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Each record is a registered study, a systematic-review registration or a publication. A registered or ongoing study is not a finding, and animal or cell research does not show an effect in people. The same study can appear under more than one subject, so the number of records is not a count of independent studies. You can also search an exact DOI, PubMed ID, NCT or CRD number. How to read these records.

21 study records (showing up to 30 per record type)

• Systematic review registration CRD42023474941 Registered protocol, no results here: Review Ongoing
  Leucine Supplementation's Acute Effect on Recovery in Exercise: Systematic Review and Meta-Analysis
  Condition or outcome area: Leucine has been thought to augment adaptations to strength training by acting as the primary signal to activate protein synthesis (e.g. regulation of translation initiation). Leucine (Leu), have been shown to enhance MPS and reduce muscle protein breakdown by stimulating anabolic factors and reducing catabolic factors. Moreover, leucine appears to decrease skeletal muscle soreness following eccentric exercise, and prevent declines in both circulating testosterone and skeletal muscle power follo
  2023-11-08 · Subject: Leucinum; Leucine; L-leucine; leucine; 61-90-5; (S)-Leucine; H-Leu-OH; (S)-2-Amino-4-methylpentanoic acid; (2S)-2-amino-4-methylpentanoic acid; Leucin · open the ingredient record
• Systematic review registration CRD42023463333 Registered protocol, no results here: Review Ongoing
  Effectiveness of sequential Letrozole and Gonadotropins therapy for ovulation induction in infertile women with PCOS: A systematic review and meta-analysis of randomized controlled trials (RCTs)
  Condition or outcome area: Polycystic ovarian syndrome (PCOS) is a highly prevalent, genetically complex, and heterogeneous endocrine disorder in reproductive-aged women, affecting 5% to 20% worldwide. It is a common cause of hyperandrogenism, anovulatory infertility, menstrual dysfunction, and hirsutism. It appears to be associated with an increased risk of metabolic abnormalities such as insulin resistance, hyperinsulinism, type 2 diabetes mellitus, dyslipidaemia, cardiovascular diseases, and endometrial carcinoma. PCOS
  2023-09-24 · Subject: Femara; Letrozole; letrozole; 112809-51-5; 4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile; Letrozol; CGS 20267; Letoval; CGS-20267; Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis- · open the ingredient record
• Systematic review registration CRD42023438775 Registered protocol, no results here: Review Ongoing
  Tirofiban combined with butylphthalide in the treatment of progressive cerebral infarction: a systematic review and meta-analysis of randomized controlled trials.
  Condition or outcome area: Progressive cerebral infarction is a kind of cerebral infarction with gradual aggravation of neurological function that suddenly appears within 48-72 hours after the occurrence of ischemic cerebral infarction. The main mechanism is that the progression of thrombus leads to local cerebral ischemia and hypoxic necrosis, and corresponding neurological deficits and other manifestations appear. It is relatively dangerous and is a type with poor prognosis in ischemic cerebral infarction. It is more ha
  2023-07-03 · Subject: Butylphthalide; 6066-49-5; 3-n-Butylphthalide; 3-BUTYLPHTHALIDE; 3-butylisobenzofuran-1(3H)-one; Phthalide, 3-butyl-; 1(3H)-Isobenzofuranone, 3-butyl-; 3-N-BUTYLPHATHLIDE; 3-Butyl-1(3H)-isobenzofuranone; FEMA No. 3334 · open the ingredient record
• Systematic review registration CRD42023372462 Registered protocol, no results here: Review Ongoing
  Systematic review and meta-analysis of the effectiveness of Ayurvedic herbs/spices compared to placebo/control for improving the severity of symptoms in patients with irritable bowel syndrome (IBS)
  Condition or outcome area: Irritable bowel syndrome (IBS). IBS is the condition being studied. IBS is a disorder of the digestive system characterised by symptoms including diarrhoea, constipation, abdominal discomfort and abdominal distention. The pathophysiology of IBS appears to be multifactorial, and factors include genetic, environmental, psychosocial factors or gut oversensitivity. Certain symptoms can also co-occur within all types of IBS, including abdominal discomfort, abdominal distention, mucus in stool and fat
  2023-09-07 · Subject: Lu Hui; 芦荟; Aloe; Aloes · open the herb record
• Systematic review registration CRD42022371577 Registered protocol, no results here: Review Ongoing
  Efficacy and Safety of the Three Commonly Used Chinese Patent Medicines Combined with Conventional Western Medicine in Treating Non-Proliferative Diabetic Retinopathy: A Network Meta-analysis
  Condition or outcome area: Diabetic retinopathy is now recognized as one of the serious diabetic microangiopathies. It is divided into non-proliferative and proliferative lesions according to whether neovascularization appears in the fundus. Once the disease progresses to PDR, the condition is serious and the treatment cost is high, so it is extremely important to actively take pharmacological treatment during the period of NPDR. In recent years, the application of Chinese medicine has made great progress in the treatmen
  2022-11-17 · Subject: Qiming Ke Li; 芪明颗粒; Qiming Granule · open the formula record
• Systematic review registration CRD42018087260 Registered protocol, no results here: Review Ongoing
  The efficacy and safety of xiaofeng powder (xiao feng san) for the treatment of urticaria: a meta-analysis of randomized controlled trials
  Condition or outcome area: Urticaria is defined as the sudden development of transient hives (wheals), and angioedema, or both. A wheal is characterized by its transient nature, and is a circumscribed superficial edema of the skin, mostly surrounded by a bright red erythema, and associated with a strong itching or burning sensation. Usually, angioedema appears as skin-colored or slightly red swellings and, compared to wheals, they develop slowly, and may persist for several days. Patient quality of life is often severely
  2018-02-05 · Subject: Xiao Feng San; 消风散; Xiao Feng Powder · open the formula record
• Systematic review registration CRD42022367677 Registered protocol, no results here: Review Ongoing
  Efficacy and safety of Qili Qiangxin capsule in the treatment of high blood pressure complicated with heart failure： A Systematic Review and Meta-Analysis
  Condition or outcome area: Heart failure is a group of syndromes characterized by impairment of ventricular ejection and filling function. These impairments are caused by structural or functional abnormalities of the heart. Heart failure is also the end stage of various heart diseases. Hypertension patients due to long-term hypertension state, resulting in their systemic circulation arterial pressure also maintain a high-pressure condition, with the prolongation of time, their left ventricle gradually appears to hypertrop
  2022-10-26 · Subject: Qili Qiangxin Jiaonang; 芪苈强心胶囊; Qili Qiangxin Capsule; Qi Li Qiang Xin Capsule · open the formula record
• Systematic review registration CRD42022371577 Registered protocol, no results here: Review Ongoing
  Efficacy and Safety of the Three Commonly Used Chinese Patent Medicines Combined with Conventional Western Medicine in Treating Non-Proliferative Diabetic Retinopathy: A Network Meta-analysis
  Condition or outcome area: Diabetic retinopathy is now recognized as one of the serious diabetic microangiopathies. It is divided into non-proliferative and proliferative lesions according to whether neovascularization appears in the fundus. Once the disease progresses to PDR, the condition is serious and the treatment cost is high, so it is extremely important to actively take pharmacological treatment during the period of NPDR. In recent years, the application of Chinese medicine has made great progress in the treatmen
  2022-11-17 · Subject: Fufang Xueshuantong Jiaonang; 复方血栓通胶囊; Fufang Xueshuantong Capsule; Compound Xue Shuan Tong Capsule · open the formula record
• Systematic review registration CRD42022371577 Registered protocol, no results here: Review Ongoing
  Efficacy and Safety of the Three Commonly Used Chinese Patent Medicines Combined with Conventional Western Medicine in Treating Non-Proliferative Diabetic Retinopathy: A Network Meta-analysis
  Condition or outcome area: Diabetic retinopathy is now recognized as one of the serious diabetic microangiopathies. It is divided into non-proliferative and proliferative lesions according to whether neovascularization appears in the fundus. Once the disease progresses to PDR, the condition is serious and the treatment cost is high, so it is extremely important to actively take pharmacological treatment during the period of NPDR. In recent years, the application of Chinese medicine has made great progress in the treatmen
  2022-11-17 · Subject: Fufang Danshen Diwan; 复方丹参滴丸; Fufang Danshen Dripping Pills; Compound Dan Shen Dripping Pills · open the formula record
• Systematic review registration CRD42022367173 Registered protocol, no results here: Review Ongoing
  Effect of vitamin C supplementation on blood pressure: a systematic review and meta-analysis of randomised clinical trials
  Condition or outcome area: Hypertension represents a global epidemic and it is strongly associated with an increased risk for cardiovascular and metabolic diseases. Nutritional interventions represent cornerstone strategies for the prevention and treatment of hypertension. Vitamin C is a soluble vitamin with potent anti-oxidant properties. Additional roles include synthesis of collagen and facilitating the absorption of iron. Vitamin C appears also to promote the conversion of nitrite into nitric oxide (NO) in the gastric
  2022-11-22 · Subject: Vitamin c; Ascorbic Acid; l-ascorbic acid; ascorbic acid; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid · open the ingredient record
• Systematic review registration CRD42013004567 Registered protocol, no results here: Review Completed published
  Effects of Vitamin C on the endothelial function: a systematic review (and meta-analysis)
  Condition or outcome area: Cardiovascular diseases is considered to be the leading cause of death world-wide (Kapil et al. 2010). Previous studies demonstrated that endothelial dysfunction appears at early stages of vascular disorders and is a major contributor to the progression and later development of clinical complications (Khazaei et al. 2008). The major cause of endothelial dysfunction is the oxidative stress and the reduction of nitric oxide (NO) bioavailability (Förstermann, 2010). The reactive oxygen species and
  2013-05-14 · Subject: Vitamin c; Ascorbic Acid; l-ascorbic acid; ascorbic acid; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid · open the ingredient record
• Systematic review registration CRD42013005209 Registered protocol, no results here: Review Ongoing
  Progesterone for moderate and severe traumatic brain injury
  Condition or outcome area: Traumatic brain injury (TBI) remains the main cause of death and disability in young adults worldwide. It is a heterogeneous disease with respect to cause, pathology, severity, and prognosis. Despite multiple attempts to find useful pharmacological treatments for more than 30 years, most of clinical phase II and III for the management of moderate and severe TBI failed. Progesterone appears to be a promising drug for neuroprotection after TBI in humans. The neuroprotective potential of progestero
  2013-07-31 · Subject: Progesterone; 57-83-0; Pregn-4-ene-3,20-dione; Agolutin; Crinone; 4-Pregnene-3,20-dione; Prometrium; Utrogestan; Progestin; Luteol · open the ingredient record
• Systematic review registration CRD42020176749 Registered protocol, no results here: Review Completed published
  Evaluating adherence to nicotine replacement therapy and its impact on smoking cessation: Systematic review and meta-analysis
  Condition or outcome area: Smoking cessation is one of the most important and cost-effective preventive health measures to reduce premature mortality and morbidity. The use of smoking cessation pharmacotherapies alone or in combination with behavioural interventions appears to be effective for abruptly or gradually quitting smoking. We will conduct the review on studies that evaluate the use of nicotine replacement therapy, which is considered first line treatment and commonly prescribed smoking cessation medication. Nico
  2020-04-28 · Subject: (?)-nicotine; Nicotine; nicotine; L-Nicotine; 54-11-5; (-)-Nicotine; (S)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-(-)-Nicotine; Habitrol · open the ingredient record
• Systematic review registration CRD42020166645 Registered protocol, no results here: Review Ongoing
  Communicating relative health risk of nicotine vaping products to smokers and non-smokers: a mixed-methods review of source credibility, and impact on harm perception and behavioural intentions
  Condition or outcome area: There has been a substantial increase in popularity and use of new nicotine delivery technologies such as nicotine vaping products (NVPs). The relative safety of nicotine containing products can be put in the context of continuum of risk as ‘no harm’ (no use), ‘much less harm’ (smokeless tobacco, nicotine replacement therapies and NVPs) and ‘extreme toxicity’ (combustible cigarettes). There appears to be a direct relationship between smokers’ perception of the relative harm of NVPs and combustib
  2020-02-12 · Subject: (?)-nicotine; Nicotine; nicotine; L-Nicotine; 54-11-5; (-)-Nicotine; (S)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-(-)-Nicotine; Habitrol · open the ingredient record
• Systematic review registration CRD42022354874 Registered protocol, no results here: Review Ongoing
  A meta-analysis of melatonin to delirium prevention in the intensive care unit
  Condition or outcome area: Delirium is a complex neuropsychiatric syndrome characterized by cognitive impairment and attentional deficits. Delirium in the intensive care unit (ICU) has a high incidence (30–60%) and is strongly associated with adverse outcomes. As increasingly recognized, delirium has become one of the most concerning problems for intensive care physicians. Although delirium appears to have a high incidence and is associated with adverse outcomes, clinical strategies have been very limited. Melatonin is a
  2022-09-06 · Subject: Melatonin; 73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine · open the ingredient record
• Systematic review registration CRD42020184503 Registered protocol, no results here: Review Ongoing
  Exogenous melatonin during coronary revascularization procedures and myocardial ischemia-reperfusion injury: systematic review and meta-analysis
  Condition or outcome area: Ischemic heart disease is the single largest cause of death worldwide according to the WHO and current trends demonstrate that mortality and morbidity burden from this medical condition are increasing in developing countries. Several hypotheses have been outlined with regards to the mechanisms of melatonin activity in coronary artery disease. In particular, melatonin appears to exert its antioxidative effects in reducing ischemia-reperfusion injury both in myocardial infarction and revasculariza
  2020-07-05 · Subject: Melatonin; 73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine · open the ingredient record
• Systematic review registration CRD42019130950 Registered protocol, no results here: Review Ongoing
  Lycopene for management of patients with oral sub mucous fibrosis– a systematic review and meta analysis
  Condition or outcome area: Oral submucous fibrosis, first described by Schwartz is a chronic, progressive, scarring disease. Oral submucous fibrosis is an insidious disease of the oral mucosa, mainly associated with betel/areca nut chewing. It causes a significant functional morbidity, and has a potential to transform in malignant disorder. The condition usually appears among people of South and Southeast Asia, due to history of areca nut / betel nut or its product users. The prevalence of OSMF is on rise since last four
  2019-07-30 · Subject: Lycopene; 502-65-8; all-trans-Lycopene; Psi,psi-carotene; trans-Lycopene; Lycopene 7; lycored; Redivivo; Mexoryl SAQ; Tomat-O-Red · open the ingredient record
• Systematic review registration CRD42020170251 Registered protocol, no results here: Review Ongoing
  Efficacy and Safety of Colchicine after Myocardial Infarction
  Condition or outcome area: Inflammation appears to play an important role in atherosclerosis.Colchicine is an inexpensive, orally administered, potent antiinflammatory medication has been used for centuries.The results of previous colchicine treatment of myocardial infarction are inconsistent.
  2020-07-14 · Subject: Colchicine; 64-86-8; Colchisol; Colchicinum; Colchicin; Colchicina; Colchineos; Condylon; Colcin; Colsaloid · open the ingredient record
• Systematic review registration CRD42022333796 Registered protocol, no results here: Review Ongoing
  Effect of a supersaturated calcium-phosphate rinse on oral mucositis in patients undergoing hematopoietic stem cell transplantation (HSCT): a systematic review and meta-analysis
  Condition or outcome area: Oral mucositis (OM) is an inflammation of the mucosa and can occur anywhere in the gastrointestinal tract. OM is characterized by edema, erythema, bleeding, pseudomembranes and ulcerations. Erythema appears first, and progressively transforms into ulcerations covered with a pseudomembrane. Oral ulcerations can be very painful and can negatively affect a person’s daily life. It affects all functions of the mouth; drinking, eating, speaking and oral care. Previous studies have shown that patients
  2022-05-29 · Subject: Calcium; 7440-70-2; Ca; Elemental calcium; Calcium, elemental; HSDB 273; UNII-SY7Q814VUP; SY7Q814VUP; EINECS 231-179-5; Kalzium · open the ingredient record
• Systematic review registration CRD42020150838 Registered protocol, no results here: Review Completed published
  Effect of calcium on weight regulation and body adiposity of adolescents and adults: a systematic review
  Condition or outcome area: Calcium from dairy sources appears to exert greater effects on obesity compared to calcium from supplemental or fortified sources. Some plausible explanations for this is that low calcium intake increases serum calcitriol levels, which may stimulate adipocyte calcium flow through vitamin D membrane receptors, identified as associated with the steroid-responsive membrane. Increasing intracellular calcium levels, in turn, increases acid-synthase synthase activity, inhibits hormone-sensitive lipase
  2020-02-20 · Subject: Calcium; 7440-70-2; Ca; Elemental calcium; Calcium, elemental; HSDB 273; UNII-SY7Q814VUP; SY7Q814VUP; EINECS 231-179-5; Kalzium · open the ingredient record
• Systematic review registration CRD42016045832 Registered protocol, no results here: Review Ongoing
  Auricular therapy for hypertension
  Condition or outcome area: Blood pressure (BP) is an important common modifiable risk factor for cardiovascular disease. Hypertension is defined as values >= 140mmHg SBP and/or >=90mmHg DBP. Overall the prevalence of hypertension appears to be around 30-45% of the general population, with a steep increase with ageing. In patients with uncomplicated hypertension, ACEI or ARBs, calcium channel blockers and thiazide diuretics are all suitable first-line antihypertensive drugs. However, few drug therapies specifically t
  2016-08-23 · Subject: Bei Ai; 北艾; Mugwort; Artemisia Vulgaris · open the herb record