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trials · metas · refs
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⚗️ Ingredient

Alpha-lipoic acid

Open on HERB 2.0 ↗
8
Clinical Trials
38
Meta-Analyses
0
PubMed References
Top Conditions Studied with Alpha-lipoic acid
Healthy, overweight or obese individuals, and those with any 2 Women with polycystic ovary syndrome 1 Alpha-lipoic acid supplementation for type 2 diabetes patien 1 Obesity 1 Ischemic Cardiomyopathy|Diabetes Mellitus 1 Endothelial dysfunction has been considered as an early feat 1 Tolerability and efficacy of alpha-lipoic acid for the manag 1 Alpha-lipoic acid supplementation for type 1 diabetes patien 1 Burning Mouth Syndrome 1 Non-alcoholic fatty liver diseases (NAFLD) 1 Effect of riboflavin, magnesium, vitamin D, Q10, omega-3, al 1 Tinnitus in adults with chronic or acute tinnitus through th 1
📋 Sample Trials
NCT05485259
Effect of Alpha-lipoic Acid on Regression of Low-grade Squamous Intraepithelial Lesions (LSIL)
Completed
NCT05808946
Alpha-Lipoic Acid in Patients With Sepsis
Recruiting · Phase 2|Phase 3
NCT06056687
Alpha-lipoic Acid in Diabetic Patients With Ischemic Cardiomyopathy
Completed
📊 Sample Meta-Analyses
CRD42016045210
Effect of alpha-lipoic acid supplementation on endothelial function: a systematic review and meta-analysis of randomized controlled trials
Endothelial dysfunction has been considered as an early feature in the progressi
CRD42017055776
Alpha-lipoic acid supplement in obesity treatment: a systematic review and meta-analysis of clinical trials
Obesity
CRD42022321714
Alpha-lipoic acid reduce CRP level: a meta-analysis of randomized clinical trials
CRP. Alpha-lipoic acid.
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for Alpha-lipoic acid
⚗️ Identity
Name
Alpha-lipoic acid
Aliases / Synonyms
thioctic acid; dl-Thioctic acid; 1077-28-7; 5-(1,2-Dithiolan-3-yl)pentanoic acid; DL-alpha-Lipoic acid; 1,2-dithiolane-3-pentanoic acid; alpha Lipoic Acid; Biletan; 6,8-Thioctic acid
🧪 Chemistry
Molecular Weight
206.3320
LogP
2.7851
Drug-likeness
0.554
H-Bond Acceptors
3
H-Bond Donors
1
Rotatable Bonds
5
🔬 Structures
Canonical SMILES
C1CSSC1CCCCC(=O)O
Isomeric SMILES
C1CSSC1CCCCC(=O)O
InChIKey
AGBQKNBQESQNJD-UHFFFAOYSA-N
InChI
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
🔗 External References
HERB DB
HBIN015585 ↗
PubChem CID
864 ↗
TCMID
23187; 12894
TCM-ID
10022
🔍 Raw view — every non-empty column on this row (28 fields)
name
Alpha-lipoic acid
common names
thioctic acid; dl-Thioctic acid; 1077-28-7; 5-(1,2-Dithiolan-3-yl)pentanoic acid; DL-alpha-Lipoic acid; 1,2-dithiolane-3-pentanoic acid; alpha Lipoic Acid; Biletan; 6,8-Thioctic acid
herb ingredient id
HBIN015585
canonical smiles
C1CSSC1CCCCC(=O)O
isomeric smiles
C1CSSC1CCCCC(=O)O
inchi
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
inchikey
AGBQKNBQESQNJD-UHFFFAOYSA-N
mol wt
206.3320
num h acceptors
3
num h donors
1
mol logp
2.7851
num rotatable bonds
5
drug likeness
0.554
tcmid ingredient id
23187; 12894
tcm id ingredient id
10022
pubchem cid
864

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)
Burning Mouth Syndrome
syndrome
Sepsis
syndrome

📋 Clinical Trials

8 · subject of clinical study
NCT05485259 Effect of Alpha-lipoic Acid on Regression of Low-grade Squamous Intraepithelial
→ Low-Grade Squamous Intraepithelial Lesions
NCT05808946 Alpha-Lipoic Acid in Patients With Sepsis
→ Sepsis
NCT06056687 Alpha-lipoic Acid in Diabetic Patients With Ischemic Cardiomyopathy
→ Ischemic Cardiomyopathy|Diabetes Mellitus
NCT06151652 Effect of Alpha-Lipoic Acid Supplementation on the Incidence of Postoperative At
→ Postoperative Atrial Fibrillation
NCT05813496 Phase IV Trial to Evaluate Efficacy of Alpha-Lipoic Acid in Treating Symptomatic
→ Polyneuropathy, Diabetic
NCT05729529 Impact of Alpha Lipoic Acid Efficacy in Burning Mouth Syndrome
→ Burning Mouth Syndrome
NCT05913986 Supplementation With Alpha-lipoic Acid and Silybum Marianum(LUDLEV®) for the Imp
→ Metabolic Associated Fatty Liver Disease
NCT06131918 Assessment of Antioxidant Therapy on Oxidative Stress Biomarkers in Type 2 Diabe
→ Peripheral Diabetic Neuropathy

📊 Meta-Analyses

12 · systematic review
CRD42016045210 Effect of alpha-lipoic acid supplementation on endothelial function: a systemati
→ Endothelial dysfunction has been considered as an
CRD42017055776 Alpha-lipoic acid supplement in obesity treatment: a systematic review and meta-
→ Obesity
CRD42022321714 Alpha-lipoic acid reduce CRP level: a meta-analysis of randomized clinical trial
→ CRP. Alpha-lipoic acid.
CRD42022322953 The effects of alpha-lipoic acid supplementation in patients with metabolic diso
→ However, people consume alpha-lipoic acid for thes
CRD42021289390 Efficacy of Alpha-Lipoic Acid for the Treatment of Carpal Tunnel Syndrome: A Sys
→ Carpal tunnel syndrome (CTS) refers to symptoms an
CRD42021290489 Efficacy of alpha-lipoic acid (ALA) in patients with burning mouth syndrome (BMS
→ Burning Mouth Syndrome (BMS)
CRD42017073803 Effect of alpha-lipoic acid supplementation on inflammatory and metabolic factor
→ Alpha-lipoic acid, inflammatory markers, metabolic
CRD42019145592 Effect of oral alpha-lipoic acid on the treatment of male infertility: a systema
→ There are approximately 200 million infertile pati
CRD42020165857 The effects of Alpha-Lipoic acid supplementation on obesity measures: An updated
→ Healthy, overweight or obese individuals, and thos
CRD42020178466 Effects of inositol and alpha-lipoic acid combination in women with polycystic o
→ Polycystic ovary syndrome (PCOS) is a common endoc
CRD42020180226 The effects of Alpha-Lipoic acid supplementation on inflammation markers: An upd
→ Healthy, overweight or obese individuals, and thos
CRD42020180241 The effects of Alpha-Lipoic acid supplementation on glycemic markers: An updated
→ Healthy, overweight or obese individuals, and thos
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables