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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Aldosterone

Open on HERB 2.0 ↗
5
Clinical Trials
9
Meta-Analyses
0
PubMed References
Top Conditions Studied with Aldosterone
Heart failure (HF) is a severe clinical syndrome that result 1 Diabetes Mellitus 1 Coronavirus disease 2019 (COVID-19), a global pandemic, emer 1 Aldosteronism 1 Contrast-induced nephropathy 1 Chronic Kidney Disease. The efficacy and safety of Renin–Ang 1 Chronic kidney disease 1 Atrial fibrillation is the most common cardiac arrhythmia. R 1 Acute kidney injury, Renin Angiotensin Aldosterone System in 1 Acute coronary syndrome, ST elevation myocardial infarction, 1 Inflammation 1 Hyperaldosteronism; Primary 1
📋 Sample Trials
NCT00700479
Studies on Aldosterone and Vascular Function
Completed · Phase 1
NCT00732160
Aldosterone and Glucose Homeostasis
Completed
NCT01944384
Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart
Completed · Phase 4
📊 Sample Meta-Analyses
CRD42017077269
Outcomes of early aldosterone inhibition in acute coronary syndrome: a meta-analysis
Acute coronary syndrome, ST elevation myocardial infarction, non-ST elevation my
CRD42019145995
Aldosterone antagonists for people with chronic kidney disease requiring dialysis [Cochrane protocol]
The Cochrane Kidney and Transplant Group
CRD42020151388
Impact of renin-angiotensin-aldosterone system (RAAS) blockade on contrast-induced nephropathy in patients with renal insufficiency: a meta-analysis
Contrast-induced nephropathy
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for Aldosterone
⚗️ Identity
Name
Aldosterone
Aliases / Synonyms
52-39-1; Electrocortin; Aldocortin; Aldocorten; Aldocortene; (+)-Aldosterone; Reichstein X; Elektrocortin; d-Aldosterone
🧪 Chemistry
Molecular Weight
360.4500
LogP
1.8457
Drug-likeness
0.75
H-Bond Acceptors
5
H-Bond Donors
2
Rotatable Bonds
3
🔬 Structures
Canonical SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
InChIKey
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
InChI
InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
🔗 External References
HERB DB
HBIN015105 ↗
PubChem CID
5839 ↗
NPASS
NPC192428
HIT
C0868
TCMID
880
TCM-ID
7046
🔍 Raw view — every non-empty column on this row (30 fields)
name
Aldosterone
common names
52-39-1; Electrocortin; Aldocortin; Aldocorten; Aldocortene; (+)-Aldosterone; Reichstein X; Elektrocortin; d-Aldosterone
herb ingredient id
HBIN015105
canonical smiles
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
isomeric smiles
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C=O)O
inchi
InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1
inchikey
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
mol wt
360.4500
num h acceptors
5
num h donors
2
mol logp
1.8457
num rotatable bonds
3
drug likeness
0.75
tcmid ingredient id
880
tcm id ingredient id
7046
pubchem cid
5839
npass id
NPC192428
hit id
C0868

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)
Diabetes Mellitus
group
Inflammation
phenotype

📋 Clinical Trials

5 · subject of clinical study
NCT00700479 Studies on Aldosterone and Vascular Function
→ Inflammation
NCT00732160 Aldosterone and Glucose Homeostasis
→ Diabetes Mellitus
NCT01944384 Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patient
→ Diastolic Heart Failure
NCT05640128 Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of
→ Hyperaldosteronism; Primary
NCT05232162 Establishment of Aldosterone and Renin Reference Range
→ Aldosteronism

📊 Meta-Analyses

9 · systematic review
CRD42017077269 Outcomes of early aldosterone inhibition in acute coronary syndrome: a meta-anal
→ Acute coronary syndrome, ST elevation myocardial i
CRD42019145995 Aldosterone antagonists for people with chronic kidney disease requiring dialysi
→ The Cochrane Kidney and Transplant Group
CRD42020151388 Impact of renin-angiotensin-aldosterone system (RAAS) blockade on contrast-induc
→ Contrast-induced nephropathy
CRD42020179398 Efficacy and Safety of Dual vs. Single Renin–Angiotensin–Aldosterone System Bloc
→ Chronic Kidney Disease. The efficacy and safety of
CRD42020204885 The effect of Renin Angiotensin Aldosterone System inhibitor major kidney outcom
→ Acute kidney injury, Renin Angiotensin Aldosterone
CRD42020207248 The effects of ACEI/ARB, aldosterone receptor antagonists and statins on prevent
→ Atrial fibrillation is the most common cardiac arr
CRD42020208447 Individual patient data meta-analysis of renin-angiotensin-aldosterone system in
→ Coronavirus disease 2019 (COVID-19), a global pand
CRD42021256586 Effect of aldosterone antagonists on outcomes and cardiac function in patients w
→ Heart failure (HF) is a severe clinical syndrome t
CRD42021261806 Clinical outcomes of renin-angiotensin aldosterone blockade in patient with adva
→ Chronic kidney disease
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables