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Herb Research & Evidence

How much research exists on herbs, what a PubMed count does and does not show, how to read herb studies, and where the gaps are. Includes an evidence snapshot for 26 herbs.

Content last updated . This page has not been medically reviewed.

Safety first. Natural products can cause side effects and interact with medicines. Read herb safety and interactions before you use anything on this page.

A lot of published research on an herb does not mean the herb works. It can mean the opposite: many careful studies sometimes end in "not shown to help". This page shows how much research exists for common herbs, what the sources say it found, and how to read herb studies yourself. Research about whether an herb helps is a separate question from whether it is safe, and both questions are only answered for one herb, one form and one use at a time.

Evidence snapshot

The snapshot counts PubMed records that mention each herb. A count shows how much has been published, not whether an herb works. The searches match words in titles and abstracts, so they include laboratory, animal and food research, and curcumin and silymarin are counted with their plants.

HerbRecords tagged as randomized controlled trialsRecords tagged as any clinical trialAll PubMed records that mention itCheck it yourself
Turmeric / curcumin59770531,898PubMed search
Elderberry18291,372PubMed search
Milk thistle1472024,909PubMed search
Ginger2773126,632PubMed search
Green tea54666920,779PubMed search
Garlic2232819,502PubMed search
Echinacea69931,546PubMed search
Chamomile1011161,843PubMed search
Saw palmetto85103669PubMed search
Valerian6277966PubMed search
Ginkgo3374135,886PubMed search
St. John's wort1672444,195PubMed search
Aloe vera1281482,944PubMed search
Cranberry1551822,233PubMed search
Black cohosh4962705PubMed search
Passionflower1921287PubMed search
Lemon balm5156898PubMed search
Cinnamon1101295,992PubMed search
Fenugreek50592,051PubMed search
Feverfew914442PubMed search
Hawthorn47531,868PubMed search
Boswellia / frankincense871011,358PubMed search
Kava3842884PubMed search
Nettle26331,001PubMed search
Hibiscus41522,209PubMed search
Moringa34403,315PubMed search

Counted 2026-10-22 using NCBI E-utilities. Counts include studies of extracts, blends and non-health topics, and a trial can find no effect. A higher count means more human research has been indexed, not that something works.

Lots of studies, different answers

The table shows what a U.S. government source says about six herbs that are widely studied. The labels in the third column follow this library's evidence labels.

HerbWhat the source saysEvidence label
Turmeric (Curcuma longa L.)Many studies exist, yet NIH's NCCIH says it does not know enough to conclude that turmeric or curcumin is beneficial for any health purpose. [1]Insufficient evidence
Ginkgo (Ginkgo biloba L.)NCCIH says ginkgo has not been shown to be effective for any condition studied. [2]No good evidence of benefit
Elderberry (Sambucus nigra L.)Few studies. NCCIH calls the research on colds and flu preliminary. [3]Promising but limited
Saw palmetto (Serenoa repens)NCCIH says we know enough to conclude it is probably not helpful for urinary symptoms of an enlarged prostate. [4]No good evidence of benefit (for that use)
Echinacea (Echinacea purpurea (L.) Moench)NCCIH says it may slightly reduce the chance of catching a cold. [5] A Cochrane review found that its products have not been shown to treat colds, though a weak benefit from some products is possible. [6]Mixed
Ginger (Zingiber officinale Roscoe)NCCIH notes that most nausea studies tested supplements rather than foods. [7]Depends on use and form (see the ginger page)

NCCIH also says that some herbal and dietary supplements have failed to show a benefit when scientists studied them. [8] Plain "natural" is not a result: only the studies are.

How to read an herb study

  • Which herb, which part, which product? A Cochrane review of echinacea found that the trials used different species and plant parts. [6] NCCIH warns that supplements you buy may differ in important ways from products tested in studies. [9]
  • People or the lab? Findings in cells or animals are preclinical. NCCIH says clinical trials give the clearest information about whether a treatment is effective and safe in humans. [10]
  • How many people? Small studies are more likely to produce results due to chance. [11]
  • Is it one study? A single study rarely provides a final, definitive answer. [12]
  • Who paid for it? NCCIH suggests asking whether the sponsor or investigators have a financial or reputational "stake" in the outcome. [12]
  • Negative results count. A result of "no benefit" is evidence too, as with ginkgo for dementia. [2]

Our guide to reading a herb study or news headline goes through these steps with examples, and how herb trials are designed explains why results differ.

What is not known

Proper evidence not found for a single measure of "how many herbs work". We looked at the NCCIH herb pages and the Cochrane review cited here, and each answers one herb at a time. This page therefore makes no overall claim.

Traditional use is a different kind of evidence. It tells you how people have used a plant, not whether a trial confirmed it. See traditional use versus research evidence.

Frequently asked questions

Does more research mean an herb works?

No. More studies mean more has been tested. Ginkgo has been studied a great deal and NCCIH says it has not been shown to be effective for any condition studied. [2]

Why do studies of the same herb disagree?

Products differ in species, plant part, extract and amount, and studies differ in size and quality. A Cochrane review of echinacea trials declined to pool results because they were so different. [6] See why herb studies disagree.

Are lab and animal results enough?

No. Laboratory and animal findings are preclinical. Human clinical trials give the clearest information on whether something is effective and safe in people. [10] The Research Library explains human, animal and laboratory research.

Is "no benefit found" the same as "unsafe"?

No. It means the studies did not show that the herb helped for that use. Safety is judged separately, from side effects, interactions and case reports.

Where do I find out about a particular herb?

Start with its profile, such as turmeric, ginkgo or echinacea, then ask a pharmacist how it fits with your medicines.

More details: evidence, limits and cautions

The details behind this page: cautions, limits of the evidence and where sources disagree. Open any note to read it.

Safety is a separate question

A study count says nothing about safety. For example, NCCIH says highly bioavailable curcumin formulations may harm the liver. [1] Anyone who takes prescription medicines, is pregnant or breastfeeding, has liver or kidney disease or faces surgery should ask a pharmacist or clinician before using any herb. See the medicine interactions guide and herbs and liver injury.

References
  1. National Center for Complementary and Integrative Health (NCCIH). Turmeric. Last updated April 2025. Read 2026-10-22.
  2. National Center for Complementary and Integrative Health (NCCIH). Ginkgo. Last updated February 2025. Read 2026-10-22.
  3. National Center for Complementary and Integrative Health (NCCIH). Elderberry. Last updated November 2024. Read 2026-10-22.
  4. National Center for Complementary and Integrative Health (NCCIH). Saw Palmetto. Last updated April 2025. Read 2026-10-22.
  5. National Center for Complementary and Integrative Health (NCCIH). Echinacea. Last updated November 2024. Read 2026-10-22.
  6. Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev. 2014. PMID 24554461. Read 2026-10-22.
  7. National Center for Complementary and Integrative Health (NCCIH). Ginger. Last updated February 2025. Read 2026-10-22.
  8. National Center for Complementary and Integrative Health (NCCIH). Natural Doesn't Necessarily Mean Safer, or Better. Read 2026-10-22.
  9. National Center for Complementary and Integrative Health (NCCIH). Using Dietary Supplements Wisely. Read 2026-10-22.
  10. National Center for Complementary and Integrative Health (NCCIH). Know the Science: Types of Research. Read 2026-10-22.
  11. National Center for Complementary and Integrative Health (NCCIH). Know the Science: Size of the Study. Read 2026-10-22.
  12. National Center for Complementary and Integrative Health (NCCIH). Know the Science: Results. Read 2026-10-22.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.