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Supplements, Teas and Adaptogens for Stress Compared

Ashwagandha, rhodiola, L-theanine, magnesium, chamomile, lavender, kava, CBD and aromatherapy compared for stress and anxiety, with evidence labels, study populations and safety flags.

Content last updated . This page has not been medically reviewed.

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No supplement is a proven default treatment for stress or anxiety. The first steps are the habits and techniques elsewhere in this section, and, if symptoms are significant, professional care. NCCIH reminds readers that "natural" does not always mean safe, and that a label saying "standardized" or "certified" does not guarantee quality. [1] Supplements may also interact with medicines; read How interactions work before taking anything if you use prescriptions, and check with a pharmacist or doctor. If you are pregnant or breastfeeding, see Pregnancy and breastfeeding.

Evidence labels: promising but limited, mixed, insufficient evidence, and proper evidence not found. Amounts mentioned below are the amounts used in the cited studies, not recommendations. Studies in healthy adults, in people with anxiety disorders and in people with other illnesses are kept separate.

Comparison at a glance

OptionWhat the sources foundEvidence labelMain safety flags
Ashwagandha (root/leaf extracts)NCCIH: some preparations may be effective for insomnia and stress; evidence about anxiety is unclear; many studies are small and use different preparations. [2] A 2022 meta-analysis of 12 trials (1,002 adults aged 25 to 48) found lower stress and anxiety than placebo, but certainty of the evidence was low and the studies differed a great deal from one another. [3] A 2024 meta-analysis of 9 trials (558 people) found lower perceived stress and anxiety scores. [4]Promising but limitedRare liver injury; avoid in pregnancy and while breastfeeding; not recommended before surgery or with autoimmune or thyroid disorders; may interact with diabetes, blood pressure, immunosuppressant, sedative, seizure and thyroid medicines. [2] Short-term use (up to 3 months) may be safe; long-term safety is unknown. [2]
RhodiolaA 2022 narrative review calls the clinical evidence for life-stress symptoms "encouraging," but it is a narrative review, not a pooled analysis. [5] No NIH fact sheet on rhodiola was read for this page.Promising but limitedSafety and interaction details: proper evidence not found in sources read; check with a clinician. See Energy supplements compared.
L-theanine (an amino acid from tea, taken as a supplement)A systematic review of 9 randomized trials suggests 200 to 400 mg a day (study amounts) may help reduce stress and anxiety in people exposed to stressful conditions; the authors call for longer, larger trials. [6] This is the isolated supplement, not green tea.Promising but limitedSafety details: proper evidence not found in sources read. See Green tea for the food/tea.
MagnesiumA 2017 systematic review of 18 studies found suggestive benefit for subjective anxiety in people already prone to anxiety (mildly anxious, PMS, postpartum, hypertension), but the evidence quality was poor and no study measured stress with a validated tool. [7]Promising but limited (poor-quality evidence)See Magnesium for sleep and Interactions by drug class.
ChamomileTwo NCCIH-supported studies suggest a chamomile supplement might help generalized anxiety disorder, but they are preliminary. A 2019 review of three trials showed no significant reduction in situational anxiety. [1]MixedAllergic reactions (more likely if allergic to ragweed, daisies and related plants); might weaken birth control pills (preliminary studies); reported interactions with warfarin and some liver-metabolized drugs. [8]
Lavender (oral oil product)Small studies suggest an oral lavender oil product might help anxiety, but small size, lack of independent funding and lack of diversity limit conclusions. [9] A 2019 analysis of 65 randomized trials suggested oral lavender may be effective, with low study quality. [1]Promising but limitedOral: diarrhea, headache, nausea; skin products can cause allergic reactions; possible interactions with sedatives; little known in pregnancy. [9]
KavaMay have a small effect and need several weeks to work; does not appear helpful for generalized anxiety disorder in NCCIH's summary. [10] A 2018 review of 12 studies suggested it may be effective for GAD but needed more research. [1]MixedSevere liver injury has been linked to kava, some fatal. Do not combine with alcohol or sedatives. [10] See Liver safety.
ValerianNot enough evidence to conclude whether it helps anxiety. [1]Insufficient evidenceGenerally safe short-term; long-term safety unknown. [1] See Valerian.
PassionflowerA small amount of research suggests it might help reduce anxiety, including before a dental procedure; conclusions are not definite. [1]Insufficient evidenceSee Passionflower tea.
Lemon balm, tulsi (holy basil)Proper evidence not found in the NIH sources read for this page.Not ratedSee Lemon balm tea and Tulsi tea for each profile.

Teas

Tea is a food-like form and is not the same as an extract or capsule, so do not assume capsule findings apply to tea. NCCIH says chamomile is likely safe in the amounts commonly found in teas. [8] See Chamomile tea, Lavender tea, Herbal tea safety and, for the plant itself, Chamomile.

Adaptogens

A 2021 review describes adaptogens as plant extracts (or synthetic compounds) thought to increase the body's resistance to stress, naming Panax ginseng, Rhodiola rosea and others, and notes that human clinical trials are limited. [11] Whether the category as a whole works is not established; evidence is herb by herb and preparation by preparation, as the ashwagandha and rhodiola rows show. For definitions, product forms and safety, see What are adaptogens?, Adaptogens by wellness goal and Adaptogen safety. For the "adrenal support" label, see Cortisol and "adrenal fatigue".

Aromatherapy

NCCIH says it is unclear whether lavender aromatherapy helps anxiety, stress, depression symptoms, pain or sleep, although some people report an improved sense of quality of life. It is considered possibly safe but may cause headache or coughing. [9] A 2022 meta-analysis in people with cancer (17 studies; 10 in the pooled analysis) found aromatherapy reduced anxiety, most clearly with aromatic massage and lavender oil, but not depression; this is a specific illness group. [12] See Aromatherapy and Lavender oil.

CBD (cannabidiol)

Evidence labels: mixed, with legal and product-quality problems.
  • NCCIH says a small amount of human research suggests cannabinoids might reduce anxiety; one study of 24 people with social anxiety disorder found less anxiety in a simulated public speaking test after CBD than after placebo. [13]
  • A 2024 meta-analysis of 8 studies (316 people) reported a significant effect on anxiety but with a very wide confidence interval; the authors say to be cautious because of the small sample. [14]
  • In the US, the FDA has determined that products containing THC or CBD cannot be sold legally as dietary supplements. Over-the-counter CBD products may contain more or less CBD than stated on the label and may contain contaminants such as THC. [13]
  • CBD may cause decreased alertness, mood changes, decreased appetite and diarrhea, and use has been associated with liver injury, male reproductive harm and drug interactions. [13]

Quality and regulation

Dietary supplements are not approved by the FDA before sale, and manufacturers are responsible for evaluating safety and labeling. [2] See How supplements are regulated and Product quality and contamination.

When to get help

Do not use supplements as a substitute for treatment of an anxiety disorder, and never stop a prescribed medicine without talking to the prescriber. Talk to a provider if anxiety or stress lasts or interferes with life. [15] For emotional distress or thoughts of suicide in the US, call or text 988 (free, 24/7). [16] If someone has taken too much of a supplement or medicine, call 911 or US Poison Help at 1-800-222-1222 (Poison help by country). See Stress and anxiety safety.

Frequently asked questions

What is the best supplement for stress?

No supplement is proven best. Ashwagandha, L-theanine and magnesium have small studies suggesting benefit, but certainty is low or evidence quality is poor. [3][6][7]

Is ashwagandha safe?

It may be safe short term (up to 3 months), but there are rare reports of liver injury and several interactions and avoidance groups. [2]

Is kava a good option for anxiety?

Kava may have a small effect, but it has been linked to rare severe liver injury, so it carries a significant safety concern. [10]

Is CBD legal as a supplement for anxiety?

In the US, the FDA has determined CBD products cannot be sold legally as dietary supplements. [13]

Do adaptogens lower cortisol?

One 2024 meta-analysis found lower serum cortisol with ashwagandha than placebo; this is a lab marker and not proof of better health. [4]

References

  1. National Center for Complementary and Integrative Health. Anxiety and Complementary Health Approaches. Read 2026-10-22.
  2. National Center for Complementary and Integrative Health. Ashwagandha. Read 2026-10-22.
  3. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2022. PMID 36017529. Read 2026-10-22.
  4. Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis. Explore (NY) 2024. PMID 39348746. Read 2026-10-22.
  5. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. Molecules 2022. PMID 35745023. Read 2026-10-22.
  6. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr 2020. PMID 31758301. Read 2026-10-22.
  7. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients 2017. PMID 28445426. Read 2026-10-22.
  8. National Center for Complementary and Integrative Health. Chamomile. Read 2026-10-22.
  9. National Center for Complementary and Integrative Health. Lavender. Read 2026-10-22.
  10. National Center for Complementary and Integrative Health. Kava. Read 2026-10-22.
  11. Plant Adaptogens-History and Future Perspectives. Nutrients 2021. PMID 34445021. Read 2026-10-22.
  12. The Effects of Aromatherapy on Anxiety and Depression in People With Cancer: A Systematic Review and Meta-Analysis. Front Public Health 2022. PMID 35757624. Read 2026-10-22.
  13. National Center for Complementary and Integrative Health. Cannabis (Marijuana) and Cannabinoids: What You Need To Know. Read 2026-10-22.
  14. Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis. Psychiatry Res 2024. PMID 38924898. Read 2026-10-22.
  15. National Institute of Mental Health. Generalized Anxiety Disorder: What You Need to Know. Read 2026-10-22.
  16. 988 Suicide & Crisis Lifeline. 988 Lifeline home page. Read 2026-10-22.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.