natural remedies · Ingredient
(?)-nicotine
Formula: C10H14N2 · MW: 162.236 · Drug-likeness: 0.626
⚗️ Identity
Name
(?)-nicotine
Aliases / Synonyms
nicotine; L-Nicotine; 54-11-5; (-)-Nicotine; (S)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-(-)-Nicotine; Habitrol; Nicotrol; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
🧪 Chemistry
Molecular Weight
162.2360
LogP
1.8483
Drug-likeness
0.626
H-Bond Acceptors
2
Rotatable Bonds
1
🔗 External References
256
Clinical Trials
51
Meta-Analyses
10
PubMed References
Top Conditions Studied with (?)-nicotine
📋 Sample Trials
NCT02102100
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
Completed · Nicotine Dependence
NCT04124432
Behavioral Pharmacology of Cannabis and Nicotine
Completed · Phase 1 · Cannabis|Nicotine
NCT02747628
Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief
Completed · Phase 4 · Postoperative Pain Relief
NCT00033592
Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking
Completed · Phase 3 · Lung Cancer
NCT00064844
Combination Nicotine Replacement for Alcoholic Smokers
Completed · Phase 4 · Smoking|Alcoholism
NCT00124683
Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1
Completed · Phase 2 · Tobacco Use Cessation|Tobacco Use Disord
📊 Sample Meta-Analyses
CRD42019127882
An adapted systematic review of the effectiveness of electronic nicotine delivery systems (ENDS) for smoking cessation; a review of randomised control trials and prospective cohort studies
Smoking remains the leading cause of preventable death and disability. Tobacco s
CRD42019146801
Substitutability between cigarette and electronic nicotine delivery system consumption: systematic review and meta-analysis
Country health ministries should raise awareness about the risks associated with
CRD42020169416
Smoking cessation in individuals who use vaping as compared to traditional nicotine replacement therapies; protocol for a systematic review and meta-analysis
Smoking cessation ENDS use non-electronic nicotine replacement therapy health ca
CRD42022326445
The Use of Psilocybin, Cannabis, Nicotine, and Morphine in the management of Obsessive-Compulsive Disorder; A Systematic Review
Obsessive-Compulsive Disorder (OCD) is a common, chronic, and long-lasting anxie
CRD42015019219
Nursing best practice guideline: integrating tobacco and nicotine interventions into daily practice
Tobacco or nicotine use in the adult population.
CRD42015020570
Does nicotine replacement therapy affect mortality, delirium, or duration of ICU therapy in critically ill smokers?
Intensive care patients
📚 Sample References
PMID 34273166
Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells
Cardiovasc Res · 2021
PMID 34647621
Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications
J Cell Physiol · 2021
PMID 35581520
Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain
Mol Neurobiol · 2022
PMID 35678315
Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction
Clin Sci (Lond) · 2022
PMID 35841068
The effect of nicotine-containing products and fetal sex on placenta-associated circulating midpregnancy biomarkers
Biol Sex Differ · 2022
PMID 36005607
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids
Metabolites · 2022
🏥 Linked Health Topics 12 · matched via study conditions