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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Artesunate

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Artesunate

Pregnancy|Malaria 1 Plasmodium Falciparum Infection 1 The systematic review focuses on malaria treatment. It conta 1 The protozoan parasite Plasmodium falciparum is responsible 1 Severe malaria causes more than 800, 000 deaths every year. 1 Praziquantel (PZQ) is recommended for the treatment and cont 1 Vulvar Diseases|HPV Infection|Vulvar HSIL|Pre-Cancerous Dysp 1

📋 Sample Trials

NCT05285735

Observational Study of the Safety of Intravenous Artesunate Treatment of Pregnant Women and Their Infants

Recruiting

NCT06075264

Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3)

Recruiting · Phase 2

NCT05750459

Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria

Recruiting · Phase 4

📊 Sample Meta-Analyses

CRD42017054193

Artesunate plus mefloquine for treating uncomplicated Plasmodium falciparum malaria

The protozoan parasite Plasmodium falciparum is responsible for over 90% of mala

CRD42020197640

A systematic review and meta-analysis of adjunctive therapy with artesunate in patients with severe malaria

Severe malaria causes more than 800, 000 deaths every year. Primary therapy with

CRD42023432718

Monitoring of the efficacy of artemisinin-based combination therapies and trend of resistance molecular markers of Plasmodium falciparum to antimalarial drugs over ten years in sub-Saharan Africa: a systematic review and meta-analysis

The systematic review focuses on malaria treatment. It contains two parts. First

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Artesunate

⚗️ Identity

Name

Artesunate

Aliases / Synonyms

Artesunic acid; Arsumax; 88495-63-0; Plasmotrin; Qinghaozhi; Saphnate; Artesunatum; Arinate; Dihydroqinghasu hemsuccinate

🧪 Chemistry

Molecular Weight

384.4250

LogP

2.6024

Drug-likeness

0.583

Oral Bioavailability

15.8910

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C

Isomeric SMILES

C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C

InChIKey

FIHJKUPKCHIPAT-AHIGJZGOSA-N

InChI

InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

SymMap

8872

TCMSP

MOL007434

🔍 Raw view — every non-empty column on this row (31 fields)

name

Artesunate

common names

Artesunic acid; Arsumax; 88495-63-0; Plasmotrin; Qinghaozhi; Saphnate; Artesunatum; Arinate; Dihydroqinghasu hemsuccinate

herb ingredient id

HBIN016977

canonical smiles

CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C

isomeric smiles

C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C

inchi

InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1

inchikey

FIHJKUPKCHIPAT-AHIGJZGOSA-N

mol wt

384.4250

num h acceptors

num h donors

mol logp

2.6024

num rotatable bonds

drug likeness

0.583

ob score

15.8910

cas id

88495-63-0

symmap mol id

8872

tcmsp ingredient id

MOL007434

pubchem cid

6917864

drugbank id

DB09274

📋 Clinical Trials

3 · subject of clinical study

NCT05285735 Observational Study of the Safety of Intravenous Artesunate Treatment of Pregnan

→ Pregnancy|Malaria

NCT06075264 Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squ

→ Vulvar Diseases|HPV Infection|Vulvar HSIL|Pre-Canc

NCT05750459 Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria

→ Plasmodium Falciparum Infection

📊 Meta-Analyses

4 · systematic review

CRD42017054193 Artesunate plus mefloquine for treating uncomplicated Plasmodium falciparum mala

→ The protozoan parasite Plasmodium falciparum is re

CRD42020197640 A systematic review and meta-analysis of adjunctive therapy with artesunate in p

→ Severe malaria causes more than 800, 000 deaths ev

CRD42023432718 Monitoring of the efficacy of artemisinin-based combination therapies and trend

→ The systematic review focuses on malaria treatment

CRD42023467293 Efficacy and safety of Praziquantel and Artemisinin-based combination therapy fo

→ Praziquantel (PZQ) is recommended for the treatmen

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables