Soda & Diet Soda: Nutrients, What Research Shows and Safety
Sugar-sweetened soda and diet soda compared: USDA calories and caffeine, what pooled studies found on weight, diabetes, teeth and bones, sweetener reviews, and pregnancy.
Content last updated . This page has not been medically reviewed.

Soda, also called soft drink or pop, is a sweet fizzy drink. The regular kind is sweetened with sugar or syrup. The "diet" kind is sweetened with low- or no-calorie sweeteners instead. Many people drink it for the taste, the bubbles or the caffeine, and many switch to diet soda hoping to cut sugar without giving up the habit. This page looks at both kinds as drinks, says what pooled studies and official bodies found, and says plainly where the evidence is weak. It does not cover flavored sparkling water without sweeteners, which is a different product. [1] [2] [4]
Read this first
- A regular soda is mostly sugar and water. USDA lists about 151 kcal and 38 g of carbohydrate in a 12 fl oz can of a caffeinated pepper-type soda. [1] The CDC calls sugar-sweetened drinks a leading source of added sugars in the American diet. [4]
- A diet soda has no calories in the USDA data, and USDA lists no sugar in the diet cola it measured. [2]
- Caffeine is in many sodas. USDA lists about 37 mg in the regular can and about 39 mg in the diet can. [1] [2] The FDA says about 400 mg a day is an amount not generally linked to negative effects in most healthy adults. [13] The NHS advises no more than 200 mg a day in pregnancy. [14]
- The evidence in one line: pooled studies link sugar-sweetened soda to weight gain and to type 2 diabetes, and to tooth erosion. For diet soda the picture is unsettled: it may help some people cut calories, but WHO advises against sweeteners for weight control, and observational links to disease are hard to interpret. [6] [7] [9] [10] [15]
- If you have PKU (phenylketonuria, a rare inherited condition), the FDA says to avoid or restrict aspartame, and labels must say the product contains phenylalanine. [12]
What is in it (USDA values)
Two USDA FoodData Central items (SR Legacy) are used. The regular soda is a caffeinated pepper-type soda (item 173209). The diet soda is a low-calorie cola or pepper-type drink sweetened with sodium saccharin (item 171876). [1] [2] USDA household portions are used for the serving: 12 fl oz (368 g) for the regular item and 12 fl oz (355 g) for the diet item. Soda made with other sweeteners will differ, so check the label.
| Nutrient | Regular, per 100 g | Regular, per 12 fl oz (368 g) | Diet, per 100 g | Diet, per 12 fl oz (355 g) |
|---|---|---|---|---|
| Energy | 41 kcal | 151 kcal | 0 kcal | 0 kcal |
| Carbohydrate | 10.4 g | 38.3 g | 0.1 g | 0.4 g |
| Sodium | 10 mg | 36.8 mg | 16 mg | 56.8 mg |
| Phosphorus | 11 mg | 40.5 mg | 11 mg | 39.1 mg |
| Caffeine | 10 mg | 36.8 mg | 11 mg | 39.1 mg |
The % Daily Value for carbohydrate (FDA 2016 Daily Value 275 g) works out to about 14% in a regular can. Sodium is about 2% of the 2,300 mg Daily Value in either can, and phosphorus about 3%. Other vitamins and minerals are at or near zero in both items. [1] [2] USDA lists no separate "total sugars" value for the regular item, so the table shows carbohydrate; for a sugar-sweetened soda the Nutrition Facts label on your can lists sugars and added sugars. The serving figures are the 100 g values multiplied by the serving weight.
Soda also contains acids (such as phosphoric or citric acid), flavorings and sometimes colors. Our USDA file does not list them, so we do not describe their amounts.
What research says
| Health goal | What the sources found | Strength of evidence | What was studied |
|---|---|---|---|
| Weight | A 2013 meta-analysis of 32 studies pooled cohort studies and randomized trials. In cohort studies, each extra daily serving of sugar-sweetened drinks went with a small extra gain over a year (about 0.12 to 0.22 kg in adults). In five adult trials, adding sugary drinks raised body weight by about 0.85 kg on average. In children, trials that cut sugary drinks showed smaller BMI gains, but the range of results included no effect. [6] | Promising but limited (trials were small and short) | Sugar-sweetened drinks, children and adults |
| Type 2 diabetes | A 2015 meta-analysis of 17 cohort studies found 18% higher diabetes incidence per daily serving, and 13% after adjusting for body fat. Results differed a lot between studies. [7] An older 2010 meta-analysis found 26% higher risk in the highest-intake group compared with the lowest. [8] | Mixed; observational, cannot prove cause | Sugar-sweetened drinks, adults |
| Diet soda and weight | The AHA wrote in 2018 that low-calorie sweetened drinks may help control calorie intake and aid weight loss, but evidence on possible harms is thin. [10] WHO (2023) recommends against non-sugar sweeteners for weight control, based on a systematic review that found no long-term benefit for body fat. [9] | Mixed (official bodies differ in emphasis) | Low-calorie sweetened drinks, mostly short-term |
| Diet soda and diabetes or heart disease | In the 2015 meta-analysis, diet drinks went with 25% higher diabetes incidence per daily serving, falling to 8% after adjusting for body fat. The authors noted publication bias and likely residual confounding. [7] The WHO page says the link may be confounded by people's baseline characteristics. [9] | Insufficient evidence to say diet soda causes harm | Artificially sweetened drinks, observational |
| Teeth | A 2026 meta-analysis of 24 studies in adolescents found carbonated drinks went with about double the odds of dental erosion (odds ratio 1.98) and 37.6% overall prevalence of erosion. [15] The CDC lists tooth decay and cavities among the problems linked to frequent sugary-drink intake. [4] | Promising but limited; observational | Carbonated drinks, adolescents |
| Bone density | In the Framingham Osteoporosis Study (1,413 women and 1,125 men), cola but not other carbonated drinks went with lower hip bone density in women. No link was found in men. The authors said more research is needed. [16] | Mixed; one observational study | Cola, adults |
| Kidney stones | In three large US cohorts, drinking sugar-sweetened non-cola soda daily went with about 33% higher stone risk, and sugar-sweetened cola with about 23% higher risk (the range for cola included no effect). Artificially sweetened cola went with no higher risk. [17] | Mixed; observational | Soda, adults |
What the pooled studies cannot show. These are mostly observational studies of what people reported drinking. People who drink diet soda often differ from those who do not, and some may have switched because they already gained weight. [7] [9]
How much is a normal serving
The USDA household portions are 12 fl oz (about 355 to 368 g) for a can and 16 fl oz for a bottle. [1] [2] That is information, not a prescription. For sugar, WHO recommends that free sugars make up less than 10% of daily energy (about 50 g for a 2,000-calorie diet), and says 5% or less may bring extra benefit. [3] One regular can has about 38 g of carbohydrate in the USDA item, so one can may use up much of a day's allowance if that carbohydrate is nearly all sugar; check your label. The CDC says to choose water over sugary drinks. [4] [5]
Safety, allergy and medicines
- Caffeine. A 12 fl oz caffeinated soda typically has 23 to 83 mg, depending on the product. [13] In pregnancy, the NHS advises no more than 200 mg of caffeine a day from all sources. [14] The FDA says the Dietary Guidelines advise avoiding caffeinated drinks for children under 2, and that experts advise against energy drinks for children and teens. [13] Many sodas are caffeine-free, so read the label.
- Aspartame. In 2023 the International Agency for Research on Cancer classified aspartame as "possibly carcinogenic to humans" (Group 2B), based on limited evidence. The expert committee JECFA (FAO/WHO) found no reason to change its acceptable daily intake of 0 to 40 mg per kg of body weight, and WHO said an adult of 70 kg would need to drink more than 9 to 14 cans a day of a diet soft drink with 200 to 300 mg of aspartame to exceed it, with no other sources. [11] The FDA disagrees with the IARC classification, has no safety concerns at approved use, and lists its own acceptable daily intake as 50 mg per kg. [12]
- Saccharin (in the diet item USDA measured): FDA says the bladder cancer seen in rats was not relevant to humans, and the National Toxicology Program removed it from its list of potential carcinogens in 2000. [12]
- Phenylketonuria. People with PKU should avoid or restrict aspartame; labels must say the product contains phenylalanine. [12]
- Children. The AHA advised in 2018 against prolonged use of low-calorie sweetened drinks by children, with water as the best choice. [10] The CDC says the Dietary Guidelines recommend no added sugar for children younger than 11. [4] [5]
- Teeth. Frequent sipping of any acidic or sugary drink keeps teeth exposed longer; the studies we read were observational or lab-based. [15] A 2026 study of tooth-surface pH found a non-alcoholic soft drink had the lowest starting pH of the drinks it tested, and that pH recovered within 10 to 15 minutes. [18]
- Allergy and medicines. The sources we read did not link plain soda to a food allergy or a medicine interaction. Colors or flavorings can differ by product; check labels.
- Kidney disease, diabetes and pregnancy. Regular soda adds sugar without protein or fiber; diabetes and kidney advice differs by person, so ask a clinician. The sources we read did not give specific kidney-disease advice for soda.
- Emergency. For trouble breathing or swelling of the face or throat after any food or drink, call 911 (or your local emergency number).
Choosing, storing and food safety
- Read the Nutrition Facts for sugars, added sugars and caffeine; labels differ more than the single USDA items suggest.
- Look for "caffeine-free" if you want to avoid caffeine.
- If you drink soda, a smaller portion and less often is the simplest change; water is the baseline drink. [4] [10]
- We did not read a source on storage of opened cans or bottles.
Related pages
Health connections for Soda & Diet Soda
What research links to eating or drinking this food, and how strong the evidence is. Many studies are observational or use juice, powder, oil or extracts rather than the food as eaten; each card says which.
Sugar-sweetened soda and type 2 diabetes risk
Preliminary or mixedMeta-analyses of cohort studies found higher type 2 diabetes incidence with more sugar-sweetened drinks, about 13% per daily serving after adjusting for body fat. Studies differed a lot and cannot prove cause.
Supplements: Not applicable.
Diet soda and weight control
Preliminary or mixedThe AHA said low-calorie sweetened drinks may help control calorie intake and aid weight loss, but long-term harm data are thin. WHO (2023) recommends against non-sugar sweeteners for weight control, finding no long-term benefit for body fat.
Supplements: Not applicable.
Diet soda and diabetes or heart disease associations
Preliminary or mixedObservational studies link diet drinks with higher diabetes risk, but the link shrank after adjusting for body fat, and the authors saw publication bias and likely residual confounding. WHO says the link may be confounded.
Supplements: Not applicable.
Aspartame and saccharin safety reviews
Preliminary or mixedIARC classified aspartame as possibly carcinogenic (Group 2B) on limited evidence in 2023, while JECFA kept its acceptable daily intake at 0 to 40 mg per kg of body weight. The FDA disagrees with the IARC classification and found no safety concern at approved use.
Supplements: Not applicable.
Cola and bone density in women
Preliminary or mixedIn the Framingham Osteoporosis Study, cola but not other carbonated drinks went with lower hip bone density in women, and no link in men. One observational study; more research was called for.
Supplements: Not applicable.
Soda and kidney stones
Preliminary or mixedIn three large US cohorts, daily sugar-sweetened non-cola soda went with about 33% higher kidney stone risk and sugar-sweetened cola with about 23% higher (range for cola included no effect). Artificially sweetened cola went with no higher risk.
Supplements: Not applicable.
Connected topics
Open a group to see how each topic connects and how strong the evidence is.
Health goals (5)
- Weight ManagementDocumented risk
Pooled studies link sugar-sweetened soda to weight gain. Diet soda may help some people cut calories, but WHO advises against sweeteners for weight control.
- Blood Sugar BalancePreliminary or mixed
Sugar-sweetened soda goes with higher type 2 diabetes incidence in cohort studies; this is observational and cannot prove cause.
- Metabolic HealthPreliminary or mixed
A meta-analysis linked sugar-sweetened drinks with metabolic syndrome and type 2 diabetes. Observational.
- Bone HealthPreliminary or mixed
One observational study linked cola, but not other carbonated drinks, with lower hip bone density in women.
- Heart HealthPreliminary or mixed
The CDC lists heart disease among conditions associated with frequent sugary-drink intake; the AHA reviewed diet drinks and found little evidence on harms.
Body systems (4)
- Metabolism & WeightDocumented risk
Sugar-sweetened soda adds energy and is linked with weight gain in pooled studies.
- Blood Sugar SupportPreliminary or mixed
Cohort studies link sugar-sweetened soda with type 2 diabetes incidence.
- Bones, Joints & MusclesPreliminary or mixed
One observational study linked cola with lower bone density in women.
- Kidney & UrinaryPreliminary or mixed
Sugar-sweetened soda went with higher kidney stone risk in three large cohorts; artificially sweetened cola did not.
Body parts (2)
Root causes (2)
- Blood Sugar ImbalancePreliminary or mixed
Sugar-sweetened soda delivers a large dose of sugar in a drink; cohort studies link it with type 2 diabetes.
- Poor DietDocumented risk
The CDC says sodas and other sugary drinks contain calories but little nutritional value and are leading sources of added sugars.
Habits (2)
- Balanced NutritionDocumented risk
WHO advises keeping free sugars under 10% of daily energy; sugary drinks make this harder.
- HydrationDocumented risk
Swapping soda for plain water is advice from the CDC and the AHA; water has no calories and counts toward fluid intake.
Conditions & symptoms (6)
- Weight GainDocumented risk
Adding sugary drinks raised body weight in adult trials by about 0.85 kg on average in a meta-analysis.
- Dental CariesDocumented risk
The CDC lists tooth decay and cavities among problems linked to frequent sugary-drink intake.
- Diabetes Mellitus, Non-Insulin-DependentPreliminary or mixed
Sugar-sweetened soda goes with higher diabetes incidence in cohort studies; for diet soda the link shrank after adjusting for body fat.
- ObesityDocumented risk
Pooled cohort studies and trials link sugar-sweetened drinks with weight gain.
- PhenylketonuriasDocumented risk
People with PKU should avoid or restrict aspartame; labels must declare phenylalanine.
- NephrolithiasisPreliminary or mixed
Higher stone risk with sugar-sweetened soda in cohort studies.
Documented risks and interactions (5)
- Sugar-sweetened soda and weight gain. A pooled analysis of cohort studies and trials linked sugar-sweetened drinks to weight gain in adults and children. A can of the regular soda USDA lists has about 151 kcal and 38 g of carbohydrate.
- Added sugar limits and sugary drinks. WHO recommends free sugars under 10% of daily energy and says under 5% may give extra benefit. One regular can has about 38 g of carbohydrate in the USDA item.
- Phenylalanine in aspartame and phenylketonuria. People with PKU, a rare inherited condition, should avoid or restrict aspartame; labels must state that the product contains phenylalanine.
- Carbonated drinks and tooth erosion. A 2026 meta-analysis of 24 studies in adolescents found carbonated drinks went with about twice the odds of dental erosion. The CDC lists tooth decay and cavities among problems linked to frequent sugary-drink intake.
- Caffeine in soda. USDA lists about 37 mg of caffeine in a 12 fl oz regular can and 39 mg in the diet can. The FDA says about 400 mg a day is not generally linked to negative effects in most healthy adults; the NHS advises no more than 200 mg a day in pregnancy.
Frequently asked questions
Is diet soda better than regular soda?
For calories and sugar, yes: the diet cola USDA measured has 0 kcal. [2] For long-term health the evidence is unsettled. The AHA says low-calorie sweetened drinks may help adults who drink a lot of sugary drinks cut back, while WHO advises against non-sugar sweeteners for weight control. [9] [10]
Does aspartame cause cancer?
IARC classified it as "possibly carcinogenic" (Group 2B) in 2023 based on limited evidence, while JECFA reaffirmed the acceptable daily intake of 0 to 40 mg per kg of body weight. The FDA says it has no safety concerns at approved use. [11] [12]
How much caffeine is in a can of soda?
In the USDA items, about 37 mg in a 12 fl oz regular can and about 39 mg in the diet can. [1] [2] The FDA gives a range of 23 to 83 mg for caffeinated sodas. [13]
Is soda bad for teeth?
A 2026 meta-analysis found carbonated drinks went with higher odds of dental erosion in adolescents, and the CDC lists tooth decay among the problems linked to frequent sugary drinks. These are observational findings. [4] [15]
Can I drink soda when pregnant?
The NHS advises no more than 200 mg of caffeine a day in pregnancy, from all sources. [14] The FDA suggests talking with your health care provider about caffeine in pregnancy or breastfeeding. [13]
References
- U.S. Department of Agriculture. FoodData Central: Beverages, carbonated, pepper-type, contains caffeine (FDC 173209). SR Legacy, April 2018. Read 2026-10-24.
- U.S. Department of Agriculture. FoodData Central: Beverages, carbonated, low calorie, cola or pepper-types, with sodium saccharin, contains caffeine (FDC 171876). SR Legacy, April 2018. Read 2026-10-24.
- World Health Organization. Healthy diet fact sheet. Read 2026-10-24.
- Centers for Disease Control and Prevention. Sugar-sweetened beverages. Page dated April 14, 2026. Read 2026-10-24.
- Centers for Disease Control and Prevention. Added sugars. Read 2026-10-24.
- Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr 2013. PMID 23966427. Read 2026-10-24.
- Imamura F, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes. BMJ 2015. PMID 26199070. Read 2026-10-24.
- Malik VS, et al. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 2010. PMID 20693348. Read 2026-10-24.
- World Health Organization. WHO advises not to use non-sugar sweeteners for weight control in newly released guideline. 2023. Read 2026-10-24.
- Low-calorie sweetened beverages and cardiometabolic health: a science advisory from the American Heart Association. Circulation 2018. PMID 30354445. Read 2026-10-24.
- World Health Organization. Aspartame hazard and risk assessment results released. 2023. Read 2026-10-24.
- U.S. Food and Drug Administration. Aspartame and other sweeteners in food. Read 2026-10-24.
- U.S. Food and Drug Administration. Spilling the beans: how much caffeine is too much?. Read 2026-10-24.
- NHS. Foods to avoid in pregnancy. Read 2026-10-24.
- Prevalence and risk of dental erosion linked to carbonated drinks in adolescents: a systematic review and meta-analysis. 2026. PMID 42113589. Abstract read 2026-10-24.
- Tucker KL, et al. Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: the Framingham Osteoporosis Study. Am J Clin Nutr 2006. PMID 17023723. Read 2026-10-24.
- Ferraro PM, et al. Soda and other beverages and the risk of kidney stones. Clin J Am Soc Nephrol 2013. Read 2026-10-24.
- An in vitro and in vivo assessment of acidogenicity of several alcoholic and non-alcoholic beverages. Clin Exp Dent Res 2026. PMID 42830648. Abstract read 2026-10-24.