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Close-up of rolled cassia (Cinnamomum cassia) bark
Illustrative close-up of rolled cassia (Cinnamomum cassia) bark, one of the two plant parts the oil is made from.

Essential Oils & Aromatherapy · Essential oil

Cassia Oil

Cinnamomum cassia (also named Cinnamomum aromaticum) · also called Cassia oil, cassia bark oil, Chinese cinnamon oil, cassia cinnamon oil

Cassia oil is a strong, spicy-sweet essential oil from the bark or leaves of the Chinese cassia tree, a close relative of cinnamon. It is mostly cinnamaldehyde, the compound that gives cinnamon its smell. People use it for scent and try it for infections and nausea, but the evidence is thin: one small gel pilot and lab work. The main caution: aromatherapy groups and NCCIH describe it as a strong skin irritant and sensitiser, and it must never be swallowed or used undiluted.

General information, not medical advice. Last substantive update · Not medically reviewed. A named clinician has not signed off on this page. How this page is made

About Cassia Oil

Cassia oil is a strong, spicy scent made from the bark or leaves of a cinnamon relative. The human research is thin: a pilot of a mouth gel that also held pomegranate extract, and a trial of cinnamon leaf oil for nausea that found no benefit. Safety comes first: aromatherapy groups and NCCIH describe it as a skin irritant and sensitiser, it must not be swallowed or used undiluted, and coumarin, linked to the liver in reports about the bark spice, is a question to keep separate for the oil.

What cassia oil is

Cassia oil comes from the Chinese cassia tree, a cinnamon relative in the laurel family (Lauraceae). The tree has two scientific names in use: most papers on the oil say Cinnamomum cassia, while NCCIH and GBIF accept Cinnamomum aromaticum. The oil can be made from bark or from leaves.

The oil is mostly cinnamaldehyde, about 87% to 92% in the oils measured, which gives the cinnamon smell. It is also the cinnamal skin allergen. Bark and leaf oils differ in smaller compounds, and across 20 oils researchers found four chemotypes (kinds).

Cassia is not the same as Ceylon cinnamon. The two trees differ in coumarin: a review gives up to 3.6 g/kg in cassia against 15 mg/kg or less in Ceylon cinnamon (spice figures).

7 15 4 16 5 9 10 3 20

What people use it for, and how strong the evidence is

For thrush, the one human study of a cassia oil product was a 2026 pilot of a gel that also held pomegranate peel extract, in denture wearers. Symptoms resolved after 14 days, while the comparison medicine gave partial improvement. The abstract gives no patient numbers, so this is a promising lead at best.

For nausea after cesarean section, a trial of cinnamon leaf oil (species not stated) with oxygen found no difference from saline.

Everything else is laboratory or animal work. Test tubes show the oil slowing bacteria, Candida and moulds, and a mouse study shows less lung inflammation. Neither shows a benefit in people.

22 21 16 4 9 12

The spice is a different product

Most human trials of cinnamon, mainly for blood sugar, used the spice or extracts of mixed species. They report modest falls in blood sugar. They say nothing about the essential oil, and the coumarin question belongs to the bark spice. NCCIH says research does not clearly support cinnamon for any health condition.

3 15 1

The research in one view

No trial of cassia bark oil alone in people was found. The only human studies are a pilot of a two-plant gel and a null trial of cinnamon leaf oil. No meta-analysis of the oil was found.

Lab evidence is not human evidence. Strong germ-killing in a dish goes with strong irritation of living tissue.

22 21

What regulators and expert groups say

NCCIH says research does not clearly support cinnamon for any health condition and describes skin irritation, coumarin and liver reports, and theoretical interactions. The European Commission's lay summary of a 2012 safety opinion lists cinnamal, cinnamyl alcohol, coumarin and eugenol among the fragrance chemicals most often reported as contact allergens.

We did not find or read a statement from IFRA, FDA or EMA about cassia oil, and we did not open the EFSA coumarin opinion.

15 6

At a glance

Traditional uses history, not proof

  • NCCIH says the bark, leaves, flowers, fruits and roots of cinnamon have a long history in traditional medicine and cooking in China, India and Persia (this covers cinnamon in general).
  • The authors of a 2024 mouse study say cassia is recorded in an old Chinese herbal text for lung problems and inflammation; we did not read that text.
  • We did not find a history specific to the essential oil in the sources read, so none is claimed.

Studied for research

  • Oral thrush, a mouth gel with pomegranate extract, very-low
  • Nausea after surgery, inhaled cinnamon leaf oil, insufficient (no benefit found)
  • Germ-killing in the laboratory, insufficient
  • Lung inflammation in mice, insufficient
  • Blood sugar, studied only with the spice, insufficient for the oil
  • Mosquito repellent, unclear (NCCIH)

Main compounds

  • Cinnamaldehyde, about 87% to 92% of the oils measured
  • Coumarin, a minor constituent in one bark oil analysis
  • o-Methoxycinnamaldehyde, a main compound in one oil
  • Caryophyllene, borneol and nerolidol, aroma compounds

Common forms

  • Essential oil from the bark
  • Essential oil from the leaves
  • A prepared mouth gel with cassia oil (research product)
  • Cassia bark as a spice, tea or capsule (a different product)

Research links: NCCIH: Cinnamon usefulness and safety · Poison Control: Essential oils · Pet Poison Helpline: Essential oils · Tisserand Institute: Cinnamon survey (summary) · NAHA: Aromatherapy safety · Cassia oil gel for oral thrush, pilot (abstract) · Cinnamon leaf oil and nausea, randomised trial (abstract) · Mud bath dermatitis from cinnamon oil, case report (abstract) · GBIF: Cinnamomum aromaticum · Research Library · Genes & Biomarkers Library

What it is and its history

Accepted scientific name
Cinnamomum aromaticum
Naming authority
Nees
Synonyms
Name: Cinnamomum cassia; Note: Name used in most papers on the oil; see naming note.
Common names
Cassia oil (English); Cassia bark oil (English); Chinese cinnamon oil (English); Cassia cinnamon oil (English)
Family or group
Lauraceae (laurel family), per GBIF.
Classification
Plantae > Tracheophyta > Magnoliopsida > Laurales > Lauraceae > Cinnamomum > Cinnamomum aromaticum
Native range
NCCIH says cassia cinnamon is grown in areas of southeastern Asia and is the most common type sold in North America. Native range not checked in a botanical source.
Habitat
Not checked in a source read.
What it looks like
Part used: Oil is made from bark or from leaves. One paper hydrodistilled both; bark gave 1.56% and leaf 0.83% of oil. This page does not describe how to recognise the tree.
Look-alikes and adulterants
Name: Ceylon cinnamon (Cinnamomum verum, also called C. zeylanicum) and other Cinnamomum species such as C. burmannii and C. loureiroi; Note: Different trees with different coumarin levels and oil chemistry; results do not carry between them. Labels and papers often do not say which was used.
Sustainability and conservation
Not checked (no IUCN or CITES source read).

Photographs

Close-up of rolled cassia (Cinnamomum cassia) bark
Illustrative close-up of rolled cassia (Cinnamomum cassia) bark, one of the two plant parts the oil is made from.

Traditional use and history history, not clinical proof

Tradition or eraDocumented useSource
Traditional medicine, spice and cuisineNCCIH says the bark, leaves, flowers, fruits and roots of cinnamon have a long history in traditional medicine and cuisine in China, India and Persia, and that cinnamon was thought to help inflammation, nerve pain, heart disease and cough. This covers the spice and cinnamon in general.NCCIH, Cinnamon: Usefulness and Safety (2024)
Traditional Chinese medicineThe authors of a 2024 mouse study say cassia is recorded in Shennong's Herbal Classic and used for respiratory conditions and inflammation. We did not read that text and treat this as the authors' statement.Liu et al. 2024 (abstract)

Traditional use shows how it was used. It does not show that it works or is safe today.

What is inside, and how it may work

What it contains and how those compounds act in cells and animals. Laboratory and animal mechanisms are not proven effects in people.

Main compounds

CompoundFamilyWhere it is concentratedActivity studiedLevel of evidence
Cinnamaldehyde (trans-cinnamaldehyde)
PubChem 637511
phenylpropanoid aldehydeBark and leaf oil
About 87% in one bark oil, 89% in another; a review gives 55% to 85% of bark oil; 91% to 93% in spring and autumn leaf oil. Varies.
The main aroma compound; the authors say it activates TRPA1 and TRPV1 channels that give the sense of spiciness. Strong activity against germs in test tubes. It is also the cinnamal skin allergen. 20 4 16 3 5 10 6Laboratory
Coumarin
PubChem 323
benzopyroneCassia bark spice; minor constituent in one bark oil
Spice: up to 3.6 g/kg in cassia (review); up to 43.73 mg/g in some extracts (lab study). No figure for oils in the abstracts read.
Linked to liver problems in reports about the spice; on the European fragrance allergen list. 20 3 13 4 15 6Human case reports
o-Methoxycinnamaldehydephenylpropanoid aldehydeBark oil
Named a main compound in one mouse-study oil; amount not given in the abstract.
Not described beyond its listing. 12Laboratory
alpha-Caryophyllene, borneol, nerolidolterpenesBark (caryophyllene, borneol) and leaf (caryophyllene, nerolidol) oil
Odour-active compounds in one study; amounts not given in the abstract.
Contribute to the aroma; no health activity described in the abstract. 10Laboratory

Mechanisms, receptors and pathways

Target or pathwayGene or receptorWhat was foundLevel
Bacterial and mould growth (test tube)Not specifiedCassia bark oil slowed or killed gram-positive and gram-negative bacteria and moulds; whole oil acted better than purified cinnamaldehyde in one study; computer docking predicted coumarin binding to germ proteins. 4 16Laboratory research
Candida albicans cell membrane and lipid metabolism (test tube and computer)Docking targets named in the paper, a prediction onlyThe oil damaged Candida cell membranes; metabolic changes pointed to fatty-acid and lipid pathways; six components were predicted to be functional. 9Laboratory research
Macrophage polarisation and TLR4/MyD88/NF-kB signalling (mouse)TLR4, MyD88, NF-kB p65In mice with toxin-induced lung injury the oil lowered inflammatory signals and shifted macrophage types. 12Animal research
Skin allergyNot specifiedCinnamal, cinnamyl alcohol, coumarin and eugenol are recognised contact allergens; patch tests in a mud-bath case were positive to several of them. This is an immune reaction, not a lab mechanism. 6 8Human case reports

Absorption, metabolism and elimination

Absorption
Not established in the sources read.
Distribution
Not established.
Metabolism
Not established.
Elimination
Not established.
Bioavailability
Not established.

Isolated compounds versus whole extracts

In one test-tube study the whole bark oil slowed bacteria better than purified cinnamaldehyde although it had less of it. Oils differ by plant part, season and origin (four chemotypes in 20 oils), so a result for one oil or one compound does not describe another.

Nutritional composition

Cassia oil is not a food or a nutrient. Cassia bark spice is a separate product with its own coumarin question.

6benefits and uses looked at
25studies and sources checked
Very low certaintybest evidence rating found
4lab markers tracked in trials

1 very low certainty5 not enough evidence

What is Cassia Oil good for?

The uses people ask about and how strong the evidence is for each. Read the certainty label first: nothing here is better than very low, and several results are about the spice or other cinnamon oils, not cassia bark oil.

Benefits, one by one

Each card is a research question, not a promise. Tap a goal to filter. Open a card to see the studies, doses and limits.

Oral thrush in denture wearers (a gel made with cassia oil and pomegranate peel extract)

Very low certainty

In one 2026 pilot study, a gel containing cassia oil and pomegranate peel extract was followed by resolution of thrush symptoms in denture wearers after 14 days, while the comparison antifungal medicine (nystatin) gave only partial improvement. It was a two-ingredient gel, the abstract gives no patient numbers or blinding, and it says nothing about bottled oil.

1 studiesNot covered. This page gives no amounts and no way to use the oil.

Studies, doses and limits

What the trials found

One pilot clinical study of a finished mouth gel (cassia essential oil plus Punica granatum peel extract) against nystatin for 14 days. Number of patients not given in the abstract.

Results

The gel group had a satisfactory response with resolution of symptoms at the end of 14 days, and did better on ease of application, no irritation and less interference with speech and swallowing. The nystatin group improved only partly, and some needed more treatment. The authors call the gel promising and ask for longer follow-up.

Effect sizes as reported

No effect sizes or p-values in the abstract.

Why this rating

A pilot with no stated size, blinding or randomisation in the abstract; the gel has two plants so cassia oil cannot be credited alone; one short follow-up.

Form and dose studied

Not covered. This page gives no amounts and no way to use the oil.

Who was studied

Denture wearers with thrush.

Limits

Only the abstract was read. This is a prepared pharmaceutical gel, not evidence for putting bottled essential oil in the mouth. Cassia oil is a known irritant and sensitiser (see Safety).

Why researchers looked

Thrush (Candida) is common under dentures, and researchers look for plant-based options.

Traditional use

The authors say both plants are recognised for antimicrobial activity; the abstract gives no source.

Proposed mechanism Preliminary mechanism

In the test tube the two plant materials together slowed Candida albicans more than expected (synergy). Why the gel worked in people was not tested.

A proposed mechanism does not show that the effect happens in people.

A mouth gel is a finished product. Do not put essential oil in the mouth; cassia and cinnamon oils irritate mucous membranes and skin.

22

Nausea after cesarean section (inhaled cinnamon leaf oil with oxygen)

Not enough evidence

In one 2026 trial of 60 women having a cesarean section, breathing cinnamon leaf oil with oxygen did not reduce nausea or vomiting in the first 6 hours compared with saline. It used leaf oil of an unstated species, so it cannot be credited to cassia bark oil.

1 studiesNot covered. This page gives no amounts and no way to use the oil.

Studies, doses and limits

What the trials found

One double-blind randomised trial: 60 women in four groups (28% or 40% oxygen, each with or without cinnamon leaf oil).

Results

No statistically significant difference between groups in vomiting episodes or nausea severity at the end of recovery or 6 hours later. The authors conclude neither high oxygen alone nor with cinnamon oil reduced nausea in that time.

Effect sizes as reported

No effect sizes in the abstract; the differences were not significant.

Why this rating

A single small trial with a null result. A null result from 60 people does not show the oil never helps, and the species of the leaf oil is unknown.

Form and dose studied

Not covered. This page gives no amounts and no way to use the oil.

Who was studied

Women having a planned cesarean under spinal anesthesia in Iran.

Limits

Leaf oil of unstated species. Abstract only.

Why researchers looked

Nausea after surgery is common, and earlier work has suggested inhaled cinnamon oil may help nausea after chemotherapy (the trial authors say so; their abstract gives no source).

Traditional use

None given.

Proposed mechanism Preliminary mechanism

Not assessed in this trial.

A proposed mechanism does not show that the effect happens in people.

Inhaled oil was used under supervision in a hospital. This is not advice to diffuse cassia oil.

21

Germ-killing action in the laboratory (bacteria, yeast and moulds)

Not enough evidence

In test tubes, cassia bark and leaf oils slowed or killed several bacteria, a yeast (Candida albicans) and moulds. This is laboratory work only. A dish of germs is very different from an infection in a body, and strong oils that kill germs also irritate skin.

4 studiesNot covered. This page gives no amounts and no way to use the oil.

Studies, doses and limits

What the trials found

None. Laboratory studies of cassia bark oil and leaf oil.

Results

Bark oil (cinnamaldehyde 87.14%) slowed S. aureus, B. subtilis, E. coli and P. aeruginosa (MIC 0.52-1.04 mg/mL) and acted on the moulds Alternaria alternata and Aspergillus niger. In another paper whole bark oil beat purified cinnamaldehyde against six bacteria. A third showed strong action on Candida albicans with damage to its cell membrane. Leaf oil from spring had the lowest MIC (0.25 mg/mL) against S. aureus and L. monocytogenes, and its makeup changed by season. Across 20 cassia oils, composition fell into four chemotypes.

Effect sizes as reported

Test-tube MIC values only.

Why this rating

Test-tube and computer work only; amounts in a dish are not what reaches the body, and the oils differ between batches, plant parts and seasons.

Form and dose studied

Not covered. This page gives no amounts and no way to use the oil.

Who was studied

None (laboratory).

Limits

Does not show treatment of any infection. Some of the authors speak of food preservative use; none of this is advice to swallow or apply the oil.

Why researchers looked

Researchers screen plant oils as natural preservatives and germ-fighters.

Traditional use

One paper says the plant has wide use in traditional Chinese medicine for bacterial and fungal infections; this is the authors' statement.

Proposed mechanism Preliminary mechanism

Cinnamaldehyde is the main compound (about 87% to 92% in the oils measured). In one study cassia oil damaged the cell membranes of Candida, and in another the whole oil beat purified cinnamaldehyde. Computer docking predictions are guesses, not proof.

A proposed mechanism does not show that the effect happens in people.

Test-tube activity does not make the oil safe or useful on the body.

16 4 9 5

Lung inflammation in mice (animal study)

Not enough evidence

In mice given a bacterial toxin into the lungs, cassia bark oil given by mouth reduced signs of lung inflammation and damage. This is animal work only and says nothing about people breathing or swallowing the oil.

1 studiesNot covered. This page gives no amounts and no way to use the oil.

Studies, doses and limits

What the trials found

None. Mouse study.

Results

The oil lowered inflammatory signals (TNF-alpha, IL-6, IL-1beta), lung fluid and tissue damage and improved lung function in the injured mice.

Effect sizes as reported

No human effect sizes.

Why this rating

Animal only.

Form and dose studied

Not covered. This page gives no amounts and no way to use the oil.

Who was studied

Mice.

Limits

Does not show any effect or safety in people. A swallowed essential oil can reach the lungs and cause pneumonia (Poison Control).

Why researchers looked

The authors say the plant is recorded in an old Chinese herbal text for lung conditions and inflammation.

Traditional use

Recorded in "Shennong's Herbal Classic" according to the paper's abstract; we did not read that text.

Proposed mechanism Preliminary mechanism

The authors report effects on macrophage types and the TLR4/MyD88/NF-kB signalling pathway in mice.

A proposed mechanism does not show that the effect happens in people.

Poison Control warns that oil entering the lungs can cause pneumonia.

12

Blood sugar (studied with the spice and extracts, not the oil)

Not enough evidence

Reviews of trials of whole cinnamon spice or extracts report modest drops in fasting blood sugar and HbA1c, but the species, preparation and amount differ too much to compare. No source we read tested the essential oil for blood sugar. NCCIH says research does not clearly support cinnamon for any health condition.

2 studiesNot covered. This page gives no amounts and no way to use the oil.

Studies, doses and limits

What the trials found

Review of trials of spice or extract (mixed species) and an NCCIH summary. No trial of the oil.

Results

Spice and extract trials show consistent but modest falls in fasting glucose and HbA1c, most reliably in people with established blood sugar problems. NCCIH says it is unclear whether cinnamon supplements help diabetes or weight loss. Cassia spice can carry high coumarin (see Safety).

Effect sizes as reported

Modest reductions; no figures taken from the abstract.

Why this rating

These are spice or extract results, mixed species, and not the oil. Nothing here supports using the oil for blood sugar.

Form and dose studied

Not covered. This page gives no amounts and no way to use the oil.

Who was studied

People with and without diabetes, in spice and extract trials.

Limits

Different product from the oil. Keep the spice evidence separate from this page's subject.

Why researchers looked

Cinnamon is widely marketed for diabetes and weight loss.

Traditional use

NCCIH says cinnamon was thought to help inflammation, nerve pain, heart disease and cough in traditional medicine.

Proposed mechanism Preliminary mechanism

Preclinical work suggests several ways cinnamon compounds act on glucose; none was tested for the oil.

A proposed mechanism does not show that the effect happens in people.

Do not swallow the oil. People on diabetes medicines should ask a pharmacist before any cinnamon product.

3 15

Mosquito repellent claim

Not enough evidence

NCCIH says it is unclear whether cassia cinnamon works as a mosquito repellent. We found no trial of the oil, and the oil is a strong skin sensitiser.

1 studiesNot covered. This page gives no amounts and no way to use the oil.

Studies, doses and limits

What the trials found

None found.

Results

NCCIH: unclear. No human repellent trial of cassia oil was read.

Effect sizes as reported

None.

Why this rating

No trial found; regulator summary says unclear.

Form and dose studied

Not covered. This page gives no amounts and no way to use the oil.

Who was studied

None.

Limits

Only an NCCIH page was read on this topic.

Why researchers looked

Cassia cinnamon is promoted for use on the skin to repel mosquitoes.

Traditional use

NCCIH lists it among promoted uses.

Proposed mechanism Preliminary mechanism

Not assessed.

A proposed mechanism does not show that the effect happens in people.

Strong skin sensitiser: do not put it on skin for this purpose.

15

Connections to the rest of health

How Cassia Oil connects to the rest of our health knowledge graph. Every link says what kind of connection it is. A safety link (for example to the liver) is a warning, not a benefit. A study that merely mentions a topic never creates a benefit link.

Explore every connection: goals, body systems, organs, symptoms, genes

A. Wellness goals

Connected toKind of connectionEvidence statusContextStudies
Immune Support Very low certainty Oral thrush in denture wearers (a gel made with cassia oil and pomegranate peel extract): In one 2026 pilot study, a gel containing cassia oil and pomegranate peel extract was followed by resolution of thrush symptoms in denture wearers after 14 days, while the comparison antifungal medicine (nystatin) gave only partial improvement. It was a two-ingredient gel, the abstract gives no patient numbers or blinding, and it says nothing about bottled oil. 22
Digestive Support Not enough evidence Nausea after cesarean section (inhaled cinnamon leaf oil with oxygen): In one 2026 trial of 60 women having a cesarean section, breathing cinnamon leaf oil with oxygen did not reduce nausea or vomiting in the first 6 hours compared with saline. It used leaf oil of an unstated species, so it cannot be credited to cassia bark oil. 21
Immune Support Not enough evidence Germ-killing action in the laboratory (bacteria, yeast and moulds): In test tubes, cassia bark and leaf oils slowed or killed several bacteria, a yeast (Candida albicans) and moulds. This is laboratory work only. A dish of germs is very different from an infection in a body, and strong oils that kill germs also irritate skin. 16 4 9 5
Lung Support Not enough evidence Lung inflammation in mice (animal study): In mice given a bacterial toxin into the lungs, cassia bark oil given by mouth reduced signs of lung inflammation and damage. This is animal work only and says nothing about people breathing or swallowing the oil. 12
Blood Sugar Balance Not enough evidence Blood sugar (studied with the spice and extracts, not the oil): Reviews of trials of whole cinnamon spice or extracts report modest drops in fasting blood sugar and HbA1c, but the species, preparation and amount differ too much to compare. No source we read tested the essential oil for blood sugar. NCCIH says research does not clearly support cinnamon for any health condition. 3 15
Healthy Skin Not enough evidence Mosquito repellent claim: NCCIH says it is unclear whether cassia cinnamon works as a mosquito repellent. We found no trial of the oil, and the oil is a strong skin sensitiser. 15

B. Body systems

Connected toKind of connectionEvidence statusContextStudies
Immune System Biological association Very low certainty Studied for: Oral thrush in denture wearers (a gel made with cassia oil and pomegranate peel extract) Studied for: Germ-killing action in the laboratory (bacteria, yeast and moulds) 22 16 4 9 5
Digestive System Biological association Not enough evidence Studied for: Nausea after cesarean section (inhaled cinnamon leaf oil with oxygen) 21
Respiratory System Biological association Not enough evidence Studied for: Lung inflammation in mice (animal study) 12
Endocrine System Biological association Not enough evidence Studied for: Blood sugar (studied with the spice and extracts, not the oil) 3 15
Integumentary System Biological association Not enough evidence Studied for: Mosquito repellent claim 15

E. Health conditions

Connected toKind of connectionEvidence statusContextStudies
Contact dermatitis Adverse effect or risk Documented risk Tisserand, NAHA and NCCIH describe high skin-reaction risk; case reports show blistering and lasting allergy.
Preparation or compound: Cassia or cinnamon oil on skin
23 14 15 8
Pregnancy Not enough evidence Safety in pregnancy not clearly demonstrated; no cassia-specific data found.
Preparation or compound: Essential oils in general
11

I. Biomarkers

Connected toKind of connectionEvidence statusContextStudies
Oral thrush symptoms (clinical signs in the mouth) Biological association Very low certainty Measured in trials: improvement. A lab change is not the same as a health benefit. 22
Nausea severity (visual scale) and vomiting episodes Biological association Not enough evidence Measured in trials: decrease. A lab change is not the same as a health benefit. 21
Minimum inhibitory concentration (MIC) in the laboratory Biological association Not enough evidence Measured in trials: lower MIC = stronger action in a dish. A lab change is not the same as a health benefit. 4 5
Fasting blood glucose and HbA1c (in spice and extract trials) Biological association Not enough evidence Measured in trials: decrease. A lab change is not the same as a health benefit. 3

L. Active compounds

Connected toKind of connectionEvidence statusContextStudies
Cinnamaldehyde (trans-cinnamaldehyde) Biological association Laboratory The main aroma compound; the authors say it activates TRPA1 and TRPV1 channels that give the sense of spiciness. Strong activity against germs in test tubes. It is also the cinnamal skin allergen.
Preparation or compound: Bark and leaf oil
20 4 16 3 5 10 6
Coumarin Biological association Human case reports Linked to liver problems in reports about the spice; on the European fragrance allergen list.
Preparation or compound: Cassia bark spice; minor constituent in one bark oil
20 3 13 4 15 6
o-Methoxycinnamaldehyde Biological association Laboratory Not described beyond its listing.
Preparation or compound: Bark oil
12
alpha-Caryophyllene, borneol, nerolidol Biological association Laboratory Contribute to the aroma; no health activity described in the abstract.
Preparation or compound: Bark (caryophyllene, borneol) and leaf (caryophyllene, nerolidol) oil
10

Each connection is stored with the ingredient, the connected record, the kind of connection, the evidence status, the supporting studies, the preparation or compound involved, and a review date (last reviewed October 25, 2026).

The evidence

The research centre for Cassia Oil. Every record here was checked against PubMed or the publisher's page; we never list a study we have not verified.

Evidence by outcome

Bars show how many studies we found for each outcome, not how well it works. People are added up across trials only (reviews are not added, to avoid double counting).

How we rate evidence

High certainty

Several well-run trials or reviews agree; further research is unlikely to change the picture much.

Moderate certainty

Good trials point the same way, but some doubt remains.

Low certainty

Small, short or inconsistent trials. The finding could change with better research.

Very low certainty

Very little or very weak human data. Treat as a possibility only.

Mixed findings

Trials or reviews disagree with each other.

Not enough evidence

Not enough human research to say either way.

Evidence against

Good research found no benefit, or found harm.

We take the reviewers' own risk-of-bias and GRADE statements where they exist, and otherwise judge from study size, design, consistency, directness and whether a product matches what is sold. Many publications do not make evidence high. Method note: We read the abstracts of 19 PubMed papers, the NCCIH, Poison Control, Pet Poison Helpline, NAHA and European Commission pages, and the free Tisserand summary, and checked the plant name in GBIF and two compounds in PubChem. We did not read LiverTox, LactMed, IFRA or FDA statements.

Study library: every study we checked 25
StudyDesignPeopleProduct, dose, lengthResult
Abraham 2010
Toxicology and risk assessment of coumarin: focus on human data.
Mol Nutr Food Res · PMID 20024932 · DOI
Narrative review plus telephone survey
review
Coumarin intake in Germany; review of human liver data Coumarin from food, mainly cassia cinnamon spice
Spice Not repeated here n/a · vs n/a
Coumarin has liver-damaging and carcinogenic properties in animals. The review says EFSA set a tolerable daily intake from animal liver data and that human data from people treated with coumarin as a drug confirmed the same value, with a subgroup of people more susceptible than animals, for unknown reasons. Food exposure is mainly from cassia cinnamon in cookies and sweet dishes, and heavy consumers of cassia cinnamon may reach a coumarin intake equal to the limit.
Methods, limits and funding

Outcomes: Liver toxicity, tolerable daily intake

Limitations: About the spice and coumarin as a drug, not the essential oil. 2010 review; abstract only.

Funding and conflicts: Not stated in the abstract (German federal risk institute authors).

Read: abstract

Ackermann 2009
Occupational allergic contact dermatitis from cinnamon including one case from airborne exposure.
Contact Dermatitis · PMID 19207380 · DOI
Case series (clinic records)
human case series
6
Six patients with delayed contact allergy to cinnamon at two Helsinki skin clinics
Cinnamon spice (bark); the abstract says its flavour is from an oil containing mainly cinnamal
Bark spice Not repeated here n/a · vs n/a
Six patients had delayed (type IV) contact allergy to cinnamon. In four, cinnamon was the main cause of occupational dermatitis (hands in three, face and neck in one, shown to be airborne). One case was cross-allergy to fragrances. Five reacted to cinnamal separately and to fragrance mix I. None had immediate-type allergy. The authors call occupational cinnamon allergy rare and say cinnamal is possibly the main allergen.
Methods, limits and funding

Outcomes: Contact allergy; patch tests

Limitations: Spice exposure at work, not the pure oil; six patients; species not named in the abstract.

Funding and conflicts: Not stated in the abstract.

Read: abstract

Balkrishna 2026
A critical appraisal of anti-hyperglycemic mechanisms, matrix-dependent bioavailability, and species-stratified safety of Cinnamomum spp. as functional food ingredients.
Food Res Int · PMID 42169286 · DOI
Narrative review (more than 150 studies)
review of human and preclinical work
Cinnamon as a food ingredient; blood sugar Whole cinnamon spice or extracts (mixed species)
Bark spice and extracts, not essential oil Not repeated here n/a · vs n/a
Preclinical studies suggest several ways cinnamon compounds act on glucose. Clinical trials of whole spice or extracts report consistent, modest drops in fasting glucose and HbA1c, most reliably in people who already have blood sugar problems, but species, preparation and dose differ too much to compare. The review gives cinnamaldehyde as 55-85% of bark oil and says cassia varieties may contain up to 3.6 g/kg coumarin versus 15 mg/kg or less in C. verum, with implications for intake relative to the EFSA tolerable daily intake.
Methods, limits and funding

Outcomes: Blood sugar mechanisms, matrix effects, species-related safety

Limitations: Spice and extract, not oil. The authors are from a company-linked institution (Patanjali); the abstract declares no competing interests. Only the abstract was read.

Funding and conflicts: Authors declared no competing interests.

Read: abstract

Bouguerra 2026
Antimicrobial Activity of Cinnamomum cassia Essential Oil: Phytochemical Profiling, In Vitro Evaluation, and Molecular Docking.
Chem Biodivers · PMID 42801756 · DOI
Laboratory study with computer docking
laboratory
Four bacterial strains and two moulds in the laboratory Cinnamomum cassia bark oil (yield 2.51%)
Bark Not repeated here n/a · vs n/a
Seven constituents were identified, with (E)-cinnamaldehyde the main one (87.14%) and coumarin named as a minor constituent. The oil slowed or killed S. aureus, B. subtilis, E. coli and P. aeruginosa (MIC 0.52-1.04 mg/mL, MBC 0.52-2.08 mg/mL), with gram-positive strains more susceptible, and acted on the moulds Alternaria alternata and Aspergillus niger. Computer docking predicted coumarin to bind strongly to bacterial and fungal targets. The authors suggest a natural food preservative.
Methods, limits and funding

Outcomes: Composition, inhibition zones, MIC and MBC, docking

Limitations: Test tube and computer prediction only; the coumarin amount in the oil is not given in the abstract.

Funding and conflicts: Authors declared no competing interests.

Read: abstract

Cheng 2024
Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from Cinnamomum cassia Leaves.
Plants (Basel) · PMID 39795342 · DOI
Laboratory study
laboratory
Cassia leaf oils from four seasons, tested in the laboratory Cinnamomum cassia leaf oil
Leaf Not repeated here n/a · vs n/a
Leaf oil yield and trans-cinnamaldehyde were highest in spring and autumn (2.20% and 1.95% oil; 92.59% and 91.10% trans-cinnamaldehyde). The spring oil slowed S. aureus and L. monocytogenes at the lowest MIC (0.25 mg/mL). Composition changed with season, temperature and humidity.
Methods, limits and funding

Outcomes: Composition, antioxidant and antibacterial activity

Limitations: Leaf oil, test tube only. Shows the oil varies by season.

Funding and conflicts: Authors declared no competing interests.

Read: abstract

European Commission 2012
Perfume allergies, introduction (European Commission, lay summary of the 2012 SCCS opinion)
n/a · Source
Authoritative web page
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
Lists cinnamal, cinnamyl alcohol, coumarin and eugenol (with others) in List A: fragrance chemicals most frequently reported and well recognised as consumer contact allergens.
Methods, limits and funding

Outcomes: Safety statements

Limitations: A lay summary page; the SCCS opinion itself was not opened. About fragrance chemicals, not a ruling on cassia oil.

Read: full-text

GBIF 2026
GBIF Backbone Taxonomy: Cinnamomum aromaticum Nees and Cinnamomum cassia (match API read 2026-10-25)
n/a · Source
Registry or database
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
GBIF accepts Cinnamomum aromaticum Nees (species key 3033982, family Lauraceae). In the GBIF backbone the name Cinnamomum cassia (L.) J.Presl is listed as a synonym of Neolitsea cassia (L.) Kosterm., a different plant, and Cinnamomum cassia Nees ex Blume is listed as doubtful. NCCIH treats C. aromaticum as also known as C. cassia. The names are therefore unsettled, and papers use C. cassia (often Blume or Presl) for the Chinese cassia tree that gives the oil.
Methods, limits and funding

Outcomes: Accepted name and family

Limitations: Names read from the match and species-search API only; the nomenclature literature was not read.

Read: full-text

Garcia-Abujeta 2005
Mud bath dermatitis due to cinnamon oil.
Contact Dermatitis · PMID 15860002 · DOI
Case report
human case report
1
One 74-year-old woman (Spain)
Cinnamon essential oil in a spa mud bath (species not stated in the abstract)
Not stated Not repeated here Single bath; patch tests 5 years later · vs n/a
Long-lasting, extensive eczematous and bullous (blistering) dermatitis on exposed arms and legs began within 24 hours of a mud bath with cinnamon essential oil. Patch tests five years later were positive to fragrance mix, cinnamon essence, eugenol, cinnamic alcohol and cinnamic aldehyde.
Methods, limits and funding

Outcomes: Skin reaction; patch tests

Limitations: One case, species of cinnamon not stated, so it cannot be tied to cassia. Abstract only.

Funding and conflicts: Not stated.

Read: abstract

Gu 2024
Deciphering the antifungal mechanism and functional components of cinnamomum cassia essential oil against Candida albicans through integration of network-based metabolomics and pharmacology, the greedy algorithm, and molecular docking.
J Ethnopharmacol · PMID 37729978 · DOI
Laboratory study with computer modelling
laboratory
Candida albicans cells in the laboratory Cinnamomum cassia essential oil (hydrodistilled)
Not stated in the abstract Not repeated here n/a · vs n/a
Cassia oil showed strong antifungal activity and damaged C. albicans cell membranes in a concentration-dependent way. Metabolic changes pointed to fatty-acid and lipid metabolism. Six components, including trans-cinnamaldehyde, were predicted to be the functional ones by computer docking. Across 20 cassia oils from different places the makeup differed widely, with four major chemotypes.
Methods, limits and funding

Outcomes: Antifungal effect, cell damage, metabolic changes, composition across 20 oils

Limitations: Test tube and computer. Not a test in infected people.

Funding and conflicts: Not stated in the abstract.

Read: abstract

Huang 2025
Compounds of Essential Oils from Different Parts of Cinnamomum cassia and the Perception Mechanism of Their Characteristic Flavors.
Foods · PMID 41154105 · DOI
Laboratory chemistry
laboratory
Oils from C. cassia (Xijiang) bark and leaf, hydrodistilled Cinnamomum cassia bark oil and leaf oil
Bark and leaf Not repeated here n/a · vs n/a
Yield was 1.56% for bark and 0.83% for leaf. Bark oil had 45 compounds and leaf oil 50. Cinnamaldehyde was the leading aroma compound in both (odour activity value 935 bark, 849 leaf); alpha-caryophyllene mattered in both, borneol in bark, nerolidol in leaf. The authors say cinnamaldehyde activates the TRPA1 and TRPV1 channels that give the sense of spiciness, and suggest food uses.
Methods, limits and funding

Outcomes: Composition (GC-MS), odour and flavour

Limitations: Chemistry and flavour only; one variety; nothing about health.

Funding and conflicts: Authors declared no competing interests.

Read: abstract

Lis-Balchin 1999
Possible health and safety problems in the use of novel plant essential oils and extracts in aromatherapy.
J R Soc Promot Health · PMID 10673845 · DOI
Narrative review
review
Aromatherapy practice Essential oils in general
n/a Not repeated here n/a · vs n/a
The review says that most commonly used oils in massage have low systemic toxicity when properly diluted and not adulterated, but their safety in pregnancy, childbirth and babies has not been clearly demonstrated, and sensitisation is a growing concern.
Methods, limits and funding

Outcomes: Safety

Limitations: 1999 review of oils in general. Abstract only.

Funding and conflicts: Not stated.

Read: abstract

Liu 2024
Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-kB pathway.
Phytomedicine · PMID 38688144 · DOI
Animal study
animal (mouse)
Mice given a bacterial toxin (LPS) into the airways to cause lung injury Cinnamomum cassia bark oil (supercritical CO2 extraction)
Bark Not repeated here n/a · vs Untreated injured mice
In mice, the oil reduced lung fluid, inflammatory signals (TNF-alpha, IL-6, IL-1beta) and lung tissue damage, and the authors report it acted through the TLR4/MyD88/NF-kB pathway. The main components were trans-cinnamaldehyde and o-methoxycinnamaldehyde.
Methods, limits and funding

Outcomes: Lung inflammation markers, lung function, macrophage types

Limitations: Mouse study with an oil given by mouth; says nothing about safety or benefit in people. This page does not advise swallowing any oil.

Funding and conflicts: Not stated in the abstract.

Read: abstract

Mancak 2025
Are cinnamon derivatives effective and safe for diabetes?
Turk J Med Sci · PMID 40104311 · DOI
Laboratory analysis of 7 commercial samples
laboratory
7
Seven bought cinnamon products (sticks, tea bags, capsules)
Cinnamon sticks, tea bags and capsules (aqueous and ethanol extracts)
Bark products Not repeated here n/a · vs n/a
Samples inhibited diabetes-related enzymes in the lab. Extracts held 7.73-333.69 mg/g trans-cinnamaldehyde and up to 43.73 mg/g coumarin. Extracts of C. cassia, C. burmannii and C. loureiroi sticks held high coumarin that could pose a health risk by EFSA data. The ready-made herbalist products showed activity but no detectable trans-cinnamaldehyde or coumarin. The authors stress that the source of cinnamon matters.
Methods, limits and funding

Outcomes: Chemical content and enzyme inhibition

Limitations: Spice and extracts, not essential oil; seven samples; laboratory only.

Funding and conflicts: Not stated in the abstract.

Read: abstract

NAHA (US professional association) 2026
Safety (National Association for Holistic Aromatherapy)
n/a · Source
Authoritative web page
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
NAHA lists cassia (Cinnamomum cassia) among oils considered dermal sensitizers that are not recommended for aromatherapy massage. Its tables of skin irritants and mucous-membrane irritants name cinnamon bark or leaf (C. zeylanicum), not cassia, and it says cinnamon bark should be avoided in baths completely.
Methods, limits and funding

Outcomes: Safety statements

Limitations: The irritant tables name Ceylon cinnamon, so they cannot be read as statements about cassia. Page undated. Read in full on 2026-10-25.

Read: full-text

NCCIH (US National Institutes of Health) 2024
Cinnamon: Usefulness and Safety (NCCIH; last updated November 2024)
n/a · Source
Authoritative web page
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
Lists Cinnamomum aromaticum (also known as C. cassia) as cassia cinnamon. Research does not clearly support cinnamon for any health condition and many studies do not state species or part. Coumarin in cassia cinnamon has been reported to interact with the liver; usual food amounts do not generally contain enough to cause significant problems, but some cassia products contain high levels, and prolonged use could be an issue for sensitive people such as those with liver disease. Some topical cinnamon oil or powder may cause skin irritation or contact dermatitis. Theoretical interactions of cinnamon components with an anticancer medicine and nicotine. Large amounts of Ceylon cinnamon in pregnancy are considered unsafe and little is known about larger amounts while breastfeeding. It is unclear whether cassia cinnamon works as a mosquito repellent.
Methods, limits and funding

Outcomes: Safety statements

Limitations: Page about the spice and cinnamon in general, not specifically the essential oil. Read in full on 2026-10-25.

Read: full-text

Nguyen 2023
Short communication: Antibacterial effects of essential oils from Cinnamomum cassia bark and Eucalyptus globulus leaves-The involvements of major constituents.
PLoS One · PMID 37450504 · DOI
Laboratory study
laboratory
Six gram-positive and gram-negative bacteria in the laboratory Cinnamomum cassia bark oil (E-cinnamaldehyde 89.1%) against purified cinnamaldehyde
Bark Not repeated here n/a · vs Purified (E)-cinnamaldehyde and 1,8-cineole
In all three methods, the whole bark oil produced better antibacterial effects than purified cinnamaldehyde, even though the oil had less cinnamaldehyde (89.1% against 99% or more). The authors suggest this supports whole oils in traditional use.
Methods, limits and funding

Outcomes: Antibacterial effect in liquid and vapour

Limitations: Test tube only. The authors say the oils were traditionally applied by aromatherapy and by mouth; this page does not support swallowing any oil. No effect in people was tested.

Funding and conflicts: Authors declared no competing interests.

Read: abstract

Pet Poison Helpline 2026
Essential Oils (Pet Poison Helpline)
n/a · Source
Authoritative web page
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
Essential oil poisoning can affect cats, dogs, birds, small mammals, large animals and exotic species, with cats and birds at the greatest risk. The page text read does not name cassia or cinnamon.
Methods, limits and funding

Outcomes: Safety statements

Limitations: A general statement, not cassia data. Read on 2026-10-25.

Read: full-text

Pilapil 1989
Toxic manifestations of cinnamon oil ingestion in a child.
Clin Pediatr (Phila) · PMID 2721094
Case report (title only)
human case report
1
A child
Cinnamon oil swallowed (species not known)
Not known Not repeated here Not known · vs n/a
Only the title could be read: PubMed holds no abstract for this 1989 case report. We therefore do not describe what happened, how much was swallowed or the outcome.
Methods, limits and funding

Outcomes: Not known

Limitations: Title only; nothing beyond the fact that a case report with this title exists is claimed.

Funding and conflicts: Not known.

Read: title-only

Poison Control (National Capital Poison Center) 2026
Essential oils: Poisonous when misused (Poison Control)
n/a · Source
Authoritative web page
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
Misuse of essential oils can cause serious poisoning. Some oils are poisonous if swallowed or absorbed through skin; breathing an oil into the lungs can cause pneumonia. Children have thin skin and immature livers and may be more susceptible. Oils may interact with medications. Products are not well regulated, so it can be hard to know species, concentration or contaminants. Pure oils are potent; diluting in a carrier oil is the best way to avoid a bad reaction from direct skin contact; do not use on damaged skin. The most common allergic reaction is a skin rash: wash it off. Keep oils locked away from children and pets. For a swallowed oil, call 1-800-222-1222 (US). Cassia and cinnamon oil are not named on the page.
Methods, limits and funding

Outcomes: Safety statements

Limitations: Not specific to cassia. The page text read carries no date. Read in full on 2026-10-25.

Read: full-text

PubChem 2026
PubChem compound records: cinnamaldehyde (CID 637511) and coumarin (CID 323), read 2026-10-25
n/a · Source
Registry or database
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
Cinnamaldehyde: CID 637511, formula C9H8O, (E)-3-phenylprop-2-enal. Coumarin: CID 323, formula C9H6O2, chromen-2-one.
Methods, limits and funding

Outcomes: Compound identity

Limitations: Identity only.

Read: full-text

Sadeghi 2026
The Effect of Combination of Cinnamon and Oxygen Different Concentrations Inhalation Aromatherapy on, Nausea, Assessment in Cesarean Section Under Spinal Anesthesia: A Clinical Trial.
J Perianesth Nurs · PMID 42412022 · DOI
Randomized double blind trial
60
Women having a planned cesarean section under spinal anesthesia (Iran)
Inhaled cinnamon leaf oil with oxygen at two oxygen strengths, against saline
Leaf (species not stated in the abstract) Not repeated here During surgery; nausea followed for 6 hours · vs Saline with oxygen
No statistically significant difference between the four groups in vomiting episodes or nausea severity at the end of recovery or at 6 hours (P > 0.05). The authors conclude that high oxygen alone or with cinnamon oil did not reduce nausea in the first 6 hours.
No difference between groups
Methods, limits and funding

Outcomes: Nausea severity (visual scale) and number of vomiting episodes at the end of recovery and 6 hours after surgery

Limitations: Cinnamon LEAF oil of an unstated species, so it cannot be credited to cassia bark oil. Small trial, one setting, abstract only.

Funding and conflicts: Funding statement not given in the abstract.

Read: abstract

Santana 2026
Mucoadhesive Gel Based on Cinnamomum cassia Essential Oil and Punica granatum Extract for Oral Candidiasis: A Pilot Study of Plant Synergism.
Pharmaceutics · PMID 42654031 · DOI
Pilot clinical study with laboratory synergy test
human (pilot) plus laboratory
Denture wearers with clinical signs of oral candidiasis (thrush); number not given in the abstract Mucoadhesive gel containing Cinnamomum cassia essential oil plus Punica granatum (pomegranate) peel extract
Not stated in the abstract Not repeated here 14 days · vs nystatin
The two plant materials together were synergistic against C. albicans in the test tube (inhibitory concentration 0.1953 mg/mL for both). In patients, the gel group had a satisfactory response with resolution of symptoms at the end of 14 days. The gel group also did better on ease of application, absence of irritation and less interference with speech and swallowing. The nystatin group had only partial improvement, with more treatment needed in some cases. The authors call the gel promising and ask for longer follow-up.
Methods, limits and funding

Outcomes: Symptom response; ease of application; irritation; interference with speech and swallowing; checkerboard test against Candida albicans in the laboratory

Limitations: A two-ingredient finished gel, so cassia oil cannot be credited alone. The abstract gives no number of patients, no blinding, no randomisation statement and no p-values. Only the abstract was read. This is not evidence for bottled oil in the mouth or on the skin.

Funding and conflicts: Authors declared no conflicts of interest.

Read: abstract

Tisserand Institute (Ablard 2015
Cinnamon Survey Special Report (Tisserand Institute; survey of May-June 2015)
n/a · Source
Authoritative web page
n/a
n/a n/a
n/a Not repeated here n/a · vs n/a
The public summary says dermatologists and aromatherapists regard cinnamon bark and cassia essential oils as high risk for adverse skin reactions, yet consumers use them widely. A 2015 survey of 345 people was run to describe how often reactions happen, and the Institute says the findings confirm these are high-risk oils when used on the skin.
Methods, limits and funding

Outcomes: Safety statements

Limitations: Only the free summary of a paid 16-page report was read, so the actual reaction rates are not known here. A survey of volunteers cannot give a true rate. No dilution figure is repeated on this page.

Read: full-text

Yesukumar 2025
Probable Cinnamon-Induced Mixed Hepatocellular-Cholestatic Liver Injury in a Young Woman: A Case Report.
Cureus · PMID 41158894 · DOI
Case report
human case report
1
One 34-year-old woman (Qatar)
Cinnamon taken for weight loss over a long period (species and form not stated in the abstract)
Not stated Not repeated here Prolonged · vs n/a
She had abdominal pain, jaundice and dark urine, with blood tests showing acute liver injury. Cinnamon was stopped and she was treated conservatively. Her liver tests returned to normal. The authors call it probable cinnamon-induced liver injury and mention coumarin.
Methods, limits and funding

Outcomes: Liver injury; recovery

Limitations: One case. The abstract does not say which species or product, so it cannot be tied to cassia, and it is not about the oil. Only the abstract was read.

Funding and conflicts: Authors declared no financial support or conflicts.

Read: abstract

de Groot 2016
Essential Oils, Part IV: Contact Allergy.
Dermatitis · PMID 27427818 · DOI
Narrative review
review
Patients patch-tested for suspected contact dermatitis Essential oils in general
n/a Not repeated here n/a · vs n/a
Nearly 80 essential oils have caused contact allergy. Nine of 55 tested in consecutive patients showed more than 2% positive patch tests (laurel, turpentine, orange, tea tree, citronella, ylang-ylang, sandalwood, clove, costus root); the abstract does not name cassia or cinnamon. Most reactions follow pure oils or high-concentration products. Occupational dermatitis may occur in people who give massages. Co-reactivity with other essential oils and fragrance mix is frequent.
Methods, limits and funding

Outcomes: Contact allergy

Limitations: Covers essential oils as a group; the abstract does not mention cassia. Abstract only.

Funding and conflicts: Not stated in the abstract.

Read: abstract

What we do not know yet

  • What the evidence supports: a pilot gel result (very-low) and a null leaf-oil nausea trial; everything else is lab or animal work.
  • No trial of cassia bark oil alone in people was found.
  • No patch-test rate, asthma, eye or sun-sensitivity data for cassia oil were found, and no coumarin amount for the oil.
  • No study of cassia oil in pregnancy, breastfeeding, children or pets.
  • No IFRA, FDA, EMA, LiverTox or LactMed statement was read, and the EFSA coumarin opinion was not opened.

How new research is added

New studies are found by a saved PubMed search and are placed in a review queue. A person reads each one before it is added.

Lab markers

What changed in blood or saliva tests during trials. A changed number is not the same as feeling or being healthier, and we give no "normal ranges".

Other 4

●

Oral thrush symptoms (clinical signs in the mouth)

Improvement in trials

Whether the redness, soreness and white patches of oral Candida infection go away.

Very low certainty
Results and what it means

Why it was measured

Main outcome of the gel pilot.

Statistical vs. clinical meaning

A clinical sign judged in the clinic; no culture result is given in the abstract.

Safety implication

A better mouth does not make the oil safe to put in the mouth.

StudyResultPeopleProduct
22Symptoms resolved at day 14 in the gel group; partial improvement with nystatin (no numbers in the abstract).

22

●

Nausea severity (visual scale) and vomiting episodes

Decrease in trials

Self-rated nausea on a line scale, plus a count of vomiting episodes.

Not enough evidence
Results and what it means

Why it was measured

Main outcomes in the cesarean trial.

Statistical vs. clinical meaning

Self-rated and short-term.

Safety implication

Absence of a difference says nothing about safety.

StudyResultPeopleProduct
21No significant difference between the four groups at the end of recovery or at 6 hours.

21

●

Minimum inhibitory concentration (MIC) in the laboratory

Lower MIC = stronger action in a dish in trials

The lowest concentration of an oil that stops germs growing in a dish.

Not enough evidence
Results and what it means

Why it was measured

The standard test-tube measure in the germ studies.

Statistical vs. clinical meaning

A dish measure that does not predict what happens in the body.

Safety implication

Strong germ-killing in a dish goes with strong irritation of living tissue.

StudyResultPeopleProduct
4Bark oil MIC 0.52-1.04 mg/mL against four bacteria; gram-positive strains more susceptible.
5Spring leaf oil MIC 0.25 mg/mL against S. aureus and L. monocytogenes.

4 5

●

Fasting blood glucose and HbA1c (in spice and extract trials)

Decrease in trials

Blood sugar now (fasting glucose) and over about three months (HbA1c).

Not enough evidence
Results and what it means

Why it was measured

The usual outcomes in cinnamon trials.

Statistical vs. clinical meaning

Spice evidence only.

Safety implication

Cassia spice carries coumarin; see Safety.

StudyResultPeopleProduct
3Trials of whole spice or extracts report consistent, modest reductions, mixed species and preparations; none of the oil.

3

Safety

What studies and official sources say about side effects, medicines and who should check first. Each point shows what kind of evidence it comes from.

Main points to know 6
  • Skin: cassia oil is on the high-risk list for rashes and lasting allergy. Never put it on skin undiluted.. The Tisserand Institute (aromatherapy safety educators) says cinnamon bark and cassia oils are regarded by dermatologists and aromatherapists as high risk for adverse skin reactions, and that its 2015 survey of 345 users confirmed they are high-risk oils on the skin. We read only the free summary, not the paid report, so no reaction rate is given here. NAHA lists cassia as a dermal sensitiser that is not recommended in aromatherapy massage. NCCIH says some cinnamon oil or powder on the skin may cause irritation or contact dermatitis. Cinnamal (the allergen name for cinnamaldehyde), cinnamyl alcohol, coumarin and eugenol are on the European list of fragrance chemicals most often reported as consumer contact allergens. Case reports show how bad it can get: one woman had long-lasting, blistering dermatitis within 24 hours of a spa mud bath with cinnamon oil and was still allergic to cinnamal and related fragrances 5 years later; six patients had delayed allergy to cinnamon, one from airborne exposure. Poison Control says pure oils are potent, that a rash should be washed off at once, and that oils should not go on damaged skin. A sensitisation allergy can last for years and can spread to other fragrances. Authoritative guidance 23 14 15 6 8 2 19
  • Do not swallow cassia oil, and do not put it in the mouth, in baths or near the eyes.. Poison Control says misuse of essential oils can cause serious poisoning, that some are poisonous if swallowed or absorbed, and that swallowed oil can enter the lungs and cause pneumonia. NAHA says cinnamon bark oil irritates mucous membranes and should be avoided in baths completely; its tables name cinnamon bark (Ceylon), not cassia, so we cannot say whether cassia is milder. A 1989 case report of toxic effects after a child swallowed cinnamon oil exists, but PubMed holds only its title, so we cannot describe what happened. We found no cassia-specific poisoning series and no toxic amount, and this page gives none. If an oil may have been swallowed, call poison control (US: 1-800-222-1222) or your emergency number. Authoritative guidance 19 14 18
  • Coumarin and the liver: a question about cassia bark spice, not shown for the oil.. NCCIH says coumarin in cassia cinnamon has been reported to interact with the liver, that usual food amounts do not generally contain enough to cause significant problems, that some cassia products contain high levels, and that prolonged use could be an issue for sensitive people such as those with liver disease. A review of coumarin says it is toxic to the liver, that a subgroup of people is more susceptible than animals for unknown reasons, and that heavy consumers of cassia cinnamon may reach the tolerable daily intake. Another review gives up to 3.6 g/kg coumarin in cassia against 15 mg/kg or less in Ceylon cinnamon, and a 2025 lab study found up to 43.73 mg/g coumarin in extracts of some cinnamon products. A 2025 case report describes liver injury in a woman after long-term cinnamon for weight loss (species not stated); it cleared after she stopped. For the oil: one 2026 analysis of a cassia bark oil lists coumarin as a minor constituent, with no amount in the abstract. No source we read measured coumarin across oils, so do not assume the spice figures apply to the oil. Authoritative guidance 15 1 3 13 24 4
  • Keep it away from children and pets.. Poison Control says children have thin skin and immature livers and may be more susceptible to toxic effects, and that oils at home must be locked out of sight and reach of children and pets (or discarded if young children are in the home). Pet Poison Helpline says essential oil poisoning can affect many species and that cats and birds are at the greatest risk; its page does not name cassia or cinnamon, which is not proof that it is safe. We found no study of cassia oil in children or pets. Authoritative guidance 19 17
  • Pregnancy and breastfeeding: not shown to be safe.. A 1999 review says the safety of aromatherapy oils in pregnancy, childbirth and babies has not been clearly demonstrated. NCCIH says larger amounts of Ceylon cinnamon in pregnancy are considered unsafe and little is known about larger amounts of Ceylon or cassia while breastfeeding; those statements are about the spice, not the oil. We found no study of cassia oil in pregnancy or breastfeeding. Not having data is not proof of safety. Ask a midwife or doctor before using any essential oil. Narrative review 11 15
  • Quality: a bottle may not be what the label says.. Poison Control says essential oils are not well regulated and it can be hard to know the species, concentration or contaminants. NCCIH says cinnamon products often do not state species or part, and that the types and parts differ in chemistry. Cassia oils vary a lot (four chemotypes across 20 oils; leaf oil changes with season), and in one 2025 lab study ready-made cinnamon products bought from a herbalist showed no detectable cinnamaldehyde or coumarin. Authoritative guidance 19 15 9 5 13
Side effects 6
EffectHow oftenSeverity and recoveryEvidence
Skin irritation, burning and allergic contact dermatitis
Delayed allergy; patch tests in the mud-bath case were positive to cinnamon essence, cinnamic aldehyde, cinnamic alcohol, eugenol and fragrance mix.
No rate available; the Tisserand survey rate sits behind a paywallCan be severe, with blistering, in the case report
A rash may clear when exposure stops, but in the mud-bath case it was long-lasting and the allergy was still present 5 years later
Case report 8 2 23 14 15
Allergy from airborne exposure at work
Cinnamon spice in a workplace; the oil was not the exposure measured.
One case among six patientsDermatitis on the face and neck
Not stated
Case report 2
Cross-reaction with fragrance mix, eugenol (clove) and cinnamic alcohol
A review says co-reactivity among essential oils and fragrance mix is frequent.
Five of six patients reacted to cinnamal and fragrance mix INot stated
Not stated
Case report 2 8 25
Poisoning, drowsiness, lung inflammation after swallowing
Poison Control describes the general risks of swallowed oils; it does not name cassia.
No rate; a 1989 child case exists but only its title was readNot described for cassia
Not described
Authoritative guidance 19 18
Liver injury (linked to cassia cinnamon and coumarin, not shown for the oil)
The case does not state species or product.
Reported in case reports; rareA 2025 case had jaundice and dark urine
Liver tests returned to normal after the cinnamon was stopped
Case report 15 24
Headache, asthma, eye or throat irritation
The nausea trial abstract reports no side effects, which is not proof of none; it used leaf oil of unstated species.
Not described in the sources readn/a
n/a
Insufficient 21
Liver

NCCIH says coumarin in cassia cinnamon has been linked to liver problems in reports and that prolonged use could matter for people with liver disease. A 2025 case report describes liver injury after long-term cinnamon for weight loss, which recovered after stopping. These concern the bark spice. One analysis of a cassia bark oil lists coumarin as a minor constituent without an amount, so the oil is not known to be free of it. LiverTox was not opened. 15 24 1 4

How often. Not established.

Monitoring. Not applicable. People with liver disease should ask a clinician about any cinnamon product.

This is a safety connection. It is not evidence that Cassia Oil supports liver health.

Medicines and supplements 5
WithWhy it mattersImportanceEvidenceWhat to do
Fragrance mix, clove or eugenol products, cinnamic alcohol, other essential oils
allergy
Shared allergens (cinnamal, cinnamyl alcohol, eugenol) and frequent co-reactivity among oils.If you have reacted to a perfume or oil, you may react to cassia oil.Case report Low certainty 8 2 25 6If you have reacted to perfume or an oil, tell a pharmacist or dermatologist before trying another.
An anticancer medicine and nicotine (cinnamon components)
medicines
NCCIH says there are theoretical reasons, from research it partly funded, to suspect interactions.Theoretical; about cinnamon components, not tested for the oil.Authoritative guidance Not enough evidence 15Tell your doctor or pharmacist about any cinnamon product or oil you use.
Prescription and over-the-counter medicines in general
medicines
Poison Control says essential oils may interact with medications.General statement; no cassia-specific interaction was read.Authoritative guidance Not enough evidence 19Ask a pharmacist.
Diabetes medicines
blood-sugar-medicines
Spice and extract trials show modest falls in blood sugar; whether the oil does anything is not known.Not studied for the oil; an extrapolation from spice trials, not a documented interaction.Insufficient Not enough evidence 3Ask a pharmacist if you use diabetes medicines and any cinnamon product.
Medicines or alcohol that stress the liver
liver-medicines
Coumarin in cassia spice has been linked to liver effects.Not studied for the oil.Insufficient Not enough evidence 15Ask a pharmacist if you have liver disease or take liver-affecting medicines.
Who should check first 5
SituationAdviceEvidence
Known allergy to cinnamon, cinnamal, cinnamic alcohol, eugenol (clove), fragrance mix or essential oils; a history of reacting to perfumesAvoid. Cross-reactions are described.Case report 8 2 25
Swallowing the oil, especially by or near childrenDo not swallow. If a child or pet may have swallowed any essential oil, call poison control (US: 1-800-222-1222) or your emergency number.Authoritative guidance 19
Broken or damaged skin, baths and mucous membranesPoison Control says do not use essential oils on damaged skin; NAHA says avoid cinnamon bark oil in baths completely.Authoritative guidance 19 14
Liver diseaseNCCIH says prolonged use of cassia cinnamon could be an issue for sensitive people such as those with liver disease. The oil was not tested; ask a clinician.Authoritative guidance 15
Pregnancy or breastfeedingSafety is not established. Ask a midwife or doctor.Narrative review 11 15
Overdose, product quality and regulators

Summary. No lethal or toxic amount for cassia oil is described in the sources we read, and none is stated here. Poison centres warn about essential oils in general.

Amounts. No safe amount is established, and this page gives none.

Onset and course. Not described for cassia oil.

Repeated use. Repeated skin exposure is the route linked to contact allergy in oils generally; occupational allergy to cinnamon is described (six patients).

Animal data. A mouse study reports an oral toxicity test of cassia bark oil; the number is not repeated because it is animal data and could be mistaken for guidance. Pet Poison Helpline names cats and birds as most at risk from oils in general and does not name cassia.

Toxic parts. The oil is a concentrate from bark or leaf. Cinnamaldehyde (about 87% to 92% of the oils measured) is the main compound and the cinnamal allergen. Coumarin was a minor constituent in one bark oil.

Not read. The full EFSA coumarin opinion, IFRA and EU cosmetic limits, Tisserand's paid survey report and safety data, LiverTox, LactMed and veterinary papers were not read.

What is in a bottle can differ from the label, and cassia oil varies a lot.

Unknown species, strength and contaminants. Poison Control says it can be hard to know the species, concentration or contaminants in an essential oil. NCCIH says cinnamon products may not say which species or part was used. 19 15

Composition varies. Twenty cassia oils from different places fell into four chemotypes; leaf oil changed with the season (trans-cinnamaldehyde about 91% to 93% in spring and autumn); bark and leaf oils differ in minor aroma compounds. 9 5 10

Different plants sold as cinnamon. Cassia (C. cassia or C. aromaticum) and Ceylon cinnamon (C. verum or C. zeylanicum) are different trees with different coumarin levels; NCCIH says studies often do not say which was used. Labels such as cinnamon bark oil and cassia oil may or may not be the same species. 15 3

Products without the expected compounds. In a 2025 lab study, ready-made cinnamon products bought from a herbalist showed activity but no detectable cinnamaldehyde or coumarin. That study was of spice products, not oils; it shows how much labels can differ from contents. 13

BodyActionDate
NCCIH (US National Institutes of Health) (United States)Page on cinnamon (spice and oil): research does not clearly support cinnamon for any health condition; coumarin and liver; skin irritation; theoretical interactions; pregnancy and breastfeeding notes. source2024-11
Poison Control (National Capital Poison Center) (United States)General warnings on essential oils: poisoning if swallowed or absorbed, pneumonia if aspirated, rash and allergy, children and pets, possible medicine interactions. source2026-10-25
Pet Poison Helpline (United States)General warnings on essential oil poisoning in pets: cats and birds at greatest risk. source2026-10-25
European Commission, Scientific Committee on Consumer Safety (lay summary of the 2012 opinion) (European Union)Cinnamal, cinnamyl alcohol, coumarin and eugenol are on List A, the fragrance chemicals most often reported as consumer contact allergens. source2012
When to get medical help
  • If a child or pet may have swallowed any essential oil, call poison control (US: 1-800-222-1222) or your local emergency number right away. For a pet, call a vet or an animal poison helpline.
  • Swelling of the face or throat, trouble breathing, or a spreading or blistering rash after contact with an oil needs urgent medical care.
  • Choking or coughing after oil is swallowed can mean it has entered the lungs: seek emergency care.
  • A rash after use: stop, wash the oil off, and see a doctor if it does not clear.
  • Yellow skin or eyes, dark urine or belly pain after taking any cinnamon product: see a doctor.

Stop using the product and contact a clinician or emergency service. In the US, Poison Control is 1-800-222-1222.

General information only, not medical advice. Ask a clinician or pharmacist before use, especially with medicines, in pregnancy or with a health condition. See the Natural Remedy Safety guide.

Frequently asked questions

Is cassia oil safe to swallow?

No. Do not swallow essential oil. Poison Control warns that some oils are poisonous if swallowed and that oil entering the lungs can cause pneumonia. We found no safe amount for cassia oil and give none. If a child or pet may have swallowed any essential oil, call poison control (US: 1-800-222-1222) or your emergency number.

19

Can cassia oil burn or irritate skin?

Yes, it is on the high-risk list. The Tisserand Institute and NAHA describe cassia and cinnamon bark oils as high-risk skin oils and sensitisers, and NCCIH says cinnamon oil may cause irritation or contact dermatitis. Never use it undiluted. Stop and wash it off if a rash appears.

23 14 15 19

Can you become allergic to cassia oil?

Yes. Cinnamal and related fragrance chemicals are well-known contact allergens. In one case a woman was still allergic 5 years after a bad reaction to a cinnamon oil mud bath. Allergy can spread to fragrance mix, clove (eugenol) and cinnamic alcohol.

6 8 2

Does cassia oil contain coumarin, and is that a liver risk?

The bark spice is known for coumarin, and NCCIH says it has been linked to liver problems in reports, mainly with high-coumarin products or long use. One analysis of a cassia bark oil lists coumarin as a minor constituent without an amount. We found no liver case tied to the oil. Anyone with liver disease should ask a clinician before using any cinnamon product.

15 3 4 24

Does cassia oil treat oral thrush or other infections?

Not proven. A 2026 pilot of a mouth gel with cassia oil and pomegranate peel extract reported resolved thrush symptoms after 14 days, but it gave no patient numbers and used two plants. Test-tube results do not show treatment of infections in people. See a doctor for a persistent mouth infection.

22 16 4

Does cassia oil help nausea?

Not shown. In 60 women after cesarean section, inhaled cinnamon leaf oil with oxygen did not reduce nausea over 6 hours compared with saline. The leaf oil species was not stated.

21

Does cassia oil lower blood sugar?

No evidence for the oil. Trials of cinnamon spice or extracts report modest falls in blood sugar with mixed species, and NCCIH says research does not clearly support cinnamon for any condition. People on diabetes medicines should ask a pharmacist before using any cinnamon product.

3 15

Is cassia oil safe in pregnancy or breastfeeding?

Not shown to be safe. A 1999 review says safety of aromatherapy oils in pregnancy has not been clearly demonstrated. NCCIH says little is known about larger amounts of cinnamon while breastfeeding. We found no study of cassia oil. Ask your midwife or doctor.

11 15

Is cassia oil safe for children and pets?

Keep it out of reach. Poison Control says children have thin skin and immature livers and may be more susceptible. Pet Poison Helpline says cats and birds are at greatest risk from essential oils and does not name cassia, which is not proof of safety. Ask a doctor or vet.

19 17

Does cassia oil interact with medicines?

No cassia-specific interaction was found. NCCIH says there are theoretical reasons that some cinnamon components may interact with an anticancer medicine or nicotine, and Poison Control says essential oils may interact with medications. Ask a pharmacist.

15 19

Is cassia oil the same as cinnamon oil?

Not always. Cassia comes from a different tree than Ceylon cinnamon, and the two differ in coumarin and chemistry. Labels and papers often do not say which was used, so results do not always carry between them.

15 3

Why does the plant have two Latin names?

Most papers on the oil use Cinnamomum cassia, while NCCIH and GBIF accept Cinnamomum aromaticum. GBIF lists one version of the name C. cassia under a different genus, so the naming is unsettled. We use both.

7 15

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Editorial transparency
Written by
AlternativeMed editorial team. Research compiled with AI assistance, then checked against PubMed records.
Medical review
None. This page has not been reviewed by a physician or pharmacist.
First published
2026-10-25
Last substantive update
2026-10-25
How we research
We read the abstracts of 19 PubMed papers, the NCCIH, Poison Control, Pet Poison Helpline, NAHA and European Commission pages, and the free Tisserand summary, and checked the plant name in GBIF and two compounds in PubChem. We did not read LiverTox, LactMed, IFRA or FDA statements.
How we rate evidence
See "How we rate evidence" in the Evidence tab.
Independence
No product is promoted on this page. No affiliate links are shown. Industry funding is labelled where the abstract gave it.
Sources 25

Each source was opened and checked. Where we read only the abstract, it says so. The small numbers in the text point here.

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  2. Ackermann L, Aalto-Korte K, Jolanki R, Alanko K. Occupational allergic contact dermatitis from cinnamon including one case from airborne exposure.. Contact Dermatitis. 2009. PMID 19207380. DOI 10.1111/j.1600-0536.2008.01486.x. (abstract)
  3. Balkrishna A, Tripathi SK, Singh SK, et al. A critical appraisal of anti-hyperglycemic mechanisms, matrix-dependent bioavailability, and species-stratified safety of Cinnamomum spp. as functional food ingredients.. Food Res Int. 2026. PMID 42169286. DOI 10.1016/j.foodres.2026.119322. (abstract)
  4. Bouguerra A, Meziti A, Guergour H, et al. Antimicrobial Activity of Cinnamomum cassia Essential Oil: Phytochemical Profiling, In Vitro Evaluation, and Molecular Docking.. Chem Biodivers. 2026. PMID 42801756. DOI 10.1002/cbdv.71767. (abstract)
  5. Cheng Y, Fu Y, Gu D, et al. Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from Cinnamomum cassia Leaves.. Plants (Basel). 2024. PMID 39795342. DOI 10.3390/plants14010081. (abstract)
  6. European Commission, Scientific Committee on Consumer Safety. Perfume allergies, introduction (European Commission, lay summary of the 2012 SCCS opinion). n/a. 2012. (full-text)
  7. GBIF. GBIF Backbone Taxonomy: Cinnamomum aromaticum Nees and Cinnamomum cassia (match API read 2026-10-25). n/a. 2026. (full-text)
  8. Garcia-Abujeta JL, de Larramendi CH, Berna JP, Palomino EM. Mud bath dermatitis due to cinnamon oil.. Contact Dermatitis. 2005. PMID 15860002. DOI 10.1111/j.0105-1873.2005.0566h.x. (abstract)
  9. Gu K, Feng S, Zhang X, et al. Deciphering the antifungal mechanism and functional components of cinnamomum cassia essential oil against Candida albicans through integration of network-based metabolomics and pharmacology, the greedy algorithm, and molecular docking.. J Ethnopharmacol. 2024. PMID 37729978. DOI 10.1016/j.jep.2023.117156. (abstract)
  10. Huang Y, Wang W, Xin X, et al. Compounds of Essential Oils from Different Parts of Cinnamomum cassia and the Perception Mechanism of Their Characteristic Flavors.. Foods. 2025. PMID 41154105. DOI 10.3390/foods14203570. (abstract)
  11. Lis-Balchin M. Possible health and safety problems in the use of novel plant essential oils and extracts in aromatherapy.. J R Soc Promot Health. 1999. PMID 10673845. DOI 10.1177/146642409911900407. (abstract)
  12. Liu F, Yang Y, Dong H, et al. Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-kB pathway.. Phytomedicine. 2024. PMID 38688144. DOI 10.1016/j.phymed.2024.155651. (abstract)
  13. Mancak M, Caliskan UK. Are cinnamon derivatives effective and safe for diabetes?. Turk J Med Sci. 2025. PMID 40104311. DOI 10.55730/1300-0144.5972. (abstract)
  14. NAHA (US professional association). Safety (National Association for Holistic Aromatherapy). n/a. 2026. (full-text)
  15. NCCIH (US National Institutes of Health). Cinnamon: Usefulness and Safety (NCCIH; last updated November 2024). n/a. 2024. (full-text)
  16. Nguyen HTT, Miyamoto A, Nguyen HT, et al. Short communication: Antibacterial effects of essential oils from Cinnamomum cassia bark and Eucalyptus globulus leaves-The involvements of major constituents.. PLoS One. 2023. PMID 37450504. DOI 10.1371/journal.pone.0288787. (abstract)
  17. Pet Poison Helpline. Essential Oils (Pet Poison Helpline). n/a. 2026. (full-text)
  18. Pilapil VR. Toxic manifestations of cinnamon oil ingestion in a child.. Clin Pediatr (Phila). 1989. PMID 2721094. (title-only)
  19. Poison Control (National Capital Poison Center). Essential oils: Poisonous when misused (Poison Control). n/a. 2026. (full-text)
  20. PubChem. PubChem compound records: cinnamaldehyde (CID 637511) and coumarin (CID 323), read 2026-10-25. n/a. 2026. (full-text)
  21. Sadeghi N, Nasimi F, Zeidabadinejad S, et al. The Effect of Combination of Cinnamon and Oxygen Different Concentrations Inhalation Aromatherapy on, Nausea, Assessment in Cesarean Section Under Spinal Anesthesia: A Clinical Trial.. J Perianesth Nurs. 2026. PMID 42412022. DOI 10.1016/j.jopan.2026.05.007. (abstract)
  22. Santana NN, Engel LA, Adamczuk MS, et al. Mucoadhesive Gel Based on Cinnamomum cassia Essential Oil and Punica granatum Extract for Oral Candidiasis: A Pilot Study of Plant Synergism.. Pharmaceutics. 2026. PMID 42654031. DOI 10.3390/pharmaceutics18080914. (abstract)
  23. Tisserand Institute (Ablard, Carson, Tisserand). Cinnamon Survey Special Report (Tisserand Institute; survey of May-June 2015). n/a. 2015. (full-text)
  24. Yesukumar SJ, Bakir L, Mohamed IA, Danjuma M. Probable Cinnamon-Induced Mixed Hepatocellular-Cholestatic Liver Injury in a Young Woman: A Case Report.. Cureus. 2025. PMID 41158894. DOI 10.7759/cureus.93328. (abstract)
  25. de Groot AC, Schmidt E. Essential Oils, Part IV: Contact Allergy.. Dermatitis. 2016. PMID 27427818. DOI 10.1097/DER.0000000000000197. (abstract)
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.