Psychedelic Therapy · Plant
Hawaiian baby woodrose
Argyreia nervosa · also called Elephant creeper; baby wood-rose; Vriddhadaruka (Ayurveda)
Case reports describe vomiting, blood-pressure problems, psychosis and, in one case, a death after a fall, and potency varies a lot between seeds. No trial shows the seeds help any condition. In Ayurveda the plant, called Vriddhadaruka, has its own long history of medicinal use.
General information, not medical advice. Last substantive update · Not medically reviewed. A named clinician has not signed off on this page. Needs Indigenous and cultural review. How this page is made
About Hawaiian baby woodrose
Hawaiian baby woodrose (Argyreia nervosa) is a climbing plant of the morning glory family. Its seeds contain lysergic acid amide (LSA) and other ergot alkaloids, and are sold as a "legal high" in some places. Case reports describe vomiting, blood-pressure problems and psychosis, and potency varies a lot. No trial shows the seeds help any condition. In Ayurveda the plant has a separate medicinal history.
Danger first: ergot alkaloids in the seeds
The seeds contain LSA, ergometrine and other ergot alkaloids. A 2025 systematic review of 17 human studies reports euphoria, hallucinations, nausea and anxiety, and severe outcomes including psychosis, hypertension and hospitalisation. It concludes LSA poses significant health risks.
In a German volunteer study, 3 of 4 people had severe reactions (cardiovascular dysregulation in two, a psychosis-like state in one) and the study was stopped. All recovered within 9 hours. In Texas poison-centre records (29 cases over 2000-2018), 45% had stomach effects and 41% neurological effects, and 7% had a major medical outcome.
A Danish forensic report describes a death after a fall from a building, but THC and alcohol were also in the blood, so the seeds cannot be blamed alone. If someone is very unwell, call emergency services.
What the plant is
Argyreia nervosa is an accepted species in the morning glory family, Convolvulaceae, according to GBIF. It is also called elephant creeper. Many older names exist, including Argyreia speciosa.
In morning glories tested, ergot alkaloids always occurred together with symbiotic fungi (Periglandula) living on the plant.
No two seeds are alike
Lab studies found that total ergot alkaloids differed 8.6-fold between two products and that LSA varied several-fold even between single seeds. Reactions also differed greatly between people. The authors say the intensity of an experience is unpredictable. Seeds also hold ergometrine and many related alkaloids.
What research shows
There is no clinical trial of the seeds for any condition. A single case report describes self-reported relief of cluster headache. Rat and cell studies of root extracts report higher testosterone and lower blood sugar. A small Ayurvedic study of a two-herb mixture reported symptom improvement in filariasis, with no placebo group.
None of this is proof the plant helps people.
Tradition belongs to the people who keep it
In Ayurveda the plant is called Vriddhadaruka and is listed for many conditions, including as a brain tonic. It is also used in tribal medicine in Assam. We describe only what the sources say and do not speak for any tradition. Tradition is not clinical evidence.
Law differs by country and changes
In the US federal Schedule III text we read, lysergic acid amide is listed, and the plant and seeds are not named. We could not verify state laws such as Louisiana, or Australian and other national law. This is not legal advice; always check current law where you live.
At a glance
Traditional uses history, not proof
- In Ayurveda the plant (Vriddhadaruka) is traditionally listed as a brain tonic and for cerebral disorders, diabetes, ulcers and as an aphrodisiac (Bharati & Bansal 2014).
- Also used in tribal medicine in Assam, for example by the Santali and Lodha peoples (Paulke et al. 2013).
- Root powder is used in classical Ayurvedic preparations, for example in a 2012 study of filariasis (Prasad & Naidu 2012).
Studied for research
- Cluster headache: one self-reported case, not enough evidence
- Male fertility and testosterone: rat and cell work on root extracts, very low certainty
- Blood sugar: diabetic rats given a root extract, very low certainty
- Filariasis: one small Ayurvedic study of a two-herb mixture, no placebo
- Colorectal cancer cells: one isolated compound in a dish
Main compounds
- Ergometrine (ergonovine)
- Other ergoline alkaloids in small amounts
Common forms
- The seeds, sold as a "legal high" in some places (potency varies)
- Root, used in Ayurvedic preparations
Research links: Systematic review of LSA: effects and adverse outcomes (abstract) · Texas poison-centre exposures to the seeds (abstract) · Variable severe reactions in volunteers (abstract) · Large differences in alkaloid content between products (abstract) · Poison Control (US): call 1-800-222-1222 · US eCFR: 21 CFR 1308.13 Schedule III · Research Library · Genes & Biomarkers Library
What it is and its history
- Accepted scientific name
- Argyreia nervosa
- Naming authority
- (Burm.fil.) Bojer
- Synonyms
- Argyreia speciosa (L.fil.) Sweet; Convolvulus nervosus Burm.fil.; Convolvulus speciosus L.fil.; Ipomoea nervosa (Burm.fil.) J.R.I.Wood & Scotland; Lettsomia nervosa (Burm.fil.) Roxb.; Rivea nervosa (Burm.fil.) Hallier fil.
- Common names
- Hawaiian baby woodrose (English); Elephant creeper (English); Baby wood-rose (English); Vriddhadaruka (Sanskrit (Ayurvedic name, per a phytochemistry paper)); Hawaiianische Holzrose (German (GBIF))
- Family or group
- Convolvulaceae (morning glory family). A woody climber (per a 2014 paper). The part sold as a psychoactive is the seed; roots are used in Ayurvedic preparations.
- Classification
- Plantae > Tracheophyta > Magnoliopsida > Solanales > Convolvulaceae > Argyreia > Argyreia nervosa
- Native range
- Not verified in a source we read (Plants of the World Online was not read).
- Habitat
- Not checked.
- What it looks like
- Part used: Seeds (psychoactive use) and roots (traditional Ayurvedic use). This page does not describe how to recognise the plant.
- Look-alikes and adulterants
- Name: Other morning glories (Ipomoea species); Note: Seeds of several Convolvulaceae contain related ergot alkaloids, and web reports mix species. A name or photo is never proof of what a seed contains.
- Sustainability and conservation
- Not checked (no IUCN or CITES source read).
Traditional use and history history, not clinical proof
| Tradition or era | Documented use | Source |
|---|---|---|
| Ayurveda and tribal medicine in India | A 2014 paper says the plant (Sanskrit Vriddhadaruka) is traditionally used for gonorrhoea, strangury, chronic ulcers, diabetes, anaemia and cerebral disorders, and as an appetiser, brain tonic, cardiotonic and aphrodisiac. A 2013 paper adds nervousness, bronchitis, tuberculosis and arthritis, and notes use in tribal medicine in Assam (Santali, Lodha peoples). | Bharati & Bansal 2014; Paulke et al. 2013 |
| Ayurvedic clinical study (2012) | A study in India used Vriddhadaru Mula Churna (root powder) mixed with another herb in filariasis. | Prasad & Naidu 2012 |
| 1965: ergoline alkaloids identified | Science report that extracts of the plant held ergoline alkaloids, tentatively ergine, isoergine and penniclavine. | Hylin & Watson 1965 |
| 2000s onward: "legal high" sold online | Papers describe the seeds sold as a legal or herbal high in Germany and elsewhere, and case reports from several countries. | Sobanski 2021; Graziano 2017 |
Traditional use shows how it was used. It does not show that it works or is safe today.
What is inside, and how it may work
What it contains and how those compounds act in cells and animals. Laboratory and animal mechanisms are not proven effects in people.
Main compounds
| Compound | Family | Where it is concentrated | Activity studied | Level of evidence |
|---|---|---|---|---|
| Lysergic acid amide (LSA, ergine) PubChem 442072 | ergot alkaloid (ergoline) | Seeds; 83-84% of alkaloids in two products Varies several-fold between seeds and 8.6-fold between two products. No typical value applies. | 28 15 | Laboratory |
| Ergometrine (ergonovine) PubChem 443884 | ergot alkaloid | Seeds; 10-17% in two products Varies by product. | Discussed as a concern for fetal distress in pregnancy (German paper). 22 15 3 | Review |
| Other ergoline alkaloids (lysergol, elymoclavine, chanoclavine, isoergine, penniclavine and others) | ergot alkaloids | Seeds Minor components (under 6.1% in one product). | Receptor binding predicted at serotonin and dopamine receptors by computer; not tested in people. 16 15 8 | Laboratory |
| Scopoletin and geranyl isovalerate | coumarin; terpene ester | Root (scopoletin); extract fraction (geranyl isovalerate) Not given. | Raised testosterone-pathway markers in cells (scopoletin); reduced cancer-cell viability in a dish (geranyl isovalerate). 13 19 | Laboratory |
Mechanisms, receptors and pathways
| Target or pathway | Gene or receptor | What was found | Level |
|---|---|---|---|
| Serotonin, adrenergic and dopamine receptors | 5-HT1A, 5-HT2, alpha-2, others | Laboratory research | |
| Testosterone synthesis pathway | StAR, 3-beta-HSD | Root fractions raised expression of these genes and testosterone in cells and rats. 13 21 | In vivo animal |
| Where the alkaloids come from | dmaW (fungal gene) | Ergot alkaloids in morning glories co-occur with symbiotic Periglandula fungi, which carry the gene for the first biosynthetic step. Across eight species tested, including A. nervosa, seed alkaloids ranged from 15.8 to 3223.0 micrograms per gram. 1 | Laboratory research |
Absorption, metabolism and elimination
- Absorption
- In four volunteers who ate seeds, serum LSA was 0.66 to 3.15 ng/mL about 2 hours later.
- Distribution
- Not established.
- Metabolism
- The isomer iso-LSA was also found in serum and urine in varying ratios; a forensic report found hydroxylated metabolites of LSA and ergonovine in urine.
- Elimination
- LSA was found in urine 1 to 24 hours after ingestion and not at 48 hours.
- Bioavailability
- Not established.
Isolated compounds versus whole extracts
Seeds, root extracts and isolated compounds are different things. Almost all human data are on seeds taken as a recreational drug; the animal and lab data are mostly on root extracts or isolated compounds. Results do not carry across.
Nutritional composition
The seeds are not a food or a nutrient.
2 very low certainty4 not enough evidence
What was looked at
The 6 benefits and uses checked for Hawaiian baby woodrose, each with how strong the evidence is. Tap one to open it.
- Cluster headache (case report only)Not enough evidence
- Traditional nervous-system uses (Ayurveda)Not enough evidence
- Male fertility and testosterone (rat and cell work on root extracts)Very low certainty
- Blood sugar in diabetic rats (and male infertility)Very low certainty
- Filariasis symptoms (Ayurvedic mixture, small study)Not enough evidence
- Colorectal cancer cells (geranyl isovalerate, lab only)Not enough evidence
Lab markers tracked in the studies
Blood level of LSA after eating seedsTestosterone in rats given root fractionsFasting blood glucose in diabetic rats
What is Hawaiian baby woodrose good for?
The uses people ask about and how strong the evidence is. None is proven for the seeds. Read every row together with the Safety tab.
Benefits, one by one
Each card is a research question, not a promise. Tap a goal to filter. Open a card to see the studies, doses and limits.
Cluster headache (case report only)
Not enough evidenceOne woman in Australia said the seeds relieved her cluster headache and low mood. That is one self-report. A 2025 systematic review notes some evidence "suggests" possible use for cluster headaches, but also says the research base is small and the risks are significant.
1 studiesNot covered. This page gives no amounts or ways of using the seeds.
Studies, doses and limits
What the trials found
A single case report. No trial.
Results
A 48-year-old woman in an Australian clinic reported using Hawaiian baby woodrose to relieve cluster headache and accompanying low mood. The case report authors call for research. The review authors say the potential is only "suggested".
Effect sizes as reported
No effect sizes; one person.
Why this rating
One self-reported case with no control and no measurement of what was taken.
Form and dose studied
Not covered. This page gives no amounts or ways of using the seeds.
Who was studied
One woman, 48.
Limits
A single self-report is not evidence of benefit. Seed alkaloid content varies and the seeds carry serious risks.
Why researchers looked
The case report authors cite preliminary evidence that psychedelics may help cluster headache, so related seeds attract questions.
Traditional use
The sources we read do not describe a traditional use for headache.
Proposed mechanism Laboratory research
Not established for this plant.
A proposed mechanism does not show that the effect happens in people.
Anyone with cluster headache should see a doctor. Treatments with evidence exist; this page does not recommend the seeds.
Traditional nervous-system uses (Ayurveda)
Not enough evidenceIn Ayurveda the plant is called Vriddhadaruka. Sources describe traditional use as a brain tonic and for "nervousness" and cerebral disorders. This is tradition, not tested benefit.
1 studiesNot covered. This page gives no amounts or ways of using the seeds.
Studies, doses and limits
Results
No tests of these uses were found. The sources only list the traditional uses.
Effect sizes as reported
No effect sizes.
Why this rating
Only descriptions of traditional use.
Form and dose studied
Not covered. This page gives no amounts or ways of using the seeds.
Limits
Traditional use is not clinical evidence. The seeds are the part sold as a legal high.
Why researchers looked
The plant is an important traditional medicine in India, and the western "legal high" use is a separate, newer story.
Traditional use
A phytochemistry paper says the plant is traditionally used for cerebral disorders and as a brain tonic; a pharmacology paper lists nervousness among traditional uses. We describe only what the sources say and do not speak for any tradition.
Proposed mechanism Laboratory research
No mechanism established for these uses.
A proposed mechanism does not show that the effect happens in people.
The seeds carry risks (see Safety). Traditional use of one plant part says nothing about another.
Male fertility and testosterone (rat and cell work on root extracts)
Very low certaintyIn rats, fractions of the root raised testosterone and sperm counts. This matches the root's traditional use as an aphrodisiac and for fertility, but it is animal and lab work on extract fractions, not on the seeds and not tested in men.
2 studiesNot covered. This page gives no amounts or ways of using the seeds.
Studies, doses and limits
Results
Rats given root fractions had testicular testosterone up 3.57 to 3.84-fold. An alkaloidal root fraction at the highest dose raised serum testosterone 100% and sperm concentration 30.26%, with more mounting behaviour.
Effect sizes as reported
Rat results, fold changes versus controls; no human effect sizes.
Why this rating
Rats and cells; extract fractions; research from one group in the same institute.
Form and dose studied
Not covered. This page gives no amounts or ways of using the seeds.
Who was studied
Male Wistar rats; TM-3 cells.
Limits
Different plant part (root) from the seeds. Not tested in people. Extract fractions are not the plain root.
Why researchers looked
Root is traditionally used as an aphrodisiac and for male infertility.
Traditional use
Roots are described in the sources as traditionally used as an aphrodisiac and spermatogenic.
Proposed mechanism In vivo animal
Root fractions and scopoletin raised expression of steroid-making genes (StAR, 3-beta-HSD) in cells and rat testes.
A proposed mechanism does not show that the effect happens in people.
Do not treat this as support for using roots or seeds. The seeds contain ergot alkaloids with real risks.
Blood sugar in diabetic rats (and male infertility)
Very low certaintyIn diabetic rats a root extract lowered fasting glucose and improved sperm quality. It was not tested in people.
2 studiesNot covered. This page gives no amounts or ways of using the seeds.
Studies, doses and limits
Results
At the higher extract dose diabetic rats had fasting glucose 0.52-fold of the untreated diabetic level, fewer abnormal sperm, and higher testicular testosterone (1.40-fold), FSH (1.91-fold) and LH (1.69-fold).
Effect sizes as reported
Fold changes in rats.
Why this rating
Animal study of a root extract only.
Form and dose studied
Not covered. This page gives no amounts or ways of using the seeds.
Who was studied
Diabetic rats (high-fat diet plus streptozotocin).
Limits
Rat model; root extract; not tested in people.
Why researchers looked
Root is traditionally listed for diabetes, and diabetes can harm male fertility.
Traditional use
A phytochemistry paper lists diabetes among traditional uses of the plant.
Proposed mechanism In vivo animal
Authors propose less oxidative stress and inflammation in testis tissue.
A proposed mechanism does not show that the effect happens in people.
This is not advice to use the plant for diabetes. Do not change diabetes treatment without your doctor.
Filariasis symptoms (Ayurvedic mixture, small study)
Not enough evidenceIn India, 133 people with filariasis were given a mixture of Argyreia nervosa root powder and Caesalpinia bonduc leaf powder (with or without an oil). Symptoms such as swelling and pain improved, but there was no placebo and the mixture has two herbs.
1 studiesNot covered. This page gives no amounts or ways of using the seeds.
Studies, doses and limits
What the trials found
One three-group clinical study, no placebo.
Results
Groups given the mixture improved significantly (P<0.0001) on lymphoedema, lymphadenitis, lymphangitis, pain and fever; the Ayurvedic reference group also improved. 120 of 133 completed.
Effect sizes as reported
P values only in the abstract.
Why this rating
No placebo, two herbs combined, Ayurvedic comparator, small groups.
Form and dose studied
Not covered. This page gives no amounts or ways of using the seeds.
Who was studied
133 adults with manifested filariasis.
Limits
Cannot separate this root from the other herb or from the natural course of the illness. Not seeds.
Why researchers looked
Vriddhadaru root is part of classical Ayurvedic preparations.
Traditional use
The paper describes classical Ayurvedic drugs and uses Vriddhadaru Mula Churna (root powder). We describe only what the abstract says.
Proposed mechanism Laboratory research
Not studied.
A proposed mechanism does not show that the effect happens in people.
Filariasis needs medical care. This is not a treatment recommendation.
Colorectal cancer cells (geranyl isovalerate, lab only)
Not enough evidenceOne compound found in a plant extract, also used as a food flavouring, killed colorectal cancer cells in a dish. This says nothing about the plant or seeds in people.
1 studiesNot covered. This page gives no amounts or ways of using the seeds.
Studies, doses and limits
Results
The compound reduced cell viability in a dose- and time-dependent way in HCT116 cells.
Effect sizes as reported
Cell results only.
Why this rating
One cell line; one isolated compound.
Form and dose studied
Not covered. This page gives no amounts or ways of using the seeds.
Who was studied
HCT116 human colorectal cancer cell line.
Limits
Isolated compound in a dish; no animals or people.
Why researchers looked
Researchers look for new lead molecules in plant extracts.
Traditional use
Not described.
Proposed mechanism Laboratory research
The compound shifted apoptosis-related genes in the cells.
A proposed mechanism does not show that the effect happens in people.
Not a cancer treatment. Do not use the plant for cancer.
Connections to the rest of health
How Hawaiian baby woodrose connects to the rest of our health knowledge graph. Every link says what kind of connection it is. A safety link (for example to the liver) is a warning, not a benefit. A study that merely mentions a topic never creates a benefit link.
Explore every connection: goals, body systems, organs, symptoms, genes
B. Body systems
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Nervous System | Biological association | Not enough evidence | Studied for: Cluster headache (case report only) Studied for: Traditional nervous-system uses (Ayurveda) | 9 2 |
| Reproductive System | Biological association | Very low certainty | Studied for: Male fertility and testosterone (rat and cell work on root extracts) | 13 21 |
| Endocrine System | Biological association | Very low certainty | Studied for: Blood sugar in diabetic rats (and male infertility) | 6 2 |
| Immune System | Biological association | Not enough evidence | Studied for: Filariasis symptoms (Ayurvedic mixture, small study) | 18 |
| Digestive System | Biological association | Not enough evidence | Studied for: Colorectal cancer cells (geranyl isovalerate, lab only) | 19 |
I. Biomarkers
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Blood level of LSA after eating seeds | Biological association | Very low certainty | Measured in trials: n/a. A lab change is not the same as a health benefit. | 14 |
| Testosterone in rats given root fractions | Biological association | Very low certainty | Measured in trials: increase. A lab change is not the same as a health benefit. | 13 21 |
| Fasting blood glucose in diabetic rats | Biological association | Very low certainty | Measured in trials: decrease. A lab change is not the same as a health benefit. | 6 |
J. Genes, receptors and enzymes
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| 5-HT2 and 5-HT1A receptors | Preliminary mechanism | In vitro | Lab binding targets of LSA. |
L. Active compounds
| Connected to | Kind of connection | Evidence status | Context | Studies |
|---|---|---|---|---|
| Low certainty | Preparation or compound: LSA (ergine) |
3 | ||
| Ergometrine (ergonovine) | Low certainty | Found with LSA in seeds; discussed as a concern in pregnancy. Preparation or compound: Seeds |
15 3 | |
| Lysergic acid amide (LSA, ergine) | Biological association | Laboratory | Preparation or compound: Seeds; 83-84% of alkaloids in two products |
28 15 |
| Ergometrine (ergonovine) | Biological association | Review | Discussed as a concern for fetal distress in pregnancy (German paper). Preparation or compound: Seeds; 10-17% in two products |
22 15 3 |
| Other ergoline alkaloids (lysergol, elymoclavine, chanoclavine, isoergine, penniclavine and others) | Biological association | Laboratory | Receptor binding predicted at serotonin and dopamine receptors by computer; not tested in people. Preparation or compound: Seeds |
16 15 8 |
| Scopoletin and geranyl isovalerate | Biological association | Laboratory | Raised testosterone-pathway markers in cells (scopoletin); reduced cancer-cell viability in a dish (geranyl isovalerate). Preparation or compound: Root (scopoletin); extract fraction (geranyl isovalerate) |
13 19 |
Each connection is stored with the ingredient, the connected record, the kind of connection, the evidence status, the supporting studies, the preparation or compound involved, and a review date (last reviewed October 25, 2026).
Evidence at a glance: what the research found for 6 outcomes
Each outcome below is one thing researchers measured. Certainty is how far the evidence can be trusted, not how well it works. The full studies are on the next tab.
The evidence
The research centre for Hawaiian baby woodrose. Every record here was checked against PubMed or the publisher's page; we never list a study we have not verified.
Evidence by outcome
Bars show how many studies we found for each outcome, not how well it works. People are added up across trials only (reviews are not added, to avoid double counting).
How we rate evidence
High certainty
Several well-run trials or reviews agree; further research is unlikely to change the picture much.
Moderate certainty
Good trials point the same way, but some doubt remains.
Low certainty
Small, short or inconsistent trials. The finding could change with better research.
Very low certainty
Very little or very weak human data. Treat as a possibility only.
Mixed findings
Trials or reviews disagree with each other.
Not enough evidence
Not enough human research to say either way.
Evidence against
Good research found no benefit, or found harm.
We take the reviewers' own risk-of-bias and GRADE statements where they exist, and otherwise judge from study size, design, consistency, directness and whether a product matches what is sold. Many publications do not make evidence high. Method note: We searched PubMed and read the abstracts of 23 papers, read the US eCFR Schedule I and III text and poison-help pages from the US and UK, and checked the plant name and chemical identifiers in GBIF and PubChem. Statements we could not verify are marked as such.
Study library: every study we checked 28
| Study | Design | People | Product, dose, length | Result |
|---|---|---|---|---|
| Beaulieu 2015 Phylogenetic and chemotypic diversity of Periglandula species in eight new morning glory hosts (Convolvulaceae). Mycologia · PMID 25977213 · DOI |
Laboratory survey plant / fungus |
8 Eight Convolvulaceae species including Argyreia nervosa |
Seeds and young leaves of morning glories seeds Not reported here |
Across the eight species tested, seeds contained ergot alkaloids at 15.8-3223.0 micrograms per gram in four chemotypes. Each species carried characteristic Periglandula fungi on young leaves. The authors conclude ergot alkaloids in morning glories always co-occur with these symbiotic fungi. Methods, limits and fundingOutcomes: Ergot alkaloids and associated fungi Limitations: Figures are across eight species, not for A. nervosa alone. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Bharati 2014 Phytochemical investigation of natural and in vitro raised Vriddhadaruka plants. Anc Sci Life · PMID 25861141 · DOI |
Laboratory phytochemical study with background on traditional use plant |
Plant parts grown naturally and in tissue culture | Argyreia nervosa (elephant creeper, Sanskrit Vriddhadaruka) seeds, leaf, stem, callus Not reported here |
The background says the plant is traditionally used for gonorrhoea, strangury, chronic ulcers, diabetes, anaemia and cerebral disorders, and as an appetiser, brain tonic, cardiotonic and aphrodisiac, and that seeds contain ergot alkaloids including lysergic acid amide. Screening found flavonoids, alkaloids and terpenoids. Methods, limits and fundingOutcomes: Traditional uses; phytochemical screening Limitations: Traditional-use list is background, not a test; screening shows presence only. Funding and conflicts: Conflict of interest: none declared. Read: abstract |
| Borsutzky 2002 Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration [German]. Nervenarzt · PMID 12215884 · DOI |
Case oriented pharmacological review |
1 One intoxication case plus pharmacology |
Argyreia nervosa seeds seeds Not reported here |
They also discuss potential fetal distress because of the ergometrine in the seeds. Methods, limits and fundingOutcomes: Psychopharmacological profile Limitations: German-language abstract; one case. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Forrester 2018 Argyreia nervosa exposures reported to Texas poison centers. J Addict Dis · PMID 31305228 · DOI |
Case series (poison centre records) |
29 29 exposures reported to Texas poison centers, 2000-2018 |
Argyreia nervosa seeds seeds Not reported here |
79% of patients were male; mean age 24 (range 16-53); 97% ingestion. Outcomes: 3% no effect, 31% minor, 38% moderate, 7% major. Most frequent effects were gastrointestinal (45%) and neurological (41%). Most frequent treatments were intravenous fluids (28%) and benzodiazepines (21%). Methods, limits and fundingOutcomes: Patient characteristics, clinical effects, outcome and treatment Limitations: Voluntary reports; small number; no confirmation of what was taken. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Gertsch 2003 Case report: an ingestion of Hawaiian Baby Woodrose seeds associated with acute psychosis. Hawaii Med J · PMID 12886727 |
Case report |
1 An 18-year-old man |
Hawaiian baby woodrose seeds seeds Not reported here |
The man needed hospital care for psychotic behaviour. The authors call it the second documented case of acute psychosis ascribed to ingestion of this plant and suggest it belongs in the differential diagnosis of an acutely psychotic young adult. Methods, limits and fundingOutcomes: Psychiatric presentation Limitations: Single case. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Gori 2025 Argyreia nervosa (Brum.f.) Bojer. alleviates diabetes mellitus-induced male infertility. Mol Biol Rep · PMID 40465059 · DOI |
Rat study rat |
Diabetic rats (high-fat diet plus streptozotocin) | Hydro-alcoholic root extract root Not reported here |
At the higher extract dose, diabetic rats had lower fasting glucose (0.52-fold), fewer abnormal sperm, and higher testicular testosterone (1.40-fold), FSH and LH, with lower inflammation and oxidative-stress markers. Methods, limits and fundingOutcomes: Blood glucose, sperm quality, hormones, oxidative stress Limitations: Rats; extract, not the whole plant; authors from the same institution as other root studies. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Graziano 2017 Herbal Highs: Review on Psychoactive Effects and Neuropharmacology. Curr Neuropharmacol · PMID 27799032 · DOI |
Narrative review |
Reviewed herbal highs including Argyreia nervosa | Herbal highs plant parts Not reported here |
Limited information exists for some plants on subjective effects and toxicity, alone or combined with other drugs. The authors say some herbal highs should be classed as harmful drugs; for others studies are lacking. Methods, limits and fundingOutcomes: Psychoactive effects, neuropharmacology and toxicity Limitations: Narrative review covering several plants. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Hylin 1965 Ergoline Alkaloids in Tropical Wood Roses. Science · PMID 17842841 · DOI |
Chemical analysis plant |
Extracts of Argyreia nervosa | Extracts Not reported here |
Extracts contained appreciable quantities of ergoline alkaloids tentatively identified as ergine, isoergine and penniclavine, with related substances. Methods, limits and fundingOutcomes: Alkaloid identification Limitations: Very short report; identifications were tentative. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Johnson 2020 Can Psychedelics Alleviate Symptoms of Cluster Headache and Accompanying Mental Health Problems? A Case Report Involving Hawaiian Baby Woodrose. J Psychoactive Drugs · PMID 32375602 · DOI |
Case report |
1 A 48-year-old woman in an Australian clinic |
Hawaiian baby woodrose (self-reported use) seeds Not reported here |
The woman reported that she used Hawaiian baby woodrose to relieve cluster headache and accompanying mental health problems. The authors say this is the first case report to examine analgesic and psycho-spiritual effects and call for research. They also noted incidental benefits of antiviral therapy. Methods, limits and fundingOutcomes: Cluster headache and mood Limitations: One self-report; no control; no measurement of the product. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Juszczak 2013 Recreational use of D-lysergamide from the seeds of Argyreia nervosa, Ipomoea tricolor, Ipomoea violacea, and Ipomoea purpurea in Poland. J Psychoactive Drugs · PMID 23662334 · DOI |
Analysis of user reports from a recreational web site, compared with case reports |
User reports on a recreational web site | Convolvulaceae seeds including Argyreia nervosa seeds Not reported here |
Symptoms reported by users were comparable with the few medical case reports. The most worrying symptom was suicidal ideation, reported by two subjects who ingested A. nervosa and Ipomoea seeds. Seeds were often taken with other drugs such as cannabis and hashish, and also dextromethorphan. Methods, limits and fundingOutcomes: Reported symptoms; comparison with medical case reports Limitations: Self-reports on a web site cannot be verified; it mixes several species. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Klinke 2010 Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose. Forensic Sci Int · PMID 20018470 · DOI |
Case report (2 cases) |
2 Two people; one died, one survived |
Argyreia nervosa seeds seeds Not reported here |
One death from falling from a building and one survivor. LSA, ergonovine (ergometrine) and lysergic acid alpha-hydroxyethylamide were found. The case story noted the will to jump out of the window. The dead person also had THC and alcohol in the blood. Methods, limits and fundingOutcomes: LSA in blood and urine; circumstances Limitations: Two cases; other substances present, so the seeds cannot be blamed for the death alone. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Kremer 2012 Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds. Forensic Sci Int · PMID 21803515 · DOI |
Human volunteer study stopped early |
4 4 volunteers |
Argyreia nervosa seeds seeds Not reported here |
The study could not continue because of severe adverse effects in 3 of 4 subjects: cardiovascular dysregulation in two and a psychosis-like state in one. All recovered completely within 9 hours. Reactions differed greatly between people despite body-weight-adjusted equal doses. The authors say fluctuating alkaloid content and multi-drug intoxications make use more dangerous than commonly believed. Methods, limits and fundingOutcomes: Driving-ability study; adverse effects Limitations: Four people; stopped early. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Patel 2022 Beneficial effects of roots of Argyreia nervosa (Brum.f.) Bojer on testosterone biosynthesis in testis and spermatogenesis in Wistar rats. J Ethnopharmacol · PMID 35074455 · DOI |
Cell and rat study in vitro / rat |
TM-3 cells and Wistar rats | Root extract fractions and isolated scopoletin root Not reported here |
Root fractions and scopoletin raised testosterone in cells; in rats the fractions raised testicular testosterone 3.57 to 3.84-fold and sperm concentration, with higher expression of steroid-making genes. Methods, limits and fundingOutcomes: Testosterone, enzyme expression, sperm concentration Limitations: Animals and cells only; extract fractions, not plain root. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Paulke 2012 Analysis of lysergic acid amide in human serum and urine after ingestion of Argyreia nervosa seeds. Anal Bioanal Chem · PMID 22695498 · DOI |
Laboratory method applied to human samples |
4 Serum and urine from volunteers who ingested seeds |
Argyreia nervosa seeds seeds Not reported here |
Serum LSA was 0.66 to 3.15 ng/mL about 2 hours after ingestion. In urine LSA was found 1 to 24 hours after ingestion and not at 48 hours. The isomer iso-LSA was also found. Low serum levels went with severe autonomic effects (nausea, weakness, fatigue, tremor, raised blood pressure) and a psychosis-like state that ended the study. Methods, limits and fundingOutcomes: LSA levels in serum and urine Limitations: Same four-person study; measures blood levels, not safety limits. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Paulke 2014 Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int · PMID 25036782 · DOI |
Laboratory analysis of two commercial products laboratory |
2 One seed set and one capsule product |
Argyreia nervosa seeds and capsules seeds Not reported here |
LSA and its isomers made up 83-84% of the alkaloids, with ergometrine/ergometrinine 10-17%. Total ergot alkaloid amounts differed by a factor of 8.6 between the two products, and LSA varied several-fold even between single seeds. The authors conclude potency depends on alkaloid amount and that the intensity is unpredictable. Methods, limits and fundingOutcomes: Ergot alkaloid content Limitations: Two products only. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Paulke 2015 Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high. Forensic Sci Int · PMID 25747328 · DOI |
Laboratory analysis of seed samples laboratory |
Seeds of different origin and labelling | Argyreia nervosa seeds seeds Not reported here |
Besides LSA and ergometrine, many related ergot alkaloids were identified, and fragments suggest ergopeptides may also be present. Alkaloid content depends on the quality of the material, which a consumer cannot foresee. Methods, limits and fundingOutcomes: Alkaloid composition Limitations: Identification study; amounts not generalisable. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Ponte 2017 Psychoactive effects of legal high: About lysergic acid amide (LSA) [French]. Therapie · PMID 28457570 · DOI |
Pharmacovigilance case report |
4 4 cases reported to the Toulouse Addictovigilance Centre in 2016 |
LSA-containing plant products seeds Not reported here |
Four cases in 2016 caused unintended psychic effects; two led to hospitalisation. The authors note other serious LSA intoxications are published, including a death, and that LSA is freely available and sometimes hidden behind various plant names. Methods, limits and fundingOutcomes: Reported effects; hospitalisation Limitations: Four cases; French-language abstract. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Prasad 2012 Effect of Kuberaksha Patra Churna, Vriddhadaru Mula Churna and Kandughna Taila in Shlipada (Manifested filariasis). Ayu · PMID 23049193 · DOI |
Three group clinical study (Ayurvedic) |
133 133 patients with manifested filariasis; 120 completed |
Root powder of Argyreia nervosa mixed with Caesalpinia bonduc leaf powder, with or without an external oil, versus an Ayurvedic reference drug root Not reported here |
Groups given the root and leaf powder mixture (with or without oil) showed highly significant improvement (P<0.0001) on lymphoedema, lymphadenitis, lymphangitis, pain and other symptoms. The reference group also improved. There was no placebo group. Methods, limits and fundingOutcomes: Lymphoedema, lymphadenitis, pain, fever and other symptoms Limitations: Mixture of two herbs, so the root cannot be credited alone; no placebo; Ayurvedic reference comparator; small groups. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Rasool 2021 Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Argyreia nervosa Extract in Colorectal Cancer Cells. Front Pharmacol · PMID 34616295 · DOI |
Cell line study in vitro |
HCT116 human colorectal cancer cells | Isolated geranyl isovalerate Not reported here |
Geranyl isovalerate reduced cell viability in a dose- and time-dependent way and shifted apoptosis-related genes in the dish. It is also used as a food flavouring. Methods, limits and fundingOutcomes: Cell viability and apoptosis markers Limitations: Cells only; an isolated compound, not the plant. Funding and conflicts: The authors declare no commercial or financial relationships. Read: abstract |
| Sobanski 2021 Herbal High: Substance-Induced Psychosis after Consumption of Seeds of the Hawaiian Baby Woodrose. Z Kinder Jugendpsychiatr Psychother · PMID 33661700 · DOI |
Case report with short review |
1 An adolescent |
Hawaiian baby woodrose seeds seeds Not reported here |
The abstract says LSA content in seeds is highly variable, that adverse psychiatric and somatic effects are not related to LSA dose, and that there are no treatment recommendations for LSA-induced psychiatric syndromes. The adolescent had used the seeds once before without negative effects. Methods, limits and fundingOutcomes: Clinical course and treatment of drug-induced psychosis Limitations: Single case. Funding and conflicts: Not stated in the abstract. Read: abstract |
| Vyas 2022 Aphrodisiac and spermatogenic potential of alkaloidal fraction of Argyreia nervosa (Burm. f.) Bojer roots in male rats. Nat Prod Res · PMID 33426924 · DOI |
Rat study rat |
Male rats | Alkaloidal fraction of root root Not reported here |
At the highest dose tested, serum testosterone rose 100%, mounting frequency rose 135% and sperm concentration rose 30.26% compared with controls. Methods, limits and fundingOutcomes: Serum testosterone, mating behaviour, sperm concentration Limitations: Rats; a purified fraction, not the whole root. Funding and conflicts: Not stated in the abstract. Read: abstract |
| n/a 2026 PubChem compound record: ergometrine (ergonovine), CID 443884 (REST API, read 2026-10-25) n/a · Source |
Registry or database n/a |
n/a | n/a |
Formula C19H23N3O2; molecular weight 325.4. Methods, limits and fundingOutcomes: Chemical identity Read: full-text |
| n/a 2026 Poison Control (US): Poison Help line (poison.org, read 2026-10-25) n/a · Source |
Authoritative guidance n/a |
n/a | n/a |
Gives the US Poison Help line 1-800-222-1222. Methods, limits and fundingOutcomes: Emergency contact Read: full-text |
| n/a 2026 NHS: Poisoning (nhs.uk, read 2026-10-25) n/a · Source |
Authoritative guidance n/a |
n/a | n/a |
UK guidance: call 999 for emergencies; NHS 111 if unsure. Methods, limits and fundingOutcomes: Emergency contact Read: full-text |
| n/a 2026 US eCFR: 21 CFR 1308.13 Schedule III (read 2026-10-25, current to 21 October 2026) n/a · Source |
Registry or database n/a |
n/a | n/a |
Lysergic acid (7300) and lysergic acid amide (7310) are listed in Schedule III, in paragraph (c) which is headed Depressants. The words Argyreia, baby woodrose and ergine do not appear in the section. Methods, limits and fundingOutcomes: Schedule III listing Read: full-text |
| n/a 2026 US eCFR: 21 CFR 1308.11 Schedule I (read 2026-10-25, current to 21 October 2026) n/a · Source |
Registry or database n/a |
n/a | n/a |
Lysergic acid diethylamide (7315) is listed. Methods, limits and fundingOutcomes: Schedule I listing Read: full-text |
| n/a 2026 GBIF Backbone Taxonomy: Argyreia nervosa (Burm.fil.) Bojer, species key 2928692 (GBIF API, read 2026-10-25) n/a · Source |
Registry or database n/a |
n/a | n/a |
Accepted species in family Convolvulaceae, order Solanales. Published in Hortus Maurit. 224 (Bojer 1837). Synonyms include Argyreia speciosa, Convolvulus speciosus, Ipomoea nervosa and Rivea nervosa. English vernacular names include Hawaiian baby woodrose, elephant creeper and baby wood-rose. Methods, limits and fundingOutcomes: Accepted name, family, synonyms, common names Read: full-text |
| n/a 2026 PubChem compound record: Lysergamide (lysergic acid amide, ergine), CID 442072 (REST API, read 2026-10-25) n/a · Source |
Registry or database n/a |
n/a | n/a |
Formula C16H17N3O; molecular weight 267.33; CAS 478-94-4 among synonyms. Methods, limits and fundingOutcomes: Chemical identity Read: full-text |
What we do not know yet
- No clinical trial of the seeds for any use.
- No safety study in pregnancy, breastfeeding, children or older adults.
- No interaction study with medicines.
- Louisiana, Australian and other national law not verified against primary texts.
- Native range and conservation status not checked.
How new research is added
New studies are found by a saved PubMed search and placed in a review queue. A person reads each before it changes this page. Regulator statements are rechecked on a schedule.
Lab markers
What changed in blood or saliva tests during trials. A changed number is not the same as feeling or being healthier, and we give no "normal ranges".
Other 3
Blood level of LSA after eating seeds
N/a in trials
The amount of lysergic acid amide measured in blood serum.
Very low certaintyResults and what it means
Why it was measured
To show what the body takes up and how it relates to reactions.
Statistical vs. clinical meaning
Shows exposure, not benefit or safety limits.
Safety implication
Even low blood levels accompanied severe reactions in this study.
| Study | Result | People | Product |
|---|---|---|---|
| 14 | 0.66 to 3.15 ng/mL about 2 hours after ingestion; urine positive 1 to 24 hours, negative at 48 hours; low levels went with severe autonomic effects and a psychosis-like state. | Volunteers in a 4-person study | Argyreia nervosa seeds, single ingestion |
Testosterone in rats given root fractions
Increase in trials
Testosterone measured in rat testes or blood.
Very low certaintyResults and what it means
Why it was measured
To test the traditional claim of improved fertility.
Statistical vs. clinical meaning
Animal marker only.
Safety implication
Not applicable.
Fasting blood glucose in diabetic rats
Decrease in trials
Blood sugar after fasting.
Very low certaintyResults and what it means
Why it was measured
To see whether the root extract lowers blood sugar in a diabetes model.
Statistical vs. clinical meaning
Animal marker only.
Safety implication
Not applicable.
| Study | Result | People | Product |
|---|---|---|---|
| 6 | 0.52-fold of the diabetic control level at the higher extract dose. | Diabetic rats | Hydro-alcoholic root extract |
Safety
What studies and official sources say about side effects, medicines and who should check first. Each point shows what kind of evidence it comes from.
Main points to know 4
- Danger first: the seeds contain ergot alkaloids, and reactions have included psychosis, severe vomiting, blood-pressure problems and a death. The seeds contain lysergic acid amide (LSA) and other ergot alkaloids, including ergometrine. A systematic review of 17 human studies lists euphoria, hallucinations, nausea and anxiety, and severe outcomes such as psychosis, hypertension and hospitalisation. In a small volunteer study, 3 of 4 people had severe reactions and the study had to stop. Case reports describe psychosis, and one forensic report describes a death from a fall from a building, with other substances also present. Review 12 11 5
- Nobody can know how strong a seed is. Lab studies of seed products found large differences in alkaloid content: total ergot alkaloids differed 8.6-fold between two products, and single seeds differed several-fold. Reactions also differed greatly between people given body-weight-matched amounts. The authors say the intensity of an experience is unpredictable. Laboratory 15 12 16
- Pregnancy: the seeds contain ergometrine. A German paper discusses potential fetal distress because of the ergometrine in the seeds. No study of the seeds in pregnancy was found. Do not use in pregnancy; ask a doctor. Review 3 22
- Mixed with other drugs. Web reports describe the seeds taken with cannabis, hashish and dextromethorphan. The fatal case also had THC and alcohol in the blood. Mixing is not studied and cannot be called safe. Survey 10 11
Side effects 6
| Effect | How often | Severity and recovery | Evidence |
|---|---|---|---|
| Nausea, vomiting and other stomach effects The review also lists nausea among common effects. | Gastrointestinal effects in 45% of 29 poison-centre exposures (Texas, 2000-2018) | mild to moderate Usually passes; most reports recovered | Case series 4 |
| Neurological effects Treatments most often given were intravenous fluids (28%) and benzodiazepines (21%). | 41% of the same 29 poison-centre exposures | moderate Not stated in the abstract | Case series 4 |
| Psychosis-like states A French centre reported 4 cases in 2016, 2 hospitalised. The 2021 paper says psychiatric effects were not related to LSA amount and no treatment recommendations exist. | 1 of 4 volunteers; several case reports including an adolescent | severe Recovered in 9 hours in the volunteer; others needed hospital care | Case report 12 5 20 17 |
| Cardiovascular dysregulation and raised blood pressure Nausea, weakness, fatigue, tremor and raised blood pressure went with low serum LSA levels. | 2 of 4 volunteers (cardiovascular dysregulation); hypertension in the review | moderate to severe Recovered within 9 hours in the volunteers | Human study 12 14 |
| Suicidal thoughts Self-reports on a recreational web site; also one fatal fall. | Two subjects in an analysis of web reports | severe Not stated | Survey 10 |
| Death after a fall (single case) THC and alcohol were also present, so the seeds cannot be blamed alone. | 1 of 2 cases in a forensic report | fatal Not applicable | Case report 11 |
Liver
We did not find liver injury described for the seeds in the sources we read. No LiverTox record was checked.
How often. Not established.
This is a safety connection. It is not evidence that Hawaiian baby woodrose supports liver health.
Medicines and supplements 2
| With | Why it matters | Importance | Evidence | What to do |
|---|---|---|---|---|
| Cannabis, alcohol, dextromethorphan and other drugs recreational | Not studied. The seeds act on serotonin, dopamine and other receptors in lab tests. | Users report taking the seeds with cannabis, hashish and dextromethorphan; the fatal case had THC and alcohol present. | Survey Not enough evidence 10 11 | Avoid mixing with any drug or alcohol; combinations are not studied. |
| Antidepressants and other serotonin-active medicines prescription | LSA binds serotonin receptors in the lab, so serotonin-active medicines are a theoretical concern. No interaction study was found. | Not studied. See the serotonin-medicines guide. | Theoretical Not enough evidence | Ask a doctor or pharmacist before combining with antidepressants or other serotonin-active medicines. Do not stop prescribed medicine on your own. |
Who should check first 5
| Situation | Advice | Evidence |
|---|---|---|
| Pregnancy or breastfeeding | Avoid. Seeds contain ergometrine and no safety data exist. Ask a doctor. | Review 3 22 |
| Personal or family history of psychosis or mania | Avoid; psychosis has been reported after the seeds, including in an adolescent. | Case report 5 20 |
| High blood pressure, heart or circulation problems | Avoid; cardiovascular dysregulation and hypertension have been reported. | Human study 12 |
| Children and teenagers | Avoid; the Texas poison-centre cases included patients from age 16 and a German adolescent had psychosis. | Case series 4 20 |
| Driving or operating machinery | Do not drive. The volunteer study was originally about driving ability and was stopped because of severe reactions; effects lasted hours. | Human study 12 |
Overdose, product quality and regulators
Summary. Toxicity has been described in case reports, a small volunteer study and poison-centre records. There is no established safe amount. Reactions varied between people given equal body-weight doses.
Amounts. No safe amount is established, and this page gives none.
Onset and course. In volunteers, blood levels were measured about 2 hours after eating seeds; urine tests were positive 1 to 24 hours and negative at 48 hours; the volunteers recovered within 9 hours.
Repeated use. Not studied.
Animal data. Not reviewed.
Toxic parts. Seeds are the part with the ergot alkaloids described here. Vasoconstriction and seed-coating pesticides were not described in any source we read.
Not read. Full texts of case reports, any animal toxicology, and gut and circulation effects of ergot alkaloids were not read.
Seed potency and make-up vary widely, and products sold as seeds or capsules differ. We found no source about pesticide or other coatings on seeds, so we say nothing about it.
Potency varies. Total ergot alkaloids differed 8.6-fold between two products; LSA varied several-fold even between single seeds. 15
Many related alkaloids. Seeds also held ergometrine and several other ergot alkaloids; ergopeptide fragments hint at more. Content depends on seed quality, which a consumer cannot know. 16
Symbiotic fungus. In morning glories tested (including this species) ergot alkaloids always occurred together with Periglandula fungi on the plant. 1
| Body | Action | Date |
|---|---|---|
| US Drug Enforcement Administration, via the Code of Federal Regulations (United States) | In 21 CFR 1308.13 (Schedule III) lysergic acid amide (code 7310) and lysergic acid (7300) are listed, in a paragraph headed Depressants. The plant and its seeds are not named in the section. This is our reading of two sections, not legal advice; state laws and how the law treats seeds were not checked. source | 2026-10-21 |
When to get medical help
- Trouble breathing, collapse, a seizure, or being unable to wake someone: call emergency services at once.
- Confusion, hallucinations or frightening thoughts that do not settle, or any thought of self-harm: get urgent medical help.
- Chest pain, a very fast or irregular heartbeat, or severe headache after taking seeds: call emergency services.
- In the US, Poison Help is 1-800-222-1222. In the UK, call 999 for emergencies or NHS 111 if unsure. Tell staff everything taken.
If someone may be poisoned or in a crisis, contact a clinician or emergency service straight away. In the US, Poison Control is 1-800-222-1222.
General information only, not medical advice. Ask a clinician or pharmacist before use, especially with medicines, in pregnancy or with a health condition. See the Natural Remedy Safety guide.
Frequently asked questions
What is Hawaiian baby woodrose?
No.
What are the dangers?
Can the strength be predicted?
Has anyone died?
Does it treat cluster headache?
No trial exists. One woman reported relief in a case report. A 2025 review says possible use is only suggested.
Is it safe in pregnancy?
No. A German paper raises concern about fetal distress from the ergometrine in the seeds, and no safety study exists. Ask a doctor.
Can I take it with other drugs?
What is its role in Ayurveda?
In Ayurveda it is called Vriddhadaruka and is traditionally used for many conditions, including as a brain tonic. This is tradition, not tested benefit.
Is it legal?
Do the root studies apply to the seeds?
Explore by health goal
Editorial transparency
- Written by
- AlternativeMed editorial team. Research compiled with AI assistance, then checked against PubMed records, GBIF, PubChem and regulator pages.
- Medical review
- None. This page has not been reviewed by a physician or pharmacist.
- First published
- 2026-10-25
- Last substantive update
- 2026-10-25
- How we research
- We searched PubMed and read the abstracts of 23 papers, read the US eCFR Schedule I and III text and poison-help pages from the US and UK, and checked the plant name and chemical identifiers in GBIF and PubChem. Statements we could not verify are marked as such.
- How we rate evidence
- See "How we rate evidence" in the Evidence tab.
- Independence
- No product is promoted. No affiliate links are shown and none will be added. This page gives no dose, preparation, growing, foraging or sourcing advice.
Sources 28
Each source was opened and checked. Where we read only the abstract, it says so. The small numbers in the text point here.
- Beaulieu WT, Panaccione DG, Ryan KL, et al. Phylogenetic and chemotypic diversity of Periglandula species in eight new morning glory hosts (Convolvulaceae).. Mycologia. 2015. PMID 25977213. DOI 10.3852/14-239. (abstract)
- Bharati AJ, Bansal YK. Phytochemical investigation of natural and in vitro raised Vriddhadaruka plants.. Anc Sci Life. 2014. PMID 25861141. DOI 10.4103/0257-7941.153463. (abstract)
- Borsutzky M, Passie T, Paetzold W, et al. Hawaiian baby woodrose: (Psycho-) Pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration [German].. Nervenarzt. 2002. PMID 12215884. DOI 10.1007/s00115-002-1374-4. (abstract)
- Forrester MB. Argyreia nervosa exposures reported to Texas poison centers.. J Addict Dis. 2018. PMID 31305228. DOI 10.1080/10550887.2019.1640057. (abstract)
- Gertsch JH, Wood C. Case report: an ingestion of Hawaiian Baby Woodrose seeds associated with acute psychosis.. Hawaii Med J. 2003. PMID 12886727. (abstract)
- Gori PV, Raval M, Patel S, et al. Argyreia nervosa (Brum.f.) Bojer. alleviates diabetes mellitus-induced male infertility.. Mol Biol Rep. 2025. PMID 40465059. DOI 10.1007/s11033-025-10654-5. (abstract)
- Graziano S, Orsolini L, Rotolo MC, et al. Herbal Highs: Review on Psychoactive Effects and Neuropharmacology.. Curr Neuropharmacol. 2017. PMID 27799032. DOI 10.2174/1570159X14666161031144427. (abstract)
- Hylin JW, Watson DP. Ergoline Alkaloids in Tropical Wood Roses.. Science. 1965. PMID 17842841. DOI 10.1126/science.148.3669.499. (abstract)
- Johnson S, Black QC. Can Psychedelics Alleviate Symptoms of Cluster Headache and Accompanying Mental Health Problems? A Case Report Involving Hawaiian Baby Woodrose.. J Psychoactive Drugs. 2020. PMID 32375602. DOI 10.1080/02791072.2020.1762023. (abstract)
- Juszczak GR, Swiergiel AH. Recreational use of D-lysergamide from the seeds of Argyreia nervosa, Ipomoea tricolor, Ipomoea violacea, and Ipomoea purpurea in Poland.. J Psychoactive Drugs. 2013. PMID 23662334. DOI 10.1080/02791072.2013.763570. (abstract)
- Klinke HB, Muller IB, Steffenrud S, Dahl-Sorensen R. Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose.. Forensic Sci Int. 2010. PMID 20018470. DOI 10.1016/j.forsciint.2009.11.017. (abstract)
- Kremer C, Paulke A, Wunder C, Toennes SW. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds.. Forensic Sci Int. 2012. PMID 21803515. DOI 10.1016/j.forsciint.2011.06.025. (abstract)
- Patel N, Patel P, Chudasama P, et al. Beneficial effects of roots of Argyreia nervosa (Brum.f.) Bojer on testosterone biosynthesis in testis and spermatogenesis in Wistar rats.. J Ethnopharmacol. 2022. PMID 35074455. DOI 10.1016/j.jep.2022.115025. (abstract)
- Paulke A, Kremer C, Wunder C, Toennes SW. Analysis of lysergic acid amide in human serum and urine after ingestion of Argyreia nervosa seeds.. Anal Bioanal Chem. 2012. PMID 22695498. DOI 10.1007/s00216-012-6121-5. (abstract)
- Paulke A, Kremer C, Wunder C, et al. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa products.. Forensic Sci Int. 2014. PMID 25036782. DOI 10.1016/j.forsciint.2014.06.025. (abstract)
- Paulke A, Kremer C, Wunder C, et al. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high.. Forensic Sci Int. 2015. PMID 25747328. DOI 10.1016/j.forsciint.2015.02.011. (abstract)
- Ponte C, Lapeyre-Mestre M. Psychoactive effects of legal high: About lysergic acid amide (LSA) [French].. Therapie. 2017. PMID 28457570. DOI 10.1016/j.therap.2017.01.012. (abstract)
- Prasad GP, Naidu ML. Effect of Kuberaksha Patra Churna, Vriddhadaru Mula Churna and Kandughna Taila in Shlipada (Manifested filariasis).. Ayu. 2012. PMID 23049193. DOI 10.4103/0974-8520.100324. (abstract)
- Rasool F, Sharma D, Anand PS, et al. Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Argyreia nervosa Extract in Colorectal Cancer Cells.. Front Pharmacol. 2021. PMID 34616295. DOI 10.3389/fphar.2021.698375. (abstract)
- Sobanski E, Dalm S, Sievers L, et al. Herbal High: Substance-Induced Psychosis after Consumption of Seeds of the Hawaiian Baby Woodrose.. Z Kinder Jugendpsychiatr Psychother. 2021. PMID 33661700. DOI 10.1024/1422-4917/a000792. (abstract)
- Vyas N, Raval M. Aphrodisiac and spermatogenic potential of alkaloidal fraction of Argyreia nervosa (Burm. f.) Bojer roots in male rats.. Nat Prod Res. 2022. PMID 33426924. DOI 10.1080/14786419.2020.1869231. (abstract)
- n/a. PubChem compound record: ergometrine (ergonovine), CID 443884 (REST API, read 2026-10-25). n/a. 2026. (full-text)
- n/a. Poison Control (US): Poison Help line (poison.org, read 2026-10-25). n/a. 2026. (full-text)
- n/a. NHS: Poisoning (nhs.uk, read 2026-10-25). n/a. 2026. (full-text)
- n/a. US eCFR: 21 CFR 1308.13 Schedule III (read 2026-10-25, current to 21 October 2026). n/a. 2026. (full-text)
- n/a. US eCFR: 21 CFR 1308.11 Schedule I (read 2026-10-25, current to 21 October 2026). n/a. 2026. (full-text)
- n/a. GBIF Backbone Taxonomy: Argyreia nervosa (Burm.fil.) Bojer, species key 2928692 (GBIF API, read 2026-10-25). n/a. 2026. (full-text)
- n/a. PubChem compound record: Lysergamide (lysergic acid amide, ergine), CID 442072 (REST API, read 2026-10-25). n/a. 2026. (full-text)
