body | Action | Date |
|---|---|---|
| US Food and Drug Administration (United States) | Names nine major food allergens, including soybeans, and requires the name of the food source of a major allergen to appear on the label. source | 2026-03-11 |
| National Health Service (United Kingdom) | Lists soybeans and peas among the foods most likely to cause allergic reactions, and says to call 999 for swelling of the lips, mouth, throat or tongue, or fast or struggling breathing. source | 2026-08-20 |
| NIDDK (US National Institutes of Health) (United States) | Says some people with chronic kidney disease may need to adjust protein so waste does not build up, that too little protein can cause malnutrition, and to work with a dietitian or health care professional. source | 2025-01 |
| NCCIH (US National Center for Complementary and Integrative Health) (United States) | States that, apart from new ingredients not sold before 1994, the FDA is not authorized to review dietary supplements for safety and effectiveness before they are marketed, and can act against adulterated or misbranded products only afterwards. source | 2019-01 |
| US Food and Drug Administration (United States) | Says supplement firms are responsible for evaluating the safety and labeling of their products before marketing, and that FDA can act against adulterated or misbranded supplements. source | 2024-10-01 |
When to get medical help
- Swelling of the lips, face, tongue or throat, hives, wheezing or trouble breathing after a powder: call emergency services (999 in the UK, 911 in the US).
- A child with a known soy or pea allergy who has any reaction after a shake: get emergency help.
- Passing much less urine, swelling of the legs or face, or new tiredness in someone with kidney disease after adding protein: see a doctor.
- Persistent vomiting or stomach pain after a product: stop it and see a doctor.
Stop using the product and contact a clinician or emergency service. In the US, Poison Control is 1-800-222-1222.
General information only, not medical advice. Ask a clinician or pharmacist before use, especially with medicines, in pregnancy or with a health condition. See the Natural Remedy Safety guide.
Frequently asked questions
What are plant protein powders?
Do plant protein powders build muscle as well as whey?
Is animal protein better for lean mass?
A 2021 review of 16 trials found no difference in absolute lean mass or strength. Animal protein leaned ahead for percent lean mass, mainly in adults under 50.
Are blends better than single plant proteins?
Do plant proteins lack essential amino acids?
How do pea, rice and hemp protein compare with whey?
Does soy protein lower cholesterol?
A pooled analysis of 43 trials found soy protein lowered LDL cholesterol by about 4.8 mg/dL compared with other proteins, roughly 3 to 4 percent. That is soy protein only, and the trials were short.
Can plant protein powders cause allergic reactions?
Do plant protein powders contain heavy metals?
Are protein powders safe for kidneys?
Are protein powders safe in pregnancy or for children?
No safety studies of plant protein powders in pregnancy, breastfeeding or children were found in the sources read. Ask a doctor, midwife or paediatrician first.
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Editorial transparency
- Written by
- AlternativeMed editorial team. Research compiled with AI assistance, then checked against the sources listed.
- Medical review
- None. This page has not been reviewed by a physician or pharmacist.
- First published
- 2026-10-26
- Last substantive update
- 2026-10-26
- How we research
- We started from our earlier summary of plant protein powders, then searched PubMed again and re-read the abstract of every review, trial and lab study cited. Only abstracts were read. Official pages from the FDA, NHS, NIDDK and NCCIH were read in full; the NIH Office of Dietary Supplements page could not be read and is marked unverified.
- How we rate evidence
- See "How we rate evidence" in the Evidence tab.
- Independence
- No product is promoted on this page. No affiliate links are shown. Two pea trials were linked to a pea-protein maker, one of them funded by it, and the protein-quality overview was written by employees of a potato-protein company; both are flagged where they appear.
Sources 24
Each source was opened and checked. Where we read only the abstract, it says so. The small numbers in the text point here.
- Babault N, Païzis C, Deley G, Guérin-Deremaux L, Saniez MH, Lefranc-Millot C, Allaert FA. Pea proteins oral supplementation promotes muscle thickness gains during resistance training: a double-blind, randomized, Placebo-controlled clinical trial vs. Whey protein.. J Int Soc Sports Nutr. 2015. PMID 25628520. DOI 10.1186/s12970-014-0064-5. (abstract)
- Banaszek A, Townsend JR, Bender D, Vantrease WC, Marshall AC, Johnson KD. The Effects of Whey vs. Pea Protein on Physical Adaptations Following 8-Weeks of High-Intensity Functional Training (HIFT): A Pilot Study.. Sports (Basel). 2019. PMID 30621129. DOI 10.3390/sports7010012. (abstract)
- Bandara SB, Towle KM, Monnot AD. A human health risk assessment of heavy metal ingestion among consumers of protein powder supplements.. Toxicol Rep. 2020. PMID 33005567. DOI 10.1016/j.toxrep.2020.08.001. (abstract)
- Blanco Mejia S, Messina M, Li SS, Viguiliouk E, Chiavaroli L, Khan TA, Srichaikul K, Mirrahimi A, Sievenpiper JL, Kris-Etherton P, Jenkins DJA. A Meta-Analysis of 46 Studies Identified by the FDA Demonstrates that Soy Protein Decreases Circulating LDL and Total Cholesterol Concentrations in Adults.. J Nutr. 2019. PMID 31006811. DOI 10.1093/jn/nxz020. (abstract)
- Devries MC, Sithamparapillai A, Brimble KS, Banfield L, Morton RW, Phillips SM. Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis.. J Nutr. 2018. PMID 30383278. DOI 10.1093/jn/nxy197. (abstract)
- Gorissen SHM, Crombag JJR, Senden JMG, Waterval WAH, Bierau J, Verdijk LB, van Loon LJC. Protein content and amino acid composition of commercially available plant-based protein isolates.. Amino Acids. 2018. PMID 30167963. DOI 10.1007/s00726-018-2640-5. (abstract)
- Govindasamy K, Parpa K, Katanic B, Clark CCT, Elayaraja M, Kambitta Valappil IN, Dulceanu C, Geantă VA, Tolan GA, Zouhal H. Effect of Plant-Based Proteins on Recovery from Resistance Exercise-Induced Muscle Damage in Healthy Young Adults-A Systematic Review.. Nutrients. 2025. PMID 40806155. DOI 10.3390/nu17152571. (abstract)
- Herreman L, Nommensen P, Pennings B, Laus MC. Comprehensive overview of the quality of plant- And animal-sourced proteins based on the digestible indispensable amino acid score.. Food Sci Nutr. 2020. PMID 33133540. DOI 10.1002/fsn3.1809. (abstract)
- Hevia-Larraín V, Gualano B, Longobardi I, Gil S, Fernandes AL, Costa LAR, Pereira RMR, Artioli GG, Phillips SM, Roschel H. High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Comparison Between Habitual Vegans and Omnivores.. Sports Med. 2021. PMID 33599941. DOI 10.1007/s40279-021-01434-9. (abstract)
- Kaviani M, Shaw KA, Candow DG, Farthing JP, Chilibeck PD. Effects of hemp supplementation during resistance training in trained young adults.. Eur J Appl Physiol. 2024. PMID 37847288. DOI 10.1007/s00421-023-05337-7. (abstract)
- Lim MT, Pan BJ, Toh DWK, Sutanto CN, Kim JE. Animal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2021. PMID 33670701. DOI 10.3390/nu13020661. (abstract)
- Messina M, Lynch H, Dickinson JM, Reed KE. No Difference Between the Effects of Supplementing With Soy Protein Versus Animal Protein on Gains in Muscle Mass and Strength in Response to Resistance Exercise.. Int J Sport Nutr Exerc Metab. 2018. PMID 29722584. DOI 10.1123/ijsnem.2018-0071. (abstract)
- Moon JM, Ratliff KM, Blumkaitis JC, Harty PS, Zabriskie HA, Stecker RA, Currier BS, Jagim AR, Jäger R, Purpura M, Kerksick CM. Effects of daily 24-gram doses of rice or whey protein on resistance training adaptations in trained males.. J Int Soc Sports Nutr. 2020. PMID 33261645. DOI 10.1186/s12970-020-00394-1. (abstract)
- Popp J, Trendelenburg V, Niggemann B, Randow S, Völker E, Vogel L, Reuter A, Spiric J, Schiller D, Beyer K, Holzhauser T. Pea (Pisum sativum) allergy in children: Pis s 1 is an immunodominant major pea allergen and presents IgE binding sites with potential diagnostic value.. Clin Exp Allergy. 2020. PMID 32078204. DOI 10.1111/cea.13590. (abstract)
- Ring G, Sheehan A, Lehane M, Furey A. Development, Validation and Application of an ICP-SFMS Method for the Determination of Metals in Protein Powder Samples, Sourced in Ireland, with Risk Assessment for Irish Consumers.. Molecules. 2021. PMID 34299622. DOI 10.3390/molecules26144347. (abstract)
- Singh RG, Guérin-Deremaux L, Lefranc-Millot C, Perreau C, Crowley DC, Lewis ED, Evans M, Moulin M. Efficacy of Pea Protein Supplementation in Combination with a Resistance Training Program on Muscle Performance in a Sedentary Adult Population: A Randomized, Comparator-Controlled, Parallel Clinical Trial.. Nutrients. 2024. PMID 38999765. DOI 10.3390/nu16132017. (abstract)
- Spolidoro GCI, Ali MM, Amera YT, Nyassi S, Lisik D, Ioannidou A, Rovner G, Khaleva E, Venter C, van Ree R, Worm M, Vlieg-Boerstra B, Sheikh A, Muraro A, Roberts G, Nwaru BI. Prevalence estimates of eight big food allergies in Europe: Updated systematic review and meta-analysis.. Allergy. 2023. PMID 37405695. DOI 10.1111/all.15801. (abstract)
- Wu J, Zhang Y, Liu W, Chen G, Sang X. Trends in microchemical detection methods for illegal adulterants and heavy metals in sports nutrition supplements.. Environ Res. 2026. PMID 42314961. DOI 10.1016/j.envres.2026.125048. (abstract)
- . FDA: Food Allergies (page content current as of 2026-03-11). . . (full-text)
- . FDA: Dietary Supplements (page content current as of 2024-10-01). . . (full-text)
- . NCCIH: Using Dietary Supplements Wisely (page shows last updated January 2019). . . (full-text)
- . NHS: Food allergy (page last reviewed 2026-08-20). . . (full-text)
- . NIDDK: Healthy Eating for Adults with Chronic Kidney Disease (last reviewed January 2025). . . (full-text)
- van Vliet S, Burd NA, van Loon LJ. The Skeletal Muscle Anabolic Response to Plant- versus Animal-Based Protein Consumption.. J Nutr. 2015. PMID 26224750. DOI 10.3945/jn.114.204305. (abstract)
Where to buy
Check the label first. Whatever you buy, look for these:
- The amount of the active ingredient per serving, not just the front-label claim
- A third-party testing mark (USP, NSF or ConsumerLab)
- Other ingredients and allergens
- Ask a pharmacist about interactions with your medicines
Talk to a pharmacist or doctor before you start any supplement, especially if you take medicines. See the Safety tab for interactions.
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