Holistic Remedies · Ingredient
Colchicine
Formula: C22H25NO6 · MW: 399.4430000000002 · Drug-likeness: 0.833
⚗️ Identity
Name
Colchicine
Aliases / Synonyms
64-86-8; Colchisol; Colchicinum; Colchicin; Colchicina; Colchineos; Condylon; Colcin; Colsaloid
🧪 Chemistry
Molecular Weight
399.4430
LogP
2.8716
Drug-likeness
0.833
H-Bond Acceptors
6
H-Bond Donors
1
Rotatable Bonds
5
🔗 External References
139
Clinical Trials
81
Meta-Analyses
17
PubMed References
Top Conditions Studied with Colchicine
📋 Sample Trials
NCT00984009
A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice
Completed · Phase 1 · Pharmacokinetics
NCT00004748
Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis
Completed · Phase 3 · Liver Cirrhosis, Biliary
NCT00128414
Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode)
Completed · Phase 3 · Pericarditis|Recurrence
NCT00128427
Study of Colchicine to Prevent the Postpericardiotomy Syndrome
Completed · Phase 3 · Postpericardiotomy Syndrome
NCT00128453
Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences
Completed · Phase 3 · Pericarditis
NCT00179413
Study of Long-term Peg Intron vs. Colchicine in Non-responders.
Completed · Phase 4 · Hepatitis C Virus|Advanced Fibrosis|Cirr
📊 Sample Meta-Analyses
CRD42015017733
Colchicine for prevention of cardiovascular events [Cochrane Protocol]
The Cochrane Heart Group
CRD42015024647
Colchicine for children with pericarditis: a systematic review of case-series and case-reports
Recurrent episodes of pericarditis can occur in up to a third of affected people
CRD42015025336
Colchicine for knee osteoarthritis
Osteoarthritis involving the knee.
CRD42016046010
Colchicine prophylactic treatment for prevention of atrial fibrillation after cardiac surgery: a systematic review and meta-analysis
Atrial fibrillation post cardiac surgery, i.e. CABG and valvular surgery Colchic
CRD42017067427
The efficacy and safety of anti-inflammatory biologics, disease-modifying anti-rheumatic drugs (DMARDs) and colchicine in osteoarthritis: protocol for a conventional meta-analysis
Osteoarthritis is the most common joint disorder, and frequently affects the kne
CRD42018099696
Colchicine intoxication and colchicine-induced rhabdomyolysis associated with concurrent macrolide antibiotics prescription: a systematic review
Colchicine is a spindle poison. It inhibits the formation of cellular microtubul
📚 Sample References
PMID 22632542
Differential effects of colchicine in blood mononuclear cells of patients with Behçet disease in relation to colchicine responsiveness
Br J Dermatol · 2012
PMID 24720919
Anti-inflammatory treatment with colchicine in stable chronic heart failure: a prospective, randomized study
JACC Heart Fail · 2014
PMID 23040570
Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: a randomized controlled study
J Am Coll Cardiol · 2012
PMID 27129183
Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation
Clin Sci (Lond) · 2016
PMID 21689407
Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines
J Biomed Sci · 2011
PMID 25362043
AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages
Ann Rheum Dis · 2016
🏥 Linked Health Topics 12 · matched via study conditions
Amyotrophic Lateral Sclerosis
syndrome
Atrial Fibrillation
syndrome
Diabetic Nephropathy
syndrome
Gout
syndrome
Heart Failure
syndrome
Multiple Myeloma
disease
Myocardial Infarction
syndrome
Pericarditis
syndrome
Familial Mediterranean Fever
syndrome
Postpericardiotomy Syndrome
phenotype
Essential Hypertension
syndrome
Fibrosis, Liver
syndrome