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Depression and gentle self-care: a mug of tea, a closed notebook and a pair of walking shoes beside a window with soft morning light and a small green plant

Improve Your Mood & Emotional Wellbeing

Depression

Depression is more than a bad week or a low patch: it is a common, treatable health condition that can change how a person feels, thinks, sleeps and functions. This page explains what it is, how it is assessed, what established care looks like in general terms, and what lifestyle and complementary approaches have and have not shown, and it is clear that none of them replace care.

General information, not medical advice. Last updated November 1, 2026. Written by the AlternativeMed editorial team. Not medically reviewed.

Start here

  • If you think you may be depressed, tell a doctor or another health professional. The NHS says it is best not to delay, and the WHO says anyone with symptoms should seek care.
  • Tell one person you trust how you feel. Depression can make reaching out feel impossible, and a small message or a short walk together still counts.
  • If you have thoughts of harming yourself, do not wait: contact local emergency services or a local crisis line now (see Get help below).

Be careful with

  • This page is information, not diagnosis or treatment. Natural and lifestyle approaches are not a replacement for professional care, and they should not delay it.
  • Do not stop or change a prescribed medicine on your own. Talk to the prescriber first, because stopping suddenly can cause problems.
  • "Natural" does not mean safe. St John's wort in particular can interact with many medicines, including some antidepressants, and should be discussed with a pharmacist or doctor first.

Get help when

  • Low mood or loss of pleasure and interest most of the day, nearly every day, for at least two weeks (the WHO description of a depressive episode), or low mood that is affecting work, relationships, sleep or looking after yourself.
  • Hopelessness, feeling worthless or excessively guilty, trouble concentrating, big changes in sleep or appetite, or constant tiredness, especially if these are getting worse.
  • Very high, unusually energetic or reckless periods alternating with low ones. The WHO notes this pattern can be bipolar disorder, which is treated differently, so it needs a clinician.
  • Depression after having a baby, during pregnancy, or after a loss, illness or major life change: these are common and treatable, and a midwife, health visitor or doctor can help.
  • If you may act on thoughts of harming yourself, or are in immediate danger, contact your local emergency services or a local crisis line now. In the US, NIMH names the 988 Suicide & Crisis Lifeline: call or text 988. You deserve support, and many people who have felt this way have found help.

About Depression

What depression is

The WHO describes depressive disorder as a common mental disorder that differs from ordinary mood changes: it involves a depressed mood or loss of pleasure or interest in activities for long periods. The NHS describes lasting feelings of unhappiness and hopelessness, losing interest in things you used to enjoy, and feeling very tearful.

It ranges from mild to severe. It is not a sign of weakness or something a person can simply snap out of.

1,2

Common symptoms

The WHO lists a depressed mood (sadness, irritability or emptiness) or loss of pleasure and interest most of the day, nearly every day, for at least two weeks, along with other symptoms such as poor concentration, excessive guilt or low self-worth, hopelessness, disrupted sleep, changes in appetite or weight, and low energy. Thoughts of death or suicide can also occur.

The NHS adds that many people also have anxiety symptoms, and that physical symptoms can include constant tiredness, sleeping badly, no appetite or sex drive, and various aches and pains.

1,2

How common it is and who it affects

The WHO estimates that about 4% of people worldwide (around 322 million) lived with depression in 2023, and that it is about 1.5 times more common in women than in men. More than 10% of pregnant women and women who have recently given birth experience it. In high-income countries only about a third of people with depression receive mental health treatment, so reaching out matters.

1

Contributing factors

The WHO says depression comes from a complex interaction of social, psychological and biological factors. Adverse events such as unemployment, bereavement or trauma raise the risk, and depression is closely linked with physical health: physical inactivity and harmful alcohol use are shared risk factors. NIMH adds genetic and environmental factors and notes links with heart disease and diabetes.

1,3

How it is assessed

A doctor or mental health professional usually asks about your symptoms, how long they have lasted, how they affect daily life, your sleep and appetite, any thoughts of self-harm, and your health history and medicines, because other conditions or medicines can affect mood. Episodes are classed as mild, moderate or severe according to the number and severity of symptoms and how much they affect functioning (WHO). The NHS directs readers to its separate diagnosis page for assessment details, which was not read for this page, so the exact steps may differ where you live.

1,2

What established care looks like, in general terms

The WHO says effective treatments include psychological treatment and medicines, with psychological treatment as the first-line option, and that medicines are not needed for mild depression. The NHS describes care by severity: for mild depression a doctor may suggest watchful waiting, exercise, guided self-help or talking therapy such as CBT; for moderate to severe depression, talking therapy is often combined with medicine; and severe depression may involve a specialist mental health team. NIMH also lists brain stimulation therapy for some people who have not improved with other treatments.

Which approach suits you is a decision to make with a clinician. This page does not recommend any medicine.

1,2,3

Realistic expectations

Depression is treatable, but recovery is often gradual and not a straight line. Some people need more than one approach. Lifestyle steps can be a useful part of the picture alongside care, and the evidence below shows how far each one has been tested.

1,2

Related conditions and symptoms

Anxiety disorders → Panic attacks → Trauma and PTSD → Burnout → Stress, anxiety, burnout and depression: how they differ → Insomnia →

A manageable starting plan

An educational starting point, not a personal prescription. Adjust it to your own situation and any advice from your clinician.

Your first actions

  • Tell a doctor or health professional if symptoms last two weeks or more or affect daily life.
  • Tell one trusted person how you feel.
  • Keep gentle routines: regular sleep, regular meals, a short daily walk, and one small enjoyable thing.
  • Go easy on alcohol and avoid illicit drugs.

Optional additions

  • Ask about talking therapy options, including guided self-help and online programmes.
  • Join a support group.
  • Ask a clinician whether bright light or supervised exercise might suit you.

What to track

  • Mood, sleep and energy on a simple 1 to 10 scale, to show to your clinician.
  • Any new herb, supplement or medicine, and any side effects.
  • Any thoughts of harming yourself, which need prompt help.

When to reassess

If self-care is not helping within a couple of weeks, or things are getting worse, speak to a doctor. If you are already in care, tell your clinician how you are doing, including any side effects, and do not change a medicine without talking to them first.

When to seek professional support

  • Tell someone you trust how you feel.
  • See a doctor or use a local talking-therapy or mental health service.
  • If you may act on thoughts of harming yourself, or are in immediate danger, contact your local emergency services or a local crisis line now. In the US, NIMH names the 988 Suicide & Crisis Lifeline: call or text 988.

What helps

Ordered by how well the research supports each step. Evidence strength is shown on every card; precautions sit next to the advice.

Start here

Regular physical activity, including walking, strength work, yoga and tai chi

Low certainty

Addresses: May reduce depression symptoms, as an addition to care

Why it may help: A 2024 network meta-analysis of 218 trials (14,170 people with major depression) found moderate reductions in depression compared with usual-care-type controls for walking or jogging, yoga, strength training, mixed aerobic exercise and tai chi or qigong, with effects greater at higher prescribed intensity; however only one study was at low risk of bias and the authors graded confidence as low or very low. A Cochrane review of 35 trials found a moderate benefit (SMD -0.62), but when only the six highest-quality trials were pooled the result was not statistically significant (-0.18). An overview of 97 reviews (1,039 trials, 128,119 people) found medium effects on depression.

How to apply it: Choose something you can do and enjoy, and build gradually; short walks count. The NHS lists more exercise among self-help steps.

Who it may suit: Most adults; the 2024 review found similar effects with and without other health conditions.

Precautions: Study quality is the main limit, and people do worse when starting too much too fast. Check with a doctor first if you have a heart or other medical condition, and do not use exercise instead of care.

4,5,6,2

Yoga → Tai chi →

Improving sleep

Moderate certainty

Addresses: Better sleep is linked with fewer depression symptoms

Why it may help: A meta-analysis of 65 randomised trials (8,608 people) found that interventions which improved sleep quality led to a medium-sized reduction in depression (g+ = -0.63), with bigger sleep gains linked to bigger mood gains. The authors concluded sleep is likely causally related to mental health difficulties. The WHO also advises keeping regular eating and sleeping habits.

How to apply it: Keep regular sleep and wake times, wind down before bed, and see a doctor if sleep problems are persistent, as insomnia is itself treatable.

Who it may suit: Anyone with low mood and poor sleep.

Precautions: The trials covered many conditions and sleep methods, not only depression. Very short sleep or being unable to sleep for days with low mood needs a clinician.

7,1

Improve Your Sleep Quality → Fall Asleep Faster → Insomnia →

Keeping up enjoyable and meaningful activities, and staying connected

Moderate certainty

Addresses: Small, planned activities and contact can counter withdrawal

Why it may help: The WHO advises continuing activities you used to enjoy and staying connected with friends and family, and the NHS suggests support groups and self-help. The structured version of this idea, behavioural activation, is covered under Therapies: a meta-analysis of 26 trials found it better than control conditions.

How to apply it: Pick one small thing a day, even when you do not feel like it, and tell someone you trust. Start with the easiest.

Who it may suit: People who are withdrawing or have stopped doing things.

Precautions: Pushing too hard when exhausted can backfire; go gently and ask a professional about structured help.

1,2,8

Rebuild Motivation → Make More Room for Enjoyment → Reduce Loneliness →

Additional options

A healthier overall diet

Low certainty

Addresses: May help as an extra, not as a treatment on its own

Why it may help: The SMILES trial (67 adults with moderate to severe depression, 12 weeks) found that seven dietitian-led sessions to improve diet reduced depression scores more than a social-support control, and 32.3% of the diet group reached remission versus 8.0% of the control group. It was small and most people also continued usual treatment.

How to apply it: Regular meals and a varied diet; the NHS lists healthy eating among self-help steps.

Who it may suit: People who feel able to make food changes with support.

Precautions: One small trial. Appetite loss or an eating disorder needs clinical support, not a food plan.

9,2

Healthy weight basics →

Mindfulness-based cognitive therapy to prevent relapse

Moderate certainty

Addresses: Lower risk of depression returning in people who have recovered or partly recovered

Why it may help: An individual patient data meta-analysis of 9 trials (1,258 people with recurrent depression) found a lower risk of relapse within 60 weeks with mindfulness-based cognitive therapy (hazard ratio 0.69) than with comparison conditions, with a larger benefit for people with more residual symptoms.

How to apply it: This is a structured, teacher-led programme rather than casual meditation.

Who it may suit: People with recurrent depression, in discussion with a clinician.

Precautions: Studied in people who were well or partly well, not as a treatment during a severe episode. Meditation can be unsettling for some, especially with trauma history; use a trained teacher.

10

Meditation →

Bright light therapy added to other care

Low certainty

Addresses: May speed or improve response in non-seasonal depression

Why it may help: A 2025 meta-analysis of 11 trials (858 patients) found higher remission (40.7% vs 23.5%) and response (60.4% vs 38.6%) rates when bright light therapy was added to other care, in nonseasonal depression.

How to apply it: Used under the guidance of a clinician, usually alongside other treatment.

Who it may suit: Adults with depression whose clinician considers it.

Precautions: Few, small trials. Light boxes can cause eye strain, headache or agitation, and people with eye conditions, bipolar disorder or on light-sensitising medicines need medical advice first.

11

Still being studied

Saffron extract

Low certainty

Addresses: Some trials show improvement in mild to moderate depression

Why it may help: A meta-analysis of nine pooled randomised trials found saffron more effective than placebo (g = 0.89) and not clearly different from the antidepressant drugs it was compared with. See the Remedies tab for cautions.

How to apply it: Not advised as self-treatment.

Who it may suit: Adults with mild to moderate depression, studied under supervision.

Precautions: Trials were small and short and many had risk of bias; products vary widely. Depression should be assessed by a clinician first.

12

Saffron →

Food & nutrition

Eating well when mood is low

The NHS lists eating healthily among self-help steps, and the WHO advises regular eating habits. The best direct evidence is the SMILES trial: in 67 adults with moderate to severe depression, dietitian-led support to improve diet over 12 weeks produced bigger improvement than social support, with remission in 32.3% versus 8.0%. It was a small trial, and most participants were also receiving usual care, so diet appears to be a possible extra rather than a treatment.

Depression can reduce appetite or increase comfort eating. Regular meals and simple foods are a reasonable goal, and a doctor or dietitian can help if weight or appetite has changed a lot.

  • Regular meals through the day
  • A varied diet in line with local healthy-eating guidance
  • Dietitian or doctor support if appetite or weight has changed a lot
2,1,9

Remedies & supplements

Traditional use, laboratory findings and human trials are kept apart. "Natural" does not mean safe.

St John's wort

Mixed findings

Studied form and route: Standardised extract (capsule or tablet)

Intended outcome: Mild to moderate depression in trials

Human evidence: A Cochrane review of 29 trials (5,489 people) found the extracts tested better than placebo and similarly effective to standard antidepressants, with fewer drop-outs due to side effects, but trials from German-speaking countries were more favourable. NCCIH says it is not consistently effective, citing a 2002 trial of 340 people and a 2011 trial in minor depression with no benefit over placebo.

Traditional use: Used traditionally in herbal medicine for low mood; this does not show it is safe or effective.

Limits: Mixed results, different extracts and products, and uncertain quality. The NCCIH page was last updated in December 2017.

Interactions and precautions: NCCIH says combining it with certain antidepressants can cause a potentially life-threatening rise in serotonin. It can weaken the effect of other medicines, including birth control pills, transplant (immunosuppressant), heart (digoxin), pain (opioid), HIV, cancer and blood-thinning medicines. Case reports describe worse psychotic symptoms in people with bipolar disorder or schizophrenia. It can also cause stomach upset, dry mouth, headache, dizziness and sun sensitivity, and may worsen anxiety. Little is known about pregnancy, breastfeeding and children. Speak to a pharmacist or doctor first and do not use it instead of care. No dose is given here.

13,14

St John's wort →

Saffron

Low certainty

Studied form and route: Standardised extract (capsule or tablet) used in trials

Intended outcome: Mild to moderate depression

Human evidence: A meta-analysis of nine pooled randomised trials found saffron more effective than placebo (g = 0.89) and not significantly different from tested antidepressant drugs. The trials were small.

Traditional use: Saffron has a long culinary and traditional-medicine history; this does not show it treats depression.

Limits: Few, small, short trials with differing products. Not tested as a replacement for care.

Interactions and precautions: Not studied well in pregnancy or breastfeeding. Check with a pharmacist or doctor if you take medicines or have bipolar disorder. Do not use instead of care. No dose is given here.

12

Saffron →

Vitamin D

Low certainty

Studied form and route: Supplement

Intended outcome: Depressive symptoms

Human evidence: A meta-analysis of 18 trials (adults with depression) found a small overall reduction in symptom scores (SMD -0.15), with benefit seen only in people whose vitamin D level was already above 50 nmol/L and no benefit in those below it. The authors note wide variation between studies.

Limits: Heterogeneous trials with different doses and durations.

Interactions and precautions: Vitamin D can build up in the body if taken in excess; ask a pharmacist or doctor about testing and need. It is not a treatment for depression. No dose is given here.

15

Vitamin D →

Therapies & care

Established care for depression is decided with a clinician. Per the WHO and NHS, psychological treatment is first-line, medicine may be added for moderate to severe depression, and severe depression may need a specialist team. Everything below is general information, not a recommendation of any medicine.

Talking therapies (CBT, behavioural activation, interpersonal and problem-solving therapy)

High certainty

Talking therapy A network meta-analysis of 331 randomised trials (34,285 patients) found all the main psychotherapies more effective than care-as-usual and waiting-list conditions, and mostly more effective than pill placebo, with little difference between them except for non-directive supportive counselling, which was less effective. The WHO names behavioural activation, CBT, interpersonal psychotherapy and problem-solving therapy as effective.

Who it may suit: Adults with mild, moderate or severe depression, as chosen with a clinician.

Precautions: Needs time and a trained therapist; waiting times and cost vary, and online or guided self-help options exist.

16,1

Therapy for anxiety and stress →

Behavioural activation

Moderate certainty

Talking therapy A therapy that helps you plan rewarding and meaningful activities. A meta-analysis of 26 trials found it better than control conditions (SMD -0.74) and than medication (SMD -0.42), although study quality was low in most trials and follow-up was short.

Who it may suit: People who are withdrawn or have lost motivation.

Precautions: Best learned with a trained therapist for depression; trial quality was low.

8,1

Rebuild Motivation →

Mindfulness-based cognitive therapy

Moderate certainty

Group programme A structured programme combining mindfulness practice and CBT skills to help prevent relapse; pooled trial data showed a lower relapse risk (HR 0.69) within 60 weeks.

Who it may suit: People with recurrent depression who are well or partly recovered.

Precautions: Needs a trained teacher; not a self-treatment for a severe episode.

10

Meditation →

Exercise programmes, yoga and tai chi

Low certainty

Lifestyle care Included in the NHS list of self-help for depression and tested in a large network meta-analysis (see Health benefits). The WHO also names exercise programmes for older adults as a prevention approach.

Who it may suit: People who are able and interested.

Precautions: Confidence in the evidence is low; start gently.

4,2,1

Yoga → Tai chi →

Acupuncture

Low certainty

Complementary therapy A Cochrane review of 64 studies (7,104 participants) found low-quality evidence that acupuncture may moderately reduce severity versus no treatment, but a small effect versus sham acupuncture, and low or very low quality evidence in other comparisons. The authors rated adverse-event reporting as unclear.

Who it may suit: People who want a complementary option alongside care.

Precautions: Use a qualified practitioner; tell your doctor; do not use it instead of care.

17

Acupuncture →

Bright light therapy

Low certainty

Complementary therapy Used as an add-on in non-seasonal depression; a 2025 meta-analysis of 11 trials found higher remission and response rates with it.

Who it may suit: Adults whose clinician considers it.

Precautions: Eye conditions, bipolar disorder and some medicines need medical advice first.

11

What to avoid

Habits, products and claims that can get in the way. Never stop a prescribed medicine without talking to the professional who prescribed it.

Risks that apply to most people

Using alcohol or drugs to numb low mood

Moderate certainty

Why: The NHS lists cutting down on alcohol as self-help, and the WHO says harmful alcohol use is a shared risk factor with depression and that illicit drugs and alcohol can worsen it.

Who it applies to: Anyone with low mood.

Try instead: Talk to a doctor or support service if you are drinking or using more to cope, and try activity, company or a relaxing routine.

2,1

Caffeine, alcohol and sleep →

Coping with it entirely alone

Moderate certainty

Why: The WHO advises talking to someone you trust, a health worker or a counsellor, or joining a support group.

Who it applies to: Anyone with symptoms lasting weeks.

Try instead: Tell one person today, or contact a doctor or counselling service.

1,2

Feel More Connected to Others →

Personal triggers to check

Long periods of inactivity and isolation

Low certainty

Why: The WHO links physical inactivity with depression risk, and withdrawal tends to feed low mood. Not every person's pattern is the same.

Who it applies to: People who stay in for days.

Try instead: Aim for one small outing or contact a day.

1

Major stressors, loss and life changes

Moderate certainty

Why: The WHO lists unemployment, bereavement and trauma as raising risk, and notes depression can in turn worsen life circumstances.

Who it applies to: People going through a difficult period.

Try instead: Seek support early, not only when things feel unbearable.

1

Cope With Difficult Life Changes →

Ongoing sleep problems

Moderate certainty

Why: Sleep and depression influence each other; trials that improve sleep also lower depression scores.

Who it applies to: People sleeping poorly for weeks.

Try instead: Treat persistent insomnia, not only mood.

7

Insomnia →

Products that need caution

Herbal and supplement "mood boosters" used as the main plan

Mixed findings

Why: Only a few herbs and supplements have been tested in depression trials, results are mixed, and products vary. NCCIH says St John's wort should not replace conventional care or delay seeing a provider.

Who it applies to: Anyone considering self-treatment.

Try instead: Talk to a doctor or pharmacist before trying anything, especially if you take medicines.

14,13

St John's wort →

Unsupported claims

"Cure depression naturally in days" claims

Evidence against

Why: Depression is a health condition that often needs structured care; none of the natural approaches reviewed here is a proven stand-alone cure.

Who it applies to: Anyone reading online claims.

Try instead: Look for sources that state limitations, and see a clinician.

1,2

"Just think positive" or "snap out of it"

Evidence against

Why: The WHO describes depression as a health condition with social, psychological and biological contributors, not a lack of effort.

Who it applies to: Anyone, and those around them.

Try instead: Support the person to seek help and offer practical, patient company.

1

Common mistakes

Stopping a prescribed medicine on your own because you feel better or worse

Not enough evidence

Why: This page cannot judge your situation and stopping suddenly can cause problems.

Who it applies to: Anyone taking a prescribed medicine.

Try instead: Talk to the prescriber before changing anything.

2

Medicines, sleep, mood and memory →

Waiting for it to pass when symptoms last weeks

Moderate certainty

Why: The NHS says it is best not to delay seeing a GP if you think you may be depressed.

Who it applies to: Anyone with symptoms lasting two weeks or more.

Try instead: Make an appointment, and take someone along if that helps.

2,1

Mixing herbs with antidepressants without asking

Moderate certainty

Why: NCCIH warns St John's wort can cause a potentially life-threatening rise in serotonin when combined with certain antidepressants.

Who it applies to: Anyone on antidepressants.

Try instead: Ask a pharmacist or prescriber before adding any herb or supplement.

14

Evidence & safety

What the research shows

The strongest evidence for depression is for psychological treatment (high certainty that the main talking therapies work), with medicines also used for moderate to severe depression. For lifestyle and complementary approaches the picture is weaker: exercise and sleep improvement have consistent but often low-quality support; diet, light therapy, saffron, vitamin D and acupuncture have limited or low-certainty evidence; St John's wort is mixed and carries serious interaction risks. None replaces professional care.

Limits of the evidence

  • Many natural-approach trials are small, short or at high risk of bias, and exercise trials are hard to blind.
  • Reviews often pooled different products, doses and populations.
  • The SMILES diet trial was small; the Cochrane exercise result shrank when only the best trials were pooled.
  • Most research is in adults; evidence for children, teenagers, pregnancy and older adults is thinner.
  • The NHS diagnosis page and some national guidelines were not read for this page.
  • The NCCIH St John's wort page was last updated in December 2017.

Precautions and interactions

  • Do not stop or change a prescribed medicine without talking to the prescriber.
  • Check every herb or supplement with a pharmacist or doctor, especially St John's wort.
  • "Natural" does not mean safe.
  • Do not use natural approaches instead of care or to delay it.

Life-stage considerations

  • Pregnancy and after birth: depression is common (the WHO notes more than 10% of pregnant women and new mothers) and treatable; talk to a midwife, health visitor or doctor, and check before using any herb or supplement.
  • Children and teenagers: involve a parent or carer and a doctor. The WHO notes antidepressants are not used for children and are not first-line for adolescents.
  • Older adults: low mood is not a normal part of ageing, and more medicines means more interaction risk with herbs; talk to a doctor.

Warning signs

  • Low mood or loss of interest for two weeks or more, or affecting daily life.
  • Thoughts of death, suicide or self-harm: If you may act on thoughts of harming yourself, or are in immediate danger, contact your local emergency services or a local crisis line now. In the US, NIMH names the 988 Suicide & Crisis Lifeline: call or text 988.
  • Very high or reckless energy alternating with low periods.
  • Being unable to look after yourself, eat or sleep, or hearing or seeing things others do not.

Claim checks

Exercise treats depression

Low certainty

Partly supported. Large reviews find moderate benefits, but confidence is low because of study quality, and the best-designed trials in a Cochrane review showed no significant effect. Exercise is best seen as an addition to care.

4,5

St John's wort works as well as antidepressants

Mixed findings

Mixed. A Cochrane review found it similar in trials, but NCCIH describes results as inconsistent, and it can interact dangerously with some medicines.

13,14

Vitamin D supplements fix depression

Low certainty

Not supported as a treatment. A meta-analysis found a small overall effect, only in people whose levels were already above 50 nmol/L.

15

Acupuncture is proven for depression

Low certainty

Not established. A Cochrane review found low or very low quality evidence and called for better trials.

17

Talking therapies work for depression

High certainty

Supported. A network meta-analysis of 331 trials found the main therapies more effective than care-as-usual or waiting list, and the WHO calls psychological treatment first-line.

16,1

Questions people ask

Is depression the same as feeling sad?

No. The WHO says depressive disorder differs from ordinary mood changes: low mood or loss of interest lasts most of the day, nearly every day, for at least two weeks, and affects daily life.

How do I know if I have depression?

Only a clinician can say. The NHS says that if you think you may be depressed, it is best not to delay seeing a doctor, who can ask about your symptoms and rule out other causes.

Can depression be treated?

Yes. The WHO says effective treatments include psychological treatment and medicines, and that psychological treatment is first-line. What suits you is decided with a clinician.

Can exercise cure depression?

Exercise may reduce symptoms, and reviews find moderate benefits, but confidence is low and the best-designed trials show less effect. It is a helpful addition rather than a replacement for care.

Is St John's wort safe for depression?

It is not risk-free. NCCIH says it can cause a potentially life-threatening rise in serotonin with certain antidepressants and weakens many other medicines. Speak to a pharmacist or doctor first, and do not use it instead of care.

Should I stop my medicine if I feel better?

Do not stop or change it on your own. Talk to the person who prescribed it first.

Do vitamin D, saffron or acupuncture treat depression?

Evidence is limited and low-certainty for each. They are not replacements for care; see the Remedies and Therapies tabs for what trials found.

What if I am having thoughts of harming myself?

If you may act on thoughts of harming yourself, or are in immediate danger, contact your local emergency services or a local crisis line now. In the US, NIMH names the 988 Suicide & Crisis Lifeline: call or text 988. Tell someone you trust as well.

Can depression happen after having a baby or during pregnancy?

Yes. The WHO says more than 10% of pregnant women and women who have recently given birth experience depression. It is treatable; talk to a midwife, health visitor or doctor.

Is it different from burnout or anxiety?

They overlap but are different conditions and can occur together; the NHS notes many people with depression also have anxiety. See the linked pages, and ask a clinician if you are unsure.

How can I support someone who may be depressed?

The WHO advises talking to someone you trust. Listen without judging, encourage them to see a doctor, offer practical help, and treat any mention of self-harm seriously by helping them contact emergency services or a crisis line.

References

  1. World Health Organization. Depressive disorder (depression): fact sheet. Read 2026-11-01. source
  2. NHS. Clinical depression: overview (symptoms, self-help, treatment by severity). Read 2026-11-01. source
  3. National Institute of Mental Health. Depression (overview and 988 Suicide & Crisis Lifeline). Read 2026-11-01. source
  4. Noetel M, Sanders T, Gallardo-Gomez D, et al. Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. BMJ. 2024;384:e075847. PMID 38355154. source
  5. Cooney GM, Dwan K, Greig CA, et al. Exercise for depression. Cochrane Database Syst Rev. 2013;(9):CD004366. PMID 24026850 (an updated version was published in 2026; not read). source
  6. Singh B, Olds T, Curtis R, et al. Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews. Br J Sports Med. 2023;57(18):1203-1209. PMID 36796860. source
  7. Scott AJ, Webb TL, Martyn-St James M, et al. Improving sleep quality leads to better mental health: a meta-analysis of randomised controlled trials. Sleep Med Rev. 2021;60:101556. PMID 34607184. source
  8. Ekers D, Webster L, Van Straten A, et al. Behavioural activation for depression; an update of meta-analysis of effectiveness and sub group analysis. PLoS One. 2014;9(6):e100100. PMID 24936656. source
  9. Jacka FN, O'Neil A, Opie R, et al. A randomised controlled trial of dietary improvement for adults with major depression (the 'SMILES' trial). BMC Med. 2017;15:23. PMID 28137247. source
  10. Kuyken W, Warren FC, Taylor RS, et al. Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse: an individual patient data meta-analysis from randomized trials. JAMA Psychiatry. 2016;73(6):565-574. PMID 27119968. source
  11. Menegaz de Almeida A, Aquino de Moraes FC, Cavalcanti Souza ME, et al. Bright light therapy for nonseasonal depressive disorders: a systematic review and meta-analysis. JAMA Psychiatry. 2025;82(1):38-46. PMID 39356500. source
  12. Toth B, Hegyi P, Lantos T, et al. The efficacy of saffron in the treatment of mild to moderate depression: a meta-analysis. Planta Med. 2019;85(1):24-31. PMID 30036891. source
  13. Linde K, Berner MM, Kriston L. St John's wort for major depression. Cochrane Database Syst Rev. 2008;(4):CD000448. PMID 18843608. source
  14. NCCIH. St. John's Wort and Depression: In Depth (page last updated December 2017). Read 2026-11-01. source
  15. Wang R, Xu F, Xia X, et al. The effect of vitamin D supplementation on primary depression: a meta-analysis. J Affect Disord. 2024;344:653-661. PMID 37852593. source
  16. Cuijpers P, Quero S, Noma H, et al. Psychotherapies for depression: a network meta-analysis covering efficacy, acceptability and long-term outcomes of all main treatment types. World Psychiatry. 2021;20(2):283-293. PMID 34002502. source
  17. Smith CA, Armour M, Lee MS, Wang LQ, Hay PJ. Acupuncture for depression. Cochrane Database Syst Rev. 2018;3(3):CD004046. PMID 29502347. source

Related on AlternativeMed

Related goals

Support a More Balanced Mood → Rebuild Motivation → Make More Room for Enjoyment → Build Emotional Resilience → Cope With Difficult Life Changes → Reduce Loneliness → Feel More Connected to Others → Improve Your Sleep Quality →

Ingredients, foods and supplements

St John's wort → Saffron → Vitamin D →

Research, safety and claim-check resources

Therapy for anxiety and stress → Medicines, sleep, mood and memory → Meditation → Yoga → Tai chi → Acupuncture → Caffeine, alcohol and sleep →