Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Abetalipoproteinemia Abortion, Habitual Agenesis Acanthamoeba Keratitis Acanthosis Nigricans Achondrogenesis Achondroplasia Acne Vulgaris Acne Keloid Apert Syndrome

🏥 Disease / Health Topic

Hypothyroidism

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

📋 Sample Trials

NCT00498238

The Effect of Levothyroxine on Arterial Stiffness and Lipid Profile in Patients With Subclinical Hypothyroidism

Completed

NCT01831869

Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism

Unknown · Phase 4

NCT01848171

Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism

Unknown · Phase 4

📊 Sample Meta-Analyses

CRD42020047084

Concomitant use of levothyroxine and proton pump inhibitors in patients with primary hypothyroidism: a systematic review

Primary hypothyroidism and dyspepsia, gastroesophageal reflux or peptic ulcer.

CRD42017079808

The impact of levothyroxine therapy in pregnant women with subclinical hypothyroidism on obstetrical and childhood outcomes: systematic review and meta-analysis of randomized controlled trials

Subclinical hypothyroidism in pregnancy.

CRD42018089578

Effectiveness of levothyroxine therapy on pregnancy outcomes in women with subclinical hypothyroidism: systematic review and meta-analysis of RCTs

Levothyroxine therapy Levothyroxine therapy for subclinical hypothyroidism

📚 Sample References

None linked yet.

🏥 All Disease / Health Topic data fields for Hypothyroidism

🏥 Names

Disease Name

Hypothyroidism

Alias Names

Hypothyroidism; Primary Hypothyroidism; Hypothyroidism, Unspecified; Hypothyroidism, Central; Tsh Deficiency; Low T4; Underactive Thyroid; Myxedema

Topic Type

syndrome

🧬 Ontology Classifications

DisGeNET Type

disease

UMLS Type

Disease or Syndrome

MeSH Class

Endocrine System Diseases

HPO Class

Abnormality of the endocrine system

DO Class

disease of anatomical entity

🔗 External References

HERB DB

MeSH

ICD-10

HPO

Disease Ontology

11634; 1459

DisGeNET

C0020676

🔍 Raw view — every non-empty column on this row (30 fields)

name

Hypothyroidism

alias name

Hypothyroidism; Primary Hypothyroidism; Hypothyroidism, Unspecified; Hypothyroidism, Central; Tsh Deficiency; Low T4; Underactive Thyroid; Myxedema

topic type

syndrome

disgenet disease type

disease

umls disease type

Disease or Syndrome

mesh disease class

Endocrine System Diseases

hpo disease class

Abnormality of the endocrine system

do disease class

disease of anatomical entity

umls disease type id

T047

mesh disease class id

C19

hpo disease class id

HP:0000818

do disease class id

DOID:7

herb disease id

HBDIS001505

disgenet id

C0020676

mesh id

D007037

hpo id

HP:0000821

do id

11634; 1459

icd10 id

E03.9

⚗️ Related Ingredients

4 · shared evidence

3,5,3',5'-tetraiodothyronine

3,5,3'-triiodothyronine

Femara

Vitamin c

📋 Clinical Trials

12 · subject of clinical study

NCT00498238 The Effect of Levothyroxine on Arterial Stiffness and Lipid Profile in Patients

→ Subclinical Hypothyroidism

NCT01831869 Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypot

→ Hypothyroidism|Thyroid Diseases|Endocrine System D

NCT01848171 Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothy

→ Hypothyroidism|Thyroid Diseases|Endocrine System D

NCT01916304 Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test F

→ Hypothyroidism

NCT02090907 Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hy

→ Subclinical Hypothyroidism

NCT02374593 Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism

→ Congenital Hypothyroidism

NCT02467244 Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascu

→ Hypothyroidism

NCT02567877 Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

→ Postsurgical Hypothyroidism|Hypothyroidism

NCT03094416 Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors

→ Hypothyroidism;Postablative

NCT03102177 Effect of Age, Weight and Sex on Levothyroxine Pharmacokinetics

→ Hypothyroidism Primary

NCT04288115 Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyro

→ Subclinical Hypothyroidism

NCT04878614 Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Fee

→ Hypothyroidism

📊 Meta-Analyses

12 · systematic review

CRD42020047084 Concomitant use of levothyroxine and proton pump inhibitors in patients with pri

→ Primary hypothyroidism and dyspepsia, gastroesopha

CRD42017079808 The impact of levothyroxine therapy in pregnant women with subclinical hypothyro

→ Subclinical hypothyroidism in pregnancy.

CRD42018089578 Effectiveness of levothyroxine therapy on pregnancy outcomes in women with subcl

→ Levothyroxine therapy Levothyroxine therapy for su

CRD42018093138 Effect of levothyroxine on blood pressure in patients with subclinical hypothyro

→ Subclinical hypothyroidism (SCH) is a state with e

CRD42018106182 Effect of levothyroxine on improvement in endothelial dysfunction in subclinical

→ Subclinical hypothyroidism

CRD42019123920 A systematic review of blinded randomized controlled trials examining how often

→ Hypothyroidism of any etiology (the cause of the h

CRD42020168962 Pregnancy and Neonatal Outcomes With Levothyroxine Treatment in Women With Subcl

→ Levothyroxine treatment for subclinical hypothyroi

CRD42020202658 Levothyroxine/liothyronine combination therapy versus levothyroxine monotherapy

→ Hypothyroidism is a highly prevalent endocrine dis

CRD42020202658 Levothyroxine/liothyronine combination therapy versus levothyroxine monotherapy

→ Hypothyroidism is a highly prevalent endocrine dis

CRD42022296723 Levothyroxine treatment and pregnancy outcomes in women with subclinical hypothy

→ Subclinical hypothyroidism (SCH) is the most commo

CRD42022298286 Association between levothyroxine usage and cancer occurrence: A systematic revi

→ Levothyroxine is a thyroid hormone derivative pres

CRD42022308006 Cardiovascular and bone health consequences of prescribing levothyroxine in the

→ Hypothyroidism is a common chronic disease caused

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables