Relationship Graph Explorer
Follow the connections
Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Herb
6,826
→
⚗️
Ingredient
44,595
→
🧬
Gene Target
15,505
→
🏥
Disease
30,170
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
🏥 Disease / Health Topic
Major Depressive Disorder
16
Clinical Trials
9
Meta-Analyses
0
PubMed References
📋 Sample Trials
NCT01496248
Efficacy Study of Korean Red Ginseng to Treat Depression
Completed
NCT00421369
Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response.
Completed
NCT01263119
A Study of LY2216684 and Warfarin in Healthy Subjects
Completed · Phase 1
📊 Sample Meta-Analyses
CRD42021265946
Monoamines and Kynurenine pathway metabolites in Cerebrospinal Fluid for depression: a systematic review
Major depressive disorder (MDD) is one of the most important causes of disabilit
CRD42015025203
The role of curcumin in patients with major depressive disorders: a mini meta-analysis of clinical trials
Major Depressive Disorders (MDD) is a serious clinical mood disorder which has a
CRD42015024796
Huperzine A for major depressive disorder: a review of the literature
Huperzine A, an alkaloid initially identified from the Chinese herbal medicine H
📚 Sample References
None linked yet.
🏥 All Disease / Health Topic data fields for Major Depressive Disorder
🏥 Names
Disease Name
Major Depressive Disorder
Alias Names
Seasonal Affective Disorder; Paraphrenia, Involutional; Melancholia; Psychosis, Involutional; Major Depressive Disorder; Unipolar Depression; Endogenous Depression; Depressive Disorder, Major; Mental Depression; Involutional Depression
Topic Type
disease
🧬 Ontology Classifications
DisGeNET Type
disease
UMLS Type
Mental or Behavioral Dysfunction
MeSH Class
Mental Disorders
DO Class
disease of mental health
🔗 External References
🔍 Raw view — every non-empty column on this row (27 fields)
name
Major Depressive Disorder
alias name
Seasonal Affective Disorder; Paraphrenia, Involutional; Melancholia; Psychosis, Involutional; Major Depressive Disorder; Unipolar Depression; Endogenous Depression; Depressive Disorder, Major; Mental Depression; Involutional Depression
topic type
disease
disgenet disease type
disease
umls disease type
Mental or Behavioral Dysfunction
mesh disease class
Mental Disorders
do disease class
disease of mental health
umls disease type id
T048
mesh disease class id
F03
do disease class id
DOID:150
herb disease id
HBDIS013025
disgenet id
C1269683
mesh id
D003865
do id
2848; 1596; 1470; 1595
omim id
608516
🌿 Related Herbs
1 · shared evidence⚗️ Related Ingredients
11 · shared evidence📜 Related Formulas
1 · contains this herb📋 Clinical Trials
12 · subject of clinical studyNCT01496248 Efficacy Study of Korean Red Ginseng to Treat Depression
→ Major Depressive Disorder
NCT00421369 Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T
→ Major Depressive Disorder
NCT01263119 A Study of LY2216684 and Warfarin in Healthy Subjects
→ Major Depressive Disorder
NCT01022632 Effect of Curcumin as Nutraceutical in Patients of Depression
→ Major Depressive Disorder
NCT01266590 A Study of LY2216684 and Digoxin in Healthy Subjects
→ Major Depressive Disorder
NCT00705003 Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and
→ Major Depressive Disorder
NCT01409096 Study Using Pregnenolone to Treat Bipolar Depression
→ Bipolar Disorder|Major Depressive Disorder
NCT03645096 Development of Pregnenolone as a Treatment for Depression
→ Major Depressive Disorder
NCT00977353 N-methylglycine (Sarcosine) Treatment for Depression
→ Major Depressive Disorder|Depression|Major Depress
NCT04975100 Evaluation of Efficacy and Safety of add-on Sarcosine in Patients With Major Dep
→ Major Depressive Disorder
NCT05148169 A Pilot Study on Effect of add-on Sulforaphane to SSRIs and Application of Niaci
→ Major Depressive Disorder
NCT01263106 A Study of LY2216684 and Theophylline in Healthy Subjects
→ Major Depressive Disorder
📊 Meta-Analyses
9 · systematic reviewCRD42021265946 Monoamines and Kynurenine pathway metabolites in Cerebrospinal Fluid for depress
→ Major depressive disorder (MDD) is one of the most
CRD42015025203 The role of curcumin in patients with major depressive disorders: a mini meta-an
→ Major Depressive Disorders (MDD) is a serious clin
CRD42015024796 Huperzine A for major depressive disorder: a review of the literature
→ Huperzine A, an alkaloid initially identified from
CRD42015024796 Huperzine A for major depressive disorder: a review of the literature
→ Huperzine A, an alkaloid initially identified from
CRD42015024796 Huperzine A for major depressive disorder: a review of the literature
→ Huperzine A, an alkaloid initially identified from
CRD42020143432 Lithium and suicide prevention in mood disorders and in the general population:
→ Bipolar disorder, Major Depressive Disorder, Schiz
CRD42022353926 A comparison of the effectiveness of available treatment options for depressive
→ Domain being studied is Depression. Depression is
CRD42023449031 Fermented Foods and Mental Health: A Systematic Review of the Evidence.
→ Depression, anxiety, and traumatic stress-related
CRD42023425213 The Efficacy of Curcumin in Reducing Depressive Symptoms: A Systematic Review
→ Depression and Major Depressive Disorder
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
empty — needs
HERB_herb_ingredientimport - Ingredient ↔ Target:
empty — needs
HERB_ingredient_targetimport - Target ↔ Disease:
empty — needs
HERB_target_diseaseimport - Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables