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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Adrenaline

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Adrenaline

Anaphylaxis (food, venom) 1 Gastric Polyp|Gastric Neoplasm|Duodenal Neoplasms|Esophageal 1 The domain being studied in the research is the treatment of 1 Acute Bronchiolitis 1 Bleeding|Hemoptysis 1 The definition of out-of-hospital cardiac arrest (OHCA) is t 1 Shoulder Rotator Cuff Tendinitis 1 Out-of-hospital cardiac arrest. 1 Shock 1 Out-hospital cardiac arrest (OHCA) are a major public health 1 Placenta Accreta|Placenta Previa 1 Neonates (≤ 28 days) Standard dose epinephrine is 0.01-0.03 1

📋 Sample Trials

NCT05439213

Comparison of the Effects of Two Concentrations of Adrenaline (0.33 mg/l vs 1 mg/l) in the Irrigation Serum of Arthroscopic Shoulder Surgery

Completed

NCT05738564

Epinephrine Nebulization Prior to Nasotracheal Intubation

Completed · Phase 3

NCT06115473

Epinephrine to Prevent Postintubation Collapse in Shocked ICU Patients

Recruiting

📊 Sample Meta-Analyses

CRD42017069109

Systematic review and meta-analysis of the need for more than 1 dose of adrenaline (epinephrine) given during anaphylaxis

Anaphylaxis (food, venom)

CRD42017079472

Protocol for a systematic review of the safety and efficacy of adrenaline therapy administered by any route for acute severe exacerbations of asthma

We are investigating the use of adrenaline/ephinephrine, administered by any rou

CRD42015026148

Impact of combining adrenaline with local anaesthetics for peripheral nerve blocks and spinal anesthesia on intra- and postoperative pain and adverse effects: a systematic review and meta-analysis of randomised trials

The study looked at health problem related to intra- and postoperative pain and

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Adrenaline

⚗️ Identity

Name

Adrenaline

Aliases / Synonyms

epinephrine; l-Adrenaline; 51-43-4; L-epinephrine; Adrenalin; Levoepinephrine; Nephridine; Adnephrine; Chelafrin

🧪 Chemistry

Molecular Weight

183.2070

LogP

0.3506

Drug-likeness

0.51

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CNCC(C1=CC(=C(C=C1)O)O)O

Isomeric SMILES

CNC[C@@H](C1=CC(=C(C=C1)O)O)O

InChIKey

UCTWMZQNUQWSLP-VIFPVBQESA-N

InChI

InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

🔗 External References

HERB DB

HBIN014742 ↗

PubChem CID

5816 ↗

TCMID

653

TCM-ID

20982

🔍 Raw view — every non-empty column on this row (28 fields)

name

Adrenaline

common names

epinephrine; l-Adrenaline; 51-43-4; L-epinephrine; Adrenalin; Levoepinephrine; Nephridine; Adnephrine; Chelafrin

herb ingredient id

HBIN014742

canonical smiles

CNCC(C1=CC(=C(C=C1)O)O)O

isomeric smiles

CNC[C@@H](C1=CC(=C(C=C1)O)O)O

inchi

InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

inchikey

UCTWMZQNUQWSLP-VIFPVBQESA-N

mol wt

183.2070

num h acceptors

num h donors

mol logp

0.3506

num rotatable bonds

drug likeness

0.51

tcmid ingredient id

653

tcm id ingredient id

20982

pubchem cid

5816

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Shock

phenotype

📋 Clinical Trials

11 · subject of clinical study

NCT05439213 Comparison of the Effects of Two Concentrations of Adrenaline (0.33 mg/l vs 1 mg

→ Shoulder Rotator Cuff Tendinitis

NCT05738564 Epinephrine Nebulization Prior to Nasotracheal Intubation

→ Nasal Bleeding

NCT06115473 Epinephrine to Prevent Postintubation Collapse in Shocked ICU Patients

→ Shock

NCT05881915 Epinephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal A

→ Hypotension During Surgery

NCT06149091 Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and H

→ Iatrogenic Endobronchial Bleeding

NCT05867342 Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus

→ Intraoperative Bleeding

NCT05822765 Effect of Adrenaline Concentration on Intraoperative Hemodynamics of Liposuction

→ Intraoperative Hemodynamics|Liposuction

NCT06030479 Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bl

→ Placenta Accreta|Placenta Previa

NCT06145191 Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy

→ Bleeding|Hemoptysis

NCT05688020 Tranexamic Acid During Upper GI Endoscopic Resection Procedures

→ Gastric Polyp|Gastric Neoplasm|Duodenal Neoplasms|

NCT05806307 Methods Decreasing Bleeding in Open Myomectomy

→ Misoprostol Allergy|Oxytocin Allergy|Tranexamic Ac

📊 Meta-Analyses

12 · systematic review

CRD42017069109 Systematic review and meta-analysis of the need for more than 1 dose of adrenali

→ Anaphylaxis (food, venom)

CRD42017079472 Protocol for a systematic review of the safety and efficacy of adrenaline therap

→ We are investigating the use of adrenaline/ephinep

CRD42015026148 Impact of combining adrenaline with local anaesthetics for peripheral nerve bloc

→ The study looked at health problem related to intr

CRD42017057292 Appropriate use of adrenaline-containing local anaesthetics in adult dental pati

→ Interaction of adrenaline-containing local anaesth

CRD42018111763 The effect of adrenaline in return of spontaneous circulation in out-of-hospital

→ Out-of-hospital cardiac arrest.

CRD42019119926 Pharmacokinetic and pharmacodynamic evidence of adrenaline administered via auto

→ Treatment of anaphylaxis using an adrenaline auto-

CRD42019132219 Timing, route and dose of epinephrine (adrenaline)

→ Neonates (≤ 28 days) Standard dose epinephrine is

CRD42019134415 Prehospital adrenaline administration for out of hospital cardiac arrest: a syst

→ The definition of out-of-hospital cardiac arrest (

CRD42020183961 Intravenous versus intraosseous adrenaline administration in out-of-hospital car

→ Out-hospital cardiac arrest (OHCA) are a major pub

CRD42020199195 Efficacy of adrenaline for traumatic out-of-hospital cardiac arrest: a systemati

→ Clinical studies evaluating the effect of adrenali

CRD42020211518 Effects of nebulized adrenaline in association with hypertonic saline for infant

→ Acute Bronchiolitis

CRD42021279446 Clonidine versus Adrenaline as an adjunct to Lignocaine on hemodynamic parameter

→ hemodynamic parameters when clonidine is used as a

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables