natural remedies · Ingredient
(e)-2-[(3s,6's,7's,8'as)-6'-ethyl-2-keto-spiro[indoline-3,1'-indolizidine]-7'-yl]-3-methoxy-acrylic acid methyl ester
Formula: C22H28N2O4 · MW: 384.4760000000001 · Drug-likeness: 0.491
⚗️ Identity
Name
(e)-2-[(3s,6's,7's,8'as)-6'-ethyl-2-keto-spiro[indoline-3,1'-indolizidine]-7'-yl]-3-methoxy-acrylic acid methyl ester
Aliases / Synonyms
Corynoxine; 6877-32-3; CHEBI:70072; methyl (E)-2-[(3S,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate; 1443767-78-9; Methyl (E)-2-((3S,6'S,7'S,8a'S)-6'-ethyl-2-oxo-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)-3-methoxyacrylate; methyl (E)-2-((3S,6'S,7'S,8'aS)-6'-ethyl-2-oxospiro(1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine)-7'-yl)-3-methoxyprop-2-enoate; CHEMBL1909424; DTX...
🧪 Chemistry
Molecular Weight
384.4760
LogP
2.7002
Drug-likeness
0.491
Oral Bioavailability
57.8540
H-Bond Acceptors
5
H-Bond Donors
1
Rotatable Bonds
4
🔗 External References
0
Clinical Trials
0
Meta-Analyses
2
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 33927622
Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease
Front Pharmacol · 2021
PMID 36229578
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects
Br J Cancer · 2022