natural remedies · Ingredient
Fisetin
Formula: C15H10O6 · MW: 286.239 · Drug-likeness: 0.511
⚗️ Identity
Name
Fisetin
Aliases / Synonyms
528-48-3; 5-Desoxyquercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 3,3',4',7-Tetrahydroxyflavone; Fustel; Viset; 3,7,3',4'-Tetrahydroxyflavone; Fisetholz; Superfustel
🧪 Chemistry
Molecular Weight
286.2390
LogP
2.2824
Drug-likeness
0.511
Oral Bioavailability
52.5960
H-Bond Acceptors
6
H-Bond Donors
4
Rotatable Bonds
1
🔗 External References
7
Clinical Trials
1
Meta-Analyses
32
PubMed References
Top Conditions Studied with Fisetin
📋 Sample Trials
NCT04476953
COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation
Enrolling_By_Invitation · Phase 2 · Covid19
NCT04771611
COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications
Completed · Phase 2 · Covid19|Coronavirus Infection
NCT03430037
Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women
Enrolling_By_Invitation · Phase 2 · Frail Elderly Syndrome
NCT03675724
Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults
Enrolling_By_Invitation · Phase 2 · Frail Elderly Syndrome
NCT04537299
COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes
Active_Not_Recruiting · Phase 2 · Covid19|SARS-CoV Infection
NCT05416515
A Study of Fisetin to Treat Carpal Tunnel Syndrome
Active_Not_Recruiting · Phase 2 · Carpal Tunnel Syndrome
📊 Sample Meta-Analyses
CRD42021298815
The effects of fisetin on musculoskeletal system: A systematic review.
📚 Sample References
PMID 31540162
Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
Cells · 2019
PMID 31438640
Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9
Cells · 2019
PMID 31207963
Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment
J Clin Med · 2019
PMID 30760707
Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
Cell Death Dis · 2019
PMID 31634424
Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells
Biofactors · 2020
PMID 31835147
Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling
J Nutr Biochem · 2020
🏥 Linked Health Topics 1 · matched via study conditions