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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿
Herb
6,826
→
⚗️
Ingredient
44,598
→
🧬
Gene Target
15,695
→
🏥
Disease
30,467
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
Quick picks: A1BG A2M NAT1 NAT2 SERPINA3 AADAC AAMP AANAT AARS1 ABAT
🧬 Gene Target

EGFR

Open on HERB 2.0 ↗
5
Clinical Trials
0
Meta-Analyses
127
PubMed References
📋 Sample Trials
NCT00861627
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation
Completed · Phase 2
NCT05118074
Nova Max Creatinine and eGFR Meter System
Suspended
NCT00063401
Phase II Study in Patients With Epidermal Growth Factor Receptor (EGFR) + Advanced Stage Ovarian, Primary Peritoneal and Fallopian Tube Cancer
Completed · Phase 2
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 27864022
Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
Pharmacol Res · 2017
PMID 30016965
Lycorine inhibits glioblastoma multiforme growth through EGFR suppression
J Exp Clin Cancer Res · 2018
PMID 31202781
Oridonin synergistically enhances the anti-tumor efficacy of doxorubicin against aggressive breast cancer via pro-apoptotic and anti-angiogenic effects
Pharmacol Res · 2019
🧬 All Gene Target data fields for EGFR
🧬 Identity
Gene Symbol
EGFR
Gene Aliases
ERBB; ERBB1; HER1; NISBD2; PIG61; mENA
Protein Name
epidermal growth factor receptor
Gene Type
protein-coding
TTD Target Type
Clinical Trial target
📍 Location
Organism
Homo sapiens
Taxonomy ID
9606
Chromosome
7
Map Location
7p11.2
🔗 External References
HERB DB
HBTAR001185 ↗
Entrez
1956 ↗
OMIM
131550 ↗
HGNC
3236 ↗
Ensembl
ENSG00000146648 ↗
TTD
T64969
🔍 Raw view — every non-empty column on this row (28 fields)
name
EGFR
gene symbol
EGFR
gene alias name
ERBB; ERBB1; HER1; NISBD2; PIG61; mENA
protein name
epidermal growth factor receptor
type of gene
protein-coding
ttd target type
Clinical Trial target
organism
Homo sapiens
taxonomy id
9606
map location
7p11.2
chromosome
7
entrez id
1956
omim id
131550
hgnc id
3236
ensembl id
ENSG00000146648
ttd id
T64969
target id str
HBTAR001185
tcmsp target id
298

🌿 Related Herbs

1 · contains this compound
Ephedra
Ma Huang

⚗️ Related Ingredients

2 · compounds in this herb
Luteolin
PubChem CID 5280445
Quercetin
PubChem CID 5280343

🏥 Linked Health Topics

13 · diseases via target pathways
Squamous Cell Carcinoma
disease
Lymphangiomatosis
syndrome
Glioblastoma Multiforme
disease
Solid Tumor
disease
Colorectal cancer
disease
Cancer, unspecific
disease
Pancreatic Cancer
disease
Non-small Cell Lung Cancer
disease
Breast cancer
disease
Tumors
disease
Ovarian cancer
disease
HCV infection
disease
Head and neck tumors
disease

📋 Clinical Trials

5 · subject of clinical study
NCT00861627 Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for No
→ Carcinoma, Non-small Cell Lung
NCT05118074 Nova Max Creatinine and eGFR Meter System
→ Chronic Kidney Diseases|Acute Kidney Injury
NCT00063401 Phase II Study in Patients With Epidermal Growth Factor Receptor (EGFR) + Advanc
→ Ovarian Cancer|Peritoneal Neoplasms|Fallopian Tube
NCT04077255 EGFR-targeted Therapy for Gastric Cancer
→ Adenocarcinoma of the Stomach
NCT04245085 ABC-lung: Atezolizumab, Bevacizumab and Chemotherapy in EGFR-mutant Non-small Ce
→ EGFRmutant Stage IIIB/C or IV Non-squamous NSCLC

📚 PubMed References

12 · cited research
PMID 27864022 Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting T
Pharmacol Res
PMID 30016965 Lycorine inhibits glioblastoma multiforme growth through EGFR suppression
J Exp Clin Cancer Res
PMID 31202781 Oridonin synergistically enhances the anti-tumor efficacy of doxorubicin against
Pharmacol Res
PMID 28411855 Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-me
Pharmacol Res
PMID 31619257 Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targetin
Cell Commun Signal
PMID 30735802 Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metasta
Pharmacol Res
PMID 24520077 Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin
Cancer Res
PMID 31757048 Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A
Cancers (Basel)
PMID 29465315 Ginsenoside Rh2 inhibits vascular endothelial growth factor-induced corneal neov
FASEB J
PMID 31649278 The natural compound gracillin exerts potent antitumor activity by targeting mit
Cell Death Dis
PMID 25977334 Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Ak
Cancer Res
PMID 25407160 Tauroursodeoxycholic acid, a bile acid, promotes blood vessel repair by recruiti
Stem Cells
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables