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Publication PMID 36252771 Research model: Clinical & Cell Experiment

Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer

Condition or outcome area: lung cancer; cancer; tumors

Pharmacol Res · 2022 · Subject: Tangeretin; 481-53-8; Tangeritin; Ponkanetin; Pentamethoxyflavone; 4',5,6,7,8-Pentamethoxyflavone; 5,6,7,8,4'-Pentamethoxyflavone; 4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-; 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one; 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one · open the ingredient record · DOI 10.1016/j.phrs.2022.106514

Publication PMID 32065498 Research model: 3 Types

Sanguinarine disrupts the colocalization and interaction of HIF-1α with tyrosine and serine phosphorylated-STAT3 in breast cancer

Condition or outcome area: breast cancers; triple-negative breast cancer; Breast cancer; tumour; breast cancer

J Cell Mol Med · 2020 · Subject: Sanguinarine; Sanguinarium; 2447-54-3; Pseudochelerythrine; Sanguinarin; sangvinarin; SANGUINARIUM; Veadent; Sangrovit; Dimethylenedioxy benzphenanthridine · open the ingredient record · DOI 10.1111/jcmm.15056

Publication PMID 32052470 Research model: Cell Experiment

Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides

Condition or outcome area: thrombocytopenia; thrombopoiesis

J Pineal Res · 2020 · Subject: Melatonin; 73-31-4; Melatonine; N-Acetyl-5-methoxytryptamine; Circadin; N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide; 5-Methoxy-N-acetyltryptamine; N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide; Melatol; Melovine · open the ingredient record · DOI 10.1111/jpi.12637

Publication PMID 33474722 Research model: Animal Experiment

Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP

Condition or outcome area: atherosclerotic plaque; atherosclerosis; Atherosclerotic lesion; endothelial dysfunction

Br J Pharmacol · 2021 · Subject: Harmine; 442-51-3; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; Banisterine; Telepathine; Leucoharmine; Yageine; Yajeine; 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-; 7-Methoxy-1-methyl-9H-beta-carboline · open the ingredient record · DOI 10.1111/bph.15378

Publication PMID 33763888 Research model: Animal Experiment

Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis

Condition or outcome area: stricturing; sclerosing cholangitis; biliary inflammation; fibrosis; Sclerosing cholangitis

Phytother Res · 2021 · Subject: Geniposide; 24512-63-8; Jasminoidin; UNII-145295QLXY; CHEBI:5299; 169799-41-1; 145295QLXY; Cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)-; methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate; methyl (1S,4aS,7aR)-7-(hydroxymethyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran · open the ingredient record · DOI 10.1002/ptr.7086

Publication PMID 33571918 Research model: Animal Experiment

Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway

Condition or outcome area: diabetes-related metabolic disorders; histopathological abnormalities; renal fibrosis; diabetes; Diabetic nephropathy

Phytomedicine · 2021 · Subject: Epiberberine; 6873-09-2; VWP9N35AYS; DEHYDROSINACTINE; EPIBERBERINE ION; EPIBERBERINE CATION; Benz(a)-1,3-benzodioxolo(4,5-g)quinolizinium, 11,12-dihydro-8,9-dimethoxy-; EPIBERBERINE [WHO-DD]; MLS000563434; 16,17-dimethoxy-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaene · open the ingredient record · DOI 10.1016/j.phymed.2021.153488

Publication PMID 32534357 Research model: Animal & Cell Experiment

Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice

Condition or outcome area: Gastric cancer; malignancies; tumor; gastric cancer

Phytomedicine · 2020 · Subject: Epiberberine; 6873-09-2; VWP9N35AYS; DEHYDROSINACTINE; EPIBERBERINE ION; EPIBERBERINE CATION; Benz(a)-1,3-benzodioxolo(4,5-g)quinolizinium, 11,12-dihydro-8,9-dimethoxy-; EPIBERBERINE [WHO-DD]; MLS000563434; 16,17-dimethoxy-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaene · open the ingredient record · DOI 10.1016/j.phymed.2020.153216

Publication PMID 32648885 Research model: Animal & Cell Experiment

Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

Condition or outcome area: melanoma

Food Funct · 2020 · Subject: Cudranin; Oxyresveratrol; 29700-22-9; Hydroxyresveratrol; Tetrahydroxystilbene; (E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol; trans-oxyresveratrol; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol; 4721-07-7; 1,3-Benzenediol, 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]- · open the ingredient record · DOI 10.1039/d0fo01193b

Publication PMID 34883072 Research model: Cell Experiment

Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy

Condition or outcome area: NRCMs; cardiovascular diseases; cardiac hypertrophy; PE-induced cardiac hypertrophy; Cardiac hypertrophy

Eur J Pharmacol · 2021 · Subject: Cinnamaldehyde; trans-Cinnamaldehyde; 14371-10-9; 104-55-2; Cinnamic aldehyde; (E)-Cinnamaldehyde; 3-Phenylacrylaldehyde; Cinnamal; Zimtaldehyde; 2-Propenal, 3-phenyl- · open the ingredient record · DOI 10.1016/j.ejphar.2021.174687

Publication PMID 34884773 Research model: Cell Experiment

Opposing Effects of Chelidonine on Tyrosine and Serine Phosphorylation of STAT3 in Human Uveal Melanoma Cells

Condition or outcome area: uveal melanoma; tumor; uveal melanomas

Int J Mol Sci · 2021 · Subject: Chelidonine; 476-32-4; Chelidonin; Stylophorin; (+)-Chelidonine; Khelidonin; Helidonine; Chelidoniny; Stylophorine; CHEBI:31389 · open the ingredient record · DOI 10.3390/ijms222312974

Publication PMID 33353058 Research model: Cell Experiment

Tyrosinase Inhibitory Activity of Soybeans Fermented with Bacillus subtilis Capable of Producing a Phenolic Glycoside, Arbutin

Antioxidants (Basel) · 2020 · Subject: Arbutin; 497-76-7; Arbutoside; Ursin; Uvasol; beta-Arbutin; p-Arbutin; 4-Hydroxyphenyl beta-D-glucopyranoside; p-Hydroxyphenyl beta-D-glucoside; Arbutine · open the ingredient record · DOI 10.3390/antiox9121301

Publication PMID 36215789 Research model: Animal Experiment

Abietic acid ameliorates nephropathy progression via mitigating renal oxidative stress, inflammation, fibrosis and apoptosis in high fat diet and low dose streptozotocin-induced diabetic rats

Condition or outcome area: inflammation; nephropathy; diabetes mellitus; fibrosis; diabetic

Phytomedicine · 2022 · Subject: Abietic acid; 514-10-3; Sylvic acid; Abietate; l-Abietic acid; Rosin Acid; 7,13-Abietadien-18-oic acid; Kyselina abietova; 13-Isopropylpodocarpa-7,13-dien-15-oic acid; CCRIS 3183 · open the ingredient record · DOI 10.1016/j.phymed.2022.154464

Publication PMID 32535102 Research model: Animal & Cell Experiment

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β

Condition or outcome area: Idiopathic pulmonary fibrosis; progressive-fibrosing lung disease; pulmonary fibrosis

Biochem Pharmacol · 2020 · Subject: 3,3',4',5,5',7-hexahydroxyflavone; Myricetin; myricetin; 529-44-2; Cannabiscetin; Myricetol; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; Myricitin; 3,5,7,3',4',5'-Hexahydroxyflavone; 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one · open the ingredient record · DOI 10.1016/j.bcp.2020.114097

Publication PMID 35964659 Research model: Animal & Cell Experiment

Eucalyptol prevents bleomycin-induced pulmonary fibrosis and M2 macrophage polarization

Condition or outcome area: pulmonary fibrosis; fibrosing interstitial pneumonia; tumor; lung inflammation; Idiopathic pulmonary fibrosis

Eur J Pharmacol · 2022 · Subject: 1,8 cineole; Eucalyptol; cineole; 1,8-Cineole; 470-82-6; 1,8-Cineol; Cajeputol; 1,8-Epoxy-p-menthane; Eucalyptole; Eucapur · open the ingredient record · DOI 10.1016/j.ejphar.2022.175184

Publication PMID 34836147 Research model: Cell Experiment

Preventive Effect of M. cochinchinensis on Melanogenesis via Tyrosinase Activity Inhibition and p-PKC Signaling in Melan-A Cell

Condition or outcome area: antimelanogenesis

Nutrients · 2021 · Subject: Mu Bie Gen; 木鳖根; Cochinhina Momordica Root; Momordica Cochinchinensis · open the herb record · DOI 10.3390/nu13113894

Publication PMID 27009967 Research model: Animal Experiment

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Nat Commun · 2016 · Subject: (2r)-pterosin b; Pterosin B; 34175-96-7; (2R)-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydroinden-1-one; BI 2; PterosinB; (R)-6-(2-Hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one; 1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-; 1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-; MLS002473104 · open the ingredient record · DOI 10.1038/ncomms10959

Publication PMID 24333736 Research model: Cell Experiment

Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases

Cancer Lett · 2014 · Subject: Capillarisin; 56365-38-9; Capillarisine; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one; DTXSID30204918; 2-(p-Hydroxyphenoxy)-6-methoxy-5,7-dihydroxychromone; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one; C08999; AC1NQYDG · open the ingredient record · DOI 10.1016/j.canlet.2013.12.008

Publication PMID 22197494 Research model: Cell Experiment

Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta

Am J Obstet Gynecol · 2012 · Subject: Cis-resveratrol; cis-Resveratrol; (Z)-resveratrol; 61434-67-1; Cis resveratrol; Resveratrol, (Z)-; 5-[(Z)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; 5-[(Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; cis-3,4',5-trihydroxystilbene; (Z)-3,5,4'-trihydroxystilbene · open the ingredient record · DOI 10.1016/j.ajog.2011.11.010

Publication PMID 26482867 Research model: Cell Experiment

Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2

Free Radic Biol Med · 2015 · Subject: Cis-resveratrol; cis-Resveratrol; (Z)-resveratrol; 61434-67-1; Cis resveratrol; Resveratrol, (Z)-; 5-[(Z)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; 5-[(Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; cis-3,4',5-trihydroxystilbene; (Z)-3,5,4'-trihydroxystilbene · open the ingredient record · DOI 10.1016/j.freeradbiomed.2015.10.413

Publication PMID 24631489 Research model: Cell Experiment

Biochanin A and prunetin improve epithelial barrier function in intestinal CaCo-2 cells via downregulation of ERK, NF-κB, and tyrosine phosphorylation

Free Radic Biol Med · 2014 · Subject: Prunetin; 552-59-0; Prunusetin; 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one; 5,4'-dihydroxy-7-methoxyisoflavone; 4',5-dihydroxy-7-methoxyisoflavone; Padmakastein; 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one; 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4-benzopyrone; 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one · open the ingredient record · DOI 10.1016/j.freeradbiomed.2014.02.025

Publication PMID 29987021 Research model: Animal Experiment

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

Condition or outcome area: proteasome-addicted cancers

Proc Natl Acad Sci U S A · 2018 · Subject: Curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Kacha haldi; Indian saffron; Curcuma; Gelbwurz; Haldar; Curcumin I · open the ingredient record · DOI 10.1073/pnas.1806797115

Publication PMID 21565443 Research model: Cell Experiment

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN

Cancer Lett · 2011 · Subject: Embelin; 550-24-3; Embelic acid; 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione; Emberine; 2,5-Dihydroxy-3-undecyl-1,4-benzoquinone; 2,5-Dihydroxy-3-undecyl-p-benzoquinone; 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione; CHEBI:4778; Potassium embelate · open the ingredient record · DOI 10.1016/j.canlet.2011.04.015

Publication PMID 30525586 Research model: Animal Experiment

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

J Med Chem · 2018 · Subject: Tripterine; Celastrol; celastrol; 34157-83-0; Tripterin; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; NSC 70931; UNII-L8GG98663L; CHEBI:63959 · open the ingredient record · DOI 10.1021/acs.jmedchem.8b01224

Publication PMID 29401630 Research model: Animal Experiment

Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase

FASEB J · 2018 · Subject: Tetrandrine; 518-34-3; D-Tetrandrine; (+)-Tetrandrine; Tetrandrin; Fanchinine; Sinomenine A; (S,S)-Tetrandrine; hanjisong; DL-Tetrandine · open the ingredient record · DOI 10.1096/fj.201701148RR