natural remedies · Ingredient
(-)-epigallocatechin-3-gallate
Formula: C22H18O11 · MW: 458.3750000000002 · Drug-likeness: 0.212
⚗️ Identity
Name
(-)-epigallocatechin-3-gallate
Aliases / Synonyms
(-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin gallate; Epigallocatechin 3-gallate; Tea catechin; Epigallocatechin-3-gallate; Teavigo; (-)-Epigallocatechin-3-o-gallate; Epigallocatechin-3-monogallate
🧪 Chemistry
Molecular Weight
458.3750
LogP
2.2332
Drug-likeness
0.212
Oral Bioavailability
55.0870
H-Bond Acceptors
11
H-Bond Donors
8
Rotatable Bonds
3
🔗 External References
18
Clinical Trials
0
Meta-Analyses
56
PubMed References
Top Conditions Studied with (-)-epigallocatechin-3-gallate
Light Chain (AL) Amyloidosis|Cardiac Involvement 1
Cognitive Function|Mood 1
Irreversible Pulpitis 1
Acne Vulgaris 1
Huntington Disease 1
Frailty|Inflammation 1
Fragile X Syndrome 1
Fetal Alcohol Syndrome (FAS) 1
Relapsing-remitting Multiple Sclerosis 1
Esophageal Obstruction 1
Papilloma-induced Cervical Lesions 1
EGCG Influence on Catecholamine Metabolism 1
📋 Sample Trials
NCT00867555
Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation
Completed · Obesity|Type 2 Diabetes Mellitus
NCT01357681
Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study)
Completed · Phase 2 · Huntington Disease
NCT01687556
EGCG Improves Acne by Modulating Molecular Targets
Completed · Acne Vulgaris
NCT01699711
Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool
Completed · Phase 2 · Down Syndrome (DS)
NCT02558933
Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children
Completed · Fetal Alcohol Syndrome (FAS)
NCT02891538
Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients
Active_Not_Recruiting · Early_Phase 1 · Colon Cancer
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 30822414
A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin
J Invest Dermatol · 2019
PMID 30591655
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells
Cancers (Basel) · 2018
PMID 29882708
Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila
FASEB J · 2018
PMID 29855550
Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques
Mucosal Immunol · 2018
PMID 29031698
Aggregation of Aβ(17-36) in the Presence of Naturally Occurring Phenolic Inhibitors Using Coarse-Grained Simulations
J Mol Biol · 2017
PMID 29024813
A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer
Cancer Lett · 2018
🏥 Linked Health Topics 6 · matched via study conditions